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  1. Neurocognitive disorders and psychosocial difficulties are common in patients with Turner syndrome and multiple neurodegenerative diseases, yet there is no effective cure. Human primordial germ cells (hPGCs) a...

    Authors: Dantong Shang, Tian Lan, Yue Wang, Xuanyu Li, Quanyi Liu, Huimin Dong, Bo Xu, Hanhua Cheng and Rongjia Zhou
    Citation: Cell & Bioscience 2022 12:194
  2. Systemic identification of tumor suppressor genes (TSGs) and elucidation of their signaling provide a new angle for understanding of tumorigenesis, which is important for developing successful treatment for lu...

    Authors: Lu Liu, Yuxi Lei, Wensheng Chen, Qian Zhou, Zongyao Zheng, Guandi Zeng, Wanting Liu, Pengju Feng, Zhiyi Zhang, Lei Yu and Liang Chen
    Citation: Cell & Bioscience 2022 12:193
  3. Inhibitors of ornithine decarboxylase (ODC) are effective at preventing colorectal cancer (CRC). However, their high toxicity limits their clinical application. This study was aimed to explore the potential of...

    Authors: Ningning Liu, Tianpeng Zhang, Clifford J. Steer and Guisheng Song
    Citation: Cell & Bioscience 2022 12:192
  4. Mechanical loading promotes bone formation and osteocytes are a major mechanosensory cell in the bone. Both Piezo1 channels and connexin 43 hemichannels (Cx43 HCs) in osteocytes are important players in mechan...

    Authors: Yan Zeng, Manuel A. Riquelme, Rui Hua, Jingruo Zhang, Francisca M. Acosta, Sumin Gu and Jean X. Jiang
    Citation: Cell & Bioscience 2022 12:191
  5. Pregnenolone (P5) is a neurosteroid that promotes microtubule polymerization. It also reduces stress and negative symptoms of schizophrenia, promotes memory, as well as recovery from spinal cord injury. P5 is ...

    Authors: Viktoryia Kolas, Jose Sandino A. Bandonil, Niaz Wali, Kuo-Chiang Hsia, Jiun-Jie Shie and Bon-chu Chung
    Citation: Cell & Bioscience 2022 12:190
  6. Schizophrenia is a complex and severe neuropsychiatric disorder, with a wide range of debilitating symptoms. Several aspects of its multifactorial complexity are still unknown, and some are accepted to be an e...

    Authors: Juliana Minardi Nascimento, Verônica M. Saia-Cereda, Giuliana S. Zuccoli, Guilherme Reis-de-Oliveira, Victor Corasolla Carregari, Bradley J. Smith, Stevens K. Rehen and Daniel Martins-de-Souza
    Citation: Cell & Bioscience 2022 12:189
  7. Acute liver failure caused by drug overdose is a significant clinical problem in developed countries. Acetaminophen (APAP), a widely used analgesic and antipyretic drug, but its overdose can cause acute liver ...

    Authors: Qianhui Li, Feng Chen and Fei Wang
    Citation: Cell & Bioscience 2022 12:187
  8. Diabetic retinopathy (DR), a specific neuron-vascular complication of diabetes, is a major cause of vision loss among middle-aged people worldwide, and the number of DR patients will increase with the increasi...

    Authors: Chunyang Cai, Chunren Meng, Shuai He, Chufeng Gu, Thashi Lhamo, Deji Draga, Dawei Luo and Qinghua Qiu
    Citation: Cell & Bioscience 2022 12:186
  9. Early studies indicated that the androgen receptor (AR) could promote renal cell carcinoma (RCC) development and metastasis, but its linkage to RCC progression under hypoxia, remains unclear.

    Authors: Changcheng Guo, Yin Sun, Wei Zhai, Xudong Yao, Dongkui Gong, Bosen You, Chi-Ping Huang, Junhua Zheng and Chawnshang Chang
    Citation: Cell & Bioscience 2022 12:185
  10. Exploiting cancer metabolism during nutrient availability holds immense potential for the clinical and therapeutic benefits of hepatocellular carcinoma (HCC) patients. Dietary methionine is a metabolic depende...

    Authors: Liang Zhao, Huizhao Su, Xiaomeng Liu, Hongquan Wang, Yukuan Feng, Yan Wang, Haiqiang Chen, Luo Dai, Shihui Lai, Siqi Xu, Chong Li, Jihui Hao and Bo Tang
    Citation: Cell & Bioscience 2022 12:183
  11. Semaphorins (Sema) belong to a large family of repellent guidance cues instrumental in guiding axons during development. In particular, Class 3 Sema (Sema 3) is among the best characterized Sema family members...

