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Citation: Cell & Bioscience 2022 12:100
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Novel insights into non-alcoholic fatty liver disease and dementia: insulin resistance, hyperammonemia, gut dysbiosis, vascular impairment, and inflammation
Non-alcoholic fatty liver disease (NAFLD) is a metabolic disease characterized by multiple pathologies. The progression of dementia with NAFLD may be affected by various risk factors, including brain insulin r...
Citation: Cell & Bioscience 2022 12:99 -
DNA methyltransferase 1 knockdown reverses PTEN and VDR by mediating demethylation of promoter and protects against renal injuries in hepatitis B virus-associated glomerulonephritis
Aberrant DNA methylation patterns, including hypermethylation of key genes that inhibit fibrosis and inflammation, have been described in human kidney diseases. However, the role of DNA methyltransferase 1 (DN...
Citation: Cell & Bioscience 2022 12:98 -
Biological functions, mechanisms, and clinical significance of circular RNA in pancreatic cancer: a promising rising star
Pancreatic cancer (PC) is a highly malignant solid tumor with insidious onset and easy early metastasis. Despite tremendous efforts devoted to research in this field, the mechanisms underlying PC tumorigenesis...
Citation: Cell & Bioscience 2022 12:97 -
Macrophages derived from pluripotent stem cells: prospective applications and research gaps
Induced pluripotent stem cells (iPSCs) represent a valuable cell source able to give rise to different cell types of the body. Among the various pathways of iPSC differentiation, the differentiation into macro...
Citation: Cell & Bioscience 2022 12:96 -
Blockade of the Arid5a/IL-6/STAT3 axis underlies the anti-inflammatory effect of Rbpjl in acute pancreatitis
The microarray data analysis predicted that Rbpjl is poorly expressed in acute pancreatitis (AP). Activated IL-6/STAT3 signaling is further known to contribute to the progression of AP through immune regulatio...
Citation: Cell & Bioscience 2022 12:95 -
Mechanism of reduced muscle atrophy via ketone body (D)-3-hydroxybutyrate
Muscle atrophy is an increasingly global health problem affecting millions, there is a lack of clinical drugs or effective therapy. Excessive loss of muscle mass is the typical characteristic of muscle atrophy...
Citation: Cell & Bioscience 2022 12:94 -
Post-synaptic specialization of the neuromuscular junction: junctional folds formation, function, and disorders
Post-synaptic specialization is critical to the neurotransmitter release and action potential conduction. The neuromuscular junctions (NMJs) are the synapses between the motor neurons and muscle cells and have...
Citation: Cell & Bioscience 2022 12:93 -
Dual function of SF3B2 on chromatin and RNA to regulate transcription in head and neck squamous cell carcinoma
RNA is spliced concomitantly with transcription and the process is organized by RNA splicing factors, transcriptional regulators, and chromatin regulators. RNA is spliced in close proximity to transcription ma...
Citation: Cell & Bioscience 2022 12:92 -
Genetics of cerebral malaria: pathogenesis, biomarkers and emerging therapeutic interventions
Cerebral malaria (CM) is a preeminent cause of severe disease and premature deaths in Sub-Saharan Africa, where an estimated 90% of cases occur. The key features of CM are a deep, unarousable coma that persist...
Citation: Cell & Bioscience 2022 12:91 -
IL-1R/C3aR signaling regulates synaptic pruning in the prefrontal cortex of depression
Major depressive disorder is characterized by not only monoamine neurotransmitters deficiencies but also persistent neuroinflammation. The complement system is an attractive therapeutic target for various infl...
Citation: Cell & Bioscience 2022 12:90 -
H3K27ac mediated SS18/BAFs relocation regulates JUN induced pluripotent-somatic transition
The exit from pluripotency or pluripotent-somatic transition (PST) landmarks an event of early mammalian embryonic development, representing a model for cell fate transition.
Citation: Cell & Bioscience 2022 12:89 -
Development of a novel human CD147 knock-in NSG mouse model to test SARS-CoV-2 viral infection
An animal model that can mimic the SARS-CoV-2 infection in humans is critical to understanding the rapidly evolving SARS-CoV-2 virus and for development of prophylactic and therapeutic strategies to combat eme...
