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  1. Hepatitis B virus (HBV) infection remains a major health issue worldwide and the leading cause of cirrhosis and hepatocellular carcinoma (HCC). It has been reported previously that HBV invasion can extensively...

    Authors: Sen Yuan, Yousaf Tanzeel, Xuezhang Tian, Dandan Zheng, Naz Wajeeha, Jiaqi Xu, Yujia Ke, Zuopeng Zhang, Xiaojun Peng, Long Lu, Guihong Sun, Deyin Guo and Min Wang

    Citation: Cell & Bioscience 2021 11:75

    Content type: Research

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  2. As one of the most common malignancy, lung adenocarcinoma (LUAD) is characterized by low 5-year survival rate. This research aimed to investigate the effects of ribonucleotide reductase regulatory subunit M2 (...

    Authors: Xueping Jiang, Yangyi Li, Nannan Zhang, Yanping Gao, Linzhi Han, Shuying Li, Jiali Li, Xingyu Liu, Yan Gong and Conghua Xie

    Citation: Cell & Bioscience 2021 11:74

    Content type: Research

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  3. Dysregulation of KLF7 participates in the development of various cancers, but it is unclear whether there is a link between HCC and aberrant expression of KLF7. The aim of this study was to investigate the rol...

    Authors: Yarong Guo, Bao Chai, Junmei Jia, Mudan Yang, Yanjun Li, Rui Zhang, Shunmin Wang and Jun Xu

    Citation: Cell & Bioscience 2021 11:73

    Content type: Research

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  4. As the predominant modification in RNA, N6-methyladenosine (m6A) has attracted increasing attention in the past few years since it plays vital roles in many biological processes. This chemical modification is dyn...

    Authors: Zhihao Fang, Yiqiu Hu, Jinhui Hu, Yanqin Huang, Shu Zheng and Cheng Guo

    Citation: Cell & Bioscience 2021 11:72

    Content type: Review

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  6. Epithelial to mesenchymal transition (EMT) contributes to tumor metastasis and chemoresistance. Eukaryotic initiation factor 5A2 (EIF5A2) is highly expressed in a variety of human cancers but rarely expressed ...

    Authors: Guannan Zhao, Wenjing Zhang, Peixin Dong, Hidemichi Watari, Yuqi Guo, Lawrence M. Pfeffer, Gabor Tigyi and Junming Yue

    Citation: Cell & Bioscience 2021 11:70

    Content type: Research

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  7. Managing the limits of temperature adaptation is relevant both in medicine and in biotechnology. There are numerous scattered publications on the identification of the temperature limits of existence for vario...

    Authors: K. B. Aslanidi and D. P. Kharakoz

    Citation: Cell & Bioscience 2021 11:69

    Content type: Research

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  8. Breast cancer (BC) remains a public-health issue on a global scale. Long non-coding RNAs (lncRNAs) play functional roles in BC. This study focuses on effects of NEAT1 on BC cell invasion, migration and chemoth...

    Authors: DaoPing Zhou, Juan Gu, YuePing Wang, HuaiGuo Wu, Wei Cheng, QingPing Wang, GuoPei Zheng and XueDong Wang

    Citation: Cell & Bioscience 2021 11:68

    Content type: Research

    Published on:

  9. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Haoyu Wang, Jing Yuan, Xiaoqian Dang, Zhibin Shi, Wenrui Ban and Dong Ma

    Citation: Cell & Bioscience 2021 11:67

    Content type: Correction

    Published on:

    The original article was published in Cell & Bioscience 2021 11:52

  10. Alternative splicing (AS) regulates gene expression patterns at the post-transcriptional level and generates a striking expansion of coding capacities of genomes and cellular protein diversity. RNA splicing co...

    Authors: Yunqi Chao, Yonghui Jiang, Mianling Zhong, Kaiyan Wei, Chenxi Hu, Yifang Qin, Yiming Zuo, Lili Yang, Zheng Shen and Chaochun Zou

    Citation: Cell & Bioscience 2021 11:66

    Content type: Review

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  12. Posttranscriptional gene regulation includes mRNA transport, localization, translation, and regulation of mRNA stability. CPEB (cytoplasmic polyadenylation element binding) family proteins bind to specific sites ...