    Authors: Gabriella Ferretti, Alessia Romano, Rossana Sirabella, Sara Serafini, Thorsten Jürgen Maier and Carmela Matrone
    Citation: Cell & Bioscience 2022 12:182
  12. Human primordial germ cells (hPGCs) initiate from the early post-implantation embryo at week 2–3 and undergo epigenetic reprogramming during development. However, the regulatory mechanism of DNA methylation du...

    Authors: Zili Li, Fang Fang, Yuting Long, Qian Zhao, Xiaotong Wang, Zhen Ye, Tianqing Meng, Xiuli Gu, Wenpei Xiang, Chengliang Xiong and Honggang Li
    Citation: Cell & Bioscience 2022 12:181
  13. Neurite dystrophy is a pathologic hallmark of Alzheimer’s disease (AD). However, drug discovery targeting neurite protection in AD remains largely unexplored.

    Authors: Yuyuan Yao, Zhichu Ren, Ruihan Yang, Yilan Mei, Yuying Dai, Qian Cheng, Chong Xu, Xiaogang Xu, Sanying Wang, Kyoung Mi Kim, Ji Heon Noh, Jian Zhu, Ningwei Zhao, Yong U. Liu, Genxiang Mao and Jian Sima
    Citation: Cell & Bioscience 2022 12:180
  14. Retinoic acid(RA), an embryonic morphogen, regulates cell differentiation. Endocytosis regulates receptor signaling that governs such RA-directed cellular processes. Vacuolin-1 is a small molecule that disrupt...

    Authors: Kaiyuan Zhu, Noor Kazim, Jianbo Yue and Andrew Yen
    Citation: Cell & Bioscience 2022 12:179

    The Correction to this article has been published in Cell & Bioscience 2023 13:22

  15. Central nervous system (CNS) control of metabolism plays a pivotal role in maintaining energy balance. In the brain, Glucagon-like peptide 1 (GLP-1), encoded by the proglucagon ‘Gcg gene, produced in a distinct ...

    Authors: Ishnoor Singh, Le Wang, Baijuan Xia, Ji Liu, Azeddine Tahiri, Abdelfattah El Ouaamari, Michael B. Wheeler and Zhiping P. Pang
    Citation: Cell & Bioscience 2022 12:178
  16. Corpora amylacea of human brain, recently renamed as wasteosomes, are granular structures that appear during aging and also accumulate in specific areas of the brain in neurodegenerative conditions. Acting as was...

    Authors: Marta Riba, Joan Campo-Sabariz, Iraida Tena, Laura Molina-Porcel, Teresa Ximelis, Maria Calvo, Ruth Ferrer, Raquel Martín-Venegas, Jaume del Valle, Jordi Vilaplana and Carme Pelegrí
    Citation: Cell & Bioscience 2022 12:177
  17. DNMT1 has been shown to be highly expressed in a variety of cancers, including breast cancer. However, the mechanism is not very clear. Therefore, we aim to reveal the mechanism of DNMT1 highly express in brea...

    Authors: Zhongwei Li, Pengfei Wang, Wenjie Cui, Hongmei Yong, Diandian Wang, Tiesuo Zhao, Wenwen Wang, Ming Shi, Junnian Zheng and Jin Bai
    Citation: Cell & Bioscience 2022 12:176
  18. The human endometrium is a highly regenerative tissue that is believed to have two main types of stem cells: endometrial mesenchymal/stromal stem cells (eMSCs) and endometrial epithelial stem cells (eESCs). So...

    Authors: Wen He, Xuejing Zhu, Aijie Xin, Hongdan Zhang, Yiming Sun, Hua Xu, He Li, Tianying Yang, Dan Zhou, Hexin Yan and Xiaoxi Sun
    Citation: Cell & Bioscience 2022 12:175
  19. The kidneys require vast amounts of mitochondria to provide ample energy to reabsorb nutrients and regulate electrolyte, fluid, and blood pressure homeostasis. The lack of the human model hinders the investiga...

    Authors: Yapei Yuan, Huan Chen, Sihua Ou, Baomei Cai, Ruifang Zhang, Yue Qin, Mengjie Pan, Shangtao Cao, Duanqing Pei and Fan Fan Hou
    Citation: Cell & Bioscience 2022 12:174
  20. Coronary artery disease (CAD) is a metabolically perturbed pathological condition. However, the knowledge of metabolic signatures on outcomes of CAD and their potential causal effects and impacts on left ventr...

