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  1. Neurodegenerative diseases seriously affect patients’ physical and mental health, reduce their quality of life, and impose a heavy burden on society. However, their treatment remains challenging. Therefore, ex...

    Authors: Ziyan Hu, Yifan Luo, Jinxi Zhu, Danling Jiang, Zhenzhong Luo, Lidong Wu, Jin Li, Shengliang Peng and Jialing Hu
    Citation: Cell & Bioscience 2023 13:225
  2. The most common site of metastasis in breast cancer is the bone, where the balance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation is disrupted. This imbalance causes osteoly...

    Authors: Shenkangle Wang, Wenxin Wu, Xixi Lin, Kevin Matthew Zhang, QingLiang Wu, Mingpeng Luo and Jichun Zhou
    Citation: Cell & Bioscience 2023 13:224
  3. Activation of the Wnt pathway has been linked to colorectal cancer (CRC). Previous reports suggest that Wnt3a can activate p38. Besides, p38α feeds into the canonical Wnt/β-catenin pathway by inhibiting GSK3β ...

    Authors: Martina Lepore Signorile, Candida Fasano, Giovanna Forte, Katia De Marco, Paola Sanese, Vittoria Disciglio, Elisabetta Di Nicola, Antonino Pantaleo, Cristiano Simone and Valentina Grossi
    Citation: Cell & Bioscience 2023 13:223
  4. The scarcity of pluripotent stem cells poses a major challenge to the clinical application, given ethical and biosafety considerations. While germline stem cells commit to gamete differentiation throughout lif...

    Authors: Rui Wei, Xiaoyu Zhang, Xiaoxiao Li, Jian Wen, Hongyang Liu, Jiqiang Fu, Li Li, Wenyi Zhang, Zhen Liu, Yang Yang and Kang Zou
    Citation: Cell & Bioscience 2023 13:222
  5. Aberrant stress granules (SGs) are emerging as prime suspects in the nucleation of toxic protein aggregates. Understanding the molecular networks linked with aggregation-prone proteins (prion protein, synuclei...

    Authors: Neelam Younas, Saima Zafar, Tayyaba Saleem, Leticia Camila Fernandez Flores, Abrar Younas, Matthias Schmitz and Inga Zerr
    Citation: Cell & Bioscience 2023 13:221
  6. Metabolic homeostasis is closely related to early impairment of cell fate determination and embryo development. The protein kinase mechanistic target of rapamycin (mTOR) is a key regulator of cellular metaboli...

    Authors: Chiyuan Ma, Qin Li, Yuxin Yang, Lei Ge, Jiaxuan Cai, Juan Wang, Maoxian Zhu, Yue Xiong, Wenya Zhang, Jingtong Xie, Yujing Cao, Huashan Zhao, Qing Wei, Chen Huang, Junchao Shi, Jian V. Zhang…
    Citation: Cell & Bioscience 2023 13:219
  7. l-ascorbic acid (Asc) plays a pivotal role in regulating various biological processes, including somatic cell reprogramming, through multiple pathways. However, it remains unclear whether Asc regulates reprogra.....

    Authors: Lining Liang, Meiai He, Yixin Zhang, Chenchen Wang, Zhaohui Qin, Qian Li, Tingting Yang, Fei Meng, Yusheng Zhou, Haofei Ge, Weining Song, Shiyu Chen, Linna Dong, Qiwen Ren, Changpeng Li, Lin Guo…
    Citation: Cell & Bioscience 2023 13:218
  8. The role of mast cells (MCs) in colorectal cancer (CRC) remains unclear, and a comprehensive single-cell study on CRC MCs has not been conducted. This study used a multi-omics approach, integrating single-cell...

