Articles

Transcriptome-scale spatial gene expression in rat arcuate nucleus during puberty

A variety of neurons in hypothalamus undergo a complicated regulation on transcription activity of multiple genes for hypothalamic–pituitary–gonadal axis activation during pubertal development. Identification ...

Authors: Shasha Zhou, Shaolian Zang, Yanping Hu, Yifen Shen, Hua Li, Wenlian Chen, Pin Li and Yihang Shen

Activation of TCA cycle restrains virus-metabolic hijacking and viral replication in mouse hepatitis virus-infected cells

One of coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused coronavirus disease 2019 (COVID-19) pandemic and threatened worldwide. However, therapy for COVID-19 has rarely been...

Authors: Sang R. Lee, Jeong Yeon Roh, Jihoon Ryu, Hyun-Jin Shin and Eui-Ju Hong

Replication and transcription machinery for ranaviruses: components, correlation, and functional architecture

Ranaviruses (family Iridoviridae) are promiscuous pathogens that can infect across species barriers in poikilotherms and can replicate in amphibian and fish cells and even in cultured mammalian cells. However, as...

Authors: Fei Ke, Xue-Dong Yu, Zi-Hao Wang, Jian-Fang Gui and Qi-Ya Zhang

Offspring production of haploid spermatid-like cells derived from mouse female germline stem cells with chromatin condensation

During male meiosis, the Y chromosome can form perfect pairing with the X chromosome. However, it is unclear whether mammalian Female germline stem cells (FGSCs) without a Y chromosome can transdifferentiate i...

Authors: Xiaopeng Hu, Hu Wang, Geng. G. Tian, Changliang Hou, Bo Xu, Xinyan Zhao, Yongqiang Zhao, Qian Fang, Xinyue Li, Lin He, Xuejin Chen, Shangang Li and Ji Wu

Y chromosome is moving out of sex determination shadow

Although sex hormones play a key role in sex differences in susceptibility, severity, outcomes, and response to therapy of different diseases, sex chromosomes are also increasingly recognized as an important f...

Authors: Raheleh Heydari, Zohreh Jangravi, Samaneh Maleknia, Mehrshad Seresht-Ahmadi, Zahra Bahari, Ghasem Hosseini Salekdeh and Anna Meyfour

Ontogeny of RORγt⁺ cells in the intestine of newborns and its role in the development of experimental necrotizing enterocolitis

Neonates possess an immature and plastic immune system, which is a major cause of some diseases in newborns. Necrotizing enterocolitis (NEC) is a severe and devastating intestinal disease that typically affect...

Authors: Xiuhao Zhao, Wenhua Liang, Yonghui Wang, Ruirong Yi, Lingjie Luo, Weifang Wang, Nannan Sun, Mingcheng Yu, Weijue Xu, Qingfeng Sheng, Li Lu, Jianfeng Pang, Zhibao Lv and Feng Wang

Turning the tide on Alzheimer’s disease: modulation of γ-secretase

Alzheimer’s disease (AD) is the most common type of neurodegenerative disorder. Amyloid-beta (Aβ) plaques are integral to the “amyloid hypothesis,” which states that the accumulation of Aβ peptides triggers a ...

Authors: Joanna E. Luo and Yue-Ming Li

The interplay of autophagy and oxidative stress in the pathogenesis and therapy of retinal degenerative diseases

Oxidative stress is mainly caused by intracellular reactive oxygen species (ROS) production, which is highly associated with normal physiological homeostasis and the pathogenesis of diseases, particularly ocul...

Authors: Kun-Che Chang, Pei-Feng Liu, Chia-Hsuan Chang, Ying-Cheng Lin, Yen-Ju Chen and Chih-Wen Shu

BVES is a novel interactor of ANO5 and regulates myoblast differentiation

Anoctamin 5 (ANO5) is a membrane protein belonging to the TMEM16/Anoctamin family and its deficiency leads to the development of limb girdle muscular dystrophy R12 (LGMDR12). However, little has been known abo...

