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  1. Non-alcoholic fatty liver disease (NAFLD) is a metabolic disease characterized by multiple pathologies. The progression of dementia with NAFLD may be affected by various risk factors, including brain insulin r...

    Authors: So Yeong Cheon and Juhyun Song
    Citation: Cell & Bioscience 2022 12:99
  2. Aberrant DNA methylation patterns, including hypermethylation of key genes that inhibit fibrosis and inflammation, have been described in human kidney diseases. However, the role of DNA methyltransferase 1 (DN...

    Authors: Haochen Guan, Nan Zhu, Gang Tang, Yi Du, Ling Wang and Weijie Yuan
    Citation: Cell & Bioscience 2022 12:98
  3. Pancreatic cancer (PC) is a highly malignant solid tumor with insidious onset and easy early metastasis. Despite tremendous efforts devoted to research in this field, the mechanisms underlying PC tumorigenesis...

    Authors: Qun Chen, Jiajia Li, Peng Shen, Hao Yuan, Jie Yin, Wanli Ge, Wujun Wang, Guangbin Chen, Taoyue Yang, Bin Xiao, Yi Miao, Zipeng Lu, Pengfei Wu and Kuirong Jiang
    Citation: Cell & Bioscience 2022 12:97
  4. The microarray data analysis predicted that Rbpjl is poorly expressed in acute pancreatitis (AP). Activated IL-6/STAT3 signaling is further known to contribute to the progression of AP through immune regulatio...

    Authors: Jiachen Lv, Min Fang, Shijie Sun, Gang Wang, Songbin Fu, Bei Sun and Jinxue Tong
    Citation: Cell & Bioscience 2022 12:95
  5. Muscle atrophy is an increasingly global health problem affecting millions, there is a lack of clinical drugs or effective therapy. Excessive loss of muscle mass is the typical characteristic of muscle atrophy...

    Authors: Jin Chen, Zihua Li, Yudian Zhang, Xu Zhang, Shujie Zhang, Zonghan Liu, Huimei Yuan, Xiangsheng Pang, Yaxuan Liu, Wuchen Tao, Xiaoping Chen, Peng Zhang and Guo-Qiang Chen
    Citation: Cell & Bioscience 2022 12:94
  6. RNA is spliced concomitantly with transcription and the process is organized by RNA splicing factors, transcriptional regulators, and chromatin regulators. RNA is spliced in close proximity to transcription ma...

    Authors: Koji Kitamura, Hidefumi Suzuki, Ryota Abe, Hidenori Inohara, Yasufumi Kaneda, Hidehisa Takahashi and Keisuke Nimura
    Citation: Cell & Bioscience 2022 12:92
  7. Cerebral malaria (CM) is a preeminent cause of severe disease and premature deaths in Sub-Saharan Africa, where an estimated 90% of cases occur. The key features of CM are a deep, unarousable coma that persist...

    Authors: Lydia Nkuah Nortey, Alberta Serwah Anning, Gideon Kwesi Nakotey, Abdala Mumuni Ussif, Yeboah Kwaku Opoku, Silas Acheampong Osei, Benjamin Aboagye and George Ghartey-Kwansah
    Citation: Cell & Bioscience 2022 12:91
  8. Major depressive disorder is characterized by not only monoamine neurotransmitters deficiencies but also persistent neuroinflammation. The complement system is an attractive therapeutic target for various infl...

    Authors: Man-Man Zhang, Min-Xia Guo, Qiu-Ping Zhang, Xue-Qin Chen, Na-Zhi Li, Qing Liu, Jie Cheng, Shi-Le Wang, Guang-Hui Xu, Cheng-Fu Li, Ji-Xiao Zhu and Li-Tao Yi
    Citation: Cell & Bioscience 2022 12:90
  9. The exit from pluripotency or pluripotent-somatic transition (PST) landmarks an event of early mammalian embryonic development, representing a model for cell fate transition.

