Babaodan (BBD), a traditional Chinese medicine, has been shown to have protective effects during liver injury and ameliorate liver disease progression, but little is known about its effect on non-alcoholic fat...
Authors: Dandan Sheng, Shanmin Zhao, Lu Gao, Huifei Zheng, Wenting Liu, Jing Hou, Yuxiang Jin, Fei Ye, Qiudong Zhao, Rong Li, Naping Zhao, Li Zhang, Zhipeng Han and Lixin Wei
The prognosis of esophageal cancer is still dismal because of its high probability of metastasis that is likely related to the cellular process of epithelial–mesenchymal transition (EMT). Recent studies have s...
Authors: Yuxiang Jin, Xinye Lu, Mingdong Wang, Xuewei Zhao and Lei Xue
Cervical cancer is the most common gynecological malignancy with low terminal cure rate, and therefore new therapeutic targets are urgently needed to combat this disease. SMYD2, as an oncogene, is abnormal hig...
Authors: Jun-Jie Sun, Hong-Lin Li, Hui Ma, Yang Shi, Li-Rong Yin and Su-Jie Guo
Whether neurogenesis occurs in the adult human brain has been a long-debated topic fueled by conflicting data both for and against neurogenesis in the mature brain. Recent reports from two independent teams ma...
Authors: Xinjuan Lei, Yajun Wu, MengMeng Xu, Odell D. Jones, Jianjie Ma and Xuehong Xu
Modulation of the embryonic stem cell state is beneficial for elucidating the innate mechanisms of development and regenerative medicine. Ion flux plays important roles in modulating the transition between ste...
Increasing evidence has revealed that long non-coding RNAs (lncRNAs) play a pivotal role in the development of nervous system. Our previous studies have demonstrated that enhanced cholinergic neurogenesis occu...
Authors: Xiang Cheng, Haoming Li, Heyan Zhao, Wen Li, Jianbing Qin and Guohua Jin
Pluripotency is proposed to exist in two different stages: Naive and Primed. Conventional human pluripotent cells are essentially in the primed stage. In recent years, several protocols have claimed to generat...
Authors: Meisam Yousefi, Sayed-Amir Marashi, Ali Sharifi-Zarchi and Sara Taleahmad
Dual-specificity phosphatases (DUSPs) are a subset of protein tyrosine phosphatases (PTPs), many of which dephosphorylate the residues of phosphor-serine/threonine and phosphor-tyrosine on mitogen-activated pr...
Authors: Tao Ding, Ya Zhou, Runying Long, Chao Chen, Juanjuan Zhao, Panpan Cui, Mengmeng Guo, Guiyou Liang and Lin Xu
Congenital coagulation factor (F) VII deficiency is a rare bleeding disorder caused by mutations in the F7 gene. The missense factor FVII variant p.Q160R is the disease-causing mutation in all Norwegian FVII defi...
Authors: Elisabeth Andersen, Maria Eugenia Chollet, Marcello Baroni, Mirko Pinotti, Francesco Bernardi, Ellen Skarpen, Per Morten Sandset and Grethe Skretting
The protective effect of metformin (MET) on abdominal aortic aneurysm (AAA) has been reported. However, the related mechanism is still poor understood. In this study, we deeply investigated the role of metform...
Authors: Zhu Wang, Jingjing Guo, Xinqiang Han, Ming Xue, Wenming Wang, Lei Mi, Yuguo Sheng, Chao Ma, Jian Wu and Xuejun Wu
Epitranscriptomics, also known as “RNA epigenetics”, is a chemical modification for RNA regulation. Ribonucleic acid (RNA) methylation is considered to be a major discovery following the deoxyribonucleic acid ...
Authors: Jiashuo Li, Xinxin Yang, Zhipeng Qi, Yanqi Sang, Yanan Liu, Bin Xu, Wei Liu, Zhaofa Xu and Yu Deng
Autophagy is a catabolic process for degradation of intracellular components. Damaged proteins and organelles are engulfed in double-membrane vesicles ultimately fused with lysosomes. These vesicles, known as ...
Authors: Bahareh Kardideh, Zahra Samimi, Fatemeh Norooznezhad, Sarah Kiani and Kamran Mansouri
Chronic hepatitis B virus (HBV) infection is one of the most serious global public health problems. The role of steroid receptor coactivator 3 (SRC-3) in HBV biosynthesis is unknown. The aim of this study is t...
Authors: Ming Li, Yi Wang, Xiaochun Xia, Pingli Mo, Jianming Xu, Chundong Yu and Wengang Li
Non-small-cell lung cancer (NSCLC) is the most common malignancy worldwide. Platinum-based chemotherapy is the standard of care for these patients. Recent research showed that miR-7 methylation status is a bio...