    Authors: Qian Zhu, Min Qin, Zixian Wang, Yonglin Wu, Xiaoping Chen, Chen Liu, Qilin Ma, Yibin Liu, Weihua Lai, Hui Chen, Jingjing Cai, Yemao Liu, Fang Lei, Bin Zhang, Shuyao Zhang, Guodong He…
    Citation: Cell & Bioscience 2022 12:173

    The Correction to this article has been published in Cell & Bioscience 2022 12:201

  21. NAFLD has become the most common chronic liver disease worldwide. Human antigen R (HuR), an RNA-binding protein, is an important post-transcriptional regulator. HuR has been reported as a key player in regulat...

    Authors: Yanyan Wang, Yun-Ling Tai, Grayson Way, Jing Zeng, Derrick Zhao, Lianyong Su, Xixian Jiang, Kaitlyn G. Jackson, Xuan Wang, Emily C. Gurley, Jinze Liu, Jinpeng Liu, Weidong Chen, Xiang-Yang Wang, Arun J. Sanyal, Phillip B. Hylemon…
    Citation: Cell & Bioscience 2022 12:172
  22. Chemokine CXC motif receptor 7 (CXCR7) is an atypical G protein-coupled receptor (GPCR) that signals in a biased fashion. CXCL12/CXCR7 biased signal has been reported to play crucial roles in multiple stages o...

    Authors: Mahan Si, Yujia Song, Xiaohui Wang, Dong Wang, Xiaohui Liu, Xianjun Qu, Zhiyu Song and Xinfeng Yu
    Citation: Cell & Bioscience 2022 12:171
  23. Pro-opiomelanocortin (POMC) neurons play a sexually dimorphic role in body weight and glucose balance. However, the mechanisms for the sex differences in POMC neuron functions are not fully understood.

    Authors: Meng Yu, Jonathan C. Bean, Hailan Liu, Yang He, Yongjie Yang, Xing Cai, Kaifan Yu, Zhou Pei, Hesong Liu, Longlong Tu, Kristine M. Conde, Mengjie Wang, Yongxiang Li, Na Yin, Nan Zhang, Junying Han…
    Citation: Cell & Bioscience 2022 12:170
  24. Osteosarcoma is the most common primary bone tumor, with a poor prognosis owing to the lack of efficient molecular-based targeted therapies. Previous studies have suggested an association between CD151 and dis...

    Authors: Hongsheng Wang, Xinmeng Jin, Yangfeng Zhang, Zhuoying Wang, Tao Zhang, Jing Xu, Jiakang Shen, Pengfei Zan, Mengxiong Sun, Chongren Wang, Yingqi Hua, Xiaojun Ma and Wei Sun
    Citation: Cell & Bioscience 2022 12:169
  25. Early pregnancy loss (EPL) presents as sporadic or recurrent miscarriage during the first trimester. In addition to chromosomal defects, EPL may result from impairment of the placental-decidual interface at ea...

    Authors: Yuhua Zheng, Jing Pan, Chenglai Xia, Haiying Chen, Huadong Zhou, Weina Ju, Jerzy Wegiel, Leslie Myatt, James M. Roberts, Xiaoling Guo and Nanbert Zhong
    Citation: Cell & Bioscience 2022 12:168
  26. Huntington’s disease (HD) is a neurodegenerative disorder caused by aggregation of the mutant huntingtin (mHTT) protein encoded from extra tracts of CAG repeats in exon 1 of the HTT gene. mHTT proteins are neu...

    Authors: Jiahui Long, Xia Luo, Dongmei Fang, Haikun Song, Weibin Fang, Hao Shan, Peiqing Liu, Boxun Lu, Xiao-Ming Yin, Liang Hong and Min Li
    Citation: Cell & Bioscience 2022 12:167
  27. Krüppel-like factor 7 (klf7), a transcription factor in the nervous system to regulate cell proliferation and differentiation, has been recently identified as a causal gene for autism spectrum disorder (ASD), ...

    Authors: Hui Tian, Yanwen Jiao, Mingyue Guo, Yilin Wang, Ruiqi Wang, Cao Wang, Xiongbiao Chen and Weiming Tian
    Citation: Cell & Bioscience 2022 12:166
  28. Intrauterine inflammation (IUI) alters epigenetic modifications in offspring, leading to lung injury. However, the epigenetic mechanism underlying IUI-induced lung injury remains uncertain. In the present stud...

