Articles

β-adrenergic receptor inhibition enhances oncolytic herpes virus propagation through STAT3 activation in gastric cancer

Oncolytic viruses (OVs) are considered a promising therapeutic alternative for cancer. However, OVs could activate the host innate immunity, then impair the viral propagation in tumor cells. In this study, we ...

Authors: Jiali Hu, Ruitao Lu, Yu Zhang, Wei Li, Qian Hu, Cuiyu Chen, Zhaoqian Liu, Wei Zhang, Ling Chen, Ran Xu, Jia Luo, Howard L. McLeod and Yijing He

The hepatic senescence-associated secretory phenotype promotes hepatocarcinogenesis through Bcl3-dependent activation of macrophages

Liver cancer is one of the most common malignancies in the world with a poor prognosis. Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer, accounting for 80–90% of cases. The initiation...

Authors: Yihua Huang, Xue Yang, Yan Meng, Changchun Shao, Jianping Liao, Fengwei Li, Rong Li, Yingying Jing and Aimin Huang

Loss of signal transducer and activator of transcription 3 impaired the osteogenesis of mesenchymal progenitor cells in vivo and in vitro

Signal transducer and activator of transcription 3 (Stat3) is a cytoplasmic transcription factor that participates in various biologic processes. Loss of Stat3 causes hyperimmunoglobulin E syndrome, presenting...

Authors: Zijing Huang, Jingyi Feng, Xin Feng, Laiting Chan, Jiarui Lu, Lizhen Lei, Zhuwei Huang and Xiaolei Zhang

Inferring SARS-CoV-2 functional genomics from viral transcriptome with identification of potential antiviral drugs and therapeutic targets

Coronavirus disease 2019 (COVID-19) is an emerging infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and has posed a serious threat to global health. Here, we syste...

Authors: Xu Pan, Xin Li, Shangwei Ning and Hui Zhi

Huaier polysaccharides suppress triple-negative breast cancer metastasis and epithelial-mesenchymal transition by inducing autophagic degradation of Snail

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, and the targeted therapies are lacking for this type of cancer. We previously demonstrated that Huaier effectively improve ...

Authors: Yuan Tian, Jin Wu, Lingjuan Zeng, Linxi Zhou, Ying Hu, Qinwen Pan, Wei Liu, Yuzhao Yan, Ziwei Wu, Zhaoyu Wang, Zhen Zeng, Peng Tang, Jun Jiang and Minghao Wang

Long noncoding RNA SNHG1 promotes TERT expression by sponging miR-18b-5p in breast cancer

Long noncoding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) plays a positive role in the progression of human malignant tumors. However, the molecular mechanism of SNHG1 remains elusive in breast cancer.

Authors: Yujuan Kang, Lin Wan, Qin Wang, Yanling Yin, Jiena Liu, Lei Liu, Hao Wu, Lei Zhang, Xin Zhang, Shouping Xu and Da Pang

Epigallocatechin gallate from green tea effectively blocks infection of SARS-CoV-2 and new variants by inhibiting spike binding to ACE2 receptor

As the COVID-19 pandemic rages on, the new SARS-CoV-2 variants have emerged in the different regions of the world. These newly emerged variants have mutations in their spike (S) protein that may confer resista...

Authors: Jinbiao Liu, Brittany H. Bodnar, Fengzhen Meng, Adil I. Khan, Xu Wang, Sami Saribas, Tao Wang, Saroj Chandra Lohani, Peng Wang, Zhengyu Wei, Jinjun Luo, Lina Zhou, Jianguo Wu, Guangxiang Luo, Qingsheng Li, Wenhui Hu…

The mechanism of Annexin A1 to modulate TRPV1 and nociception in dorsal root ganglion neurons

Annexin A1 (ANXA1) exerts anti-nociceptive effect through ANXA1 receptor formyl peptide receptor 2 (FPR2/ALX (receptor for lipoxin A4), FPR2) at the dorsal root ganglia (DRG) level. However, the mechanisms rem...