    Authors: Eugene Kozlov, Yulii V. Shidlovskii, Rudolf Gilmutdinov, Paul Schedl and Mariya Zhukova

    Citation: Cell & Bioscience 2021 11:64

    Content type: Review

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  13. Temozolomide (TMZ)-resistance hampers the therapeutic efficacy of this drug for glioblastoma (GBM) treatment in clinic, and emerging evidences suggested that exosomes from GBM-derived stem cells (GSCs) contrib...

    Authors: Yong Zheng, Liang Liu, Yan Wang, Shan Xiao, Rongkang Mai, Zifeng Zhu and Yiyao Cao

    Citation: Cell & Bioscience 2021 11:63

    Content type: Research

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  14. Astrocytes participate in innate inflammatory responses within the mammalian central nervous system (CNS). HECT domain E3 ubiquitin protein ligase 1 (HECTD1) functions during microglial activation, suggesting ...

    Authors: Ying Tang, Mengchun Zhou, Rongrong Huang, Ling Shen, Li Yang, Zhongqiu Zhou, Hui Ren and Ying Bai

    Citation: Cell & Bioscience 2021 11:62

    Content type: Research

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  16. Genomic AZFb deletions in Yq11 coined “classical” (i.e. length of Y DNA deletion: 6.23 Mb) are associated with meiotic arrest (MA) of patient spermatogenesis, i.e., absence of any postmeiotic germ cells. These AZ...

    Authors: P. H. Vogt, U. Bender, B. Deibel, F. Kiesewetter, J. Zimmer and T. Strowitzki

    Citation: Cell & Bioscience 2021 11:60

    Content type: Review

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  17. SARS-CoV-2 causes COVID-19 with a widely diverse disease profile that affects many different tissues. The mechanisms underlying its pathogenicity in host organisms remain unclear. Animal models for studying th...

    Authors: Jun-yi Zhu, Jin-Gu Lee, Joyce van de Leemput, Hangnoh Lee and Zhe Han

    Citation: Cell & Bioscience 2021 11:59

    Content type: Research

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  18. SARS-CoV-2 causes COVID-19 which has a widely diverse disease profile. The mechanisms underlying its pathogenicity remain unclear. We set out to identify the SARS-CoV-2 pathogenic proteins that through host in...

    Authors: Jin-Gu Lee, Weiliang Huang, Hangnoh Lee, Joyce van de Leemput, Maureen A. Kane and Zhe Han

    Citation: Cell & Bioscience 2021 11:58

    Content type: Research

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  19. Ewing's sarcoma is an aggressive childhood malignancy whose outcome has not substantially improved over the last two decades. In this study, combination treatments of the HSP90 inhibitor AUY922 with either the...

    Authors: Christian Marx, Marc U. Schaarschmidt, Joanna Kirkpatrick, Lisa Marx-Blümel, Melisa Halilovic, Martin Westermann, Doerte Hoelzer, Felix B. Meyer, Yibo Geng, Katrin Buder, Hauke M. Schadwinkel, Kanstantsin Siniuk, Sabine Becker, René Thierbach, James F. Beck, Jürgen Sonnemann…

    Citation: Cell & Bioscience 2021 11:57

    Content type: Research

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  22. Genome editing in mice using either classical approaches like homologous recombination or CRISPR/Cas9 has been reported to harbor off target effects (insertion/deletion, frame shifts or gene segment duplicatio...

    Authors: Sabrina Sailer, Stefan Coassin, Katharina Lackner, Caroline Fischer, Eileen McNeill, Gertraud Streiter, Christian Kremser, Manuel Maglione, Catherine M. Green, Daniela Moralli, Alexander R. Moschen, Markus A. Keller, Georg Golderer, Gabriele Werner-Felmayer, Irmgard Tegeder, Keith M. Channon…

    Citation: Cell & Bioscience 2021 11:54

    Content type: Research

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  23. The availability of a reliable tumor target for advanced colorectal cancer (CRC) therapeutic approaches is critical since current treatments are limited. Epidermal growth factor-like domain 6 (EGFL6) has been ...