    Authors: Zhenyu Xie, Liaoran Niu, Gaozan Zheng, Kunli Du, Songchen Dai, Ruikai Li, Hanjun Dan, Lili Duan, Hongze Wu, Guangming Ren, Xinyu Dou, Fan Feng, Jian Zhang and Jianyong Zheng
    Citation: Cell & Bioscience 2023 13:217
  9. Primary biliary cholangitis (PBC) is an autoimmune liver disease. The aetiology of PBC remains unclear, and its pathogenesis is complex. Animal models are essential to clarify the pathogenesis of PBC and explo...

    Authors: Xu Wang, Yi Wei, Yanlei Yang, Yunjiao Yang, Haolong Li, Yongzhe Li, Fengchun Zhang and Li Wang
    Citation: Cell & Bioscience 2023 13:214
  10. Abnormalities in the 5-HT system and synaptic plasticity are hallmark features of schizophrenia. Previous studies suggest that the human endogenous retrovirus W family envelope (ERVWE1) is an influential risk ...

    Authors: Xiulin Wu, Lianzhong Liu, Xing Xue, Xuhang Li, Kexin Zhao, Jiahang Zhang, Wenshi Li, Wei Yao, Shuang Ding, Chen Jia and Fan Zhu
    Citation: Cell & Bioscience 2023 13:213
  11. Tachykinins and their cognate receptors, neurokinin receptors (NKs) including NK1, NK2, and NK3 play vital roles in regulating various physiological processes including neurotransmission, nociception, inflamma...

    Authors: Lan Phuong Nguyen, Minyeong Cho, Thai Uy Nguyen, Hee-Kyung Park, Huong Thi Nguyen, Kateryna Mykhailova, Sunghoon Hurh, Hong-Rae Kim, Jae Young Seong, Cheol Soon Lee, Byung-Joo Ham and Jong-Ik Hwang
    Citation: Cell & Bioscience 2023 13:212
  12. Prostate cancer is a leading cause of cancer-related deaths among men worldwide. Docetaxel chemotherapy has proven effective in improving overall survival in patients with castration-resistant prostate cancer ...

    Authors: Bisheng Cheng, Lingfeng Li, Yongxin Wu, Tianlong Luo, Chen Tang, Qiong Wang, Qianghua Zhou, Jilin Wu, Yiming Lai, Dingjun Zhu, Tao Du and Hai Huang
    Citation: Cell & Bioscience 2023 13:211

    The Correction to this article has been published in Cell & Bioscience 2024 14:17

  13. To date, most countries lifted the restriction requirement and coexisted with SARS-CoV-2. Thus, dietary behavior for preventing SARS-CoV-2 infection becomes an interesting issue on a daily basis. Coffee consum...

    Authors: Chen-Shiou Wu, Yi-Chuan Li, Shin-Lei Peng, Chung-Yu Chen, Hsiao-Fan Chen, Po-Ren Hsueh, Wei-Jan Wang, Yen-Yi Liu, Ciao-Ling Jiang, Wei-Chao Chang, Shao-Chun Wang and Mien-Chie Hung
    Citation: Cell & Bioscience 2023 13:210
  14. Synucleinopathies are a group of neurodegenerative disorders characterized by pathologic aggregates of neural and glial α-synuclein (α-syn) in the form of Lewy bodies (LBs), Lewy neurites, and cytoplasmic incl...

    Authors: Mai M. Abdelmoaty, Eugene Lu, Rana Kadry, Emma G. Foster, Shaurav Bhattarai, R. Lee Mosley and Howard E. Gendelman
    Citation: Cell & Bioscience 2023 13:209
  15. Except for gene fusions, FGFR2 genetic alterations in intrahepatic cholangiocarcinomas (ICCs) have received limited attention, leaving patients harboring activating FGFR2 gene mutations with inadequate access ...

    Authors: Xiaohong Pu, Liang Qi, Jia Wu Yan, Zihe Ai, Ping Wu, Fei Yang, Yao Fu, Xing Li, Min Zhang, Beicheng Sun, Shen Yue and Jun Chen
    Citation: Cell & Bioscience 2023 13:208
  16. Paediatric-type diffuse High-Grade Gliomas (PDHGG) are highly heterogeneous tumours which include distinct cell sub-populations co-existing within the same tumour mass. We have previously shown that primary pa...