Authors: Yufen Zhang, Sehui Ma, Xiao Ke, Yao Yi, Hongyan Yu, Dian Yu, Qiang Li, You Shang, Youming Lu and Lei Pei

A novel mechanism for C1GALT1 in the regulation of gastric cancer progression

Gastric cancer (GC) is a highly aggressive and lethal disease around the world. High expression of core 1 β 1, 3-galactosyltransferase 1 (C1GALT1), the primary enzyme responsible for protein O-glycosylation, play...

Authors: Xiaoxia Dong, Chunli Chen, Xinzhou Deng, Yongyu Liu, Qiwen Duan, Zhen Peng, Zhiguo Luo and Li Shen

Intracellular proteome compartmentalization: a biotin ligase-based proximity labeling approach

Specialized biological processes occur in different regions and organelles of the cell. Additionally, the function of proteins correlate greatly with their interactions and subcellular localization. Understand...

Authors: Olanrewaju Ayodeji Durojaye

An update on novel approaches for diagnosis and treatment of SARS-CoV-2 infection

The ongoing pandemic of coronavirus disease 2019 (COVID-19) has made a serious public health and economic crisis worldwide which united global efforts to develop rapid, precise, and cost-efficient diagnostics,...

Authors: Azadeh Safarchi, Shadma Fatima, Zahra Ayati and Fatemeh Vafaee

AKR1B10 promotes breast cancer cell proliferation and migration via the PI3K/AKT/NF-κB signaling pathway

Aberrant expression of Aldo-Keto reductase family 1 member B10 (AKR1B10) was associated with tumor size and metastasis of breast cancer in our published preliminary studies. However, little is known about the ...

Authors: Jiayao Qu, Jia Li, Yaming Zhang, Rongzhang He, Xiangting Liu, Ke Gong, Lili Duan, Weihao Luo, Zheng Hu, Gengsheng Wang, Chenglai Xia and Dixian Luo

Genetic composition and evolution of the prevalent Mycobacterium tuberculosis lineages 2 and 4 in the Chinese and Zhejiang Province populations

There are seven human-adaptation lineages of Mycobacterium tuberculosis (Mtb). Tuberculosis (TB) dissemination is strongly influenced by human movements and host genetics. The detailed lineage distribution evolut...

Authors: Beibei Wu, Wenlong Zhu, Yue Wang, Qi Wang, Lin Zhou, Zhengwei Liu, Lijun Bi, Mathema Barun, Barry N. Kreiswirth, Liang Chen, Songhua Chen, Xiaomeng Wang and Weibing Wang

JAZF1 heterozygous knockout mice show altered adipose development and metabolism

Juxtaposed with another zinc finger protein 1 (JAZF1) is associated with metabolic disorders, including type 2 diabetes mellitus (T2DM). Several studies showed that JAZF1 and body fat mass are closely related....

Authors: Jain Jeong, Soyoung Jang, Song Park, Wookbong Kwon, Si-Yong Kim, Soyoen Jang, Jiwon Ko, Si Jun Park, Su-geun Lim, Duhak Yoon, Junkoo Yi, Sanggyu Lee, Myoung Ok Kim, Seong-Kyoon Choi and Zae Young Ryoo

Influence of miR-221/222 on cardiomyocyte calcium handling and function

Cardiovascular disease is the leading cause of death worldwide. Cardiac electrical remodeling including altered ion channel expression and imbalance of calcium homeostasis can have detrimental effects on cardi...

Authors: Maria Knyrim, Sindy Rabe, Claudia Grossmann, Michael Gekle and Barbara Schreier

Multiple functions of autophagy in vascular calcification

Vascular calcification is a closely linked to cardiovascular diseases, such as atherosclerosis, chronic kidney disease, diabetes, hypertension and aging. The extent of vascular calcification is closely correl...