Authors: Carlos Rodríguez-Antolín, Laura Felguera-Selas, Olga Pernía, Olga Vera, Isabel Esteban, Itsaso Losantos García, Javier de Castro, Rocío Rosas-Alonso and Inmaculada Ibanez de Caceres
Colon-cancer-cell-derived exosomes (CDEs) are emerging mediators of tumorigenesis and serve as messengers of intercellular communication; however, whether the CDEs affect the proliferation of colon cancer cell...
Authors: Ruixue Ren, Hua Sun, Cui Ma, Jiatao Liu and Hua Wang
Senescence is a well-known risk factor for several diseases, such as neurodegenerative disorders. Therefore, studies exploring the mechanisms underlying aging are expected to guide the discovery of novel drug ...
Authors: Ayumi Ando, Masahiro Oka and Yoshinori Satomi
Mutated epidermal growth factor receptor (EGFR) is one of the most successful targets in cancer targeted therapy. While this treatment has benefited many patients with an activating EGFR mutation (EGFRm), almo...
Water scarcity is considered to be a severe environmental constraint to plant survival and productivity. Studies on drought-tolerant plants would definitely promote a better understanding of the regulatory mec...
Authors: Huihui Gu, Yan Yang, Minghui Xing, Caipeng Yue, Fang Wei, Yanjie Zhang, Wenen Zhao and Jinyong Huang
Recent evidence has shown that C-X-C chemokine receptor type 4 (CXCR4) plays a crucial role in acute lung injury (ALI). Macrophages are key factors in the pathogenesis of ALI. The aim of this study was to inve...
Authors: Xue Tian, Guogang Xie, Hui Xiao, Fengming Ding, Wuping Bao and Min Zhang
Many studies have reported that long noncoding RNAs (lncRNAs) could act as sponges for microRNAs (miRNAs) and play important roles in the regulation of osteoarthritis (OA). Yet, the underlying mechanisms of ln...
Authors: Ying Zhang, Fuyou Wang, Guangxing Chen, Rui He and Liu Yang
Single-cell sequencing technologies can be used to detect the genome, transcriptome and other multi-omics of single cells. They can show the differences and evolutionary relationships of various cells. This re...
Authors: Xiaoning Tang, Yongmei Huang, Jinli Lei, Hui Luo and Xiao Zhu
Pyruvate kinase (PK), as one of the key enzymes for glycolysis, can encode four different subtypes from two groups of genes, although the M2 subtype PKM2 is expressed mainly during embryonic development in nor...
Authors: Ze Zhang, Xinyue Deng, Yuanda Liu, Yahui Liu, Liankun Sun and Fangfang Chen
An underlying state of inflammation is thought to be an important cause of cardiovascular disease. Among cells involved in the early steps of atherosclerosis, monocyte-derived dendritic cells (Mo-DCs) respond ...
Authors: Geneviève Hamel-Côté, Fanny Lapointe, Steeve Véronneau, Marian Mayhue, Marek Rola-Pleszczynski and Jana Stankova
Gemcitabine is the standard first-line chemotherapy regimen for pancreatic cancer. However, its therapeutic value is substantially limited in pancreatic cancer patients due to occurrence of resistance towards ...
Authors: Hehe Li, Zhengle Zhang, Chenggang Gao, Shihong Wu, Qingke Duan, Heshui Wu, Chunyou Wang, Qiang Shen and Tao Yin
Polyploidy is considered as a basic event in plant speciation and evolution in nature, and the cytological and proteomic profilings of floral buds at meiosis (FAM) would definitely contribute to a better under...
Authors: Yan Yang, Fang Wei, Janeen Braynen, Xiaochun Wei, Baoming Tian, Gongyao Shi, Gangqiang Cao, Jiachen Yuan and Xiaowei Zhang
Adipocyte accumulation is a predominant feature of age-related thymic involution, but the mechanisms responsible for thymic adipogenesis remain to be elucidated. The aim of this study was to identify key regul...
Telomere maintenance is an important factor in tumorigenesis. PinX1 is a potent telomerase regulator which also involves in telomerase loading to telomeres. Nucleophosmin (NPM) can partially attenuate PinX1 in...
The emerging threat to global health associated with the Zika virus (ZIKV) epidemics and its link to severe complications highlights a growing need to better understand the pathogenic mechanisms of ZIKV. Accum...
Authors: Yiwen Hu, Xinhuai Dong, Zhenjian He, Yun Wu, Shihao Zhang, Jiajie Lin, Yi Yang, Jiahui Chen, Shu An, Yingxian Yin, Zhiyong Shen, Gucheng Zeng, Han Tian, Junchao Cai, Yi Yang, Hongyu Guan…
Natural products from herbal medicines have long been investigated for their potentials as cancer therapeutics. Besides the development of several herbal medicine-derived anti-cancer agents, such as paclitaxel...