    Authors: Ting-Yi Sung, Han-Li Huang, Chun-Chun Cheng, Fu-Ling Chang, Po-Li Wei, Ya-Wen Cheng, Cheng-Chiao Huang, Yu-Ching Lee, Wei-Chun HuangFu and Shiow-Lin Pan

    Citation: Cell & Bioscience 2021 11:53

    Content type: Research

    Published on:

  24. Spinal cord injury (SCI) is a disabling disorder, resulting in neurological impairments. This study investigated the mechanism of methyltransferase-like 14 (Mettl14) on apoptosis of spinal cord neurons during ...

    Authors: Haoyu Wang, Jing Yuan, Xiaoqian Dang, Zhibin Shi, Wenrui Ban and Dong Ma

    Citation: Cell & Bioscience 2021 11:52

    Content type: Research

    Published on:

    The Correction to this article has been published in Cell & Bioscience 2021 11:67

  25. Adenomyosis (AM) is a common benign chronic gynaecological disorder; however, the precise pathogenesis of adenomyosis is still poorly understood. Single-cell RNA sequencing (scRNA-seq) can uncover rare subpopu...

    Authors: Zhiyong Liu, Zhonghua Sun, Hongyun Liu, Weipin Niu, Xin Wang, Na Liang, Xin Wang, Yanfei Wang, Yaxin Shi, Li Xu and Wei Shi

    Citation: Cell & Bioscience 2021 11:51

    Content type: Research

    Published on:

  26. Apolipoprotein E4 (apoE4) is a major genetic risk factor of Alzheimer’s disease. Its C-terminal-truncated apoE4 (Δ272–299) has neurotoxicity by affecting mitochondrial respiratory function. However, the molecu...

    Authors: Tao Liang, Weijian Hang, Jiehui Chen, Yue Wu, Bin Wen, Kai Xu, Bingbing Ding and Juan Chen

    Citation: Cell & Bioscience 2021 11:50

    Content type: Research

    Published on:

  27. Autophagy is a prominent mechanism to preserve homeostasis and the response to intracellular or extracellular stress. Autophagic degradation can be selectively targeted to dysfunctional subcellular compartment...

    Authors: Qi Wu, Xin Yu, Le Liu, Shengrong Sun and Si Sun

    Citation: Cell & Bioscience 2021 11:49

    Content type: Review

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  29. Skeletal development and maintenance are complex processes known to be coordinated by multiple genetic and epigenetic signaling pathways. However, the role of long non-coding RNAs (lncRNAs), a class of crucial...

    Authors: Ting-ting Yu, Qiu-fan Xu, Si-Yang Li, Hui-jie Huang, Sarah Dugan, Lei Shao, Jennifer A. Roggenbuck, Xiao-tong Liu, Huai-ze Liu, Betsy A. Hirsch, Shen Yue, Chen Liu and Steven Y. Cheng

    Citation: Cell & Bioscience 2021 11:47

    Content type: Research

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  30. Hedgehog signaling is essential to the regulation of embryonic development, tissue homeostasis, and stem cell self-renewal, making it a prime target for developing cancer therapeutics. Given the close link bet...

    Authors: Junwan Fan, Haowen Li, Lun Kuang, Zichen Zhao, Wenyan He, Chen Liu, Yongjun Wang, Steven Y. Cheng and Wei Chen

    Citation: Cell & Bioscience 2021 11:46

    Content type: Research

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  32. Emerging evidence demonstrated dapagliflozin (DAPA), a sodium-glucose cotransporter 2 inhibitor, prevented various cardiovascular events. However, the detailed mechanisms underlying its cardioprotective proper...