    Authors: Dongting Yao, Jiuru Zhao, Qianqian Zhang, Tao Wang, Meng Ni, Sudong Qi, Qianwen Shen, Wei Li, Baihe Li, Xiya Ding and Zhiwei Liu
    Citation: Cell & Bioscience 2022 12:164
  29. The liver plays crucial roles in sepsis and is one of the major targets for sepsis-related injuries. Ferroptosis, a newly emerged form of lytic cell death, has been implicated in sepsis related organ failure. ...

    Authors: Jin Wang, Qian Zhu, Rui Li, Jing Zhang, Xujun Ye and Xinyi Li
    Citation: Cell & Bioscience 2022 12:163
  30. Immune checkpoints are a set of costimulatory and inhibitory molecules that maintain self-tolerance and regulate immune homeostasis. The expression of immune checkpoints on T cells in malignancy, chronic infla...

    Authors: Ching-Tse Wu, Cheng-I Chu, Feng-Yu Wang, Hui-Yu Yang, Wei-Sung Tseng, Chuang-Rung Chang and Chien-Chung Chang
    Citation: Cell & Bioscience 2022 12:162
  31. Authors: Hongwei Wu, Fanna Liu, Yu Shangguan, Yane Yang, Wei Shi, Wenlong Hu, Zhipeng Zeng, Nan Hu, Xinzhou Zhang, Berthold Hocher, Donge Tang, Lianghong Yin and Yong Dai
    Citation: Cell & Bioscience 2022 12:161

    The original article was published in Cell & Bioscience 2022 12:80

  32. Telomere maintenance mechanisms (TMM) are a hallmark of high-risk neuroblastoma, and are conferred by activation of telomerase or alternative lengthening of telomeres (ALT). However, detection of TMM is not ye...

    Authors: Alina Meeser, Christoph Bartenhagen, Lisa Werr, Anna-Maria Hellmann, Yvonne Kahlert, Nadine Hemstedt, Peter Nürnberg, Janine Altmüller, Sandra Ackermann, Barbara Hero, Thorsten Simon, Martin Peifer, Matthias Fischer and Carolina Rosswog
    Citation: Cell & Bioscience 2022 12:160
  33. A healthy alveolar epithelium is critical to the gas exchange function of the lungs. As the major cell type of alveolar epithelium, alveolar type 2 (AT2) cells play a critical role in maintaining pulmonary hom...

    Authors: Linghuan Zhang, Wenping Luo, Jiang Liu, Maozhu Xu, Qi Peng, Wenjing Zou, Jingyi You, Yi Shu, Piao Zhao, William Wagstaff, Guozhi Zhao, Kevin Qin, Rex C. Haydon, Hue H. Luu, Russell R. Reid, Yang Bi…
    Citation: Cell & Bioscience 2022 12:159
  34. Abnormal lipid metabolism is one of the most prominent metabolic changes in cancer. Studies have shown that lipid metabolism also plays an important role in neuroblastoma. We recently discovered that the insul...

    Authors: Haibo Cao, Ran Zhuo, Zimu Zhang, Jianwei Wang, Yanfang Tao, Randong Yang, Xinyi Guo, Yanling Chen, Siqi Jia, Ye Yao, Pengcheng Yang, Juanjuan Yu, Wanyan Jiao, Xiaolu Li, Fang Fang, Yi Xie…
    Citation: Cell & Bioscience 2022 12:158
  35. Almost 400 years after the (re)discovery of the lymphatic vascular system (LVS) by Gaspare Aselli (Asellius G. De lactibus, sive lacteis venis, quarto vasorum mesaraicorum genere, novo invento Gasparis Asellii...

    Authors: Jörg Wilting and Jürgen Becker
    Citation: Cell & Bioscience 2022 12:157
  36. Clinical and animal studies demonstrated that neuroinflammation from anesthesia (sevoflurane) is the main contributor to cause perioperative neurocognitive disorders (PND). Recently, it was reported that micro...

    Authors: Feng Xu, Yafeng Wang, Linlin Han, Daling Deng, Yuanyuan Ding, LuLin Ma, Qingtong Zhang and Xiangdong Chen
    Citation: Cell & Bioscience 2022 12:156
  37. Cancer is a multifactorial disease that is responsible for 10 million deaths per year. The intra- and inter-heterogeneity of malignant tumors make it difficult to develop single targeted approaches. Similarly,...