Authors: Sabrina J. Cai, Yang Liu, Sue Han and Chunzhang Yang
Thyroid cancer is the most common malignant endocrine tumor and is classified into papillary thyroid cancer (PTC), follicular thyroid cancer (FTC) and anaplastic thyroid cancer (ATC), which have substantially ...
Authors: Le Zhang, Rong Lian, Jingjing Zhao, Xianming Feng, Runyi Ye, Lingxiao Pan, Jueheng Wu, Mengfeng Li, Yongbo Huang and Junchao Cai
Circular RNAs (circRNAs) from back-splicing have been found in every cell and tissue. By binding to miRNAs and proteins or even by encoding small proteins, circRNAs are now emerging as important regulators in ...
Two research papers, one from a group led by Dr. Haifan Lin of Yale University School of Medicine, New Haven, USA and another from two laboratories led by Drs. Yihong Ye of National Institute of Diabetes and D...
CRISPR/Cas9 mediated gene knockout is a powerful tool for genome editing with the ability to target multiple genes simultaneously. Establishing an efficient, multiplexed gene knockout system using CRISPR/Cas9 ...
Congenital chloride diarrhea (CCD) in a newborn is a rare autosomal recessive disorder with life-threatening complications, requiring early diagnostics and treatment to prevent severe dehydration and infant mo...
Authors: Nini Zhang, Daniel P. Heruth, Weibin Wu, Li Qin Zhang, Marianne N. Nsumu, Katherine Shortt, Kelvin Li, Xun Jiang, Baoxi Wang, Craig Friesen, Ding-You Li and Shui Qing Ye
Long non-coding RNAs are involved in the pathology of various tumors, including hepatocellular carcinoma. The expression of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is increased in numer...
Authors: Qiangfeng Yu, Leyang Xiang, Zhanjun Chen, Xincheng Liu, Huohui Ou, Jianyin Zhou and Dinghua Yang
The prevention of cardiovascular diseases is a matter of great concern, of which acute myocardial infarction (AMI) remains one of the leading causes of death resulting in high morbidity worldwide. Emerging evi...
CRISPR and CRISPR-associated (Cas) protein, as components of microbial adaptive immune system, allows biologists to edit genomic DNA in a precise and specific way. CRISPR-Cas systems are classified into two ma...
Human mannose binding lectin (MBL) and dendritic cell-associated C-type lectin-1 (Dectin-1) are the two prototypical PRRs of innate immunity, whose direct role in recurrent vulvovaginal infections (RVVI) defen...
Authors: Namarta Kalia, Jatinder Singh, Sujata Sharma and Manpreet Kaur
Previous studies have shown that in myogenic precursors, the homeoprotein Msx1 and its protein partners, histone methyltransferases and repressive histone marks, tend to be enriched on target myogenic regulato...
Authors: Zhangjing Ma, Huiyuan Shi, Yi Shen, Huixia Li, Yu Yang, Jiange Yang, Hui Zhao, Gang Wang and Jingqiang Wang
Cell polarity refers to spatial difference in morphology, structure, and function within different parts of a single cell, which plays important roles in a wide range of cellular processes. In eukaryotic cells...
Authors: Ying Liu, Tianrui Zhang, Dong Sun and Guangzuo Luo
Physical exercise is well known to benefit human health at every age. However, the exact mechanism through which physical exercise improves health remains unknown. Recent studies into exercise-induced myokine ...
Authors: Xin Zhou, MengMeng Xu, Joseph L. Bryant, Jianjie Ma and Xuehong Xu
Pyroptosis, a type of programmed cell death that along with inflammation, is mainly regulated by two main pathways, cysteinyl aspartate specific proteinase (caspase)-1-induced canonical inflammatory pathway an...
Authors: Xiaoli Huang, Yang Feng, Guanqing Xiong, Shona Whyte, Jing Duan, Yucen Yang, Kaiyu Wang, Shiyong Yang, Yi Geng, Yangping Ou and Defang Chen
Cancer stem cells obtain energy demand through the activation of glycolysis and lipolysis. It seems that the use of approached targeting glycolysis and lipolysis could be an effective strategy for the inhibiti...
Authors: Ayda Pouyafar, Milad Zadi Heydarabad, Jalal Abdolalizadeh, Reza Rahbarghazi and Mehdi Talebi
Although the β-carboline alkaloids harman and norharman are considered as plant metabolites, they can also be secreted by fungi such as the entomopathogen Conidiobolus coronatus. Norharman and harman are also kno...
Authors: Anna Katarzyna Wrońska and Mieczysława Irena Boguś
Small nucleolar RNA host gene 7 (SNHG7) is a novel identified oncogenic gene in tumorigenesis. However, the role that SNHG7 plays in pancreatic cancer (PC) remains unclear. In this study, we aimed to investiga...
Authors: Dongfeng Cheng, Juanjuan Fan, Yang Ma, Yiran Zhou, Kai Qin, Minmin Shi and Jingrui Yang