Authors: Xin Zhou, Sui-Ning Xu, Shu-Tong Yuan, Xinjuan Lei, Xiaoying Sun, Lu Xing, Hui-Jin Li, Chun-Xia He, Wei Qin, Dong Zhao, Peng-Quan Li, Edward Moharomd, Xuehong Xu and Hui-Ling Cao

Axon regeneration after optic nerve injury in rats can be improved via PirB knockdown in the retina

In the central nervous system (CNS), three types of myelin-associated inhibitors (MAIs) exert major inhibitory effects on nerve regeneration: Nogo-A, myelin-associated glycoprotein (MAG), and oligodendrocyte-m...

Authors: Mei Yang, Lan Jian, Wei Fan, Xing Chen, Huan Zou, Yanming Huang, Xiaofan Chen, Yuan-Guo Zhou and Rongdi Yuan

Retraction Note to: Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours

Authors: Fei Xu, Lixin Na, Yanfei Li and Linjun Chen

Modaline sulfate promotes Oct4 expression and maintains self-renewal and pluripotency of stem cells through JAK/STAT3 and Wnt signaling pathways

Stem cells have been extensively explored for a variety of regenerative medical applications and they play an important role in clinical treatment of many diseases. However, the limited amount of stem cells an...

Authors: Xianglin Mei, Hanhan Zhao, Huihan Ai, Shuyue Wang, Zhenbo Song, Lihua Zheng, Guannan Wang, Ying Sun and Yongli Bao

ADAMTS-1: a novel target gene of an estrogen-induced transcription factor, EGR1, critical for embryo implantation in the mouse uterus

Recently, we demonstrated that estrogen (E₂) induces early growth response 1 (Egr1) to mediate its actions on the uterine epithelium by controlling progesterone receptor signaling for successful embryo implantati...

Authors: Mira Park, So Hee Park, Hyunsun Park, Hye-Ryun Kim, Hyunjung J. Lim and Haengseok Song

FOXD1 promotes EMT and cell stemness of oral squamous cell carcinoma by transcriptional activation of SNAI2

Epithelial-mesenchymal transition (EMT) and cell stemness are implicated in the initiation and progression of oral squamous cell carcinoma (OSCC). Revealing the intrinsic regulatory mechanism may provide effec...

Authors: Yang Chen, Weilian Liang, Ke Liu and Zhengjun Shang

The function of LncRNA-H19 in cardiac hypertrophy

Cardiac hypertrophy, characterized by the enlargement of cardiomyocytes, is initially an adaptive response to physiological and pathological stimuli. Decompensated cardiac hypertrophy is related to fibrosis, i...

Authors: Wenhua Su, Qian Huo, Hao Wu, Lulin Wang, Xiaoxue Ding, Liwen Liang, Liang Zhou, Yan Zhao, Juhua Dan and Hong Zhang

EHMT2 promotes the pathogenesis of hepatocellular carcinoma by epigenetically silencing APC expression

Hepatocellular carcinoma (HCC), the second leading cause of cancer death worldwide, alone accounts for over half (466,100) of new cancer cases and 422,100 deaths based on the average year incidence rates of 20...

Authors: Yuan Guo, Yan-Rong Zhao, Huan Liu, Yang Xin, Jian-Zhi Yu, Yun-Jin Zang and Qing-guo Xu

Regulation of neuropeptide Y in body microenvironments and its potential application in therapies: a review

Neuropeptide Y (NPY), one of the most abundant neuropeptides in the body, is widely expressed in the central and peripheral nervous systems and acts on the cardiovascular, digestive, endocrine, and nervous sys...

Authors: Yan Zhang, Chu-Yun Liu, Wei-Can Chen, Yan-Chuan Shi, Cong-Mei Wang, Shu Lin and He-Fan He

Effects of low lead exposure on sperm quality and sperm DNA methylation in adult men

Lead (Pb) exposure is a risk factor for male infertility, but the epigenetic changes in sperm DNAattributable to lead exposure is poorly defined.

