The aim of this study was to investigate the role of long non-coding RNAs (LncRNAs) antisense non-coding RNA in the INK4 locus (ANRIL) in anti-inflammation of rhein in uric acid nephropathy (UAN) rats.
Authors: Jiacai Hu, Daochun Wang, Hao Wu, Zhijie Yang, Na Yang and Junjun Dong
Previously, we have demonstrated that IL-33 administration protecting TNBS-induced experimental colitis is associated with facilitation of Th2/Tregs responses in mice. However, whether IL-33 regulates autophag...
Authors: Zhongyan Wang, Lifeng Shi, Shuyao Hua, Chang Qi and Min Fang
Transmembrane protein 108 (Tmem108) is a risk gene of psychiatric diseases including schizophrenia, bipolar disorder and major depression disorder. However, the pathophysiological mechanisms of Tmem108 are lar...
Authors: Zheng Yu, Dong Lin, Yanzi Zhong, Bin Luo, Shengsheng Liu, Erkang Fei, Xinsheng Lai, Suqi Zou and Shunqi Wang
Calcium signaling are conserved from invertebrates to vertebrates and plays critical roles in many molecular mechanisms of embryogenesis and postnatal development. As a critical component of the signaling path...
Cellular senescence is a major hurdle for primary cell-based tissue engineering and regenerative medicine. Telomere erosion, oxidative stress, the expression of oncogenes and the loss of tumor suppressor genes...
Authors: Yiming Wang, Song Chen, Zuoqin Yan and Ming Pei
The PI3K/Akt and the STAT3 pathways are functionally associated in many tumor types. Both in vitro and in vivo studies have revealed that either biochemical or genetic manipulation of the STAT3 pathway activit...
Authors: María Elisa Picco, María Victoria Castro, María Josefina Quezada, Gastón Barbero, María Belén Villanueva, Natalia Brenda Fernández, Hyungsoo Kim and Pablo Lopez-Bergami
To determine whether and how exosomes from human umbilical vein endothelial cells (HUVEC-Exos) regulates vascular smooth muscle cells (VSMCs) calcification/senescence in high glucose condition.
Authors: Shuang Li, Jun-Kun Zhan, Yan-Jiao Wang, Xiao Lin, Jia-Yu Zhong, Yi Wang, Pan Tan, Jie-Yu He, Xing-Jun Cui, Yi-Yin Chen, Wu Huang and You-Shuo Liu
Cancer patients treated with chemotherapy often experience a rapid decline of blood neutrophils, a dose-limiting side effect called chemotherapy-induced neutropenia. This complication brings about dose reducti...
Authors: Jinseon Jeong, Yong-Jae Kim, Do Young Lee, Byoung-Gon Moon, Ki-Young Sohn, Sun Young Yoon and Jae Wha Kim
TRAF3 is known as a central mediator of type I interferon (IFN) induction by various pattern recognition receptors, but the in vivo function of TRAF3 in host defense against viral infection is poorly defined d...
Authors: Xiaoping Xie, Jin Jin, Lele Zhu, Zuliang Jie, Yanchuan Li, Baoyu Zhao, Xuhong Cheng, Pingwei Li and Shao-Cong Sun
Shaik et al. recently published online the cryo-electron microscopy structure of HIV-1 gp120 in complex with CD4 and CCR5 receptors. This is the first structure of the ternary HIV-1 gp120/CD4/CCR5 complex. Thi...
Sialic acids represent common terminal residues on numerous mammalian glycoconjugates, thereby influencing e.g. lumen formation in developing blood vessels. Interestingly, besides monosialylated also polysialy...
Authors: Sebastian Strubl, Uwe Schubert, Andrea Kühnle, Alexander Rebl, Negah Ahmadvand, Silvia Fischer, Klaus T. Preissner and Sebastian P. Galuska
Increasing evidence indicates that long non-coding RNAs (lncRNAs) regulate gene or protein expression; however, their function in the progression of hepatic fibrosis remains unclear. Hepatic fibrosis is a cont...
