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  1. Acute lung injury (ALI) is a serious disease with highly morbidity and mortality that causes serious health problems worldwide. Atypical mitogen activated protein kinases (MAPKs) play critical roles in the dev...

    Authors: Ling Mao, Ya Zhou, Longqing Chen, Lin Hu, Shiming Liu, Wen Zheng, Juanjuan Zhao, Mengmeng Guo, Chao Chen, Zhixu He and Lin Xu

    Citation: Cell & Bioscience 2020 10:121

    Content type: Research

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  2. Heat shock protein (HSP) 20 is a molecular chaperone that exerts multiple protective functions in various kinds of tissues. However, the expression of HSP20 and its specific functions in airway epithelial cell...

    Authors: Aihua Bao, Aying Ma, Hui Zhang, Lihua Qiao, Suqin Ben, Xin Zhou and Min Zhang

    Citation: Cell & Bioscience 2020 10:120

    Content type: Research

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  3. Alternative splicing (AS), a crucial post-transcriptional regulatory mechanism in expanding the coding capacities of genomes and increasing the diversity of proteins, still faces various challenges in the spli...

    Authors: Nan Zhang, Ping Zhang, Ying Chen, Shifeng Lou, Hanqing Zeng and Jianchuan Deng

    Citation: Cell & Bioscience 2020 10:118

    Content type: Research

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  4. Destruction and death of neurons can lead to neurodegenerative diseases. One possible way to treat neurodegenerative diseases and damage of the nervous system is replacing damaged and dead neurons by cell tran...

    Authors: Ziran Xu, Shengnan Su, Siyan Zhou, Wentao Yang, Xin Deng, Yingying Sun, Lisha Li and Yulin Li

    Citation: Cell & Bioscience 2020 10:116

    Content type: Review

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  5. Thyroid cancer (TC) is the most common type of endocrine malignancy and its incidence is increasing over years. Conventional surgery, radiotherapy and chemotherapy are difficult to improve the significant effe...

    Authors: Guohong Zhao, Jianqin Kang, Guanghui Xu, Jing Wei, Xiaoguang Wang, Xiaorui Jing, Lan Zhang, Aili Yang, Kai Wang, Jue Wang, Li Wang, Junfeng Hou, Qingquan Liu, Kai Jiao and Bin Gao

    Citation: Cell & Bioscience 2020 10:115

    Content type: Research

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  6. Phloretin is isolated from apple trees and could increase lipolysis in 3T3-L1 adipocytes. Previous studies have found that phloretin could prevent obesity in mice. In this study, we investigated whether phlore...

    Authors: Chian-Jiun Liou, Shu-Ju Wu, Szu-Chuan Shen, Li-Chen Chen, Ya-Ling Chen and Wen-Chung Huang

    Citation: Cell & Bioscience 2020 10:114

    Content type: Research

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  7. Angiogenesis is a critical step in the growth of pancreatic neuroendocrine tumors (PNETs) and may be a selective target for PNET therapy. However, PNETs are robustly resistant to current anti-angiogenic therap...

    Authors: Xi Luo, Jiang-yi He, Jie Xu, Shao-yi Hu, Bang-hui Mo, Qiu-xia Shu, Can Chen, Yu-zhu Gong, Xiao-long Zhao, Gan-feng Xie and Song-tao Yu

    Citation: Cell & Bioscience 2020 10:113

    Content type: Research

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  8. Spinal cord injury (SCI) is the damage to the spinal cord that can lead to temporary or permanent loss of function due to injury to the nerve. The SCI patients are often associated with poor quality of life.

    Authors: Ling Ling Liau, Qi Hao Looi, Wui Chuen Chia, Thayaalini Subramaniam, Min Hwei Ng and Jia Xian Law

    Citation: Cell & Bioscience 2020 10:112

    Content type: Review

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  9. Ten-eleven translocation (TET) proteins, encoding dioxygenase for DNA hydroxymethylation, are important players in nervous system development and disease. In addition to their proverbial enzymatic role, TET pr...

    Authors: Ming Zhang, Kaixiang Zhang, Jian Wang, Yuming Liu, Guangxin Liu, Weilin Jin, Shengxi Wu and Xianghui Zhao

    Citation: Cell & Bioscience 2020 10:110

    Content type: Research

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  10. Alzheimer’s disease (AD) is a neurodegenerative disease that leads to progressive loss of memory and dementia. The pathological hallmarks of AD include extracellular accumulation of amyloid-β peptides forming ...

    Authors: Hariharakrishnan Chidambaram, Rashmi Das and Subashchandrabose Chinnathambi

    Citation: Cell & Bioscience 2020 10:109

    Content type: Review

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  11. Fear is an adaptive response across species in the face of threatening cues. It can be either innate or learned through postnatal experience. We have previously shown that genetic deletion of both Rap1a and Ra...