    Authors: Runxia Lin, Ziwei Zhai, Junqi Kuang, Chuman Wu, Yuxiang Yao, Ruona Shi, Jiangping He, Shuyang Xu, Pengli Li, Yixin Fan, Wei Li, Zichao Wu, Xiaoxi Li, Jin Ming, Jing Guo, Bo Wang…
    Citation: Cell & Bioscience 2022 12:89
  10. An animal model that can mimic the SARS-CoV-2 infection in humans is critical to understanding the rapidly evolving SARS-CoV-2 virus and for development of prophylactic and therapeutic strategies to combat eme...

    Authors: Saiaditya Badeti, Qingkui Jiang, Alireza Naghizadeh, Hsiang-chi Tseng, Yuri Bushkin, Salvatore A. E. Marras, Annuurun Nisa, Sanjay Tyagi, Fei Chen, Peter Romanienko, Ghassan Yehia, Deborah Evans, Moises Lopez-Gonzalez, David Alland, Riccardo Russo, William Gause…
    Citation: Cell & Bioscience 2022 12:88
  11. In the evolutionary “arms race” from prokaryotes to eukaryotes, some memories of foreign DNA have been conserved for defensive purposes. Shortly after invasion by the plasmid, pEGFP-N1, the conserved the defen...

    Authors: Nan Li, Dongya Jiang, Luqingqing He, Yunyun Yue, Qinxin Zhang, Shuang Wang, Yunfeng Zhang, Yuxuan Wei and Qingshun Zhao
    Citation: Cell & Bioscience 2022 12:87
  12. Disease caused by the capsular group B meningococcus (MenB) is the leading cause of infectious death in UK infants. A novel adenovirus-based vaccine encoding the MenB factor H binding protein (fHbp) with an N-...

    Authors: Dylan Sheerin, Christina Dold, Laura Silva-Reyes, Aline Linder, Andrew J. Pollard and Christine S. Rollier
    Citation: Cell & Bioscience 2022 12:86
  13. Tumor-associated macrophages (TAMs) are abundant, nearly accounting for 30–50% of stromal cells in the tumor microenvironment. TAMs exhibit an immunosuppressive M2-like phenotype in advanced cancer, which play...

    Authors: Mengjun Li, Linye He, Jing Zhu, Peng Zhang and Shufang Liang
    Citation: Cell & Bioscience 2022 12:85
  14. Transcription factors directly regulate gene expression by recognizing and binding to specific DNA sequences, involving the dynamic alterations of chromatin structure and the formation of a complex with differ...

    Authors: Pin Zhao and Samiullah Malik
    Citation: Cell & Bioscience 2022 12:83
  15. Traumatic spinal cord injury (SCI)-induced neuroinflammation results in secondary neurological destruction and functional disorder. Previous findings showed that microglial pyroptosis plays a crucial role in n...

    Authors: Mingjie Xia, Xinyu Li, Suhui Ye, Qinyang Zhang, Tianyu Zhao, Rulin Li, Yanan Zhang, Minghan Xian, Tianqi Li, Haijun Li, Xin Hong, Shengnai Zheng, Zhanyang Qian and Lei Yang
    Citation: Cell & Bioscience 2022 12:82
  16. As important enzymes regulating acetylation, histone deacetylases (HDACs) participate in a series of cell physiological process. However, the mechanisms responsible for individual HDAC family members in regula...

    Authors: Liping Yang, Shengchuan Chen, Jingyan Xia, Ying Zhou, Linan Peng, Huimin Fan, Yu Han, Lihua Duan, Genhong Cheng, Heng Yang and Feng Xu
    Citation: Cell & Bioscience 2022 12:81
  17. Research on spatiotemporal gene landscape can provide insights into the spatial characteristics of human kidney development and facilitate kidney organoid cultivation. Here, we profiled the spatiotemporal gene...