Authors: Hu Peng, Lin-Yan Wan, Jia-Jie Liang, Yan-Qiong Zhang, Wen-Bing Ai and Jiang-Feng Wu
Evaluating the risk category of gastrointestinal stromal tumors (GISTs) is crucial for predicting prognosis and choosing treatment strategies, and tumor metastasis usually represent poor prognosis. Tumor necro...
Authors: Zequn Li, Wei Zhang, Yi Li, Shougen Cao, Shanglong Liu, Liang Ning, Xuelong Jiao, Zimin Liu, Xiaoming Xing, Yujun Li and Yanbing Zhou
Increasing evidence has suggested the involvement of long non-coding RNA taurine upregulated gene 1 (TUG1) in chemoresistance of cancer treatment. However, its function and molecular mechanisms in esophageal s...
Authors: Caihui Xu, Yinmou Guo, Haiyan Liu, Gongbin Chen, Yanju Yan and Teng Liu
Microglia activation is a crucial event in neurodegenerative disease. The depression of microglial inflammatory response is considered a promising therapeutic strategy. NFκB signaling, including IKK/IκB phosph...
Artificial nuclease-dependent DNA cleavage systems (zinc-finger nuclease, ZFN; transcription activator like effectors, TALENs) and exogenous nucleic acid defense systems (CRISPR/Cas) have been used in the new ...
Pleckstrin homology-like domain family A member 1 (PHLDA1) is a tumor suppressor gene in gastric cancer, but its role regulated by circular RNAs (circRNAs) is not known. CircRNAs are important regulators in ca...
Authors: Liang Wang, Jingyan Shen and Yushan Jiang
It has been reported that CBP/p300-Interacting Transactivator with glutamic acid [E]/aspartic acid [D]-rich C-terminal domain 1 (CITED1) is overexpressed in papillary thyroid cancer (PTC). However, the functio...
Authors: Hai Li, Hongyu Guan, Yan Guo, Weiwei Liang, Liehua Liu, Xiaoying He, Weijian Ke, Xiaopei Cao, Haipeng Xiao and Yanbing Li
Contrary to Warburg’s hypothesis, mitochondrial oxidative phosphorylation (OXPHOS) contributes significantly to fueling cancer cells. Several recent studies have demonstrated that radiotherapy-resistant and ch...
Authors: Sarada Preeta Kalainayakan, Keely E. FitzGerald, Purna Chaitanya Konduri, Chantal Vidal and Li Zhang
Fine osseointegration is the basis of long-term survival of implant. In our previous study, we observed a strong correlation between hyperlipidemia and compromised osseointegration. MicroRNA-29a-3p (miR-29a-3p...
Authors: Fei Liu, Zhifeng Wang, Fangfang Liu, Jinzhao Xu, Qibo Liu, Kaifeng Yin and Jing Lan
RNA binding proteins play a pivotal role during the oocyte-to-embryo transition and maternal phase of embryogenesis in invertebrates, but their function in these processes in mammalian systems remain largely u...
Authors: Winifred Mak, Jing Xia, Ee-Chun Cheng, Katie Lowther and Haifan Lin
The blood filtering organ in zebrafish embryos is the pronephros, which consists of two functional nephrons. Segmentation of a nephron into different domains is essential for its function and is well conserved...
Authors: Praveen Barrodia, Chinmoy Patra and Rajeeb K. Swain
Mycobacterium smegmatis, a rapidly growing non-tuberculosis mycobacterium, is a good model for studying the pathogenesis of tuberculosis because of its genetic similarity to Mycobacterium tuberculosis (Mtb). Macr...
Authors: Seon-Hwa Kim, Soo-Na Cho, Yun-Ji Lim, Ji-Ae Choi, Junghwan Lee, Dam Go and Chang-Hwa Song
Cell proliferation and differentiation are two distinct yet coupled processes in development in diverse organisms. Understanding the molecular mechanisms that regulate this process is a central theme in develo...
