Cell & Bioscience

Featured article: Class 2 CRISPR/Cas: an expanding biotechnology toolbox for and beyond genome editing

In this review, the authors discuss the myriad genome editing tools that use CRISPR/Cas9.  They elaborate on the definition, classification, structures of CRISPR/Cas Class 2 systems; advance our understanding of new molecular mechanisms and recent progress in their applications, especially beyond genome-editing applications; provide the insights on the specificity, efficiency and versatility of each tool; and elaborate the enhancement on specificity and efficiency of the CRISPR/Cas toolbox.

Editor Profile

Dr Yun-Bo Shi, Editor-in-Chief

Dr Shi is a senior investigator and the Chief of Section on Molecular Morphogenesis, NICHD, NIH, and is currently serving as the Editor-in-Chief of Cell & Bioscience in his personal capacity. Dr Shi received his BS degree from Wuhan University, China, in 1982 and his PhD degree from University of California, Berkeley, CA, in 1988. After postdoctoral training at the Carnegie Institution, he established his own research group at NICHD, NIH, in 1992. Dr Shi has been studying the molecular basis of thyroid hormone regulation of vertebrate development by using Xenopus metamorphosis as a model system. Dr Shi has published over 130 research papers and 50 reviews/book chapters, edited three books and written a monograph on amphibian metamorphosis.