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  1. Intrauterine inflammation (IUI) alters epigenetic modifications in offspring, leading to lung injury. However, the epigenetic mechanism underlying IUI-induced lung injury remains uncertain. In the present stud...

    Authors: Dongting Yao, Jiuru Zhao, Qianqian Zhang, Tao Wang, Meng Ni, Sudong Qi, Qianwen Shen, Wei Li, Baihe Li, Xiya Ding and Zhiwei Liu
    Citation: Cell & Bioscience 2022 12:164
  2. The liver plays crucial roles in sepsis and is one of the major targets for sepsis-related injuries. Ferroptosis, a newly emerged form of lytic cell death, has been implicated in sepsis related organ failure. ...

    Authors: Jin Wang, Qian Zhu, Rui Li, Jing Zhang, Xujun Ye and Xinyi Li
    Citation: Cell & Bioscience 2022 12:163
  3. Immune checkpoints are a set of costimulatory and inhibitory molecules that maintain self-tolerance and regulate immune homeostasis. The expression of immune checkpoints on T cells in malignancy, chronic infla...

    Authors: Ching-Tse Wu, Cheng-I Chu, Feng-Yu Wang, Hui-Yu Yang, Wei-Sung Tseng, Chuang-Rung Chang and Chien-Chung Chang
    Citation: Cell & Bioscience 2022 12:162
  4. Authors: Hongwei Wu, Fanna Liu, Yu Shangguan, Yane Yang, Wei Shi, Wenlong Hu, Zhipeng Zeng, Nan Hu, Xinzhou Zhang, Berthold Hocher, Donge Tang, Lianghong Yin and Yong Dai
    Citation: Cell & Bioscience 2022 12:161

    The original article was published in Cell & Bioscience 2022 12:80

  5. Telomere maintenance mechanisms (TMM) are a hallmark of high-risk neuroblastoma, and are conferred by activation of telomerase or alternative lengthening of telomeres (ALT). However, detection of TMM is not ye...

    Authors: Alina Meeser, Christoph Bartenhagen, Lisa Werr, Anna-Maria Hellmann, Yvonne Kahlert, Nadine Hemstedt, Peter Nürnberg, Janine Altmüller, Sandra Ackermann, Barbara Hero, Thorsten Simon, Martin Peifer, Matthias Fischer and Carolina Rosswog
    Citation: Cell & Bioscience 2022 12:160
  6. A healthy alveolar epithelium is critical to the gas exchange function of the lungs. As the major cell type of alveolar epithelium, alveolar type 2 (AT2) cells play a critical role in maintaining pulmonary hom...

    Authors: Linghuan Zhang, Wenping Luo, Jiang Liu, Maozhu Xu, Qi Peng, Wenjing Zou, Jingyi You, Yi Shu, Piao Zhao, William Wagstaff, Guozhi Zhao, Kevin Qin, Rex C. Haydon, Hue H. Luu, Russell R. Reid, Yang Bi…
    Citation: Cell & Bioscience 2022 12:159
  7. Abnormal lipid metabolism is one of the most prominent metabolic changes in cancer. Studies have shown that lipid metabolism also plays an important role in neuroblastoma. We recently discovered that the insul...

    Authors: Haibo Cao, Ran Zhuo, Zimu Zhang, Jianwei Wang, Yanfang Tao, Randong Yang, Xinyi Guo, Yanling Chen, Siqi Jia, Ye Yao, Pengcheng Yang, Juanjuan Yu, Wanyan Jiao, Xiaolu Li, Fang Fang, Yi Xie…
    Citation: Cell & Bioscience 2022 12:158
  8. Almost 400 years after the (re)discovery of the lymphatic vascular system (LVS) by Gaspare Aselli (Asellius G. De lactibus, sive lacteis venis, quarto vasorum mesaraicorum genere, novo invento Gasparis Asellii...

    Authors: Jörg Wilting and Jürgen Becker
    Citation: Cell & Bioscience 2022 12:157
  9. Clinical and animal studies demonstrated that neuroinflammation from anesthesia (sevoflurane) is the main contributor to cause perioperative neurocognitive disorders (PND). Recently, it was reported that micro...