We investigated the inhibitory effect of pantoprazole on signal transducer and activator of transcription 3 (STAT3) activity and invasiveness of gastric adenocarcinoma cells, and the role of SH2-containing pro...
Authors: Jin Sung Koh, Moon Kyung Joo, Jong-Jae Park, Hyo Soon Yoo, Byung Il Choi, Beom Jae Lee, Hoon Jai Chun and Sang Woo Lee
Zika virus (ZIKV) has recently become a major matter of concern since its association with microcephaly cases in newborns was determined. From then on, ZIKV has been untiringly studied, and several scientific ...
Authors: Mohamed Ziad Dabaja, Estela de Oliveira Lima, Diogo Noin de Oliveira, Tatiane Melina Guerreiro, Carlos Fernando Odir Rodrigues Melo, Karen Noda Morishita, Marcelo Lancellotti, Ana Lucia Tasca Gois Ruiz, Gisele Goulart, Diego Andreazzi Duarte and Rodrigo Ramos Catharino
Tumor necrosis factor (TNF)-alpha-induced protein 8-like 2 (TIPE2 or TNFAIP8L2) is a newly described negative immune regulator and is closely associated with various tumors. However, the expression and roles o...
Authors: Wenyu Jia, Zequn Li, Junyu Chen, Lei Sun, Chuanqian Liu, Shaping Wang, Jingwei Chi, Jun Niu and Hong Lai
Bone regenerative heterodimeric bone morphogenetic protein 2/7 (BMP2/7) enhances but all-trans retinoic acid (ATRA) inhibits osteoclastogenesis. However, the effect of ATRA on physiological and/or BMP2/7-induc...
Authors: Wenjuan Bi, Yi Liu, Jing Guo, Zhen Lin, Jinsong Liu, Miao Zhou, Daniel Wismeijer, Janak L. Pathak and Gang Wu
Endoplasmic reticulum (ER)-associated degradation (ERAD) regulates protein homeostasis in the secretory pathway by targeting misfolded or unassembled proteins for degradation by the proteasome. Hrd1 is a conse...
Authors: Yilin Ye, Suk-Hwan Baek, Yihong Ye and Ting Zhang
Diabetes mellitus is associated with an increased risk in diabetic cardiomyopathy (DCM) that is distinctly not attributed to co-morbidities with other vasculature diseases. To date, while dysregulation of calc...
Authors: Khampaseuth Thapa, Kai Connie Wu, Aishwarya Sarma, Eric M. Grund, Angela Szeto, Armando J. Mendez, Stephane Gesta, Vivek K. Vishnudas, Niven R. Narain and Rangaprasad Sarangarajan
A heterohexameric complex composed of minichromosome maintenance protein 2–7 (MCM2–7), which acts as a key replicative enzyme in eukaryotes, is crucial for initiating DNA synthesis only once per cell cycle. Th...
Two research groups led by Dr. Shui Qing Ye of University of Missouri Kansas City School of Medicine, Kansas City, USA and Dr. Dihua Yu of University of Texas MD Anderson Cancer Center, Houston, USA, respectiv...
Long non-coding RNAs (LncRNAs) have been identified as critical regulators in a variety of cancer types. Cancer susceptibility candidate 15 (CASC15), a lncRNA located at chromosome 6p22.3, has been discovered ...
Authors: Yakun Yin, Bin Zhao, Dongqin Li and Guangwen Yin
Iron accumulation in basal ganglia accompanies neuronal loss in Huntington’s disease (HD) patients and mouse disease models. Disruption of HD brain iron homeostasis occurs before the onset of clinical signs. T...
