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Featured article: Epigenetic alterations in TRAMP mice: epigenome DNA methylation profiling using MeDIP-seq

TRAMP mouse is a good mouse model to study prostate cancer. MeDIP-seq study on TRAMP model provides a novel insight into genome-wide methylation profile of prostate cancer. By comparing prostate DNA samples from TRAMP and wild type male mice using MeDIP-seq analysis, extensive difference in DNA methylation was found between them. Altered methylation levels in CREB-, HDAC2-, GSTP1- and UBC- signaling pathways were revealed. This work has discovered new targets and strategies for prevention and treatment approaches for human prostate cancer.


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Aims and scope

Cell & Bioscience, the official journal of the Society of Chinese Bioscientists in America, is an open access, peer-reviewed journal that encompasses all areas of life science research.

Award winning research

The Ming K Jeang award for excellence in Cell & Bioscience is awarded annually to outstanding research published in the journal.

Read the award winning articles and submit your own research to the journal to be considered for this year's award.

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Trophies were awarded to the esteemed editorial board of Cell & Bioscience for their excellent service to the journal over the years. BMC thanks you for your service!

Yunbo Shi

Editor Profile

Dr Yun-Bo Shi, Editor-in-Chief

Dr Shi is a senior investigator and the Chief of Section on Molecular Morphogenesis, NICHD, NIH, and is currently serving as the Editor-in-Chief of Cell & Bioscience in his personal capacity. Dr Shi received his BS degree from Wuhan University, China, in 1982 and his PhD degree from University of California, Berkeley, CA, in 1988. After postdoctoral training at the Carnegie Institution, he established his own research group at NICHD, NIH, in 1992. Dr Shi has been studying the molecular basis of thyroid hormone regulation of vertebrate development by using Xenopus metamorphosis as a model system. Dr Shi has published over 130 research papers and 50 reviews/book chapters, edited three books and written a monograph on amphibian metamorphosis. 


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