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  1. Oncolytic viruses (OVs) are considered a promising therapeutic alternative for cancer. However, OVs could activate the host innate immunity, then impair the viral propagation in tumor cells. In this study, we ...

    Authors: Jiali Hu, Ruitao Lu, Yu Zhang, Wei Li, Qian Hu, Cuiyu Chen, Zhaoqian Liu, Wei Zhang, Ling Chen, Ran Xu, Jia Luo, Howard L. McLeod and Yijing He

    Citation: Cell & Bioscience 2021 11:174

    Content type: Research

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  2. Liver cancer is one of the most common malignancies in the world with a poor prognosis. Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer, accounting for 80–90% of cases. The initiation...

    Authors: Yihua Huang, Xue Yang, Yan Meng, Changchun Shao, Jianping Liao, Fengwei Li, Rong Li, Yingying Jing and Aimin Huang

    Citation: Cell & Bioscience 2021 11:173

    Content type: Research

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  3. Signal transducer and activator of transcription 3 (Stat3) is a cytoplasmic transcription factor that participates in various biologic processes. Loss of Stat3 causes hyperimmunoglobulin E syndrome, presenting...

    Authors: Zijing Huang, Jingyi Feng, Xin Feng, Laiting Chan, Jiarui Lu, Lizhen Lei, Zhuwei Huang and Xiaolei Zhang

    Citation: Cell & Bioscience 2021 11:172

    Content type: Research

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  4. Coronavirus disease 2019 (COVID-19) is an emerging infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and has posed a serious threat to global health. Here, we syste...

    Authors: Xu Pan, Xin Li, Shangwei Ning and Hui Zhi

    Citation: Cell & Bioscience 2021 11:171

    Content type: Letter to the Editor

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  5. Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, and the targeted therapies are lacking for this type of cancer. We previously demonstrated that Huaier effectively improve ...

    Authors: Yuan Tian, Jin Wu, Lingjuan Zeng, Linxi Zhou, Ying Hu, Qinwen Pan, Wei Liu, Yuzhao Yan, Ziwei Wu, Zhaoyu Wang, Zhen Zeng, Peng Tang, Jun Jiang and Minghao Wang

    Citation: Cell & Bioscience 2021 11:170

    Content type: Research

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  6. Long noncoding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) plays a positive role in the progression of human malignant tumors. However, the molecular mechanism of SNHG1 remains elusive in breast cancer.

    Authors: Yujuan Kang, Lin Wan, Qin Wang, Yanling Yin, Jiena Liu, Lei Liu, Hao Wu, Lei Zhang, Xin Zhang, Shouping Xu and Da Pang

    Citation: Cell & Bioscience 2021 11:169

    Content type: Research

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  7. As the COVID-19 pandemic rages on, the new SARS-CoV-2 variants have emerged in the different regions of the world. These newly emerged variants have mutations in their spike (S) protein that may confer resista...

    Authors: Jinbiao Liu, Brittany H. Bodnar, Fengzhen Meng, Adil I. Khan, Xu Wang, Sami Saribas, Tao Wang, Saroj Chandra Lohani, Peng Wang, Zhengyu Wei, Jinjun Luo, Lina Zhou, Jianguo Wu, Guangxiang Luo, Qingsheng Li, Wenhui Hu…

    Citation: Cell & Bioscience 2021 11:168

    Content type: Research

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  8. Annexin A1 (ANXA1) exerts anti-nociceptive effect through ANXA1 receptor formyl peptide receptor 2 (FPR2/ALX (receptor for lipoxin A4), FPR2) at the dorsal root ganglia (DRG) level. However, the mechanisms rem...

    Authors: Yufen Zhang, Sehui Ma, Xiao Ke, Yao Yi, Hongyan Yu, Dian Yu, Qiang Li, You Shang, Youming Lu and Lei Pei

    Citation: Cell & Bioscience 2021 11:167

    Content type: Research

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  9. Gastric cancer (GC) is a highly aggressive and lethal disease around the world. High expression of core 1 β 1, 3-galactosyltransferase 1 (C1GALT1), the primary enzyme responsible for protein O-glycosylation, play...

    Authors: Xiaoxia Dong, Chunli Chen, Xinzhou Deng, Yongyu Liu, Qiwen Duan, Zhen Peng, Zhiguo Luo and Li Shen

    Citation: Cell & Bioscience 2021 11:166

    Content type: Research

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  10. Aberrant expression of Aldo-Keto reductase family 1 member B10 (AKR1B10) was associated with tumor size and metastasis of breast cancer in our published preliminary studies. However, little is known about the ...