    Authors: Camille Jubelin, Javier Muñoz-Garcia, Laurent Griscom, Denis Cochonneau, Emilie Ollivier, Marie-Françoise Heymann, François M. Vallette, Lisa Oliver and Dominique Heymann
    Citation: Cell & Bioscience 2022 12:155
  38. Sepsis is a fatal condition commonly caused by Methicillin-resistant Staphylococcus aureus (MRSA) with a high death rate. Macrophages can protect the host from various microbial pathogens by recognizing and elimi...

    Authors: Dongsheng Zhai, Wenwen Wang, Zichen Ye, Ke Xue, Guo Chen, Sijun Hu, Zhao Yan, Yanhai Guo, Fang Wang, Xubo Li, An Xiang, Xia Li, Zifan Lu and Li Wang
    Citation: Cell & Bioscience 2022 12:154
  39. Specific gene fusions and their fusion products (chimeric RNA and protein) have served as ideal diagnostic markers and therapeutic targets for cancer. However, few systematic studies for chimeric RNAs have bee...

    Authors: Qiong Wang, Junxiu Chen, Sandeep Singh, Zhongqiu Xie, Fujun Qin, Xinrui Shi, Robert Cornelison, Hui Li and Hai Huang
    Citation: Cell & Bioscience 2022 12:153
  40. Primary liver cancer (PLC) is the second leading cause of cancer mortality worldwide, and its morbidity unceasingly increases these years. Hepatitis B virus (HBV) infection accounted for approximately 50% of h...

    Authors: Renshun Dong, Bixiang Zhang and Xuewu Zhang
    Citation: Cell & Bioscience 2022 12:152
  41. Monoaminergic neurotransmitter systems play a central role in neuronal function and behaviour. Dysregulation of these systems gives rise to neuropsychiatric and neurodegenerative disorders with high prevalence...

    Authors: Mohamed H. Al-Sabri, Maryam Nikpour, Laura E. Clemensson, Misty M. Attwood, Michael J. Williams, Mathias Rask-Anderson, Jessica Mwinyi and Helgi B. Schiöth
    Citation: Cell & Bioscience 2022 12:151
  42. Extracellular vesicles (EVs) are membrane-enclosed particles released systemically by all cells, including tumours. Tumour EVs have been shown to manipulate their local environments as well as distal targets t...

    Authors: Laura Simone, Francesco Pisani, Elena Binda, Antonio Frigeri, Angelo L. Vescovi, Maria Svelto and Grazia P. Nicchia
    Citation: Cell & Bioscience 2022 12:150
  43. Apnea of prematurity (AOP) is caused by respiratory control immaturity and affects nearly 50% of premature newborns. This pathology induces perinatal intermittent hypoxia (IH), which leads to neurodevelopmenta...

    Authors: S. Leroux, A. Rodriguez-Duboc, A. Arabo, M. Basille-Dugay, D. Vaudry and D. Burel
    Citation: Cell & Bioscience 2022 12:148
  44. Sufficient nutrition contributes to rapid translational elongation and protein synthesis in eukaryotic cells and prokaryotic bacteria. Fast synthesis and accumulation of type III secretion system (T3SS) protei...

    Authors: Yue Sun, Xiaolong Shao, Yingchao Zhang, Liangliang Han, Jiadai Huang, Yingpeng Xie, Jingui Liu and Xin Deng
    Citation: Cell & Bioscience 2022 12:147
  45. Authors: Alan Carlos Alves Fernandes, Franciane Pereira de Oliveira, Gimena Fernandez, Luane da Guia Vieira, Cristiane Gugelmin Rosa, Taís do Nascimento, Suzelei de Castro França, Jose Donato Jr., Kristen R. Vella, Jose Antunes-Rodrigues, André Souza Mecawi, Mario Perello, Lucila Leico Kagohara Elias and Rodrigo Rorato
    Citation: Cell & Bioscience 2022 12:146

    The original article was published in Cell & Bioscience 2022 12:118

  46. Transcriptome analysis has been known as a functional tool for cancer research recently. Mounting evidence indicated that calcium signaling plays several key roles in cancer progression. Despite numerous studi...

    Authors: Shujin Li, Dong-Joon Lee, Hyun-Yi Kim, Jun-Young Kim, Young-Soo Jung and Han-Sung Jung
    Citation: Cell & Bioscience 2022 12:145