Editorial
Cell & Bioscience 2017 7:53
Published on: 19 October 2017
Articles
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Research
Differential impact of various reactive oxygen species (ROS) on HIF-1α/p53 direct interaction in SK-N-MC neuroblastoma cells
A vital property of eukaryotic cells physiology is their rather quick response to variation of oxygen tension, mainly by a transcription factor known as hypoxia-inducible factor-1 (HIF-1). Aside from its trans...
Cell & Bioscience 2017 7:52
Published on: 10 October 2017
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Review
Apigenin in cancer therapy: anti-cancer effects and mechanisms of action
Apigenin is a common dietary flavonoid that is abundantly present in many fruits, vegetables and Chinese medicinal herbs and serves multiple physiological functions, such as strong anti-inflammatory, antioxida...
Cell & Bioscience 2017 7:50
Published on: 5 October 2017
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Research
miR-125a suppresses viability and glycolysis and induces apoptosis by targeting Hexokinase 2 in laryngeal squamous cell carcinoma
miR-125a usually functions as a tumor suppressor in cancers. However, the role of miR-125a in laryngeal squamous cell carcinoma (LSCC) has not been determined.
Cell & Bioscience 2017 7:51
Published on: 5 October 2017
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Research Highlight
Catching global interactions in vivo
Histone proteins and transcription factors (TFs) play critical roles in gene transcription and development of multicellular organisms. Although antibody mediated protein isolation couple with mass spectrometry...
Cell & Bioscience 2017 7:49
Published on: 29 September 2017
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Research highlight
A good sugar, d-mannose, suppresses autoimmune diabetes
It is well known that too much sugar uptake causes many health problems, including diabetes and obesity (Lustig et al. in Nature 482:27–29, 2012). However, a team of researchers led by Dr. Wanjun Chen of the Nati...
Cell & Bioscience 2017 7:48
Published on: 25 September 2017
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Research
Genome editing of the HIV co-receptors CCR5 and CXCR4 by CRISPR-Cas9 protects CD4+ T cells from HIV-1 infection
The main approach to treat HIV-1 infection is combination antiretroviral therapy (cART). Although cART is effective in reducing HIV-1 viral load and controlling disease progression, it has many side effects, a...
Cell & Bioscience 2017 7:47
Published on: 9 September 2017
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Research
Enhancing antitumor immunogenicity of HPV16-E7 DNA vaccine by fusing DNA encoding E7-antigenic peptide to DNA encoding capsid protein L1 of Bovine papillomavirus
Human papillomavirus (HPV) has been identified as the primary etiologic factor of cervical cancer, the fourth leading cause of cancer death in females worldwide. We have previously shown that coadministration ...
Cell & Bioscience 2017 7:46
Published on: 23 August 2017
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Research
Investigation of host–pathogen interaction between Burkholderia pseudomallei and autophagy-related protein LC3 using hydrophobic chromatography-based technique
Burkholderia pseudomallei is an intracellular bacteria causing Melioidosis, the disease widely disseminates in Southeast Asia and Northern Australia. B. pseudomallei has ability to inv...
Cell & Bioscience 2017 7:45
Published on: 23 August 2017
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Research
Ginkgetin aglycone ameliorates LPS-induced acute kidney injury by activating SIRT1 via inhibiting the NF-κB signaling pathway
Ginkgetin aglycone (GA), a novel Ginkgo biloba extract (GBE) by acid hydrolysis and recrystallization, is characterized by higher liposolubility and antioxidation than classical GBEs. There is no study depicting ...
Cell & Bioscience 2017 7:44
Published on: 23 August 2017
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Research
Phosphorylation of astrocytic connexin43 by ERK1/2 impairs blood–brain barrier in acute cerebral ischemia
Connexins are a family of transmembrane proteins that form gap junctions, which are important for diffusion of cytosolic factors such as ions and second messenger signaling molecules. Our previous study has sh...
Cell & Bioscience 2017 7:43
Published on: 22 August 2017
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Review
Diabetic retinopathy: reversibility of epigenetic modifications and new therapeutic targets
In recent years, considerable progress has been made in the molecular mechanisms of epigenetics in disease development and progression, the reversible characteristics of epigenetic modification provide new ins...