    Authors: Jiayao Qu, Jia Li, Yaming Zhang, Rongzhang He, Xiangting Liu, Ke Gong, Lili Duan, Weihao Luo, Zheng Hu, Gengsheng Wang, Chenglai Xia and Dixian Luo

    Citation: Cell & Bioscience 2021 11:163

    Content type: Research

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  11. There are seven human-adaptation lineages of Mycobacterium tuberculosis (Mtb). Tuberculosis (TB) dissemination is strongly influenced by human movements and host genetics. The detailed lineage distribution evolut...

    Authors: Beibei Wu, Wenlong Zhu, Yue Wang, Qi Wang, Lin Zhou, Zhengwei Liu, Lijun Bi, Mathema Barun, Barry N. Kreiswirth, Liang Chen, Songhua Chen, Xiaomeng Wang and Weibing Wang

    Citation: Cell & Bioscience 2021 11:162

    Content type: Research

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  12. Juxtaposed with another zinc finger protein 1 (JAZF1) is associated with metabolic disorders, including type 2 diabetes mellitus (T2DM). Several studies showed that JAZF1 and body fat mass are closely related....

    Authors: Jain Jeong, Soyoung Jang, Song Park, Wookbong Kwon, Si-Yong Kim, Soyoen Jang, Jiwon Ko, Si Jun Park, Su-geun Lim, Duhak Yoon, Junkoo Yi, Sanggyu Lee, Myoung Ok Kim, Seong-Kyoon Choi and Zae Young Ryoo

    Citation: Cell & Bioscience 2021 11:161

    Content type: Research

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  13. Cardiovascular disease is the leading cause of death worldwide. Cardiac electrical remodeling including altered ion channel expression and imbalance of calcium homeostasis can have detrimental effects on cardi...

    Authors: Maria Knyrim, Sindy Rabe, Claudia Grossmann, Michael Gekle and Barbara Schreier

    Citation: Cell & Bioscience 2021 11:160

    Content type: Research

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  14. Vascular calcification is a closely linked to cardiovascular diseases, such as atherosclerosis, chronic kidney disease, diabetes, hypertension and aging. The extent of vascular calcification is closely correl...

    Authors: Xin Zhou, Sui-Ning Xu, Shu-Tong Yuan, Xinjuan Lei, Xiaoying Sun, Lu Xing, Hui-Jin Li, Chun-Xia He, Wei Qin, Dong Zhao, Peng-Quan Li, Edward Moharomd, Xuehong Xu and Hui-Ling Cao

    Citation: Cell & Bioscience 2021 11:159

    Content type: Review

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  15. In the central nervous system (CNS), three types of myelin-associated inhibitors (MAIs) exert major inhibitory effects on nerve regeneration: Nogo-A, myelin-associated glycoprotein (MAG), and oligodendrocyte-m...

    Authors: Mei Yang, Lan Jian, Wei Fan, Xing Chen, Huan Zou, Yanming Huang, Xiaofan Chen, Yuan-Guo Zhou and Rongdi Yuan

    Citation: Cell & Bioscience 2021 11:158

    Content type: Research

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  16. Stem cells have been extensively explored for a variety of regenerative medical applications and they play an important role in clinical treatment of many diseases. However, the limited amount of stem cells an...

    Authors: Xianglin Mei, Hanhan Zhao, Huihan Ai, Shuyue Wang, Zhenbo Song, Lihua Zheng, Guannan Wang, Ying Sun and Yongli Bao

    Citation: Cell & Bioscience 2021 11:156

    Content type: Research

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  17. Recently, we demonstrated that estrogen (E2) induces early growth response 1 (Egr1) to mediate its actions on the uterine epithelium by controlling progesterone receptor signaling for successful embryo implantati...

    Authors: Mira Park, So Hee Park, Hyunsun Park, Hye-Ryun Kim, Hyunjung J. Lim and Haengseok Song

    Citation: Cell & Bioscience 2021 11:155

    Content type: Research

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  18. Cardiac hypertrophy, characterized by the enlargement of cardiomyocytes, is initially an adaptive response to physiological and pathological stimuli. Decompensated cardiac hypertrophy is related to fibrosis, i...

    Authors: Wenhua Su, Qian Huo, Hao Wu, Lulin Wang, Xiaoxue Ding, Liwen Liang, Liang Zhou, Yan Zhao, Juhua Dan and Hong Zhang

    Citation: Cell & Bioscience 2021 11:153

    Content type: Review

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  19. Hepatocellular carcinoma (HCC), the second leading cause of cancer death worldwide, alone accounts for over half (466,100) of new cancer cases and 422,100 deaths based on the average year incidence rates of 20...

    Authors: Yuan Guo, Yan-Rong Zhao, Huan Liu, Yang Xin, Jian-Zhi Yu, Yun-Jin Zang and Qing-guo Xu

    Citation: Cell & Bioscience 2021 11:152

    Content type: Research

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  20. Neuropeptide Y (NPY), one of the most abundant neuropeptides in the body, is widely expressed in the central and peripheral nervous systems and acts on the cardiovascular, digestive, endocrine, and nervous sys...