    Authors: Giulia Pericoli, Angela Galardi, Alessandro Paolini, Lucia Lisa Petrilli, Gerardo Pepe, Alessandro Palma, Marta Colletti, Roberta Ferretti, Ezio Giorda, Stefano Levi Mortera, Anna Burford, Andrea Carai, Angela Mastronuzzi, Alan Mackay, Lorenza Putignani, Chris Jones…
    Citation: Cell & Bioscience 2023 13:207
  17. Lung cancer, the most common cause of cancer-related mortality worldwide, is predominantly associated with advanced/metastatic disease. The interaction between tumor cells and cancer-associated fibroblasts (CA...

    Authors: Parinya Samart, Gayathri Heenatigala Palliyage, Surapol Issaragrisil, Sudjit Luanpitpong and Yon Rojanasakul
    Citation: Cell & Bioscience 2023 13:205
  18. Observational studies have demonstrated an association between gut microbiota and myasthenia gravis; however, the causal relationship between the two still lacks clarity. Our goals are to ascertain the existen...

    Authors: Tengfei Su, Xiang Yin, Jiaxin Ren, Yue Lang, Weiguanliu Zhang and Li Cui
    Citation: Cell & Bioscience 2023 13:204
  19. In recent years, the role of altered cellular metabolism in tumor progression has attracted widespread attention. Related metabolic enzymes have also been considered as potential cancer therapeutic targets. Se...

    Authors: Zhe Qiao, Yu Li, Yao Cheng, Shaomin Li and Shiyuan Liu
    Citation: Cell & Bioscience 2023 13:203
  20. Ovarian cancer (OC) typically develops an immunosuppressive microenvironment by funtional changes of host immune cells. Dysregulated m6A level is associated with cancer progression via the intrinsic oncogenic pat...

    Authors: Jinyong Wang, Dakai Ling, Lulin Shi, Huayun Li, Minhua Peng, Huihong Wen, Tao Liu, Ruifang Liang, Yongjian Lin, Laiyou Wei, Guangzhi Zhang and Shanze Chen
    Citation: Cell & Bioscience 2023 13:202
  21. Research on human pluripotent stem cells (hPSCs) has shown tremendous progress in cell-based regenerative medicine. Corneal endothelial dysfunction is associated with the loss and degeneration of corneal endot...

    Authors: Juan Yu, Nianye Yu, Yao Tian, Yifan Fang, Bin An, Guihai Feng, Jun Wu, Liu Wang, Jie Hao, Liqiang Wang, Qi Zhou, Wei Li, Yukai Wang and Baoyang Hu
    Citation: Cell & Bioscience 2023 13:201
  22. Poly (ADP-ribose) polymerase inhibitors (PARPi) are approved for the treatment of BRCA-mutated breast cancer (BC), including triple-negative BC (TNBC) and ovarian cancer (OvCa). A key challenge is to identify the...

    Authors: Matias A. Bustos, Takamichi Yokoe, Yoshiaki Shoji, Yuta Kobayashi, Shodai Mizuno, Tomohiro Murakami, Xiaoqing Zhang, Sreeja C. Sekhar, SooMin Kim, Suyeon Ryu, Matthew Knarr, Steven A. Vasilev, Analisa DiFeo, Ronny Drapkin and Dave S. B. Hoon
    Citation: Cell & Bioscience 2023 13:200
  23. People of Sub-Saharan African ancestry are at higher risk of developing chronic kidney disease (CKD), attributed to the Apolipoprotein L1 (APOL1) gene risk alleles (RA) G1 and G2. The underlying mechanisms by whi...