Citation: Cell & Bioscience 2022 12:88 -
Both prokaryotes and eukaryotes produce an immune response against plasmids with 5ʹ-GTTTGTT-3ʹ
In the evolutionary “arms race” from prokaryotes to eukaryotes, some memories of foreign DNA have been conserved for defensive purposes. Shortly after invasion by the plasmid, pEGFP-N1, the conserved the defen...
Citation: Cell & Bioscience 2022 12:87 -
Inclusion of a dual signal sequence enhances the immunogenicity of a novel viral vectored vaccine against the capsular group B meningococcus
Disease caused by the capsular group B meningococcus (MenB) is the leading cause of infectious death in UK infants. A novel adenovirus-based vaccine encoding the MenB factor H binding protein (fHbp) with an N-...
Citation: Cell & Bioscience 2022 12:86 -
Targeting tumor-associated macrophages for cancer treatment
Tumor-associated macrophages (TAMs) are abundant, nearly accounting for 30–50% of stromal cells in the tumor microenvironment. TAMs exhibit an immunosuppressive M2-like phenotype in advanced cancer, which play...
Citation: Cell & Bioscience 2022 12:85 -
Hepatitis, testicular degeneration, and ataxia in DIDO3-deficient mice with altered mRNA processing
mRNA processing is an essential step of gene expression; its malfunction can lead to different degrees of physiological disorder from subclinical disease to death. We previously identified Dido1 as a stemness mar...
Citation: Cell & Bioscience 2022 12:84 -
The phosphorylation to acetylation/methylation cascade in transcriptional regulation: how kinases regulate transcriptional activities of DNA/histone-modifying enzymes
Transcription factors directly regulate gene expression by recognizing and binding to specific DNA sequences, involving the dynamic alterations of chromatin structure and the formation of a complex with differ...
Citation: Cell & Bioscience 2022 12:83 -
FANCC deficiency mediates microglial pyroptosis and secondary neuronal apoptosis in spinal cord contusion
Traumatic spinal cord injury (SCI)-induced neuroinflammation results in secondary neurological destruction and functional disorder. Previous findings showed that microglial pyroptosis plays a crucial role in n...
Citation: Cell & Bioscience 2022 12:82 -
Histone deacetylase 3 facilitates TNFα-mediated NF-κB activation through suppressing CTSB induced RIP1 degradation and is required for host defense against bacterial infection
As important enzymes regulating acetylation, histone deacetylases (HDACs) participate in a series of cell physiological process. However, the mechanisms responsible for individual HDAC family members in regula...
Citation: Cell & Bioscience 2022 12:81 -
Integrating spatial transcriptomics with single-cell transcriptomics reveals a spatiotemporal gene landscape of the human developing kidney
Research on spatiotemporal gene landscape can provide insights into the spatial characteristics of human kidney development and facilitate kidney organoid cultivation. Here, we profiled the spatiotemporal gene...
Citation: Cell & Bioscience 2022 12:80 -
A minimal bile salt excretory pump promoter allows bile acid-driven physiological regulation of transgene expression from a gene therapy vector
Bile acid (BA) homeostasis is mainly regulated by bile salt excretory pump (BSEP), a hepatocyte transporter that transfers BAs to the bile. BSEP expression is regulated by BA levels through activation of farne...
Citation: Cell & Bioscience 2022 12:79 -
Mxc, a Drosophila homolog of mental retardation-associated gene NPAT, maintains neural stem cell fate
Mental retardation is a complex neurodevelopmental disorder. NPAT, a component of the histone locus body (HLB), has been implicated as a candidate gene for mental retardation, with a mechanism yet to be elucidate...
Citation: Cell & Bioscience 2022 12:78 -
The two-faced role of ATF2 on cisplatin response in gastric cancer depends on p53 context
Activating transcription factor-2 (ATF2) is a member of the basic leucine zipper family of DNA-binding proteins, which exhibits both oncogenic and tumor suppression activity in different tumors. However, the m...
Citation: Cell & Bioscience 2022 12:77 -
Bone morphogenetic protein signaling regulation of AMPK and PI3K in lung cancer cells and C. elegans
Bone morphogenetic protein (BMP) is a phylogenetically conserved signaling pathway required for development that is aberrantly expressed in several age-related diseases including cancer, Alzheimer’s disease, o...