    Authors: Yan Zhang, Chu-Yun Liu, Wei-Can Chen, Yan-Chuan Shi, Cong-Mei Wang, Shu Lin and He-Fan He

    Citation: Cell & Bioscience 2021 11:151

    Content type: Review

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  21. Lead (Pb) exposure is a risk factor for male infertility, but the epigenetic changes in sperm DNAattributable to lead exposure is poorly defined.

    Authors: Tiancheng Zhang, Yan Fei Ru, Bin Wu, Haiyan Dong, Liang Chen, Jufen Zheng, Jianhui Li, Xin Wang, Zhikai Wang, Xuemei Wang, Xiaorong Shen, Jun Wu, Jun Qian, Maohua Miao, Yihua Gu and Huijuan Shi

    Citation: Cell & Bioscience 2021 11:150

    Content type: Research

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  22. Alcohol-related liver disease (ALD) is a major cause of chronic liver diseases. Inflammatory response is a basic pathological feature of ALD. Mucosal-associated invariant T(MAIT) cells are a novel population o...

    Authors: Yujue Zhang, Yuanyuan Fan, Wei He, Yi Han, Huarui Bao, Renjun Yang, Bingbing Wang, Derun Kong and Hua Wang

    Citation: Cell & Bioscience 2021 11:148

    Content type: Research

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  23. Autophagy is a conserved degradation process crucial to maintaining the primary function of cellular and organismal metabolism. Impaired autophagy could develop numerous diseases, including cancer, cardiomyopa...

    Authors: Xuechai Chen, Jianan Wang, Muhammad Tahir, Fangfang Zhang, Yuanyuan Ran, Zongjian Liu and Juan Wang

    Citation: Cell & Bioscience 2021 11:147

    Content type: Review

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  24. Linear ubiquitination is a novel type of ubiquitination that plays important physiological roles in signalling pathways such as tumour necrosis factor (TNF) signalling. However, little is known about the regul...

    Authors: Ruona Shi, Xue Shi, Dajiang Qin, Shibing Tang, Michiel Vermeulen and Xiaofei Zhang

    Citation: Cell & Bioscience 2021 11:146

    Content type: Research

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  25. Beta cell identity changes occur in the islets of donors with diabetes, but the molecular basis of this remains unclear. Protecting residual functional beta cells from cell identity changes may be beneficial f...

    Authors: Nicola Jeffery, David Chambers, Brandon M. Invergo, Ryan M. Ames and Lorna W. Harries

    Citation: Cell & Bioscience 2021 11:144

    Content type: Research

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  26. Mosaic chromosomal alterations (mCAs) are large chromosomal gains, losses and copy-neutral losses of heterozygosity (LOH) in peripheral leukocytes. While many individuals with detectable mCAs have no notable a...

    Authors: Shu-Hong Lin, Derek W. Brown, Brandon Rose, Felix Day, Olivia W. Lee, Sairah M. Khan, Jada Hislop, Stephen J. Chanock, John R. B. Perry and Mitchell J. Machiela

    Citation: Cell & Bioscience 2021 11:143

    Content type: Research

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  27. Nowadays, a large population around the world, especially the elderly, suffers from neurological inflammatory and degenerative disorders/diseases. Current drug delivery strategies are facing different challeng...

    Authors: Morteza Heidarzadeh, Yasemin Gürsoy-Özdemir, Mehmet Kaya, Aysan Eslami Abriz, Amir Zarebkohan, Reza Rahbarghazi and Emel Sokullu

    Citation: Cell & Bioscience 2021 11:142

    Content type: Review

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  28. Several studies stablished a relationship between metabolic disturbances and Alzheimer´s disease (AD) where inflammation plays a pivotal role. However, mechanisms involved still remain unclear. In the present ...

    Authors: Miren Ettcheto, Elena Sánchez-Lopez, Amanda Cano, Marina Carrasco, Katherine Herrera, Patricia R. Manzine, Triana Espinosa-Jimenez, Oriol Busquets, Ester Verdaguer, Jordi Olloquequi, Carme Auladell, Jaume Folch and Antoni Camins

    Citation: Cell & Bioscience 2021 11:141

    Content type: Research

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  29. Analysis of viral protein–protein interactions is an essential step to uncover the viral protein functions and the molecular mechanism for the assembly of a viral protein complex. We employed a mammalian two-h...