Authors: Li Niu, Cuifang Ye, Yun Sun, Ting Peng, Shiming Yang, Weixi Wang and He Li
Notch signaling is mainly regulated by Notch1 during development of chicken germ stem cells; however, the molecular mechanisms that contribute to generation of these germ stem cells have not been thoroughly in...
Authors: Qisheng Zuo, Chen Zhang, Kai Jin, Jin Jing, Changhua Sun, Mahmoud F. Ahmed, Jiuzhou Song, Yani Zhang, Guohong Chen and Bichun Li
Near-field fluorescence (NFF) effects were employed to develop a novel near-infrared (NIR) luminescent nanoparticle (LNP) with superior brightness. The LNP is used as imaging contrast agent for cellular and sm...
As an important danger signal, the presence of DNA in cytoplasm triggers potent immune responses. Cyclic GMP-AMP synthase (cGAS) is a recently characterized key sensor for cytoplasmic DNA. The engagement of cG...
Authors: Zhao-Shan Liu, Zi-Yu Zhang, Hong Cai, Ming Zhao, Jie Mao, Jiang Dai, Tian Xia, Xue-Min Zhang and Tao Li
Antibody blockade of the PD-1/PD-L1 pathway has elicited durable antitumor responses in the therapy of a broad spectrum of cancers. PD-L1 is constitutively expressed in certain tumors and host immune cells, an...
Previous studies have shown that inhibition of inducible NO synthase (NOS2 or iNOS) with an inhibitor can selectively protect several normal tissues against radiation during radiotherapy. However, the role of ...
Authors: Chengcheng Li, Yi Luo, Lijian Shao, Aimin Meng and Daohong Zhou
Two studies have recently focused on adult heart regeneration in Xenopus. While we reported on cardiac myogenic regeneration in Xenopus tropicalis after injury, Marshall and colleagues found no regeneration in an...
Authors: Souqi Liao, Wenyan Dong, Hui Zhao, Ruijin Huang, Xufeng Qi and Dongqing Cai
We recently used an endoscopy-based resection method to explore the consequences of cardiac injury in adult Xenopus laevis, obtaining the result that the adult Xenopus heart is unable to regenerate. At 11 months ...
Authors: Lindsey Marshall, Fabrice Girardot, Barbara A. Demeneix and Laurent Coen
Antibodies to human CTLA-4 have been shown to induce long-lasting protection against melanoma. It is assumed that these antibodies cause tumor rejection by blocking negative signaling from the B7-CTLA-4 intera...
Authors: Fei Tang, Xuexiang Du, Mingyue Liu, Pan Zheng and Yang Liu
microRNAs (miRNAs) are one kind of small non-coding RNAs widely distributed in insects. Many studies have shown that miRNAs play critical roles in development, differentiation, apoptosis, and innate immunity. ...
Authors: Xinyu Feng, Jiatong Wu, Shuisen Zhou, Jingwen Wang and Wei Hu
Organ preservation solutions are designed to minimize organ damage during transplantation. A novel preservation solution, WMO-II, was developed to have a low viscosity and to improve microvasculature perfusion...
Authors: Sheng Wang, Kristyn Gumpper, Tao Tan, Xianzhang Luo, Hui Guo, Changsheng Ming, Hanying Jiang, Jiangguo Fang, Guang Du, Hua Zhu, Jianjie Ma, Zhishui Chen and Nianqiao Gong
Innate immunity activator (INAVA) has been shown to be elevated in lung adenocarcinoma. However, its expression pattern and function in papillary thyroid cancer (PTC) are unknown. This study aimed to identify ...
Authors: Hongyu Guan, Yan Guo, Liehua Liu, Runyi Ye, Weiwei Liang, Hai Li, Haipeng Xiao and Yanbing Li
Radiation injury combined wound (CI) enhances acute radiation syndrome and subsequently mortality as compared to radiation injury alone (RI). We previously reported that ghrelin (a 28-amino-acid-peptide secret...
Authors: Juliann G. Kiang, Marsha N. Anderson and Joan T. Smith