Citation: Cell & Bioscience 2022 12:76 -
Host-dependent impairment of parasite development and reproduction in the acanthocephalan model
A central question in parasitology is why parasites mature and reproduce in some host species but not in others. Yet, a better understanding of the inability of parasites to complete their life cycles in less ...
Citation: Cell & Bioscience 2022 12:75 -
The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities
The global population of older individuals is growing, and ageing is a key risk factor for atherosclerotic cardiovascular diseases. Abnormal accumulation of senescent cells can cause potentially deleterious ef...
Citation: Cell & Bioscience 2022 12:74 -
Mosaic loss of chromosome Y in peripheral blood cells is associated with age-related macular degeneration in men
Age-related macular degeneration (AMD) is the leading cause of severe vision loss in patients over 55 years old in the industrialized world. In the past 20 years, approximately 288 million patents have been af...
Citation: Cell & Bioscience 2022 12:73 -
Fibronectin extra domain A (FN-EDA) causes glaucomatous trabecular meshwork, retina, and optic nerve damage in mice
Elevated intraocular pressure (IOP) is a major risk factor for the development and progression of primary open angle glaucoma and is due to trabecular meshwork (TM) damage. Here, we investigate the role of an ...
Citation: Cell & Bioscience 2022 12:72 -
The ventromedial hypothalamic nucleus: watchdog of whole-body glucose homeostasis
The brain, particularly the ventromedial hypothalamic nucleus (VMH), has been long known for its involvement in glucose sensing and whole-body glucose homeostasis. However, it is still not fully understood how...
Citation: Cell & Bioscience 2022 12:71 -
BHLHE40 promotes osteoclastogenesis and abnormal bone resorption via c-Fos/NFATc1
Dysregulated osteoclast activity due to altered osteoclast differentiation causes multiple bone diseases. Osteoclasts are multinucleated giant cells derived from hematopoietic stem cells and play a major role ...
Citation: Cell & Bioscience 2022 12:70 -
β-amyloid protein induces mitophagy-dependent ferroptosis through the CD36/PINK/PARKIN pathway leading to blood–brain barrier destruction in Alzheimer’s disease
Blood–brain barrier (BBB) dysfunction may occur at the onset of Alzheimer’s disease (AD). Pericytes are a vital part of the neurovascular unit and the BBB, acting as gatekeepers of the BBB. Amyloid β (Aβ) depo...
Citation: Cell & Bioscience 2022 12:69 -
Application and prospect of targeting innate immune sensors in the treatment of autoimmune diseases
Dysregulation of auto-reactive T cells and autoantibody-producing B cells and excessive inflammation are responsible for the occurrence and development of autoimmune diseases. The suppression of autoreactive T...
Citation: Cell & Bioscience 2022 12:68 -
Recent highlights in the immunomodulatory aspects of Treg cell-derived extracellular vesicles: special emphasis on autoimmune diseases and transplantation
In order to maintain immunological tolerance to self and non-self antigens, one’s T regulatory (Treg) cells play a critical role in the regulation of detrimental inflammation. Treg cells inhibit the immune sys...
Citation: Cell & Bioscience 2022 12:67 -
Mitochondrial transfer/transplantation: an emerging therapeutic approach for multiple diseases
Mitochondria play a pivotal role in energy generation and cellular physiological processes. These organelles are highly dynamic, constantly changing their morphology, cellular location, and distribution in res...
Citation: Cell & Bioscience 2022 12:66 -
Ginkgolic acid and anacardic acid are reversible inhibitors of SARS-CoV-2 3-chymotrypsin-like protease
Because of the emerging variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in different regions of the world, the battle with infectious coronavirus disease 2019 (COVID-19) caused by SARS...
Citation: Cell & Bioscience 2022 12:65 -
Single cell transcriptomic analysis of human amnion identifies cell-specific signatures associated with membrane rupture and parturition
The human amnion is an intrauterine tissue which is involved in the initiation of parturition. In-depth understanding of gene expression signatures of individual cell types in the amnion with respect to membra...
Citation: Cell & Bioscience 2022 12:64 -
Antibody engineering improves neutralization activity against K417 spike mutant SARS-CoV-2 variants
Neutralizing antibodies are approved drugs to treat coronavirus disease-2019 (COVID-19) patients, yet mutations in severe acute respiratory syndrome coronavirus (SARS-CoV-2) variants may reduce the antibody ne...