    Authors: Hongwei Wu, Fanna Liu, Yu Shangguan, Yane Yang, Wei Shi, Wenlong Hu, Zhipeng Zeng, Nan Hu, Xinzhou Zhang, Berthold Hocher, Donge Tang, Lianghong Yin and Yong Dai
    Citation: Cell & Bioscience 2022 12:80
  18. Bile acid (BA) homeostasis is mainly regulated by bile salt excretory pump (BSEP), a hepatocyte transporter that transfers BAs to the bile. BSEP expression is regulated by BA levels through activation of farne...

    Authors: Javier Martínez-García, Manuela Molina, Leticia Odriozola, Angie Molina, Gloria González-Aseguinolaza, Nicholas D. Weber and Cristian Smerdou
    Citation: Cell & Bioscience 2022 12:79
  19. Mental retardation is a complex neurodevelopmental disorder. NPAT, a component of the histone locus body (HLB), has been implicated as a candidate gene for mental retardation, with a mechanism yet to be elucidate...

    Authors: Rong Sang, Cheng Wu, Shanshan Xie, Xiao Xu, Yuhan Lou, Wanzhong Ge, Yongmei Xi and Xiaohang Yang
    Citation: Cell & Bioscience 2022 12:78
  20. Activating transcription factor-2 (ATF2) is a member of the basic leucine zipper family of DNA-binding proteins, which exhibits both oncogenic and tumor suppression activity in different tumors. However, the m...

    Authors: Lingxue Xu, Jingjing Wang, Danhua Zhang, Lijie Song, Han Wu, Jianyao Wang, Jinxin Miao, Haoran Guo, Sujuan Fang, Lingling Si, Jingfei Chen, Yifan Wu, Yangyang Wu, Lihong Wang, Na Zhang, Louisa Chard…
    Citation: Cell & Bioscience 2022 12:77
  21. Bone morphogenetic protein (BMP) is a phylogenetically conserved signaling pathway required for development that is aberrantly expressed in several age-related diseases including cancer, Alzheimer’s disease, o...

    Authors: Mehul Vora, Arindam Mondal, Dongxuan Jia, Pranya Gaddipati, Moumen Akel, John Gilleran, Jacques Roberge, Christopher Rongo and John Langenfeld
    Citation: Cell & Bioscience 2022 12:76
  22. Age-related macular degeneration (AMD) is the leading cause of severe vision loss in patients over 55 years old in the industrialized world. In the past 20 years, approximately 288 million patents have been af...

    Authors: Qinchun Duan, Yuru Gao, Xixi Cao, Shulin Wang, MengMeng Xu, Odell D. Jones and Xuehong Xu
    Citation: Cell & Bioscience 2022 12:73
  23. Elevated intraocular pressure (IOP) is a major risk factor for the development and progression of primary open angle glaucoma and is due to trabecular meshwork (TM) damage. Here, we investigate the role of an ...

    Authors: Timur A. Mavlyutov, Justin J. Myrah, Anil K. Chauhan, Yang Liu and Colleen M. McDowell
    Citation: Cell & Bioscience 2022 12:72
  24. Dysregulated osteoclast activity due to altered osteoclast differentiation causes multiple bone diseases. Osteoclasts are multinucleated giant cells derived from hematopoietic stem cells and play a major role ...

    Authors: Yufeng Zhang, Min Yang, Sheng Zhang, Zhiqiang Yang, Yufan Zhu, Yi Wang, Zhe Chen, Xuan Lv, Zan Huang, Yuanlong Xie and Lin Cai
    Citation: Cell & Bioscience 2022 12:70
  25. Blood–brain barrier (BBB) dysfunction may occur at the onset of Alzheimer’s disease (AD). Pericytes are a vital part of the neurovascular unit and the BBB, acting as gatekeepers of the BBB. Amyloid β (Aβ) depo...

    Authors: Jianhua Li, Mengyu Li, Yangyang Ge, Jiayi Chen, Jiamin Ma, Chenchen Wang, Miaomiao Sun, Li Wang, Shanglong Yao and Chengye Yao
    Citation: Cell & Bioscience 2022 12:69
  26. In order to maintain immunological tolerance to self and non-self antigens, one’s T regulatory (Treg) cells play a critical role in the regulation of detrimental inflammation. Treg cells inhibit the immune sys...