    Authors: Feng Xu, Yafeng Wang, Linlin Han, Daling Deng, Yuanyuan Ding, LuLin Ma, Qingtong Zhang and Xiangdong Chen
    Citation: Cell & Bioscience 2022 12:156
  10. Cancer is a multifactorial disease that is responsible for 10 million deaths per year. The intra- and inter-heterogeneity of malignant tumors make it difficult to develop single targeted approaches. Similarly,...

    Authors: Camille Jubelin, Javier Muñoz-Garcia, Laurent Griscom, Denis Cochonneau, Emilie Ollivier, Marie-Françoise Heymann, François M. Vallette, Lisa Oliver and Dominique Heymann
    Citation: Cell & Bioscience 2022 12:155
  11. Sepsis is a fatal condition commonly caused by Methicillin-resistant Staphylococcus aureus (MRSA) with a high death rate. Macrophages can protect the host from various microbial pathogens by recognizing and elimi...

    Authors: Dongsheng Zhai, Wenwen Wang, Zichen Ye, Ke Xue, Guo Chen, Sijun Hu, Zhao Yan, Yanhai Guo, Fang Wang, Xubo Li, An Xiang, Xia Li, Zifan Lu and Li Wang
    Citation: Cell & Bioscience 2022 12:154
  12. Specific gene fusions and their fusion products (chimeric RNA and protein) have served as ideal diagnostic markers and therapeutic targets for cancer. However, few systematic studies for chimeric RNAs have bee...

    Authors: Qiong Wang, Junxiu Chen, Sandeep Singh, Zhongqiu Xie, Fujun Qin, Xinrui Shi, Robert Cornelison, Hui Li and Hai Huang
    Citation: Cell & Bioscience 2022 12:153
  13. Primary liver cancer (PLC) is the second leading cause of cancer mortality worldwide, and its morbidity unceasingly increases these years. Hepatitis B virus (HBV) infection accounted for approximately 50% of h...

    Authors: Renshun Dong, Bixiang Zhang and Xuewu Zhang
    Citation: Cell & Bioscience 2022 12:152
  14. Monoaminergic neurotransmitter systems play a central role in neuronal function and behaviour. Dysregulation of these systems gives rise to neuropsychiatric and neurodegenerative disorders with high prevalence...

    Authors: Mohamed H. Al-Sabri, Maryam Nikpour, Laura E. Clemensson, Misty M. Attwood, Michael J. Williams, Mathias Rask-Anderson, Jessica Mwinyi and Helgi B. Schiöth
    Citation: Cell & Bioscience 2022 12:151
  15. Extracellular vesicles (EVs) are membrane-enclosed particles released systemically by all cells, including tumours. Tumour EVs have been shown to manipulate their local environments as well as distal targets t...

    Authors: Laura Simone, Francesco Pisani, Elena Binda, Antonio Frigeri, Angelo L. Vescovi, Maria Svelto and Grazia P. Nicchia
    Citation: Cell & Bioscience 2022 12:150
  16. Apnea of prematurity (AOP) is caused by respiratory control immaturity and affects nearly 50% of premature newborns. This pathology induces perinatal intermittent hypoxia (IH), which leads to neurodevelopmenta...

    Authors: S. Leroux, A. Rodriguez-Duboc, A. Arabo, M. Basille-Dugay, D. Vaudry and D. Burel
    Citation: Cell & Bioscience 2022 12:148
  17. Sufficient nutrition contributes to rapid translational elongation and protein synthesis in eukaryotic cells and prokaryotic bacteria. Fast synthesis and accumulation of type III secretion system (T3SS) protei...