    Authors: Jin-Gu Lee, Yulong Fu, Jun-yi Zhu, Pei Wen, Joyce van de Leemput, Patricio E. Ray and Zhe Han
    Citation: Cell & Bioscience 2023 13:199
  24. The efficacy of current surgery and chemotherapy for triple negative breast cancer (TNBC) is limited due to heterogenous and immunosuppressive tumor microenvironment (TME). Tumor associated macrophages (TAMs),...

    Authors: Bichen Liu, Jun Huang, Jiangming Xiao, Wenlong Xu, Hong Zhang, Yuan Yuan, Yibing Yin and Xuemei Zhang
    Citation: Cell & Bioscience 2023 13:198
  25. Organoids, three-dimensional structures cultured in vitro, can recapitulate the microenvironment, complex architecture, and cellular functions of in vivo organs or tissues. In recent decades, liver organoids h...

    Authors: Yiqing Hu, Xiaoyi Hu, Jia Luo, Jiacheng Huang, Yaohan Sun, Haoyu Li, Yinbiao Qiao, Hao Wu, Jianhui Li, Lin Zhou and Shusen Zheng
    Citation: Cell & Bioscience 2023 13:197
  26. The cilia are microtubule-based organelles that protrude from the cell surface. Abnormalities in cilia result in various ciliopathies, including polycystic kidney disease (PKD), Bardet-Biedl syndrome (BBS), an...

    Authors: Hye In Ka, Mina Cho, Seung-Hae Kwon, Se Hwan Mun, Sora Han, Min Jung Kim and Young Yang
    Citation: Cell & Bioscience 2023 13:195
  27. In eukaryotic cells, DNA double strand breaks (DSB) are primarily repaired by canonical non-homologous end joining (c-NHEJ), homologous recombination (HR) and alternative NHEJ (alt-NHEJ). Zinc finger and SCAN ...

    Authors: Li-Kuang Tsai, Min Peng, Chia-Chun Chang, Luan Wen, Lin Liu, Xiubin Liang, Y. Eugene Chen, Jie Xu and Li-Ying Sung
    Citation: Cell & Bioscience 2023 13:193
  28. Immune checkpoint blockade (ICB) represents a revolutionary advance in cancer treatment but remains limited success in triple-negative breast cancer (TNBC). Here we aim to explore the mechanism of RNA-binding ...

    Authors: Qi Zhang, Zhe Yang, Xinbao Hao, Lauren J. Dandreo, Lily He, Yuxia Zhang, Fen Wang, Xiaoqing Wu and Liang Xu
    Citation: Cell & Bioscience 2023 13:192
  29. c-Jun is a proto-oncogene functioning as a transcription factor to activate gene expression under many physiological and pathological conditions, particularly in somatic cells. However, its role in early embry...

    Authors: Dongwei Li, Ling Luo, Lin Guo, Chuman Wu, Ran Zhang, Yuling Peng, Menghua Wu, Junqi Kuang, Yan Li, Yudan Zhang, Jun Xie, Wenxiu Xie, Rui Mao, Gang Ma, Xiuling Fu, Jiekai Chen…
    Citation: Cell & Bioscience 2023 13:191
  30. It is not uncommon for some individuals to retain certain primitive characteristics even after domestication or long-term intensive selection. Wild ancestors or original varieties of animals typically possess ...

    Authors: Jiankui Wang, Guoying Hua, Jianfei Chen, Kai Cui, Zu Yang, Deping Han, Xue Yang, Xianggui Dong, Yuhao Ma, Ganxian Cai, Yuanyuan Zhang, Jinnan Li, Yurong Tai, Lai Da, Xinhai Li, Lina Ma…
    Citation: Cell & Bioscience 2023 13:190
  31. Cell proliferation and function require nutrients, energy, and biosynthesis activity to duplicate repertoires for each daughter. It is therefore not surprising that tumor microenvironment (TME) metabolic repro...