Authors: Haiwen Li, Li Xu, Yandi Gao, Yuanbojiao Zuo, Zuocheng Yang, Lingling Zhao, Zhiheng Chen, Shuliang Guo and Renzhi Han

Maresin conjugates in tissue regeneration-1 suppresses ferroptosis in septic acute kidney injury

Ferroptosis is unique among different types of regulated cell death and closely related to organ injury. Whether ferroptosis occurs in sepsis-associated acute kidney injury (SA-AKI) is not clear. Nuclear facto...

Authors: Ji Xiao, Qian Yang, Ye’an Zhang, Haoran Xu, Yang Ye, Linchao Li, Yi Yang and Shengwei Jin

Exosomes originating from infection with the cytoplasmic single-stranded RNA virus Rift Valley fever virus (RVFV) protect recipient cells by inducing RIG-I mediated IFN-B response that leads to activation of autophagy

Although multiple studies have demonstrated a role for exosomes during virus infections, our understanding of the mechanisms by which exosome exchange regulates immune response during viral infections and affe...

Authors: Farhang Alem, Adeyemi A. Olanrewaju, Samson Omole, Heather E. Hobbs, Noor Ahsan, Graham Matulis, Christine A. Brantner, Weidong Zhou, Emanuel F. Petricoin, Lance A. Liotta, Massimo Caputi, Sina Bavari, Yuntao Wu, Fatah Kashanchi and Ramin M. Hakami

The eukaryotic initiation factor 5A (eIF5A1), the molecule, mechanisms and recent insights into the pathophysiological roles

Since the demonstration of its involvement in cell proliferation, the eukaryotic initiation factor 5A (eIF5A) has been studied principally in relation to the development and progression of cancers in which the...

Authors: Michel Tauc, Marc Cougnon, Romain Carcy, Nicolas Melis, Thierry Hauet, Luc Pellerin, Nicolas Blondeau and Didier F. Pisani

Genetically modified large animal models for investigating neurodegenerative diseases

Neurodegenerative diseases represent a large group of neurological disorders including Alzheimer’s disease, amyotrophic lateral sclerosis, Parkinson’s disease, and Huntington’s disease. Although this group of ...

Authors: Weili Yang, Xiusheng Chen, Shihua Li and Xiao-Jiang Li

Antioxidant supplements promote tumor formation and growth and confer drug resistance in hepatocellular carcinoma by reducing intracellular ROS and induction of TMBIM1

Controversy over the benefits of antioxidants supplements in cancers persists for long. Using hepatocellular carcinoma (HCC) as a model, we investigated the effects of exogenous antioxidants N-acetylcysteine (NAC...

Authors: Vanilla Xin Zhang, Karen Man-Fong Sze, Lo-Kong Chan, Daniel Wai-Hung Ho, Yu-Man Tsui, Yung-Tuen Chiu, Eva Lee, Abdullah Husain, Hongyang Huang, Lu Tian, Carmen Chak-Lui Wong and Irene Oi-Lin Ng

Generation of macrophage containing alveolar organoids derived from human pluripotent stem cells for pulmonary fibrosis modeling and drug efficacy testing

Macrophages are a central immune component in various types of in vitro human organoid systems to recapitulate normal and pathological development. However, to date, generation of human alveolar organoids (AOs...

Authors: Hye-Ryeon Heo and Seok-Ho Hong

SARS-CoV-2 and COVID-19: revisiting the most important research questions

In February 2020, we highlighted the top nine important research questions on SARS-CoV-2 and COVID-19 concerning virus transmission, asymptomatic and presymptomatic virus shedding, diagnosis, treatment, vaccin...

Authors: Kit-San Yuen, Zi-Wei Ye, Sin-Yee Fung, Pak-Hin Hinson Cheung, Chi-Ping Chan and Dong-Yan Jin

Autophagy deficiency in neurodevelopmental disorders

Autophagy is a cell self-digestion pathway through lysosome and plays a critical role in maintaining cellular homeostasis and cytoprotection. Characterization of autophagy related genes in cell and animal mode...

Authors: Zhiqiang Deng, Xiaoting Zhou, Jia-Hong Lu and Zhenyu Yue

Microinjection of antisense oligonucleotides into living mouse testis enables lncRNA function study

Long non-coding RNAs (lncRNAs) have been the focus of ongoing research in a diversity of cellular processes. LncRNAs are abundant in mammalian testis, but their biological function remains poorly known.