    Authors: Yahya Asemani, Sajad Najafi, Fatemeh Ezzatifar, Naime Majidi Zolbanin and Reza Jafari
    Citation: Cell & Bioscience 2022 12:67
  27. Because of the emerging variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in different regions of the world, the battle with infectious coronavirus disease 2019 (COVID-19) caused by SARS...

    Authors: Dongsheng Li, Gangan Yan, Wenwen Zhou, Shuyi Si, Xiaoping Liu, Jing Zhang, Yan Li and Yunyu Chen
    Citation: Cell & Bioscience 2022 12:65
  28. The human amnion is an intrauterine tissue which is involved in the initiation of parturition. In-depth understanding of gene expression signatures of individual cell types in the amnion with respect to membra...

    Authors: Wang-Sheng Wang, Yi-Kai Lin, Fan Zhang, Wen-Jia Lei, Fang Pan, Ya-Nan Zhu, Jiang-Wen Lu, Chu-Yue Zhang, Qiong Zhou, Hao Ying and Kang Sun
    Citation: Cell & Bioscience 2022 12:64
  29. Neutralizing antibodies are approved drugs to treat coronavirus disease-2019 (COVID-19) patients, yet mutations in severe acute respiratory syndrome coronavirus (SARS-CoV-2) variants may reduce the antibody ne...

    Authors: Lili Li, Meiling Gao, Peng Jiao, Shulong Zu, Yong-qiang Deng, Dingyi Wan, Yang Cao, Jing Duan, Saba R Aliyari, Jie Li, Yueyue Shi, Zihe Rao, Cheng-feng Qin, Yu Guo, Genhong Cheng and Heng Yang
    Citation: Cell & Bioscience 2022 12:63
  30. Stem cell senescence is considered as a significant driver of organismal aging. As individuals age, the number of stem cells is declined, and the ability to proliferate and survive is also weakened. It has bee...

    Authors: Yanan Sun, Xiao Yu, Xingyu Gao, Chang Zhang, Hui Sun, Kaiyi Xu, Dongxu Wei, Qianwen Wang, Haiying Zhang, Yingai Shi, Lisha Li and Xu He
    Citation: Cell & Bioscience 2022 12:62
  31. We propose an efficient method to modify B-cell derived EVs by loading them with a nanotherapeutic stimuli-responsive cargo and equipping them with antibodies for efficient targeting of lymphoma cells.

    Authors: Bianca Dumontel, Francesca Susa, Tania Limongi, Veronica Vighetto, Doriana Debellis, Marta Canta and Valentina Cauda
    Citation: Cell & Bioscience 2022 12:61
  32. Epitranscriptomics studies have contributed greatly to the development of research on human cancers. In recent years, N6-methyladenosine (m6A), an RNA modification on the N-6 position of adenosine, has been fo...

    Authors: Xiaoran Duan, Li Yang, Liuya Wang, Qinghua Liu, Kai Zhang, Shasha Liu, Chaojun Liu, Qun Gao, Lifeng Li, Guohui Qin and Yi Zhang
    Citation: Cell & Bioscience 2022 12:60
  33. C–C motif chemokine receptor 2 (CCR2), the main receptor for monocyte chemoattractant protein-1 (MCP-1), is expressed on immune cells, including monocytes, macrophages, and activated T cells, and mediates cell...

    Authors: Hee-Kyung Park, Yun Hee Na, Huong Thi Nguyen, Lan Phuong Nguyen, Sunghoon Hurh, Jae Young Seong, Cheol Soon Lee, Byung-Joo Ham and Jong-Ik Hwang
    Citation: Cell & Bioscience 2022 12:59
  34. Liver fibrosis represent a major global health care burden. Data emerging from recent advances suggest TRPM8, a member of the transient receptor potential (TRP) family of ion channels, plays an essential role ...