Authors: Tiancheng Zhang, Yan Fei Ru, Bin Wu, Haiyan Dong, Liang Chen, Jufen Zheng, Jianhui Li, Xin Wang, Zhikai Wang, Xuemei Wang, Xiaorong Shen, Jun Wu, Jun Qian, Maohua Miao, Yihua Gu and Huijuan Shi

TRIM28 inhibits alternative lengthening of telomere phenotypes by protecting SETDB1 from degradation

About 10–15% of tumor cells extend telomeres through the alternative lengthening of telomeres (ALT) mechanism, which is a recombination-dependent replication pathway. It is generally believed that ALT cells ar...

Authors: Chuanle Wang, Zhou Songyang and Yan Huang

Persistent deficiency of mucosa-associated invariant T (MAIT) cells during alcohol-related liver disease

Alcohol-related liver disease (ALD) is a major cause of chronic liver diseases. Inflammatory response is a basic pathological feature of ALD. Mucosal-associated invariant T(MAIT) cells are a novel population o...

Authors: Yujue Zhang, Yuanyuan Fan, Wei He, Yi Han, Huarui Bao, Renjun Yang, Bingbing Wang, Derun Kong and Hua Wang

Current insights into the implications of m6A RNA methylation and autophagy interaction in human diseases

Autophagy is a conserved degradation process crucial to maintaining the primary function of cellular and organismal metabolism. Impaired autophagy could develop numerous diseases, including cancer, cardiomyopa...

Authors: Xuechai Chen, Jianan Wang, Muhammad Tahir, Fangfang Zhang, Yuanyuan Ran, Zongjian Liu and Juan Wang

SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation

Linear ubiquitination is a novel type of ubiquitination that plays important physiological roles in signalling pathways such as tumour necrosis factor (TNF) signalling. However, little is known about the regul...

Authors: Ruona Shi, Xue Shi, Dajiang Qin, Shibing Tang, Michiel Vermeulen and Xiaofei Zhang

Potential of helper-dependent Adenoviral vectors in CRISPR-cas9-mediated lung gene therapy

Since CRISPR/Cas9 was harnessed to edit DNA, the field of gene therapy has witnessed great advances in gene editing. New avenues were created for the treatment of diseases such as Cystic Fibrosis (CF). CF is c...

Authors: Ranmal Avinash Bandara, Ziyan Rachel Chen and Jim Hu

Changes to the identity of EndoC-βH1 beta cells may be mediated by stress-induced depletion of HNRNPD

Beta cell identity changes occur in the islets of donors with diabetes, but the molecular basis of this remains unclear. Protecting residual functional beta cells from cell identity changes may be beneficial f...

Authors: Nicola Jeffery, David Chambers, Brandon M. Invergo, Ryan M. Ames and Lorna W. Harries

Incident disease associations with mosaic chromosomal alterations on autosomes, X and Y chromosomes: insights from a phenome-wide association study in the UK Biobank

Mosaic chromosomal alterations (mCAs) are large chromosomal gains, losses and copy-neutral losses of heterozygosity (LOH) in peripheral leukocytes. While many individuals with detectable mCAs have no notable a...

Authors: Shu-Hong Lin, Derek W. Brown, Brandon Rose, Felix Day, Olivia W. Lee, Sairah M. Khan, Jada Hislop, Stephen J. Chanock, John R. B. Perry and Mitchell J. Machiela

Exosomal delivery of therapeutic modulators through the blood–brain barrier; promise and pitfalls

Nowadays, a large population around the world, especially the elderly, suffers from neurological inflammatory and degenerative disorders/diseases. Current drug delivery strategies are facing different challeng...

Authors: Morteza Heidarzadeh, Yasemin Gürsoy-Özdemir, Mehmet Kaya, Aysan Eslami Abriz, Amir Zarebkohan, Reza Rahbarghazi and Emel Sokullu

Dexibuprofen ameliorates peripheral and central risk factors associated with Alzheimer’s disease in metabolically stressed APPswe/PS1dE9 mice

Several studies stablished a relationship between metabolic disturbances and Alzheimer´s disease (AD) where inflammation plays a pivotal role. However, mechanisms involved still remain unclear. In the present ...