    Authors: Wen-Bing Chen, Han-Qing Pan, Ye He, Xue-Hui Wang, Wen-Hua Zhang and Bing-Xing Pan

    Citation: Cell & Bioscience 2020 10:107

    Content type: Research

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  12. Huntington’s disease (HD) is a neurodegenerative disease that involves a complex combination of psychiatric, cognitive and motor impairments. Synaptic dysfunction has been implicated in HD pathogenesis. Howeve...

    Authors: Li Niu, Li Li, Shiming Yang, Weixi Wang, Cuifang Ye and He Li

    Citation: Cell & Bioscience 2020 10:106

    Content type: Research

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  13. Shwachman-Diamond syndrome (SDS) is a congenital disease that affects the bone marrow, skeletal system, and pancreas. The majority of patients with SDS have mutations in the SBDS gene, involved in ribosome biogen...

    Authors: Ayushi Jain, Phubed Nilatawong, Narinrat Mamak, Laran T. Jensen and Amornrat Naranuntarat Jensen

    Citation: Cell & Bioscience 2020 10:105

    Content type: Research

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  14. Mesenchymal stem cells (MSCs), also referred to as multipotent stromal cells or mesenchymal stromal cells, are present in multiple tissues and capable of differentiating into diverse cell lineages, holding a g...

    Authors: Yizhen Sima and Yisong Chen

    Citation: Cell & Bioscience 2020 10:104

    Content type: Review

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  15. Long bones of limbs are formed through endochondral bone formation, which depends on the coordinated development of growth plates. Our previous studies have demonstrated that dysfunction of mitogen-activated p...

    Authors: Xiaoming Yang, Dongmei Zhong, Wenjie Gao, Zhiheng Liao, Yuyu Chen, Shun Zhang, Hang Zhou, Peiqiang Su and Caixia Xu

    Citation: Cell & Bioscience 2020 10:103

    Content type: Research

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  16. Patients with type 2 diabetes mellitus (T2DM), especially those with poor glycemic control, are characterized by low bone mass and destruction of bone microstructure. Nowadays, autologous mesenchymal stem cell...

    Authors: Lei Wang, Shaojie Shi, Ruiping Bai, Yue Wang, Zhao Guo and Doudou Li

    Citation: Cell & Bioscience 2020 10:102

    Content type: Research

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  17. Autophagy has a crucial role in the defense against parasites. The interplay existing between host autophagy and parasites has varied outcomes due to the kind of host cell and microorganism. The presence of au...

    Authors: George Ghartey-Kwansah, Frank Adu-Nti, Benjamin Aboagye, Amandus Ankobil, Edward Eyipe Essuman, Yeboah Kwaku Opoku, Samuel Abokyi, Emmanuel Kwasi Abu and Johnson Nyarko Boampong

    Citation: Cell & Bioscience 2020 10:101

    Content type: Review

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  18. Ribosomal protein 34 (RPL34) is a highly conserved protein belonging to the 60S large subunit of mammalian ribosomes that has been found to be dysregulated in a variety of human tumors. However, there are limi...

    Authors: Jianxin Qian, Lin Xu, Wenlong Yu, Xiaoqiang Gu, Yongjun Zuo, Ying Chen, Feng Xie and Lixin Wei

    Citation: Cell & Bioscience 2020 10:100

    Content type: Research

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  19. Schwann cells (SCs) play a crucial role in Wallerian degeneration after peripheral nerve injury. The expression of genes in SCs undergo a series of changes, which greatly affect the proliferation and apoptosis...

    Authors: Jiang-Bo Wang, Zhan Zhang, Jian-Nan Li, Tuo Yang, Shuang Du, Rang-Juan Cao and Shu-Sen Cui

    Citation: Cell & Bioscience 2020 10:98

    Content type: Research

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  20. Sex differences are prevalent in normal development, physiology and disease pathogeneses. Recent studies have demonstrated that mosaic loss of Y chromosome and aberrant activation of its genes could modify the...

    Authors: Yun-Fai Chris Lau

    Citation: Cell & Bioscience 2020 10:97

    Content type: Review

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  21. Openers of mitochondrial adenosine triphosphate-dependent potassium (mKATP) channels like diazoxide increase reactive oxygen species (ROS) production in cardiac cells and reduce Ca2+ elevations produced by ischem...

    Authors: Joice T. Gavali, Elba D. Carrillo, María C. García and Jorge A. Sánchez

    Citation: Cell & Bioscience 2020 10:96

    Content type: Research

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  22. Human pyruvate dehydrogenase phosphatase 1 (PDP1) plays an important physiological role in energy metabolism; however, its expression and function in human pancreatic adenocarcinoma (PDAC) remain unknown. This...