Authors: Zhaohui Chen, Li Ling, Xiaolian Shi, Wu Li, Huicong Zhai, Zhenlong Kang, Bangjin Zheng, Jiaqi Zhu, Suni Ye, Hao Wang, Lingxiu Tong, Juan Ni, Chaoyang Huang, Yang Li and Ke Zheng

From nasal to basal: single-cell sequencing of the bursa of Fabricius highlights the IBDV infection mechanism in chickens

Chickens, important food animals and model organisms, are susceptible to many RNA viruses that invade via the nasal cavity. To determine the nasal entry site of the virus and clarify why avians are susceptible...

Authors: Abid Ullah Shah, Yuchen Li, Wei Ouyang, Zhisheng Wang, Jinjiao Zuo, Song Shi, Qinghua Yu, Jian Lin and Qian Yang

The 2020 Ming K. Jeang awards for excellence in Cell & Bioscience

Three articles published by the research groups led by Yun-Bo Shi of the National Institute of Child Health and Human Development, National Institutes of Health, USA; Aria Baniahmad of the Institute of Human G...

Authors: Yun-Fai Chris Lau

SIRT6 inhibition delays peripheral nerve recovery by suppressing migration, phagocytosis and M2-polarization of macrophages

Silent information regulator 6 (SIRT6) is a mammalian homolog of the nicotinamide adenine dinucleotide (NAD)-dependent deacetylase sirtuin family. Prior evidences suggested that the anti-inflammatory function ...

Authors: Ying Zou, Jiaqi Zhang, Jiawei Xu, Lanya Fu, Yizhou Xu, Xianghai Wang, Zhenlin Li, Lixin Zhu, Hao Sun, Hui Zheng and Jiasong Guo

The cGAS–STING pathway: more than fighting against viruses and cancer

In the classic Cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) synthase (cGAS)-stimulator of interferon genes (STING) pathway, downstream signals can control the production of type I interferon ...

Authors: Terigen Bao, Jia Liu, Jiyan Leng and Lu Cai

Identification of Gm15441, a Txnip antisense lncRNA, as a critical regulator in liver metabolic homeostasis

The majority of mammalian genome is composed of non-coding regions, where numerous long non-coding RNAs (lncRNAs) are transcribed. Although lncRNAs have been identified to regulate fundamental biological proce...

Authors: Mingyang Xin, Qian Guo, Qingchun Lu, Juan Lu, Po-shun Wang, Yun Dong, Tao Li, Ye Chen, Glenn S. Gerhard, Xiao-feng Yang, Michael Autieri and Ling Yang

Correction to: Upregulation of IL-15 in the placenta alters trophoblasts behavior contributing to gestational diabetes mellitus

Authors: Jiaqi Li, Yuan Li, Xuan Zhou, Lijie Wei, Jingyi Zhang, Shenglan Zhu, Huiting Zhang, Xuan Gao, Lali Mwamaka Sharifu, Shaoshuai Wang, Ling Xi and Ling Feng

Characterization of novel interactions with membrane NEU1 highlights new regulatory functions for the Elastin Receptor Complex in monocyte interaction with endothelial cells

Vascular aging is associated with remodeling of elastin, one of the main extracellular matrix component of the arterial wall, and production of elastin-derived peptides (EDP). These extracellular matrix degrad...

Authors: Olivier Bocquet, Dignê Tembely, Damien Rioult, Christine Terryn, Béatrice Romier, Amar Bennasroune, Sébastien Blaise, Hervé Sartelet, Laurent Martiny, Laurent Duca and Pascal Maurice

A polygenic risk score predicts mosaic loss of chromosome Y in circulating blood cells

Mosaic loss of Y chromosome (LOY) is the most common somatic change that occurs in circulating white blood cells of older men. LOY in leukocytes is associated with increased risk for all-cause mortality and a ...

