TRAMP mouse is a good mouse model to study prostate cancer. MeDIP-seq study on TRAMP model provides a novel insight into genome-wide methylation profile of prostate cancer. By comparing prostate DNA samples from TRAMP and wild type male mice using MeDIP-seq analysis, extensive difference in DNA methylation was found between them. Altered methylation levels in CREB-, HDAC2-, GSTP1- and UBC- signaling pathways were revealed. This work has discovered new targets and strategies for prevention and treatment approaches for human prostate cancer.
Dr Shi is a senior investigator and the Chief of Section on Molecular Morphogenesis, NICHD, NIH, and is currently serving as the Editor-in-Chief of Cell & Bioscience in his personal capacity. Dr Shi received his BS degree from Wuhan University, China, in 1982 and his PhD degree from University of California, Berkeley, CA, in 1988. After postdoctoral training at the Carnegie Institution, he established his own research group at NICHD, NIH, in 1992. Dr Shi has been studying the molecular basis of thyroid hormone regulation of vertebrate development by using Xenopus metamorphosis as a model system. Dr Shi has published over 130 research papers and 50 reviews/book chapters, edited three books and written a monograph on amphibian metamorphosis.