    Authors: Kun-Ling Tsai, Pei-Ling Hsieh, Wan-Ching Chou, Hui-Ching Cheng, Yu-Ting Huang and Shih-Hung Chan

    Citation: Cell & Bioscience 2021 11:44

    Content type: Research

    Published on:

  33. MicroRNA-derived structures play impressive roles in various biological processes. So dysregulation of miRNAs can lead to different human diseases. Recent studies have extended our comprehension of the control...

    Authors: Samaneh Heydarzadeh, Maryam Ranjbar, Farokh Karimi, Farhad Seif and Mohammad Reza Alivand

    Citation: Cell & Bioscience 2021 11:43

    Content type: Review

    Published on:

  34. DNA primase subunit 1 (PRIM1) has been reported as a novel oncogene in several cancer types. However, its roles in hepatocellular carcinoma (HCC) remain unclear. This study aimed to investigate underlying mech...

    Authors: Mengqi Zhu, Mengna Wu, Saiyan Bian, Qianqian Song, Mingbing Xiao, Hua Huang, Li You, Jianping Zhang, Jie Zhang, Chun Cheng, Wenkai Ni and Wenjie Zheng

    Citation: Cell & Bioscience 2021 11:42

    Content type: Research

    Published on:

  35. Treatment and rehabilitation of spinal cord injury (SCI) is a major problem in clinical medicine. Modern medicine has achieved minimal progress in improving the functions of injured nerves in patients with SCI...

    Authors: Nan An, Jiaxu Yang, Hequn Wang, Shengfeng Sun, Hao Wu, Lisha Li and Meiying Li

    Citation: Cell & Bioscience 2021 11:41

    Content type: Review

    Published on:

  36. We report our discovery of an important player in the development of skin fibrosis, a hallmark of scleroderma. Scleroderma is a fibrotic disease, affecting 70,000 to 150,000 Americans. Fibrosis is a pathologic...

    Authors: Mary Yinghua Zhang, Shuyi Fang, Hongyu Gao, Xiaoli Zhang, Dongsheng Gu, Yunlong Liu, Jun Wan and Jingwu Xie

    Citation: Cell & Bioscience 2021 11:40

    Content type: Research

    Published on:

  37. Papillary thyroid carcinoma (PTC) is the main pathological type of thyroid carcinoma (TC). Gender is a prominent background parameter for patients with PTC. Here, we aimed to delineate the differences in cell ...

    Authors: Miaoguan Peng, Guohong Wei, Yunjian Zhang, Hai Li, Yingrong Lai, Yan Guo, Yuxin Chen, Liehua Liu, Haipeng Xiao, Hongyu Guan and Yanbing Li

    Citation: Cell & Bioscience 2021 11:39

    Content type: Research

    Published on:

  38. Emerging evidences suggests that Diosbulbin-B (DB) is effective to improve cisplatin (DDP)-sensitivity in gastric cancer (GC), but its molecular mechanisms were not fully delineated, and this study managed to ...

    Authors: Chunfeng Li, Junqiang Qiu and Yingwei Xue

    Citation: Cell & Bioscience 2021 11:38

    Content type: Research

    Published on:

  39. Small extracellular vesicles (sEVs) are nanosized vesicles involved in cell-to-cell communication. sEVs have been widely studied for clinical applications such as early detection of diseases and as therapeutic...

    Authors: Jie-Min Wang, Yong-Jiang Li, Jun-Yong Wu, Jia-Xin Cai, Jing Wen, Da-Xiong Xiang, Xiong-Bin Hu and Wen-Qun Li

    Citation: Cell & Bioscience 2021 11:37

    Content type: Research

    Published on:

  40. Alternative splicing (AS) is an important biological process for regulating the expression of various isoforms from a single gene and thus to promote proteome diversity. In this study, RNA-seq data from 15 pai...

    Authors: Jiyu Ding, Chunquan Li, Yinwei Cheng, Zepeng Du, Qiuyu Wang, Zhidong Tang, Chao Song, Qiaoxi Xia, Wenjing Bai, Ling Lin, Wei Liu, Liyan Xu, Enmin Li and Bingli Wu

    Citation: Cell & Bioscience 2021 11:36

    Content type: Research

    Published on:

  41. Autophagy is a conserved cellular degradation process in eukaryotes that facilitates the recycling and reutilization of damaged organelles and compartments. It plays a pivotal role in cellular homeostasis, pat...