Authors: Moeen Riaz, Jonas Mattisson, Galina Polekhina, Andrew Bakshi, Jonatan Halvardson, Marcus Danielsson, Adam Ameur, John McNeil, Lars A. Forsberg and Paul Lacaze

Soluble amyloid-beta isoforms predict downstream Alzheimer’s disease pathology

Changes in soluble amyloid-beta (Aβ) levels in cerebrospinal fluid (CSF) are detectable at early preclinical stages of Alzheimer’s disease (AD). However, whether Aβ levels can predict downstream AD pathologica...

Authors: Guilherme Povala, Bruna Bellaver, Marco Antônio De Bastiani, Wagner S. Brum, Pamela C. L. Ferreira, Andrei Bieger, Tharick A. Pascoal, Andrea L. Benedet, Diogo O. Souza, Ricardo M. Araujo, Bruno Zatt, Pedro Rosa-Neto and Eduardo R. Zimmer

Single-cell RNA-sequencing reveals distinct immune cell subsets and signaling pathways in IgA nephropathy

IgA nephropathy (IgAN) is the most common primary glomerulonephritis globally. Increasing evidence suggests the importance of host immunity in the development of IgAN, but its dynamics during the early stage o...

Authors: Honghui Zeng, Le Wang, Jiajia Li, Siweier Luo, Qianqian Han, Fang Su, Jing Wei, Xiaona Wei, Jianping Wu, Bin Li, Jingang Huang, Patrick Tang, Chunwei Cao, Yiming Zhou and Qiongqiong Yang

Intranasal HD-Ad vaccine protects the upper and lower respiratory tracts of hACE2 mice against SARS-CoV-2

The ongoing COVID-19 pandemic has resulted in 185 million recorded cases and over 4 million deaths worldwide. Several COVID-19 vaccines have been approved for emergency use in humans and are being used in many...

Authors: Huibi Cao, Juntao Mai, Zhichang Zhou, Zhijie Li, Rongqi Duan, Jacqueline Watt, Ziyan Chen, Ranmal Avinash Bandara, Ming Li, Sang Kyun Ahn, Betty Poon, Natasha Christie-Holmes, Scott D. Gray-Owen, Arinjay Banerjee, Karen Mossman, Rob Kozak…

Catalase deficiency facilitates the shuttling of free fatty acid to brown adipose tissue through lipolysis mediated by ROS during sustained fasting

Fatty acids (FA) derived from adipose tissue and liver serve as the main fuel in thermogenesis of brown adipose tissue (BAT). Catalase, a peroxisomal enzyme, plays an important role in maintaining intracellula...

Authors: Raghbendra Kumar Dutta, Joon No Lee, Yunash Maharjan, Channy Park, Seong-Kyu Choe, Ye-Shih Ho and Raekil Park

Low-level laser prevents doxorubicin-induced skeletal muscle atrophy by modulating AMPK/SIRT1/PCG-1α-mediated mitochondrial function, apoptosis and up-regulation of pro-inflammatory responses

Doxorubicin (Dox) is a widely used anthracycline drug to treat cancer, yet numerous adverse effects influencing different organs may offset the treatment outcome, which in turn affects the patient’s quality of...

Authors: Hsiu-Chung Ou, Pei-Ming Chu, Yu-Ting Huang, Hui-Ching Cheng, Wan-Ching Chou, Hsin-Lun Yang, Hsiu-I. Chen and Kun-Ling Tsai

Development of a simple and miniaturized sandwich-like fluorescence polarization assay for rapid screening of SARS-CoV-2 main protease inhibitors

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly transmissible and has caused a pandemic named coronavirus disease 2019 (COVID-19), which has quickly spread worldwide. Although several th...

Authors: Gangan Yan, Dongsheng Li, Yuan Lin, Zhenghao Fu, Haiyan Qi, Xiaoping Liu, Jing Zhang, Shuyi Si and Yunyu Chen

Concurrent mapping of multiple epigenetic marks and co-occupancy using ACT2-seq

Genome-wide profiling of epigenetic marks is a core technology in molecular genetics. Co-occupancy of different epigenetic marks or protein factors at the same genomic locations must often be inferred from mul...

Authors: Benjamin Carter, Wai Lim Ku, Joe Pelt and Keji Zhao

Impaired neutralizing antibody response to COVID-19 mRNA vaccines in cancer patients

There is currently a critical need to determine the efficacy of SARS-CoV-2 vaccination for immunocompromised patients. In this study, we determined the neutralizing antibody response in 160 cancer patients dia...