    Authors: Ye Li, Jia Shen, Chien-shan Cheng, HuiFeng Gao, Jiangang Zhao and Lianyu Chen

    Citation: Cell & Bioscience 2020 10:95

    Content type: Research

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  23. Gastric cancer (GC) is a malignancy with high morbidity/mortality, partly due to a lack of reliable biomarkers for early diagnosis. It is important to develop reliable biomarker(s) with specificity, sensitivit...

    Authors: Qinghua Liu, Ying Zhang, Jiwei Zhang, Kun Tao, Brett D. Hambly and Shisan Bao

    Citation: Cell & Bioscience 2020 10:94

    Content type: Research

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  24. Cancer stem cells are the main reason of relapse, metastasis and resistance to anti-cancer therapies of Hepatocellular carcinoma (HCC). Mesenchymal stem cells (MSCs) are an important part of the tumor microenv...

    Authors: Jing Hou, Naping Zhao, Pengxi Zhu, Jun Chang, Yan Du and Wei Shen

    Citation: Cell & Bioscience 2020 10:93

    Content type: Research

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  25. Vesicular system of mammalian cells is composed of two intracellular and extracellular vesicles systems, which contributes to the intra/intercellular communication and cellular homeostasis. These systems media...

    Authors: Mehdi Hassanpour, Aysa Rezabakhsh, Jafar Rezaie, Mohammad Nouri and Reza Rahbarghazi

    Citation: Cell & Bioscience 2020 10:92

    Content type: Review

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  26. Arsenic exposure has become a matter of worldwide concern, which is associated with immune-related diseases. However, little is known about its effect on inflammatory immune-related homeostasis. The purpose of...

    Authors: Nan Yan, Guowei Xu, Chenchen Zhang, Xuping Liu, Xin Li, Lin Sun, Da Wang, Xiaoxu Duan and Bing Li

    Citation: Cell & Bioscience 2020 10:91

    Content type: Research

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  27. NF-E2-related factor 2 (Nrf2) is involved in the radiation resistance of esophageal squamous cell carcinoma (ESCC), but the underlying molecular mechanism is unclear. The purpose of our study was to explore th...

    Authors: Di Xia, Xiao-Ran Zhang, Yan-Li Ma, Zhi-Jun Zhao, Ren Zhao and Yan-Yang Wang

    Citation: Cell & Bioscience 2020 10:90

    Content type: Research

    Published on:

  28. For decades, cancer metastasis has been a heated topic for its high mortality. Previous research has shown that pre-metastatic niche and metastatic niche are the 2 crucial steps in cancer metastasis, assisting...

    Authors: Jianan Zhuyan, Mingyu Chen, Tianhao Zhu, Xunxia Bao, Timing Zhen, Kaichen Xing, Qiubo Wang and Sibo Zhu

    Citation: Cell & Bioscience 2020 10:89

    Content type: Review

    Published on:

  29. Mesenchymal stem/stromal cells (MSCs) and macrophages are critical components in many tissue microenvironments, including that in adipose tissue. The close interaction between MSCs and macrophages modulates va...

    Authors: Hui Ma, Ya-nan Li, Lin Song, Rui Liu, Xiaolei Li, Qianwen Shang, Ying Wang, Changshun Shao and Yufang Shi

    Citation: Cell & Bioscience 2020 10:88

    Content type: Research

    Published on:

  30. The correct folding is a key process for a protein to acquire its functional structure and conformation. Prefoldin is a well-known chaperone protein that regulates the correct folding of proteins. Prefoldin pl...

    Authors: Jiaxin Liang, Longzheng Xia, Linda Oyang, Jinguan Lin, Shiming Tan, Pin Yi, Yaqian Han, Xia Luo, Hui Wang, Lu Tang, Qing Pan, Yutong Tian, Shan Rao, Min Su, Yingrui Shi, Deliang Cao…

    Citation: Cell & Bioscience 2020 10:87

    Content type: Review

    Published on:

  31. With the acceleration of urbanization and aging and the change of lifestyle, inflammatory diseases have become one of the important threats to the health of the global population. Matrix metalloproteinases (MM...

    Authors: Jie He, Man Qin, Yingyi Chen, Ziqi Hu, Fei Xie, Ling Ye and Tianqian Hui

    Citation: Cell & Bioscience 2020 10:86

    Content type: Review

    Published on:

  32. The chemokine receptor CCR5 is one of the co-receptor of HIV-1 infection. People with homozygous CCR5Δ32 deletion resist HIV-1 infection, which makes the CCR5 an important target for HIV-1 gene therapy. Although ...