    Authors: Qingchun Lu, Po-Shun Wang and Ling Yang

    Citation: Cell & Bioscience 2021 11:35

    Content type: Review

    Published on:

  43. Interleukin-15 (IL-15), a member of the ‘four α-helix bundle’ cytokine family, has been associated with many inflammatory and metabolic diseases. Abnormal expression of IL-15 has been linked to the occurrence ...

    Authors: Jiaqi Li, Yuan Li, Xuan Zhou, Lijie Wei, Jingyi Zhang, Shenglan Zhu, Huiting Zhang, Xuan Gao, Lali Mwamaka Sharifu, Shaoshuai Wang, Ling Xi and Ling Feng

    Citation: Cell & Bioscience 2021 11:33

    Content type: Research

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  44. Bidirectional integrin αIIbβ3 signaling is essential for platelet activation. The platelet adaptor protein Disabled-2 (Dab2) is a key regulator of integrin signaling and is phosphorylated at serine 24 in eukar...

    Authors: Hui-Ju Tsai, Ju-Chien Cheng, Man-Leng Kao, Hung-Pin Chiu, Yi-Hsuan Chiang, Ding-Ping Chen, Kun-Ming Rau, Hsiang-Ruei Liao and Ching-Ping Tseng

    Citation: Cell & Bioscience 2021 11:32

    Content type: Research

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  45. Heart failure (HF) is a clinical syndrome characterized by left ventricular dysfunction or elevated intracardiac pressures. Research supports that microRNAs (miRs) participate in HF by regulating  targeted gen...

    Authors: Jingtao Na, Haifeng Jin, Xin Wang, Kan Huang, Shuang Sun, Qiang Li and Wenting Zhang

    Citation: Cell & Bioscience 2021 11:31

    Content type: Research

    Published on:

  46. Silica exposure underlies the development of silicosis, one of the most serious occupational hazards worldwide. We aimed to explore the interaction of the silica-induced epithelial–mesenchymal transition (EMT)...

    Authors: Zhao Ju, Jianlin Shao, Meiling Zhou, Jing Jin, Huiji Pan, Ping Ding and Ruixue Huang

    Citation: Cell & Bioscience 2021 11:30

    Content type: Research

    Published on:

  47. The ketogenic diet (KD) has been recognized as a potentially effective therapy to treat neuropsychiatric diseases, including epilepsy. Previous studies have indicated that KD treatment elevates γ-Amino butyric...

    Authors: Jin Wang, Jie Huang, Yuan-Quan Li, Shan Yao, Cui-Hong Wu, Ying Wang, Feng Gao, Min-Dong Xu, Guo-Bin Huang, Chang-Qin Zhao, Jia-Hui Wu, Yun-Long Zhang, Renjie Jiao, Zi-Hao Deng, Wei Jie, Hui-Bin Li…

    Citation: Cell & Bioscience 2021 11:29

    Content type: Research

    Published on:

  48. A systemic evaluation of immune cell infiltration patterns in experimental acute pancreatitis (AP) is lacking. Using multi-dimensional flow cytometry, this study profiled infiltrating immune cell types in mult...

    Authors: Baibing Yang, Joy M. Davis, Thomas H. Gomez, Mamoun Younes, Xiurong Zhao, Qiang Shen, Run Wang, Tien C. Ko and Yanna Cao

    Citation: Cell & Bioscience 2021 11:28

    Content type: Research

    Published on:

  50. Colorectal cancer (CRC) is a gastrointestinal malignancy originating from either the colon or the rectum. A growing number of researches prove that the unfolded protein response (UPR) is closely related to the...

    Authors: Jingjing Huang, Huayang Pan, Jinge Wang, Tong Wang, Xiaoyan Huo, Yong Ma, Zhaoyang Lu, Bei Sun and Hongchi Jiang

    Citation: Cell & Bioscience 2021 11:26

    Content type: Review

    Published on:

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