Authors: Miren Ettcheto, Elena Sánchez-Lopez, Amanda Cano, Marina Carrasco, Katherine Herrera, Patricia R. Manzine, Triana Espinosa-Jimenez, Oriol Busquets, Ester Verdaguer, Jordi Olloquequi, Carme Auladell, Jaume Folch and Antoni Camins

Genome-wide analysis of protein–protein interactions and involvement of viral proteins in SARS-CoV-2 replication

Analysis of viral protein–protein interactions is an essential step to uncover the viral protein functions and the molecular mechanism for the assembly of a viral protein complex. We employed a mammalian two-h...

Authors: Yiling Jiang, Kuijie Tong, Roubin Yao, Yuanze Zhou, Hanwen Lin, Liubing Du, Yunyun Jin, Liu Cao, Jingquan Tan, Xing-Ding Zhang, Deyin Guo, Ji-An Pan and Xiaoxue Peng

Correction to: Electric signals counterbalanced posterior vs anterior PTEN signaling in directed migration of Dictyostelium

Authors: Bing Song, Yu Gu, Wenkai Jiang, Ying Li, Wayne Nishio Ayre, Zhipeng Liu, Tao Yin, Christopher Janetopoulos, Miho Iijima, Peter Devreotes and Min Zhao

rpoS-mutation variants are selected in Pseudomonas aeruginosa biofilms under imipenem pressure

Pseudomonas aeruginosa is a notorious opportunistic pathogen causing various types of biofilm-related infections. Biofilm formation is a unique microbial strategy that allows P. aeruginosa to survive adverse cond...

Authors: Xiangke Duan, Yanrong Pan, Zhao Cai, Yumei Liu, Yingdan Zhang, Moxiao Liu, Yang Liu, Ke Wang, Lianhui Zhang and Liang Yang

Differing susceptibility of C57BL/6J and DBA/2J mice—parents of the murine BXD family, to severe acute respiratory syndrome coronavirus infection

The ongoing coronavirus disease-2019 (COVID-19) pandemic, caused by a novel coronavirus termed severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that is closely related to SARS-CoV, poses a grave th...

Authors: Kui Li, Yang Shen, Mark A. Miller, Jennifer Stabenow, Robert W. Williams and Lu Lu

SARS-CoV-2: from its discovery to genome structure, transcription, and replication

SARS-CoV-2 is an extremely contagious respiratory virus causing adult atypical pneumonia COVID-19 with severe acute respiratory syndrome (SARS). SARS-CoV-2 has a single-stranded, positive-sense RNA (+RNA) geno...

Authors: Ayslan Castro Brant, Wei Tian, Vladimir Majerciak, Wei Yang and Zhi-Ming Zheng

Correction to: Aldose reductase deficiency inhibits LPS-induced M1 response in macrophages by activating autophagy

Authors: Peng Cheng, Jianwei Xie, Zhiyong Liu and Jian Wang

Lung branching morphogenesis is accompanied by temporal metabolic changes towards a glycolytic preference

Lung branching morphogenesis is characterized by epithelial-mesenchymal interactions that ultimately define the airway conducting system. Throughout this process, energy and structural macromolecules are neces...

Authors: Hugo Fernandes-Silva, Marco G. Alves, Henrique Araújo-Silva, Ana M. Silva, Jorge Correia-Pinto, Pedro F. Oliveira and Rute S. Moura

Assessment of changes in autophagic vesicles in human immune cell lines exposed to nano particles

Safe and rational development of nanomaterials for clinical translation requires the assessment of potential biocompatibility. Autophagy, a critical homeostatic pathway intrinsically linked to cellular health ...