    Authors: Zhepeng Liu, Jin Liang, Shuliang Chen, Kewu Wang, Xianhao Liu, Beibei Liu, Yang Xia, Mingxiong Guo, Xiaoshi Zhang, Guihong Sun and Geng Tian

    Citation: Cell & Bioscience 2020 10:85

    Content type: Research

    Published on:

  33. Hepatocellular carcinoma (HCC) is one of the most malignant tumor types and has a high incidence and mortality. Many miRNAs play important roles in the development of HCC. Identification of these miRNAs and th...

    Authors: Li Hui, Fang Zheng, Yuan Bo, Ma Sen-lin, Li Ai-jun, Zhou Wei-ping, Zhang Yong-jie and Yin Lei

    Citation: Cell & Bioscience 2020 10:83

    Content type: Research

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  34. Long intergenic noncoding RNA p21 was mapped on the human chromosome 6p21.2. Accordingly, it was firstly described by promoting the p53-dependent apoptosis in the mouse. Also, it is a new lncRNA playing some v...

    Authors: Roya Amirinejad, Mina Rezaei and Zeinab Shirvani-Farsani

    Citation: Cell & Bioscience 2020 10:82

    Content type: Review

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  35. Recent evidences demonstrate that dysregulated expression of microRNA-320d (miR-320d) has been associated with several cancer development and progression. However the effect of miR-320d on gastric cardiac aden...

    Authors: Xiaojie Chen, Shegan Gao, Zhiwei Zhao, Gaofeng Liang, Jinyu Kong and Xiaoshan Feng

    Citation: Cell & Bioscience 2020 10:80

    Content type: Research

    Published on:

  36. Ischemic stroke poses a severe risk to human health worldwide, and currently, clinical therapies for the disease are limited. Delta opioid receptor (DOR)-mediated neuroprotective effects against ischemia have ...

    Authors: Zelin Lai, Lingling Gu, Lu Yu, Huifen Chen, Zhenhua Yu, Cheng Zhang, Xiaoqing Xu, Mutian Zhang, Min Zhang, Mingliang Ma, Zheng Zhao and Jun Zhang

    Citation: Cell & Bioscience 2020 10:79

    Content type: Research

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  37. The X-linked inhibitor of apoptosis protein (XIAP) is the most potent caspase inhibitor of the IAP family in apoptosis pathway. This study aims to identify the molecular targets of XIAP in human breast cancer ...

    Authors: Mehdi Agha Gholizadeh, Fatemeh T. Shamsabadi, Ahad Yamchi, Masoud Golalipour, Gagan Deep Jhingan and Majid Shahbazi

    Citation: Cell & Bioscience 2020 10:78

    Content type: Research

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  38. MicroRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression at the post-transcriptional level and play critical roles in regulating physiological function, and are becoming worldwide ...

    Authors: Juanjuan Zhao, Ya Zhou, Mengmeng Guo, Dongxu Yue, Chao Chen, Guiyou Liang and Lin Xu

    Citation: Cell & Bioscience 2020 10:77

    Content type: Review

    Published on:

  39. Colorectal cancer (CRC) is the fourth most deadly malignancy throughout the world. Extensive studies have shown that Krüppel-like factors (KLFs) play essential roles in cancer development. However, the functio...

    Authors: Weilong Yao, Yue Jiao, Yanhua Zhou and Xiaoya Luo

    Citation: Cell & Bioscience 2020 10:76

    Content type: Research

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  40. Stem cell-based regenerative medicine is a promising approach for tissue reconstruction. However, a large number of cells are needed in a typical clinical study, where conventional monolayer cultures might pos...

    Authors: Benson Koh, Nadiah Sulaiman, Mh Busra Fauzi, Jia Xian Law, Min Hwei Ng, Ruszymah Bt Hj Idrus and Muhammad Dain Yazid

    Citation: Cell & Bioscience 2020 10:75

    Content type: Review

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  41. Interleukin-17A (IL-17) is an evolutionary conserved cytokine and best known for its role in boosting immune response. However, recent clinical researches showed that abundant IL-17 in tumor microenvironment w...

    Authors: Shijia Wang, Guan Wang, Liying Zhang, Fengying Li, Keli Liu, Ying Wang, Yufang Shi and Kai Cao

    Citation: Cell & Bioscience 2020 10:73

    Content type: Research

    Published on:

  42. Herpesvirus is ranked as one of the grand old members of all pathogens. Of all the viruses in the superfamily, Herpes simplex virus type 1 (HSV-1) is considered as a model virus for a variety of reasons. In a ...

    Authors: Qiaojuan Zhang, Miguel Martin-Caraballo and Shaochung V. Hsia

    Citation: Cell & Bioscience 2020 10:70

    Content type: Review

    Published on: