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  1. KIT mutations are the predominant driver mutations in gastrointestinal stromal tumors (GISTs), and targeted therapy against KIT has improved treatment outcome dramatically. However, gaining secondary mutation ...

    Authors: Guangrong Zhu, Jun Shi, Shaoting Zhang, Yue Guo, Ling Huang, Hui Zhao, Yideng Jiang and Jianmin Sun

    Citation: Cell & Bioscience 2020 10:16

    Content type: Research

    Published on:

  2. γδ T cells are an important subset of T lymphocytes that play important roles in innate and adaptive immunity via the secretion of various cytokines. Previous studies have found that long noncoding RNAs (lncRN...

    Authors: Chuan Yang, Ting Feng, Fang Lin, Tinxiang Gong, Shuo Yang, Yuhong Tao and Hong Li

    Citation: Cell & Bioscience 2020 10:15

    Content type: Research

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  4. MicroRNAs or miRNAs are a component of the non-coding RNAs family which is engaged in many cellular functions such as cell proliferation, apoptosis, gene expression, signaling pathways, angiogenesis, and etc. ...

    Authors: Mona Taghavipour, Fatemeh Sadoughi, Hamed Mirzaei, Bahman Yousefi, Bahram Moazzami, Shahla Chaichian, Mohammad Ali Mansournia and Zatollah Asemi

    Citation: Cell & Bioscience 2020 10:12

    Content type: Review

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  5. Mesenchymal stem cells (MSCs) are considered the most promising seed cells for regenerative medicine because of their considerable therapeutic properties and accessibility. Fine-tuning of cell biological proce...

    Authors: Jianhan Ren, Delan Huang, Runze Li, Weicai Wang and Chen Zhou

    Citation: Cell & Bioscience 2020 10:11

    Content type: Review

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  6. DNA mismatch repair (MMR) maintains replication fidelity by correcting mispaired nucleotides incorporated by DNA polymerases. Defects in MMR lead to cancers characterized by microsatellite instability. Recentl...

    Authors: Yaping Huang and Guo-Min Li

    Citation: Cell & Bioscience 2020 10:10

    Content type: Review

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  7. Histone marks control many cellular processes including DNA damage repair. This review will focus primarily on the active histone mark H3K36me3 in the regulation of DNA damage repair and the maintenance of gen...

    Authors: Zhongxing Sun, Yanjun Zhang, Junqi Jia, Yuan Fang, Yin Tang, Hongfei Wu and Dong Fang

    Citation: Cell & Bioscience 2020 10:9

    Content type: Review

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  9. Poly(ADP-ribosyl)ation (PARylation) mediated by poly ADP-ribose polymerases (PARPs) plays a key role in DNA damage repair. Suppression of PARylation by PARP inhibitors impairs DNA damage repair and induces apo...

    Authors: Muzaffer Ahmad Kassab, Lily L. Yu and Xiaochun Yu

    Citation: Cell & Bioscience 2020 10:7

    Content type: Review

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  11. Vascular calcification is the major reason for high mortality of cardiovascular complications for diabetes. Interleukin (IL)-1β has been implicated in this pathogenesis, but its precise role and clinical evide...

    Authors: Te-Chuan Chen, Chia-Kung Yen, Ying-Chen Lu, Chung-Sheng Shi, Rong-Ze Hsieh, Shun-Fu Chang and Cheng-Nan Chen

    Citation: Cell & Bioscience 2020 10:5

    Content type: Research

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  12. Plenty of long non-coding RNAs (lncRNAs) play vital roles in the progression of atherosclerosis. Small nucleolar RNA host gene 6 (SNHG6) is a well known lncRNA that is aberrantly high expressed in atherosclero...

    Authors: Haiyan Shan, Dawei Guo, Siyang Zhang, Huimeng Qi, Shen Liu, Yanmei Du, Yini He, Bofu Wang, Ming Xu and Xiaosong Yu

    Citation: Cell & Bioscience 2020 10:4

    Content type: Research

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  13. When a protein is covalently and irreversibly bound to DNA (i.e., a DNA–protein cross-link [DPC]), it may obstruct any DNA-based transaction, such as transcription and replication. DPC formation is very common...

    Authors: Huimin Zhang, Yun Xiong and Junjie Chen

    Citation: Cell & Bioscience 2020 10:3

    Content type: Review

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  14. A two-stage method of obtaining viable human amniotic stem cells (hAMSCs) in large-scale is described. First, human amniotic stem cells are isolated via dual enzyme (collagenase II and DNAase I) digestion. Nex...

    Authors: Bi Foua Claude Alain Gohi, Xue-Ying Liu, Hong-Yan Zeng, Sheng Xu, Kouassi Marius Honore Ake, Xiao-Ju Cao, Kai-Min Zou and Sheila Namulondo

    Citation: Cell & Bioscience 2020 10:2

    Content type: Research

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  15. miRNAs, the smallest nucleotide molecules able to regulate gene expression at post transcriptional level, are found in both animals and plants being involved in fundamental processes for growth and development...

    Authors: Bernardetta Ledda, Laura Ottaggio, Alberto Izzotti, Samir G. Sukkar and Mariangela Miele

    Citation: Cell & Bioscience 2020 10:1

    Content type: Review

    Published on:

  16. Breast cancer is a most common type of cancer in women. Circular RNAs (circRNAs) are involved in cancer development and progression, but their roles and regulatory mechanisms are unclear in breast cancer. Our ...

    Authors: Zhongli Geng, Wei Wang, Hui Chen, Jianya Mao, Zhenguo Li and Jing Zhou

    Citation: Cell & Bioscience 2019 9:104

    Content type: Research

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  17. The failure of remodeling process that constantly regenerates effete, aged bone is highly associated with bone nonunion and degenerative bone diseases. Numerous studies have demonstrated that aspirin and other...

    Authors: Yong Xie, Meng Pan, Yanpan Gao, Licheng Zhang, Wei Ge and Peifu Tang

    Citation: Cell & Bioscience 2019 9:103

    Content type: Review

    Published on:

  18. Lung cancer is one of very important malignancies which are related to high mobility and mortality in the world. Despite several efforts for improving diagnosis and treatment strategies of lung cancer, finding...

    Authors: Hadis Fathizadeh and Zatollah Asemi

    Citation: Cell & Bioscience 2019 9:102

    Content type: Review

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  19. Drosophila Prominin-like is a homolog of mammalian CD133, which is recognized as a biomarker for stem cells. The interacting proteins of CD133 and their biological functions remain elusive.

    Authors: Xuexiang Wang, Huimei Zheng, Zexiao Jia, Zhaoying Lei, Mengyao Li, Qianqian Zhuang, Hui Zhou, Yue Qiu, Yong Fu, Xiaohang Yang, Yongmei Xi and Qingfeng Yan

    Citation: Cell & Bioscience 2019 9:101

    Content type: Research

    Published on:

  20. PRC1 (Protein regulator of cytokinesis 1) regulates microtubules organization and functions as a novel regulator in Wnt/β-catenin signaling pathway. Wnt/β-catenin is involved in development of liver fibrosis (...

    Authors: Shenzong Rao, Jie Xiang, Jingsong Huang, Shangang Zhang, Min Zhang, Haoran Sun and Jian Li

    Citation: Cell & Bioscience 2019 9:100

    Content type: Research

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  21. The cDNA Library of venomous animals could provide abundant bioactive peptides coding information and is an important resource for screening bioactive peptides that target and regulate disease-related ion chan...

    Authors: Yubiao Zhang, Feng Zhang, Shujuan Shi, Xinqiao Liu, Weisong Cai, Guangtao Han, Caihua Ke, Siru Long, Zhiyong Di, Shijin Yin and Haohuan Li

    Citation: Cell & Bioscience 2019 9:99

    Content type: Research

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  23. Colorectal cancer (CRC) is the fourth leading cause of the worldwide cancer mortality. Different molecular mechanisms have been attributed to the development and progress of CRC. In this review, we will focus ...

    Authors: Zahra Koveitypour, Farnoush Panahi, Mehrdad Vakilian, Maryam Peymani, Farzad Seyed Forootan, Mohammad Hossein Nasr Esfahani and Kamran Ghaedi

    Citation: Cell & Bioscience 2019 9:97

    Content type: Review

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  24. High levels of ROS cause oxidative stress, which plays a critical role in cell death. As a ROS effector protein, PRL2 senses ROS and controls phagocyte bactericidal activity during infection. Here we report PR...

    Authors: Xinyue Du, Yang Zhang, Xiao Li, Qi Li, Chenyun Wu, Guangjie Chen, XiaoKui Guo, Yongqiang Weng and Zhaojun Wang

    Citation: Cell & Bioscience 2019 9:96

    Content type: Research

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  25. Along with the decline in oocyte quality, numerous defects such as mitochondrial insufficiency and the increase of mutation and deletion have been reported in oocyte mitochondrial DNA (mtDNA) following aging. ...