    Authors: Yue Sun, Xiaolong Shao, Yingchao Zhang, Liangliang Han, Jiadai Huang, Yingpeng Xie, Jingui Liu and Xin Deng
    Citation: Cell & Bioscience 2022 12:147
  18. Authors: Alan Carlos Alves Fernandes, Franciane Pereira de Oliveira, Gimena Fernandez, Luane da Guia Vieira, Cristiane Gugelmin Rosa, Taís do Nascimento, Suzelei de Castro França, Jose Donato Jr., Kristen R. Vella, Jose Antunes-Rodrigues, André Souza Mecawi, Mario Perello, Lucila Leico Kagohara Elias and Rodrigo Rorato
    Citation: Cell & Bioscience 2022 12:146

    The original article was published in Cell & Bioscience 2022 12:118

  19. Transcriptome analysis has been known as a functional tool for cancer research recently. Mounting evidence indicated that calcium signaling plays several key roles in cancer progression. Despite numerous studi...

    Authors: Shujin Li, Dong-Joon Lee, Hyun-Yi Kim, Jun-Young Kim, Young-Soo Jung and Han-Sung Jung
    Citation: Cell & Bioscience 2022 12:145
  20. Induced hepatic stem cells (iHepSCs) with the capacities of self-renewal and bidifferentiation into hepatocytes and cholangiocytes were generated from mouse embryonic fibroblasts (MEFs) by lineage reprogrammin...

    Authors: Chen Wang, Xinlu Yu, Sai Ding, Yang Liu, Hongxia Zhang, Jingbo Fu, Bing Yu and Haiying Zhu
    Citation: Cell & Bioscience 2022 12:143
  21. Single-cell RNA sequencing (scRNA-seq) provides a powerful tool to capture transcriptomes at single-cell resolution. However, dropout events distort the gene expression levels and underlying biological signals...

    Authors: Jing Qi, Qiongyu Sheng, Yang Zhou, Jiao Hua, Shutong Xiao and Shuilin Jin
    Citation: Cell & Bioscience 2022 12:142
  22. Cadherins play a pivotal role in facilitating intercellular interactions between spermatogonial progenitor cells (SPCs) and their surrounding microenvironment. Specifically, E-cadherin serves as a cellular mar...

    Authors: Weixiang Song, Danchen Zhang, Jiaqi Mi, Wenfei Du, Yang Yang, Rong Chen, Cong Tian, Xiaodong Zhao and Kang Zou
    Citation: Cell & Bioscience 2022 12:141
  23. Recognition of viral invasion by innate antiviral immune system triggers activation of the type I interferon (IFN-I) and proinflammatory signaling pathways. Subsequently, IFN-I induction regulates expression o...

    Authors: Shulong Zu, Chunfeng Li, Lili Li, Yong-Qiang Deng, Xiang Chen, Dan Luo, Qing Ye, Yi-Jiao Huang, Xiao-Feng Li, Rong-Rong Zhang, Nina Sun, Xianqi Zhang, Saba R. Aliyari, Karin Nielsen-Saines, Jae U. Jung, Heng Yang…
    Citation: Cell & Bioscience 2022 12:139
  24. As a member of RNA-binding protein, CDKN2AIP has been shown to play a critical role in stem cell pluripotency and somatic differentiation. Recent studies indicate that Cdkn2aip is essential for spermatogonial sel...

    Authors: Yuming Cao, Qi Sun, Zhenlie Chen, Jing Lu, Ting Geng, Ling Ma and Yuanzhen Zhang
    Citation: Cell & Bioscience 2022 12:136
  25. PI3K-Akt pathway activation and the expression of histone deacetylases (HDACs) are highly increased in esophageal cancer, suggesting that inhibition of such targets may be a viable therapeutic strategy. Herein...

    Authors: Zheng Jian, Yichao Han, Wentian Zhang, Chengqiang Li, Wei Guo, Xijia Feng, Bin Li and Hecheng Li
    Citation: Cell & Bioscience 2022 12:135
  26. Cardiac fibrosis is characterized by excessive extracellular matrix deposition that contributes to compromised cardiac function and potentially heart failure. Disruptor of telomeric silencing 1-like (Dot1L) is...

    Authors: Jie Xu, Jinghuan Wang, Fen Long, Wen Zhong, Haibi Su, Zhenghua Su and Xinhua Liu
    Citation: Cell & Bioscience 2022 12:134
  27. Age-related macular degeneration (AMD) leads to gradual central vision loss and eventual irreversible blindness. Melatonin, an endogenous hormone, exhibits anti-inflammatory and antitumor effects; however, the...

    Authors: Kai Wang, Yong-Syuan Chen, Hsiang-Wen Chien, Hui-Ling Chiou, Shun-Fa Yang and Yi-Hsien Hsieh
    Citation: Cell & Bioscience 2022 12:133
  28. Urological cancers are common malignant cancers worldwide, with annually increasing morbidity and mortality rates. For decades, two-dimensional cell cultures and animal models have been widely used to study th...

    Authors: Haotian Chen, Wentao Zhang, Niraj Maskey, Fuhan Yang, Zongtai Zheng, Cheng Li, Ruiliang Wang, Pengfei Wu, Shiyu Mao, Junfeng Zhang, Yang Yan, Wei Li and Xudong Yao
    Citation: Cell & Bioscience 2022 12:132
  29. The mammalian target of rapamycin (mTOR) plays a critical role in controlling cellular homeostasis, and its dysregulation has been implicated in Alzheimer’s disease (AD). Presenilin-1 (PS1) mutations account f...

    Authors: Cheong-Meng Chong, Yuan Tan, Jiaqi Tong, Minjing Ke, Ke Zhang, Lingli Yan, Xiaotong Cen, Jia-Hong Lu, Guobing Chen, Huanxing Su and Dajiang Qin
    Citation: Cell & Bioscience 2022 12:131
  30. The endoplasmic reticulum (ER) is a multi-layered organelle that is essential for the synthesis, folding, and structural maturation of almost one-third of the cellular proteome. It houses several resident prot...

    Authors: Nisa Syakila A. Rahman, Syazalina Zahari, Saiful Effendi Syafruddin, Mohd Firdaus-Raih, Teck Yew Low and M. Aiman Mohtar
    Citation: Cell & Bioscience 2022 12:129
  31. Reactive astrocytes are increasingly recognized as crucial regulators of innate immunity in degenerative or damaged central nervous system (CNS). Many proinflammatory mediators have been shown to drive inflamm...

    Authors: Hui Li, Bingqiang He, Xingyuan Zhang, Huifei Hao, Ting Yang, Chunshuai Sun, Honghua Song, Yingjie Wang, Yue Zhou, Zhenjie Zhu, Yuming Hu and Yongjun Wang
    Citation: Cell & Bioscience 2022 12:128
  32. Different pathologies, affecting the skeletal system, were reported to display altered bone and/or cartilage innervation profiles leading to the deregulation of the tissue homeostasis. The patterning of periph...

    Authors: Estrela Neto, Luís Leitão, José C. Mateus, Daniela M. Sousa, Cecília J. Alves, Miguel Aroso, Ana C. Monteiro, Francisco Conceição, Richard O. C. Oreffo, Jonathan West, Paulo Aguiar and Meriem Lamghari
    Citation: Cell & Bioscience 2022 12:127
  33. Alternative splicing (AS) of genes has been found to affect gene stability, and its abnormal regulation can lead to tumorigenesis. CELF2 is a vital splicing factor to participate in mRNA alternative splicing. ...

    Authors: Shihui Lai, Yan Wang, Ting Li, Yihong Dong, Yihao Lin, Liang Wang, Shangeng Weng, Xiang Zhang and Chengjie Lin
    Citation: Cell & Bioscience 2022 12:125
  34. Targeting the HGF/MET signaling pathway has been a viable therapeutic strategy for various cancer types due to hyperactivation of HGF/MET axis occurs frequently that leads to detrimental cancer progression and...