    Authors: Qiang Liu, Xiaohua Lei, Zhenyu Cao, Ju Zhang, Likun Yan, Jie Fu, Qing Tong, Wei Qin, Yaoli Shao, Chun Liu, Zhiqiang Liu, Zicheng Wang, Yuan Chu, Ge Xu, Siyuan Liu, Xueyi Wen…
    Citation: Cell & Bioscience 2022 12:58
  35. B1 cells are self-renewing innate-like B lymphocytes that provide the first line of defense against pathogens. B1 cells primarily reside in the peritoneal cavity and are known to originate from various fetal t...

    Authors: Yao Luo, Jing Wang, Kairui Li, Mingxia Li, Shasha Xu, Xingjie Liu, Zhiwei Zhang, Xiang Xu, Yu Zhang, Jiawei Pan, Pengtao Liu, Shaorong Gao, Zhichao Miao and Yong Yu
    Citation: Cell & Bioscience 2022 12:57
  36. Changes in the expression and activity of the AKT oncogene play an important role in psychiatric disease. We present translational data assessing the role of AKT in psychiatric symptoms.

    Authors: Apostolia-Maria Tsimberidou, Antonis Skliris, Alan Valentine, Jamie Shaw, Ursula Hering, Henry Hiep Vo, Tung On Chan, Roger S. Armen, Jeffrey R. Cottrell, Jen Q. Pan and Philip N. Tsichlis
    Citation: Cell & Bioscience 2022 12:56
  37. Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide with high mortality. Advanced stage upon diagnosis and cancer metastasis are the main reasons for the dismal prognosis of HCC in large...

    Authors: Sheng Sun, Yiyang Liu, Meiling Zhou, Jinyuan Wen, Lin Xue, Shenqi Han, Junnan Liang, Yufei Wang, Yi Wei, Jinjin Yu, Xin Long, Xiaoping Chen, Huifang Liang, Zhao Huang and Bixiang Zhang
    Citation: Cell & Bioscience 2022 12:55
  38. Low-density lipoprotein receptor-related protein 4 (LRP4) plays a critical role in the central nervous system (CNS), including hippocampal synaptic plasticity, maintenance of excitatory synaptic transmission, ...

    Authors: Min Yan, Mingtao Xiong, Yongqiang Wu, Dong Lin, Peng Chen, Jiang Chen, Ziyang Liu, Hang Zhang, Dongyan Ren, Erkang Fei, Xinsheng Lai, Suqi Zou and Shunqi Wang
    Citation: Cell & Bioscience 2022 12:54
  39. Ferroptosis is an iron dependent cell death closely associated with p53 signaling pathway and is aberrantly regulated in glioblastoma (GBM), yet the underlying mechanism needs more exploration. Identifying new...

    Authors: Qian Sun, Yang Xu, Fan’en Yuan, Yangzhi Qi, Yixuan Wang, Qianxue Chen and Baohui Liu
    Citation: Cell & Bioscience 2022 12:53
  40. Von Hippel-Lindau (VHL) disease is an autosomal dominant genetic neoplastic disorder caused by germline mutation or deletion of the VHL gene, characterized by the tendency to develop multisystem benign or maligna...

    Authors: Xueyou Ma, Zenglai Tan, Qin Zhang, Kaifang Ma, Jun Xiao, Xiong Wang, Yanan Wang, Mengjie Zhong, Yu Wang, Jing Li, Xing Zeng, Wei Guan, Shaogang Wang, Kan Gong, Gong-Hong Wei and Zhihua Wang
    Citation: Cell & Bioscience 2022 12:52
  41. Extracellular vesicles (EVs) are cell-derived membrane structures exerting major effects in physiological as well as pathological processes by functioning as vehicles for the delivery of biomolecules to their ...

    Authors: Ciarra Almeria, Sebastian Kreß, Viktoria Weber, Dominik Egger and Cornelia Kasper
    Citation: Cell & Bioscience 2022 12:51