    Authors: Halimeh Mobarak, Mohammad Heidarpour, Pei-Shiue Jason Tsai, Aysa Rezabakhsh, Reza Rahbarghazi, Mohammad Nouri and Mahdi Mahdipour

    Citation: Cell & Bioscience 2019 9:95

    Content type: Review

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  27. Forkhead box P3+ (FOXP3+) regulatory T cells (Tregs) are a subset of lymphocytes, critical for the maintenance of immune homeostasis. Loss-of-function mutations of the FOXP3 gene in animal models and humans resul...

    Authors: Vida Forstnerič, Irena Oven, Jernej Ogorevc, Duško Lainšček, Arne Praznik, Tina Lebar, Roman Jerala and Simon Horvat

    Citation: Cell & Bioscience 2019 9:93

    Content type: Research

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  29. Imbalance between amyloid-beta (Aβ) peptide synthesis and clearance results in Aβ deregulation. Failure to clear these peptides appears to cause the development of Alzheimer’s disease (AD). In recent years, mi...

    Authors: Soheil Madadi, Heidi Schwarzenbach, Massoud Saidijam, Reza Mahjub and Meysam Soleimani

    Citation: Cell & Bioscience 2019 9:91

    Content type: Review

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  31. Schizophrenia is a common psychiatric disease with high hereditary. The identification of schizophrenia risk genes (SRG) has shed light on its pathophysiological mechanisms. Mouse genetic models have been wide...

    Authors: Hai-Long Zhang, Jia-Wen Long, Wei Han, Jiuzhou Wang, Weichen Song, Guan Ning Lin and Dong-Min Yin

    Citation: Cell & Bioscience 2019 9:89

    Content type: Research

    Published on:

  32. Imatinib shows limited efficacy in patients with gastrointestinal stromal tumors (GISTs) carrying secondary KIT mutations. HQP1351, an orally bioavailable multikinase BCR-ABL inhibitor, is currently in clinica...

    Authors: Xuechao Liu, Guangfeng Wang, Xianglei Yan, Haibo Qiu, Ping Min, Miaoyi Wu, Chunyang Tang, Fei Zhang, Qiuqiong Tang, Saijie Zhu, Miaozhen Qiu, Wei Zhuang, Douglas D. Fang, Zhiwei Zhou, Dajun Yang and Yifan Zhai

    Citation: Cell & Bioscience 2019 9:88

    Content type: Research

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  33. Overlap extension polymerase chain reaction (PCR) is a powerful technology for DNA assembly. Based on this technology, we synthesized DNA templates, which were transcribed into sgRNA in vitro, and further dete...

    Authors: Zheng Hu, Li Wang, Zhaoying Shi, Jing Jiang, Xiangning Li, Yonglong Chen, Kai Li and Dixian Luo

    Citation: Cell & Bioscience 2019 9:87

    Content type: Letter to the Editor

    Published on:

  34. Pregnancy-associated cardiomyopathy (PAH) represents a pregnancy-associated myocardial disease that is characterized by the progression of heart failure due to marked left ventricular systolic dysfunction. Com...

    Authors: Yi Wang, Zhiheng Guo, Yongmei Gao, Ping Liang, Yanhong Shan and Jin He

    Citation: Cell & Bioscience 2019 9:86

    Content type: Research

    Published on:

  35. The growth plate is a special region of the cartilage that drives longitudinal growth of long bones. Proliferating chondrocytes in the growth plate, arranged in columns, divide perpendicular to the long axis o...

    Authors: Huiyan Gan, Wenqian Xue, Ya Gao, Guixia Zhu, Danny Chan, Kathryn S. E. Cheah and Jiandong Huang

    Citation: Cell & Bioscience 2019 9:85

    Content type: Research

    Published on:

  36. To investigate the mechanism of LncRNA H19 in Th17 cell differentiation and endometrial stromal cells (ESCs) proliferation in endometriosis (EMS).

    Authors: Zheying Liu, Liya Liu, Yun Zhong, Mingbo Cai, Junbi Gao, Chaoyue Tan, Xiaoxiao Han, Ruixia Guo and Liping Han

    Citation: Cell & Bioscience 2019 9:84

    Content type: Research

    Published on:

  37. Cellular heterogeneity, which was initially defined for tumor cells, is a fundamental property of all cellular systems, ranging from genetic diversity to cell-to-cell variation driven by stochastic molecular i...