Authors: Christopher A. W. David, M. Estela del Castillo Busto, Susana Cuello-Nuñez, Heidi Goenaga-Infante, Michael Barrow, David G. Fernig, Patricia Murray, Matthew J. Rosseinsky, Andrew Owen and Neill J. Liptrott

YTHDF2 alleviates cardiac hypertrophy via regulating Myh7 mRNA decoy

Pathological cardiac hypertrophy is a major contributor of heart failure (HF), which seriously threatens human’s health world widely. Deregulation of m6A RNA methylation, and m6A methyltransferases and de-meth...

Authors: Hongfei Xu, Zhen Wang, Miao Chen, Wenting Zhao, Tingting Tao, Liang Ma, Yiming Ni and Weidong Li

Pathological alterations in the gastrointestinal tract of a porcine model of DMD

Patients with Duchenne muscular dystrophy (DMD) develop severe skeletal and cardiac muscle pathologies, which result in premature death. Therefore, the current therapeutic efforts are mainly targeted to correc...

Authors: Xiaodong Zou, Hongsheng Ouyang, Daxin Pang, Renzhi Han and Xiaochun Tang

ADP/ATP translocase 1 protects against an α-synuclein-associated neuronal cell damage in Parkinson’s disease model

ADP/ATP translocase 1 (ANT1) is involved in the exchange of cytosolic ADP and mitochondrial ATP, and its defection plays an important role in mitochondrial pathogenesis. To reveal an etiological implication of...

Authors: Wenyong Ding, Minghua Qi, Li Ma, Xuefei Xu, Yingfei Chen and Wenli Zhang

Rev-erbα exacerbates hepatic steatosis in alcoholic liver diseases through regulating autophagy

Alcoholic fatty liver (AFL) is a liver disease caused by long-term excessive drinking and is characterized by hepatic steatosis. Understanding the regulatory mechanism of steatosis is essential for the treatme...

Authors: Qingxue Liu, Lei Xu, Meifei Wu, Yiwen Zhou, Junfa Yang, Cheng Huang, Tao Xu, Jun Li and Lei Zhang

A bivalent protein targeting glycans and HR1 domain in spike protein potently inhibited infection of SARS-CoV-2 and other human coronaviruses

Our previous studies have shown that combining the antiviral lectin GRFT and the pan-CoV fusion inhibitory peptide EK1 results in highly potent inhibitory activity against SARS-CoV-2 infection. In this study, ...

Authors: Yanxing Cai, Wei Xu, Jiayi Tang, Najing Cao, Qiaoshuai Lan, Lu Lu and Shibo Jiang

PIAS1 potentiates the anti-EBV activity of SAMHD1 through SUMOylation

Sterile alpha motif and HD domain 1 (SAMHD1) is a deoxynucleotide triphosphohydrolase (dNTPase) that restricts the infection of a variety of RNA and DNA viruses, including herpesviruses. The anti-viral functio...

Authors: Farjana Saiada, Kun Zhang and Renfeng Li

Metabolomic and transcriptomic profiling of adult mice and larval zebrafish leptin mutants reveal a common pattern of changes in metabolites and signaling pathways

Leptin plays a critical role in the regulation of metabolic homeostasis. However, the molecular mechanism and cross talks between leptin and metabolic pathways leading to metabolic homeostasis across different...

Authors: Yi Ding, Mariëlle C. Haks, Gabriel Forn-Cuní, Junling He, Natalia Nowik, Amy C. Harms, Thomas Hankemeier, Muhamed N. H. Eeza, Jörg Matysik, A. Alia and Herman P. Spaink

Single-cell transcriptomic analysis of endometriosis provides insights into fibroblast fates and immune cell heterogeneity

Endometriosis is an oestrogen-dependent disease with an unclear aetiology and pathogenesis affecting 6–10% of the global female population, predominantly those of reproductive age. Herein, we profile the trans...

Authors: Junyan Ma, Liqi Zhang, Hong Zhan, Yun Mo, Zuanjie Ren, Anwen Shao and Jun Lin