    Authors: Yiling Jiang, Kuijie Tong, Roubin Yao, Yuanze Zhou, Hanwen Lin, Liubing Du, Yunyun Jin, Liu Cao, Jingquan Tan, Xing-Ding Zhang, Deyin Guo, Ji-An Pan and Xiaoxue Peng

    Citation: Cell & Bioscience 2021 11:140

    Content type: Research

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  30. Pseudomonas aeruginosa is a notorious opportunistic pathogen causing various types of biofilm-related infections. Biofilm formation is a unique microbial strategy that allows P. aeruginosa to survive adverse cond...

    Authors: Xiangke Duan, Yanrong Pan, Zhao Cai, Yumei Liu, Yingdan Zhang, Moxiao Liu, Yang Liu, Ke Wang, Lianhui Zhang and Liang Yang

    Citation: Cell & Bioscience 2021 11:138

    Content type: Research

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  31. The ongoing coronavirus disease-2019 (COVID-19) pandemic, caused by a novel coronavirus termed severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that is closely related to SARS-CoV, poses a grave th...

    Authors: Kui Li, Yang Shen, Mark A. Miller, Jennifer Stabenow, Robert W. Williams and Lu Lu

    Citation: Cell & Bioscience 2021 11:137

    Content type: Letter to the Editor

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  32. Lung branching morphogenesis is characterized by epithelial-mesenchymal interactions that ultimately define the airway conducting system. Throughout this process, energy and structural macromolecules are neces...

    Authors: Hugo Fernandes-Silva, Marco G. Alves, Henrique Araújo-Silva, Ana M. Silva, Jorge Correia-Pinto, Pedro F. Oliveira and Rute S. Moura

    Citation: Cell & Bioscience 2021 11:134

    Content type: Research

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  33. Safe and rational development of nanomaterials for clinical translation requires the assessment of potential biocompatibility. Autophagy, a critical homeostatic pathway intrinsically linked to cellular health ...

    Authors: Christopher A. W. David, M. Estela del Castillo Busto, Susana Cuello-Nuñez, Heidi Goenaga-Infante, Michael Barrow, David G. Fernig, Patricia Murray, Matthew J. Rosseinsky, Andrew Owen and Neill J. Liptrott

    Citation: Cell & Bioscience 2021 11:133

    Content type: Research

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  34. Pathological cardiac hypertrophy is a major contributor of heart failure (HF), which seriously threatens human’s health world widely. Deregulation of m6A RNA methylation, and m6A methyltransferases and de-meth...

    Authors: Hongfei Xu, Zhen Wang, Miao Chen, Wenting Zhao, Tingting Tao, Liang Ma, Yiming Ni and Weidong Li

    Citation: Cell & Bioscience 2021 11:132

    Content type: Research

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  35. ADP/ATP translocase 1 (ANT1) is involved in the exchange of cytosolic ADP and mitochondrial ATP, and its defection plays an important role in mitochondrial pathogenesis. To reveal an etiological implication of...

    Authors: Wenyong Ding, Minghua Qi, Li Ma, Xuefei Xu, Yingfei Chen and Wenli Zhang

    Citation: Cell & Bioscience 2021 11:130

    Content type: Research

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  36. Alcoholic fatty liver (AFL) is a liver disease caused by long-term excessive drinking and is characterized by hepatic steatosis. Understanding the regulatory mechanism of steatosis is essential for the treatme...

    Authors: Qingxue Liu, Lei Xu, Meifei Wu, Yiwen Zhou, Junfa Yang, Cheng Huang, Tao Xu, Jun Li and Lei Zhang

    Citation: Cell & Bioscience 2021 11:129

    Content type: Research

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  37. Our previous studies have shown that combining the antiviral lectin GRFT and the pan-CoV fusion inhibitory peptide EK1 results in highly potent inhibitory activity against SARS-CoV-2 infection. In this study, ...

    Authors: Yanxing Cai, Wei Xu, Jiayi Tang, Najing Cao, Qiaoshuai Lan, Lu Lu and Shibo Jiang

    Citation: Cell & Bioscience 2021 11:128

    Content type: Research

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  38. Leptin plays a critical role in the regulation of metabolic homeostasis. However, the molecular mechanism and cross talks between leptin and metabolic pathways leading to metabolic homeostasis across different...

    Authors: Yi Ding, Mariëlle C. Haks, Gabriel Forn-Cuní, Junling He, Natalia Nowik, Amy C. Harms, Thomas Hankemeier, Muhamed N. H. Eeza, Jörg Matysik, A. Alia and Herman P. Spaink

    Citation: Cell & Bioscience 2021 11:126

    Content type: Research

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  39. Endometriosis is an oestrogen-dependent disease with an unclear aetiology and pathogenesis affecting 6–10% of the global female population, predominantly those of reproductive age. Herein, we profile the trans...

    Authors: Junyan Ma, Liqi Zhang, Hong Zhan, Yun Mo, Zuanjie Ren, Anwen Shao and Jun Lin

    Citation: Cell & Bioscience 2021 11:125

    Content type: Research

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