    Authors: Gang Ren and Keji Zhao

    Citation: Cell & Bioscience 2019 9:83

    Content type: Review

    Published on:

  39. Increasing evidence has indicated that long noncoding RNAs (lncRNAs) are crucial regulators affecting the progression of human cancers. Recently, lncRNA downregulated in liver cancer stem cells (lnc-DILC) was ...

    Authors: Han Zhang, Pengtao Wei, Wenwei Lv, Xingtao Han, Jinhui Yang and Shuaifeng Qin

    Citation: Cell & Bioscience 2019 9:81

    Content type: Research

    Published on:

  40. Babao Dan (BBD), a traditional Chinese medicine, has been used as a complementary and alternative medicine to treat multifarious liver diseases. In this study, we aimed to observe its protective effect on etha...

    Authors: Yang Yu, Zhi-qiang Tian, Lei Liang, Xue Yang, Dan-dan Sheng, Jian-xing Zeng, Xiao-yong Li, Rong-yu Shi, Zhi-peng Han and Li-xin Wei

    Citation: Cell & Bioscience 2019 9:80

    Content type: Research

    Published on:

  41. Hepatocellular carcinoma (HCC) is among the most prevalent and lethal cancers in the human population. HCC is an inflammation-associated cancer caused by different etiological factors. The chronic inflammation...

    Authors: Zhiqiang Tian, Xiaojuan Hou, Wenting Liu, Zhipeng Han and Lixin Wei

    Citation: Cell & Bioscience 2019 9:79

    Content type: Review

    Published on:

  42. The long non-coding RNA UCA1 is reportedly increased in several human tumors and critical for the cell migration, invasion, or proliferation of several cancer cells. However, the potential roles of UCA1 in tro...

    Authors: Hongfang Shao, Feng Jin, Jiangshan Hu, Zhangying Zhu, Fuju Tian, Minfang Tao and Yincheng Teng

    Citation: Cell & Bioscience 2019 9:78

    Content type: Research

    Published on:

  43. Babaodan (BBD), a traditional Chinese medicine, has been shown to have protective effects during liver injury and ameliorate liver disease progression, but little is known about its effect on non-alcoholic fat...

    Authors: Dandan Sheng, Shanmin Zhao, Lu Gao, Huifei Zheng, Wenting Liu, Jing Hou, Yuxiang Jin, Fei Ye, Qiudong Zhao, Rong Li, Naping Zhao, Li Zhang, Zhipeng Han and Lixin Wei

    Citation: Cell & Bioscience 2019 9:77

    Content type: Research

    Published on:

  44. The prognosis of esophageal cancer is still dismal because of its high probability of metastasis that is likely related to the cellular process of epithelial–mesenchymal transition (EMT). Recent studies have s...

    Authors: Yuxiang Jin, Xinye Lu, Mingdong Wang, Xuewei Zhao and Lei Xue

    Citation: Cell & Bioscience 2019 9:76

    Content type: Research

    Published on:

  46. Whether neurogenesis occurs in the adult human brain has been a long-debated topic fueled by conflicting data both for and against neurogenesis in the mature brain. Recent reports from two independent teams ma...

    Authors: Xinjuan Lei, Yajun Wu, MengMeng Xu, Odell D. Jones, Jianjie Ma and Xuehong Xu

    Citation: Cell & Bioscience 2019 9:74

    Content type: Research highlight

    Published on:

  48. Increasing evidence has revealed that long non-coding RNAs (lncRNAs) play a pivotal role in the development of nervous system. Our previous studies have demonstrated that enhanced cholinergic neurogenesis occu...

    Authors: Xiang Cheng, Haoming Li, Heyan Zhao, Wen Li, Jianbing Qin and Guohua Jin

    Citation: Cell & Bioscience 2019 9:72

    Content type: Research

    Published on:

  49. Pluripotency is proposed to exist in two different stages: Naive and Primed. Conventional human pluripotent cells are essentially in the primed stage. In recent years, several protocols have claimed to generat...

    Authors: Meisam Yousefi, Sayed-Amir Marashi, Ali Sharifi-Zarchi and Sara Taleahmad

    Citation: Cell & Bioscience 2019 9:71

    Content type: Research

    Published on:

  50. The protective effect of metformin (MET) on abdominal aortic aneurysm (AAA) has been reported. However, the related mechanism is still poor understood. In this study, we deeply investigated the role of metform...

    Authors: Zhu Wang, Jingjing Guo, Xinqiang Han, Ming Xue, Wenming Wang, Lei Mi, Yuguo Sheng, Chao Ma, Jian Wu and Xuejun Wu

    Citation: Cell & Bioscience 2019 9:68

    Content type: Research

    Published on:

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