Cell & Bioscience 2017 7:42
Published on: 15 August 2017
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Letter to the Editor
A human plasma derived supplement preserves function of human vascular cells in absence of fetal bovine serum
Current techniques for cell culture routinely use animal-derived components. Fetal bovine serum (FBS) is the most widely applied supplement, but it often displays significant batch-to-batch variations and is g...
Cell & Bioscience 2017 7:41
Published on: 14 August 2017
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Editorial
The 2016 Ming K Jeang Award for Excellence in
Cell & Bioscience Two research groups led by Dr. Jim Hu of University of Toronto, Canada and Dr. Renping Zhou of Rutgers University, USA, respectively, won the 2016 Ming K Jeang Award for Excellence in Cell & Bioscience. ...Cell & Bioscience 2017 7:40
Published on: 10 August 2017
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Review
The miR-290-295 cluster as multi-faceted players in mouse embryonic stem cells
Increasing evidence indicates that embryonic stem cell specific microRNAs (miRNAs) play an essential role in the early development of embryo. Among them, the miR-290-295 cluster is the most highly expressed in...
Cell & Bioscience 2017 7:38
Published on: 7 August 2017
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Review
TGF-β in pancreatic cancer initiation and progression: two sides of the same coin
Pancreatic cancer is highly lethal malignant tumor with characterised rapid progression, invasiveness and resistance to radiochemotherapy. Transforming growth factor-β (TGF-β) signaling plays a dual role in bo...
Cell & Bioscience 2017 7:39
Published on: 7 August 2017
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Review
Isocitrate dehydrogenases in physiology and cancer: biochemical and molecular insight
Isocitrate dehydrogenases play important roles in cellular metabolism and cancer. This review will discuss how the roles of isoforms 1 and 2 in normal cell and cancer metabolism are distinct from those of isof...
Cell & Bioscience 2017 7:37
Published on: 3 August 2017
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Research
Stromal Senp1 promotes mouse early folliculogenesis by regulating BMP4 expression
Mammalian folliculogenesis, maturation of the ovarian follicles, require both growth factors derived from oocyte and surrounding cells, including stromal cells. However, the mechanism by which stromal cells an...
Cell & Bioscience 2017 7:36
Published on: 25 July 2017
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Editorial
Cell & Bioscience 2017 7:35
Published on: 14 July 2017
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Review
The roles of microRNA families in hepatic fibrosis
When hepatocytes are damaged severely, a variety of signaling pathways will be triggered by inflammatory factors and cytokines involving in the process of hepatic fibrosis. The microRNA (miRNA) family consists...
Cell & Bioscience 2017 7:34
Published on: 4 July 2017
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Research
ZNF300 tight self-regulation and functioning through DNA methylation and histone acetylation
Accumulating evidence demonstrates that the KRAB-ZNFs involve in various biological processes. As a typical member of KRAB-ZNFs, dysregulation of ZNF300 contributes to multiple pathologies such as leukemia and...
Cell & Bioscience 2017 7:33
Published on: 28 June 2017
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Erratum
Cell & Bioscience 2017 7:32
Published on: 20 June 2017
The original article was published in Cell & Bioscience 2016 6:51
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Research
Kv1.3 channel blocker (ImKTx88) maintains blood–brain barrier in experimental autoimmune encephalomyelitis
Disruption of blood–brain barrier (BBB) and subsequent infiltration of auto-reactive T lymphocytes are major characteristics of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). Kv1....
Cell & Bioscience 2017 7:31
Published on: 7 June 2017
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Review
APOBEC3B, a molecular driver of mutagenesis in human cancers
Human cancers results in large part from the accumulation of multiple mutations. The progression of premalignant cells is an evolutionary process in which mutations provide the fundamental driving force for ge...
Cell & Bioscience 2017 7:29
Published on: 30 May 2017
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Research highlight
iPSCs are safe!
Induced pluripotent stem cells (iPSCs) hold great promises in cell therapy. However, the potential safety issues have dampened the enthusiasm of their clinical development. One of the biggest concerns came fro...
Cell & Bioscience 2017 7:30
Published on: 30 May 2017