Authors: Cong Zeng, John P. Evans, Sarah Reisinger, Jennifer Woyach, Christina Liscynesky, Zeinab El Boghdadly, Mark P. Rubinstein, Karthik Chakravarthy, Linda Saif, Eugene M. Oltz, Richard J. Gumina, Peter G. Shields, Zihai Li and Shan-Lu Liu

α-Synuclein-mediated neurodegeneration in Dementia with Lewy bodies: the pathobiology of a paradox

Dementia with Lewy bodies (DLB) is epitomized by the pathognomonic manifestation of α-synuclein-laden Lewy bodies within selectively vulnerable neurons in the brain. By virtue of prion-like inheritance, the α-...

Authors: Christopher Simon, Tomoko Soga, Hirotaka James Okano and Ishwar Parhar

NME6 is a phosphotransfer-inactive, monomeric NME/NDPK family member and functions in complexes at the interface of mitochondrial inner membrane and matrix

NME6 is a member of the nucleoside diphosphate kinase (NDPK/NME/Nm23) family which has key roles in nucleotide homeostasis, signal transduction, membrane remodeling and metastasis suppression. The well-studied...

Authors: Bastien Proust, Martina Radić, Nikolina Škrobot Vidaček, Cécile Cottet, Stéphane Attia, Frédéric Lamarche, Lucija Ačkar, Vlatka Godinić Mikulčić, Malgorzata Tokarska-Schlattner, Helena Ćetković, Uwe Schlattner and Maja Herak Bosnar

Methamphetamine facilitates HIV infection of primary human monocytes through inhibiting cellular viral restriction factors

Methamphetamine (METH), a potent addictive psychostimulant, is highly prevalent in HIV-infected individuals. Clinically, METH use is implicated in alteration of immune system and increase of HIV spread/replica...

Authors: Yu Liu, Feng-Zhen Meng, Xu Wang, Peng Wang, Jin-Biao Liu, Wen-Hui Hu, Won-Bin Young and Wen-Zhe Ho

The regulatory mechanism of neutrophil extracellular traps in cancer biological behavior

As the predominant host defense against pathogens, neutrophil extracellular traps (NETs) have attracted increasing attention due to their vital roles in infectious inflammation in the past few years. Interesti...

Authors: Hui Wang, Yiyin Zhang, Qianling Wang, Xiaoli Wei, Hua Wang and Kangsheng Gu

Down-regulation of EPB41L4A-AS1 mediated the brain aging and neurodegenerative diseases via damaging synthesis of NAD⁺ and ATP

Aging and neurodegenerative diseases are typical metabolic-related processes. As a metabolism-related long non-coding RNA, EPB41L4A-AS has been reported to be potentially involved in the development of brain a...

Authors: Tingpeng Yang, Yanzhi Wang, Weijie Liao, Shikuan Zhang, Songmao Wang, Naihan Xu, Weidong Xie, Cheng Luo, Yangyang Wang, Ziqiang Wang and Yaou Zhang

Anti-metastatic effect of GV1001 on prostate cancer cells; roles of GnRHR-mediated Gαs-cAMP pathway and AR-YAP1 axis

Gonadotropin-releasing hormone receptor (GnRHR) transmits its signal via two major Gα-proteins, primarily Gαq and Gαi. However, the precise mechanism underlying the functions of Gαs signal in prostate cancer c...

Authors: Ji Won Kim, Miso Park, Suntae Kim, Sung Chul Lim, Hyung Shik Kim and Keon Wook Kang

Parkinson's in the bone

Patients with Parkinson’s disease (PD) exhibit systemic deficits, including arthritis and osteoporosis-like symptoms. However, the questions, how the deficits in periphery organs or tissues occur in PD patient...

Authors: Lei Xiong, Jin-Xiu Pan, Hao-han Guo, Lin Mei and Wen-Cheng Xiong

Effect of exercise and diet intervention in NAFLD and NASH via GAB2 methylation

Nonalcoholic fatty liver disease (NAFLD) is a disorder that extends from simple hepatic steatosis to nonalcoholic steatohepatitis (NASH), which is effectively alleviated by lifestyle intervention. Nevertheless...

