Water scarcity is considered to be a severe environmental constraint to plant survival and productivity. Studies on drought-tolerant plants would definitely promote a better understanding of the regulatory mec...
Authors: Huihui Gu, Yan Yang, Minghui Xing, Caipeng Yue, Fang Wei, Yanjie Zhang, Wenen Zhao and Jinyong Huang
Recent evidence has shown that C-X-C chemokine receptor type 4 (CXCR4) plays a crucial role in acute lung injury (ALI). Macrophages are key factors in the pathogenesis of ALI. The aim of this study was to inve...
Authors: Xue Tian, Guogang Xie, Hui Xiao, Fengming Ding, Wuping Bao and Min Zhang
Many studies have reported that long noncoding RNAs (lncRNAs) could act as sponges for microRNAs (miRNAs) and play important roles in the regulation of osteoarthritis (OA). Yet, the underlying mechanisms of ln...
Authors: Ying Zhang, Fuyou Wang, Guangxing Chen, Rui He and Liu Yang
Single-cell sequencing technologies can be used to detect the genome, transcriptome and other multi-omics of single cells. They can show the differences and evolutionary relationships of various cells. This re...
Authors: Xiaoning Tang, Yongmei Huang, Jinli Lei, Hui Luo and Xiao Zhu
Pyruvate kinase (PK), as one of the key enzymes for glycolysis, can encode four different subtypes from two groups of genes, although the M2 subtype PKM2 is expressed mainly during embryonic development in nor...
Authors: Ze Zhang, Xinyue Deng, Yuanda Liu, Yahui Liu, Liankun Sun and Fangfang Chen
An underlying state of inflammation is thought to be an important cause of cardiovascular disease. Among cells involved in the early steps of atherosclerosis, monocyte-derived dendritic cells (Mo-DCs) respond ...
Authors: Geneviève Hamel-Côté, Fanny Lapointe, Steeve Véronneau, Marian Mayhue, Marek Rola-Pleszczynski and Jana Stankova
Gemcitabine is the standard first-line chemotherapy regimen for pancreatic cancer. However, its therapeutic value is substantially limited in pancreatic cancer patients due to occurrence of resistance towards ...
Authors: Hehe Li, Zhengle Zhang, Chenggang Gao, Shihong Wu, Qingke Duan, Heshui Wu, Chunyou Wang, Qiang Shen and Tao Yin
Polyploidy is considered as a basic event in plant speciation and evolution in nature, and the cytological and proteomic profilings of floral buds at meiosis (FAM) would definitely contribute to a better under...
Authors: Yan Yang, Fang Wei, Janeen Braynen, Xiaochun Wei, Baoming Tian, Gongyao Shi, Gangqiang Cao, Jiachen Yuan and Xiaowei Zhang
Adipocyte accumulation is a predominant feature of age-related thymic involution, but the mechanisms responsible for thymic adipogenesis remain to be elucidated. The aim of this study was to identify key regul...
Telomere maintenance is an important factor in tumorigenesis. PinX1 is a potent telomerase regulator which also involves in telomerase loading to telomeres. Nucleophosmin (NPM) can partially attenuate PinX1 in...
The emerging threat to global health associated with the Zika virus (ZIKV) epidemics and its link to severe complications highlights a growing need to better understand the pathogenic mechanisms of ZIKV. Accum...
Authors: Yiwen Hu, Xinhuai Dong, Zhenjian He, Yun Wu, Shihao Zhang, Jiajie Lin, Yi Yang, Jiahui Chen, Shu An, Yingxian Yin, Zhiyong Shen, Gucheng Zeng, Han Tian, Junchao Cai, Yi Yang, Hongyu Guan…
Natural products from herbal medicines have long been investigated for their potentials as cancer therapeutics. Besides the development of several herbal medicine-derived anti-cancer agents, such as paclitaxel...
Authors: Sabrina J. Cai, Yang Liu, Sue Han and Chunzhang Yang
Thyroid cancer is the most common malignant endocrine tumor and is classified into papillary thyroid cancer (PTC), follicular thyroid cancer (FTC) and anaplastic thyroid cancer (ATC), which have substantially ...
Authors: Le Zhang, Rong Lian, Jingjing Zhao, Xianming Feng, Runyi Ye, Lingxiao Pan, Jueheng Wu, Mengfeng Li, Yongbo Huang and Junchao Cai
Circular RNAs (circRNAs) from back-splicing have been found in every cell and tissue. By binding to miRNAs and proteins or even by encoding small proteins, circRNAs are now emerging as important regulators in ...
Two research papers, one from a group led by Dr. Haifan Lin of Yale University School of Medicine, New Haven, USA and another from two laboratories led by Drs. Yihong Ye of National Institute of Diabetes and D...
CRISPR/Cas9 mediated gene knockout is a powerful tool for genome editing with the ability to target multiple genes simultaneously. Establishing an efficient, multiplexed gene knockout system using CRISPR/Cas9 ...