Citation: Cell & Bioscience 2022 12:63 -
RNA sequencing profiles reveal dynamic signaling and glucose metabolic features during bone marrow mesenchymal stem cell senescence
Stem cell senescence is considered as a significant driver of organismal aging. As individuals age, the number of stem cells is declined, and the ability to proliferate and survive is also weakened. It has bee...
Citation: Cell & Bioscience 2022 12:62 -
Nanotechnological engineering of extracellular vesicles for the development of actively targeted hybrid nanodevices
We propose an efficient method to modify B-cell derived EVs by loading them with a nanotherapeutic stimuli-responsive cargo and equipping them with antibodies for efficient targeting of lymphoma cells.
Citation: Cell & Bioscience 2022 12:61 -
m6A demethylase FTO promotes tumor progression via regulation of lipid metabolism in esophageal cancer
Epitranscriptomics studies have contributed greatly to the development of research on human cancers. In recent years, N6-methyladenosine (m6A), an RNA modification on the N-6 position of adenosine, has been fo...
Citation: Cell & Bioscience 2022 12:60 -
Analysis of CCR2 splice variant expression patterns and functional properties
C–C motif chemokine receptor 2 (CCR2), the main receptor for monocyte chemoattractant protein-1 (MCP-1), is expressed on immune cells, including monocytes, macrophages, and activated T cells, and mediates cell...
Citation: Cell & Bioscience 2022 12:59 -
TRPM8 deficiency attenuates liver fibrosis through S100A9-HNF4α signaling
Liver fibrosis represent a major global health care burden. Data emerging from recent advances suggest TRPM8, a member of the transient receptor potential (TRP) family of ion channels, plays an essential role ...
Citation: Cell & Bioscience 2022 12:58 -
Single-cell genomics identifies distinct B1 cell developmental pathways and reveals aging-related changes in the B-cell receptor repertoire
B1 cells are self-renewing innate-like B lymphocytes that provide the first line of defense against pathogens. B1 cells primarily reside in the peritoneal cavity and are known to originate from various fetal t...
Citation: Cell & Bioscience 2022 12:57 -
AKT inhibition in the central nervous system induces signaling defects resulting in psychiatric symptomatology
Changes in the expression and activity of the AKT oncogene play an important role in psychiatric disease. We present translational data assessing the role of AKT in psychiatric symptoms.
Citation: Cell & Bioscience 2022 12:56 -
PA2G4 promotes the metastasis of hepatocellular carcinoma by stabilizing FYN mRNA in a YTHDF2-dependent manner
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide with high mortality. Advanced stage upon diagnosis and cancer metastasis are the main reasons for the dismal prognosis of HCC in large...
Citation: Cell & Bioscience 2022 12:55 -
LRP4 is required for the olfactory association task in the piriform cortex
Low-density lipoprotein receptor-related protein 4 (LRP4) plays a critical role in the central nervous system (CNS), including hippocampal synaptic plasticity, maintenance of excitatory synaptic transmission, ...
Citation: Cell & Bioscience 2022 12:54 -
Rho family GTPase 1 (RND1), a novel regulator of p53, enhances ferroptosis in glioblastoma
Ferroptosis is an iron dependent cell death closely associated with p53 signaling pathway and is aberrantly regulated in glioblastoma (GBM), yet the underlying mechanism needs more exploration. Identifying new...
Citation: Cell & Bioscience 2022 12:53 -
VHL Ser65 mutations enhance HIF2α signaling and promote epithelial-mesenchymal transition of renal cancer cells
Von Hippel-Lindau (VHL) disease is an autosomal dominant genetic neoplastic disorder caused by germline mutation or deletion of the VHL gene, characterized by the tendency to develop multisystem benign or maligna...
Citation: Cell & Bioscience 2022 12:52 -
Heterogeneity of mesenchymal stem cell-derived extracellular vesicles is highly impacted by the tissue/cell source and culture conditions
Extracellular vesicles (EVs) are cell-derived membrane structures exerting major effects in physiological as well as pathological processes by functioning as vehicles for the delivery of biomolecules to their ...
Citation: Cell & Bioscience 2022 12:51
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- ISSN: 2045-3701 (electronic)