    Authors: Pei-Yi Chu, Wei-Chieh Huang, Shiao-Lin Tung, Chung-Ying Tsai, Chih Jung Chen, Yu-Chin Liu, Chia-Wen Lee, Yang-Hsiang Lin, Hung-Yu Lin, Cheng-Yi Chen, Chau-Ting Yeh, Kwang-Huei Lin and Hsiang-Cheng Chi
    Citation: Cell & Bioscience 2022 12:124
  35. Fibroblasts have important roles in the synthesis and remodeling of extracellular matrix (ECM) proteins during pulmonary fibrosis. However, the spatiotemporal distribution of heterogeneous fibroblasts during d...

    Authors: Xiaoni Shi, Jing Wang, Xinxin Zhang, Shaoqi Yang, Wei Luo, Sha Wang, Jie Huang, Mengling Chen, Yusi Cheng and Jie Chao
    Citation: Cell & Bioscience 2022 12:123
  36. Constitutive activation of PI3K signaling has been well recognized in a subset of small cell lung cancer (SCLC), the cancer type which has the most aggressive clinical course amongst pulmonary tumors. Whereas ...

    Authors: Ming-Chun Hung, Wan-Ping Wang and Ya-Hui Chi
    Citation: Cell & Bioscience 2022 12:122
  37. Tick-borne encephalitis (TBE) is a disease affecting the central nervous system. Over the last decade, the incidence of TBE has steadily increased in Europe and Asia despite the availably of effective vaccines...

    Authors: Gabriele Chiffi, Denis Grandgirard, Sabrina Stöckli, Luca G. Valente, Antoine Adamantidis and Stephen L. Leib
    Citation: Cell & Bioscience 2022 12:121
  38. Colorectal liver metastases (CRLM) continue to have a low survival rate. The number of CRLM regulators and clinical indicators remains limited. Long non-coding RNAs (lncRNAs) are a new master regulator of cell...

    Authors: Zhe Wang, Jianfang Chen, Fengjun Sun, Xiang Zhao, Yan Dong, Songtao Yu, Jianjun Li and Houjie Liang
    Citation: Cell & Bioscience 2022 12:120
  39. Developmental signaling pathways such as those of Hedgehog (HH) and WNT play critical roles in cancer stem cell self-renewal, migration, and differentiation. They are often constitutively activated in many hum...

    Authors: Liu-Ya Tang, Marie Spezia, Ting Chen, Jee-Hye Shin, Feng Wang, Frank Stappenbeck, Andres M. Lebensohn, Farhad Parhami and Ying E. Zhang
    Citation: Cell & Bioscience 2022 12:119
  40. The activation of the hypothalamic–pituitary–adrenal (HPA) axis is essential for metabolic adaptation in response to fasting. However, the neurocircuitry connecting changes in the peripheral energy stores to t...

    Authors: Alan Carlos Alves Fernandes, Franciane Pereira de Oliveira, Gimena Fernandez, Luane da Guia Vieira, Cristiane Gugelmin Rosa, Taís do Nascimento, Suzelei de Castro França, Jose Donato Jr., Kristen R. Vella, Jose Antunes-Rodrigues, André Souza Mecawi, Mario Perello, Lucila Leico Kagohara Elias and Rodrigo Rorato
    Citation: Cell & Bioscience 2022 12:118

    The Correction to this article has been published in Cell & Bioscience 2022 12:146

  41. Fibrosis is a pathological feature of a variety of chronic inflammatory diseases that can affect almost all organs, which can cause severe consequences and even lead to death. Fibrosis is characterized by the ...

    Authors: Xiangyu Zhao, Jiayin Chen, Hongxiang Sun, Yao Zhang and Duowu Zou
    Citation: Cell & Bioscience 2022 12:117

    The Correction to this article has been published in Cell & Bioscience 2022 12:138

  42. The degeneration of retinal pigmented epithelium (RPE) cells results in severe diseases, such as age-related macular degeneration (AMD) that causes blindness in millions of individuals.

    Authors: Jing Li, Feng Zhang, Wei Bian, Yanyun Chen, Jianying Liu, Zhenyu Liu, Ying Xiong and Xiuhua Wan
    Citation: Cell & Bioscience 2022 12:116