Congenital chloride diarrhea (CCD) in a newborn is a rare autosomal recessive disorder with life-threatening complications, requiring early diagnostics and treatment to prevent severe dehydration and infant mo...
Authors: Nini Zhang, Daniel P. Heruth, Weibin Wu, Li Qin Zhang, Marianne N. Nsumu, Katherine Shortt, Kelvin Li, Xun Jiang, Baoxi Wang, Craig Friesen, Ding-You Li and Shui Qing Ye
Long non-coding RNAs are involved in the pathology of various tumors, including hepatocellular carcinoma. The expression of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is increased in numer...
Authors: Qiangfeng Yu, Leyang Xiang, Zhanjun Chen, Xincheng Liu, Huohui Ou, Jianyin Zhou and Dinghua Yang
The prevention of cardiovascular diseases is a matter of great concern, of which acute myocardial infarction (AMI) remains one of the leading causes of death resulting in high morbidity worldwide. Emerging evi...
CRISPR and CRISPR-associated (Cas) protein, as components of microbial adaptive immune system, allows biologists to edit genomic DNA in a precise and specific way. CRISPR-Cas systems are classified into two ma...
Human mannose binding lectin (MBL) and dendritic cell-associated C-type lectin-1 (Dectin-1) are the two prototypical PRRs of innate immunity, whose direct role in recurrent vulvovaginal infections (RVVI) defen...
Authors: Namarta Kalia, Jatinder Singh, Sujata Sharma and Manpreet Kaur
Previous studies have shown that in myogenic precursors, the homeoprotein Msx1 and its protein partners, histone methyltransferases and repressive histone marks, tend to be enriched on target myogenic regulato...
Authors: Zhangjing Ma, Huiyuan Shi, Yi Shen, Huixia Li, Yu Yang, Jiange Yang, Hui Zhao, Gang Wang and Jingqiang Wang
Cell polarity refers to spatial difference in morphology, structure, and function within different parts of a single cell, which plays important roles in a wide range of cellular processes. In eukaryotic cells...
Authors: Ying Liu, Tianrui Zhang, Dong Sun and Guangzuo Luo
Physical exercise is well known to benefit human health at every age. However, the exact mechanism through which physical exercise improves health remains unknown. Recent studies into exercise-induced myokine ...
Authors: Xin Zhou, MengMeng Xu, Joseph L. Bryant, Jianjie Ma and Xuehong Xu
Pyroptosis, a type of programmed cell death that along with inflammation, is mainly regulated by two main pathways, cysteinyl aspartate specific proteinase (caspase)-1-induced canonical inflammatory pathway an...
Authors: Xiaoli Huang, Yang Feng, Guanqing Xiong, Shona Whyte, Jing Duan, Yucen Yang, Kaiyu Wang, Shiyong Yang, Yi Geng, Yangping Ou and Defang Chen
Cancer stem cells obtain energy demand through the activation of glycolysis and lipolysis. It seems that the use of approached targeting glycolysis and lipolysis could be an effective strategy for the inhibiti...
Authors: Ayda Pouyafar, Milad Zadi Heydarabad, Jalal Abdolalizadeh, Reza Rahbarghazi and Mehdi Talebi
Although the β-carboline alkaloids harman and norharman are considered as plant metabolites, they can also be secreted by fungi such as the entomopathogen Conidiobolus coronatus. Norharman and harman are also kno...
Authors: Anna Katarzyna Wrońska and Mieczysława Irena Boguś
Small nucleolar RNA host gene 7 (SNHG7) is a novel identified oncogenic gene in tumorigenesis. However, the role that SNHG7 plays in pancreatic cancer (PC) remains unclear. In this study, we aimed to investiga...
Authors: Dongfeng Cheng, Juanjuan Fan, Yang Ma, Yiran Zhou, Kai Qin, Minmin Shi and Jingrui Yang
Mitochondria are energy factories of cells and are important pivots for intracellular interactions with other organelles. They interact with the endoplasmic reticulum, peroxisomes, and nucleus through signal t...
Authors: MengFang Xia, YaZhuo Zhang, Ke Jin, ZiTong Lu, Zhaoyang Zeng and Wei Xiong
As the main player in humoral immunity, antibodies play indispensable roles in the body’s immune system. Plasma cells (PCs), as antibody factories, are important contributors to humoral immunity. PCs, recogniz...
Authors: Xue Wang, Gui-liang Hao, Bo-ya Wang, Chen-chen Gao, Yue-xiu Wang, Li-sheng Li and Jing-dong Xu
The range of radiation threats we face today includes everything from individual radiation exposures to mass casualties resulting from a terrorist incident, and many of these exposure scenarios include the lik...
Human basal-like breast cancer (BLBC) is an aggressive malignancy with poor prognosis. Since most current treatments are ineffective, there is an urgent need to identify therapeutic targets for BLBC. Microfibr...