Authors: Na Wu, Fan Yuan, Siran Yue, Fengyan Jiang, Decheng Ren, Liangjie Liu, Yan Bi, Zhenming Guo, Lei Ji, Ke Han, Xiao Yang, Mofan Feng, Kai Su, Fengping Yang, Xi Wu, Qing Lu…

Role of FoxO transcription factors in aging and age-related metabolic and neurodegenerative diseases

Aging happens to all of us as we live. Thanks to the improved living standard and discovery of life-saving medicines, our life expectancy has increased substantially across the world in the past century. Howev...

Authors: Shuqi Du and Hui Zheng

Allogeneic vs. autologous mesenchymal stem/stromal cells in their medication practice

Mesenchymal stem/stromal cell (MSC)-based therapeutics is already available for treatment of a range of diseases or medical conditions. Autologous or allogeneic MSCs obtained from self or donors have their own...

Authors: Chenghai Li, Hua Zhao, Linna Cheng and Bin Wang

Mitochondrial dysfunction, UPR^mt signaling, and targeted therapy in metastasis tumor

In modern research, mitochondria are considered a more crucial energy plant in cells. Mitochondrial dysfunction, including mitochondrial DNA (mtDNA) mutation and denatured protein accumulation, is a common fea...

Authors: Rajendiran Keerthiga, De-Sheng Pei and Ailing Fu

PRCC reduces the sensitivity of cancer cells to DNA damage by inhibiting JNK and ATM/ATR pathways and results in a poor prognosis in hepatocellular carcinoma

The proline rich mitotic checkpoint control factor (PRCC) is involved in the splicing process of pre-mRNA. This study aims to elucidate PRCC molecular function, regulatory mechanism and diagnostic value in hep...

Authors: Chunying Liu, Xuejing Lin, Bin Sun, Ziming Mao, Lei Chen, Haihua Qian and Changqing Su

Correction to: Genetic composition and evolution of the prevalent Mycobacterium tuberculosis lineages 2 and 4 in the Chinese and Zhejiang Province populations

Authors: Beibei Wu, Wenlong Zhu, Yue Wang, Qi Wang, Lin Zhou, Zhengwei Liu, Lijun Bi, Mathema Barun, Barry N. Kreiswirth, Liang Chen, Songhua Chen, Xiaomeng Wang and Weibing Wang

Neuromedin B promotes chondrocyte differentiation of mesenchymal stromal cells via calcineurin and calcium signaling

Articular cartilage is a complex tissue with poor healing capacities. Current approaches for cartilage repair based on mesenchymal stromal cells (MSCs) are often disappointing because of the lack of relevant d...

Authors: Marie Maumus, Guillaume Fonteneau, Maxime Ruiz, Said Assou, Hassan Boukhaddaoui, Philippe Pastoureau, Frédéric De Ceuninck, Christian Jorgensen and Danièle Noel

Chorionic villus-derived mesenchymal stem cell-mediated autophagy promotes the proliferation and invasiveness of trophoblasts under hypoxia by activating the JAK2/STAT3 signalling pathway

Trophoblast dysfunction during pregnancy is fundamentally involved in preeclampsia. Several studies have revealed that human chorionic villous mesenchymal stem cells (CV-MSCs) could regulate trophoblasts funct...

Authors: Yijing Chu, Chengzhan Zhu, Chongyu Yue, Wei Peng, Weiping Chen, Guifang He, Changchang Liu, Yang Lv, Guoqiang Gao, Ke Yao, Rendong Han, Xiaoyu Hu, Yan Zhang and Yuanhua Ye

Current knowledge and challenges associated with targeted delivery of neurotrophic factors into the central nervous system: focus on available approaches

During the last decades, numerous basic and clinical studies have been conducted to assess the delivery efficiency of therapeutic agents into the brain and spinal cord parenchyma using several administration r...

Authors: Gozal Bahlakeh, Reza Rahbarghazi, Daruosh Mohammadnejad, Ali Abedelahi and Mohammad Karimipour