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Review
In recent years, considerable progress has been made in the molecular mechanisms of epigenetics in disease development and progression, the reversible characteristics of epigenetic modification provide new ins...
Cell & Bioscience 2017 7:42
Published on: 15 August 2017
Letter to the Editor
Current techniques for cell culture routinely use animal-derived components. Fetal bovine serum (FBS) is the most widely applied supplement, but it often displays significant batch-to-batch variations and is g...
Cell & Bioscience 2017 7:41
Published on: 14 August 2017
Editorial
Cell & Bioscience 2017 7:40
Published on: 10 August 2017
Review
Increasing evidence indicates that embryonic stem cell specific microRNAs (miRNAs) play an essential role in the early development of embryo. Among them, the miR-290-295 cluster is the most highly expressed in...
Cell & Bioscience 2017 7:38
Published on: 7 August 2017
Review
Pancreatic cancer is highly lethal malignant tumor with characterised rapid progression, invasiveness and resistance to radiochemotherapy. Transforming growth factor-β (TGF-β) signaling plays a dual role in bo...
Cell & Bioscience 2017 7:39
Published on: 7 August 2017
Review
Isocitrate dehydrogenases play important roles in cellular metabolism and cancer. This review will discuss how the roles of isoforms 1 and 2 in normal cell and cancer metabolism are distinct from those of isof...
Cell & Bioscience 2017 7:37
Published on: 3 August 2017
Research
Mammalian folliculogenesis, maturation of the ovarian follicles, require both growth factors derived from oocyte and surrounding cells, including stromal cells. However, the mechanism by which stromal cells an...
Cell & Bioscience 2017 7:36
Published on: 25 July 2017
Editorial
Cell & Bioscience 2017 7:35
Published on: 14 July 2017
Review
When hepatocytes are damaged severely, a variety of signaling pathways will be triggered by inflammatory factors and cytokines involving in the process of hepatic fibrosis. The microRNA (miRNA) family consists...
Cell & Bioscience 2017 7:34
Published on: 4 July 2017
Research
Accumulating evidence demonstrates that the KRAB-ZNFs involve in various biological processes. As a typical member of KRAB-ZNFs, dysregulation of ZNF300 contributes to multiple pathologies such as leukemia and...
Cell & Bioscience 2017 7:33
Published on: 28 June 2017
Erratum
Cell & Bioscience 2017 7:32
Published on: 20 June 2017
The original article was published in Cell & Bioscience 2016 6:51
Research
Disruption of blood–brain barrier (BBB) and subsequent infiltration of auto-reactive T lymphocytes are major characteristics of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). Kv1....
Cell & Bioscience 2017 7:31
Published on: 7 June 2017
Review
Human cancers results in large part from the accumulation of multiple mutations. The progression of premalignant cells is an evolutionary process in which mutations provide the fundamental driving force for ge...
Cell & Bioscience 2017 7:29
Published on: 30 May 2017
Research highlight
Induced pluripotent stem cells (iPSCs) hold great promises in cell therapy. However, the potential safety issues have dampened the enthusiasm of their clinical development. One of the biggest concerns came fro...
Cell & Bioscience 2017 7:30
Published on: 30 May 2017
Research
Bone degenerative disorders like osteoporosis may be initiated by age-related shifts in anabolic and catabolic responses that control bone homeostasis. Although there are studies suggesting that metabolic chan...
Cell & Bioscience 2017 7:27
Published on: 23 May 2017
Research
Chloroquine, a bitter tastant, inhibits Ca2+ signaling, resulting in suppression of B cell activation; however, the inhibitory mechanism remains unclear.
Cell & Bioscience 2017 7:28
Published on: 23 May 2017
Review
Nonsense-mediated RNA decay (NMD) was originally discovered as a cellular surveillance pathway that safeguards the quality of mRNA transcripts in eukaryotic cells. In its canonical function, NMD prevents trans...
Cell & Bioscience 2017 7:26
Published on: 19 May 2017
Research
Natural killer (NK)T cells and conventional T cells share phenotypic characteristic however they differ in transcription factor requirements and functional properties. The role of histone modifying enzymes in ...
Cell & Bioscience 2017 7:25
Published on: 17 May 2017
Research highlight
N6-methyladenosine (m6A) is a widespread posttranscriptional RNA modification that occurs in tRNA, rRNA, snRNA, viral RNAs, and more recently is shown to occur in mRNA in a dynamic, reversible manner. At the epic...
Cell & Bioscience 2017 7:24
Published on: 4 May 2017
Review
Regulation of lineage specification and differentiation in embryonic stem (ES) cells can be achieved through the activation of endogenous signaling, an avenue for potential application in regenerative medicine...
Cell & Bioscience 2017 7:23
Published on: 2 May 2017
Research
Oculocutaneous albinism (OCA) is an autosomal recessive disorder. A significant portion of OCA patients has been found with a single pathogenic variant either in the TYR or the OCA2 gene. Diagnostic sequencing of...
Cell & Bioscience 2017 7:22
Published on: 26 April 2017
Review
Genome editing promises giant leaps forward in advancing biotechnology, agriculture, and basic research. The process relies on the use of sequence specific nucleases (SSNs) to make DNA double stranded breaks a...
Cell & Bioscience 2017 7:21
Published on: 24 April 2017
Research
Curcumin is a major constituent of rhizomes of Curcuma longa that elicits beneficial effects for oxidative damage. The aim of this study was to investigate whether curcumin could attenuate hydrogen peroxide (H2O2
Cell & Bioscience 2017 7:20
Published on: 21 April 2017
Research
Parkinson disease (PD) is the most common movement disturbance characterized by the loss of dopaminergic (DA) neurons in midbrain. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is aberrantly ...
Cell & Bioscience 2017 7:19
Published on: 21 April 2017
Research
Persistent fetal vasculature (PFV) is a congenital developmental anomaly of the eye that accounts for about 5% of childhood blindness. The molecular mechanism of PFV remains unclear. As a glycosyltransferase o...
Cell & Bioscience 2017 7:18
Published on: 17 April 2017