Authors: Yanmei Wu, Ping Wu, Quan Zhang, Wenjin Chen, Xishui Liu and Weiqiang Zheng
Portal vein tumor thrombosis (PVTT) in hepatocellular carcinoma (HCC) is a sign of advanced stage disease, which is associated with poor prognosis. Liver resection (LR) may provide better prognosis in selected...
Authors: Lei Huo, Wenxin Wei, Zhenlin Yan, Zhengqing Lei, Yanting Xie, Renyan Gong, Shengyu Huang, Ningyang Jia and Yong Xia
Liver cancer is one of the major causes of cancer death worldwide, with significantly higher incidence and mortality among the male patients. Although sex hormones and their receptors could contribute to such ...
Dexamethasone (Dex) are widely used for the treatment of asthma. However, they may cause apoptosis of bronchial epithelial cells and delay the recovery of asthma. Therefore, it is an urgent problem to find eff...
Authors: Wenjing Zou, Chao Niu, Zhou Fu and Caihui Gong
Zinc finger 644 (Zfp644 in mouse, ZNF644 in human) gene is a transcription factor whose mutation S672G is considered a potential genetic factor of inherited high myopia. ZNF644 interacts with G9a/GLP complex, ...
Authors: Katarzyna I. Szczerkowska, Silvia Petrezselyova, Jiri Lindovsky, Marcela Palkova, Jan Dvorak, Peter Makovicky, Mingyan Fang, Chongyi Jiang, Lingyan Chen, Mingming Shi, Xiao Liu, Jianguo Zhang, Agnieszka Kubik-Zahorodna, Bjoern Schuster, Inken M. Beck, Vendula Novosadova…
Endothelial cells (EC) are sensitive to changes in the microenvironment, including hypoxia and ischemia. Disruption of the microtubular network has been reported in cases of ischemia. However, the signaling pa...
Authors: Huaming Cao, Dongsheng Yu, Xueyun Yan, Bing Wang, Zhiming Yu, Yu Song and Liang Sheng
Exosomes are nano-sized biovesicles released into surrounding body fluids upon fusion of multivesicular bodies and the plasma membrane. They were shown to carry cell-specific cargos of proteins, lipids, and ge...
Authors: Yuan Zhang, Yunfeng Liu, Haiying Liu and Wai Ho Tang
Mesenchymal stem cells (MSCs) have been extensively explored as a promising therapeutic agent in the field of bone tissue engineering due to their osteogenic differentiation ability. In this study, the osteoge...
Authors: Chongyang Shen, Chuan Yang, Shijun Xu and Hai Zhao
Neoadjuvant chemotherapy (NAC) induces a pathological complete response (pCR) in ~ 30% of patients with breast cancer. However, aberrant DNA methylation alterations are frequent events during breast cancer pro...
Authors: Yumei Luo, Juan Huang, Yi Tang, Xitu Luo, Lingxia Ge, Xiujie Sheng, Xiaofang Sun, Yaoyong Chen and Detu Zhu
More than the two decades, the question of whether vitamin D has a role in cancer frequency, development, and death has been premeditated in detail. Colorectal, breast, and prostate cancers have been a scrupul...
Authors: Suhail Razak, Tayyaba Afsar, Ali Almajwal, Iftikhar Alam and Sarwat Jahan
Breast cancer was dangerous to women health. A growing number of evidences indicate that long non-coding RNAs (lncRNAs) have many functions in the development and progression of breast cancer and may serve as ...
Authors: Xiaopeng Hu, Yun Liu, Yaying Du, Teng Cheng and Wenfei Xia
Psychological and physical stress can either enhance or suppress immune functions depending on a variety of factors such as duration and severity of stressful situation. Chronic stress exerts a significantly s...
Authors: Anna Qin, Ting Zhong, Huajiao Zou, Xiaoya Wan, Bifeng Yao, Xinbin Zheng and Deling Yin
Proliferative vitreoretinopathy (PVR) is a severe blinding complication of retinal detachment surgery. Increasing evidence demonstrate that PVR is associated with oxidative stress. Scutellarin is a natural fla...
Authors: Xin Hu, Xiaofang Wu, Bo Zhao and Yongyi Wang
The aim of this study was to investigate the role of long non-coding RNAs (LncRNAs) antisense non-coding RNA in the INK4 locus (ANRIL) in anti-inflammation of rhein in uric acid nephropathy (UAN) rats.
Authors: Jiacai Hu, Daochun Wang, Hao Wu, Zhijie Yang, Na Yang and Junjun Dong
Previously, we have demonstrated that IL-33 administration protecting TNBS-induced experimental colitis is associated with facilitation of Th2/Tregs responses in mice. However, whether IL-33 regulates autophag...
Authors: Zhongyan Wang, Lifeng Shi, Shuyao Hua, Chang Qi and Min Fang