    Authors: Jing Jin, Qijie Zhao, Zhigong Wei, Keliang Chen, Yonglin Su, Xiaolin Hu and Xingchen Peng
    Citation: Cell & Bioscience 2023 13:189
  32. Immunotherapy is one of the fastest developing areas in the field of oncology. Many immunological treatment strategies for refractory tumors have been approved and marketed. Nevertheless, much clinical and pre...

    Authors: Ciliang Guo, Lingkai Kong, Lingjun Xiao, Kua Liu, Huawei Cui, Qilei Xin, Xiaosong Gu, Chunping Jiang and Junhua Wu
    Citation: Cell & Bioscience 2023 13:188
  33. Drosophila melanogaster is excellent animal model for understanding the molecular basis of human neurological and motor disorders. The experimental conditions and chamber design varied between studies. Moreover, ...

    Authors: Kai Mi, Yiqing Li, Yuhang Yang, Julie Secombe and Xingyin Liu
    Citation: Cell & Bioscience 2023 13:187
  34. High-fat diet (HFD) is closely associated with the increased prevalence of inflammatory bowel disease (IBD). Excessive gut microbial metabolite deoxycholic acid (DCA) caused by HFD plays significant roles in e...

    Authors: Dan Li, Jiefei Zhou, Lingyu Wang, Zizhen Gong, Huijuan Le, Ye Huang, Congfeng Xu, Chunyan Tian, Wei Cai and Jin Wu
    Citation: Cell & Bioscience 2023 13:186
  35. The genetic underpinnings of late-onset Alzheimer’s disease (LOAD) are yet to be fully elucidated. Although numerous LOAD-associated loci have been discovered, the causal variants and their target genes remain...

    Authors: Julia Gamache, Daniel Gingerich, E. Keats Shwab, Julio Barrera, Melanie E. Garrett, Cordelia Hume, Gregory E. Crawford, Allison E. Ashley-Koch and Ornit Chiba-Falek
    Citation: Cell & Bioscience 2023 13:185
  36. CD24+CK19+/CD24+SOX9+ resident liver cells are activated and expanded after chronic liver injury in a ductular reaction. However, the sources and functions of these cells in liver damage remain disputed.

    Authors: Wei-Jian Huang, Bi-Jun Qiu, Xiao-Shu Qi, Cai-Yang Chen, Wen-Ming Liu, Shen-ao Zhou, Min Ding, Feng-Feng Lu, Jie Zhao, Dan Tang, Xu Zhou, Gong-Bo Fu, Zhen-Yu Wang, Hong-Qian Ma, Yu-Ling Wu, Hong-ping Wu…
    Citation: Cell & Bioscience 2023 13:184
  37. N7-methylguanosine (m7G) is one of the most conserved modifications in nucleosides impacting mRNA export, splicing, and translation. However, the precise function and molecular mechanism of internal mRNA m7G meth...

    Authors: Qingfeng Li, Hui Liu, Lishi Li, Haomin Guo, Zhihao Xie, Xuejian Kong, Jiamin Xu, Junlin Zhang, Yunxia Chen, Zhongsheng Zhang, Jun Liu and Aiguo Xuan
    Citation: Cell & Bioscience 2023 13:183
  38. Under conditions of hypoxia, cancer cells with hypoxia inducible factor-1α (HIF-1α) from heterogeneous tumor cells show greater aggression and progression in an effort to compensate for harsh environmental con...

    Authors: Hyun-Yoo Joo, Jin Kyu Jung, Mi-Yeon Kim, Seon Rang Woo, Jae Min Jeong, Eun-Ran Park, Yong-Min Kim, Joong-Jean Park, Joon Kim, Miyong Yun, Hyun-Jin Shin and Kee-Ho Lee
    Citation: Cell & Bioscience 2023 13:182
  39. The expression of major histocompatibility complex I (MHC-I) in neurons has recently been shown to regulate neurite outgrowth and synaptic plasticity. However, its contribution to neurodegenerative diseases su...

    Authors: Min-Seok Kim, Kwangmin Cho, Mi-Hyang Cho, Na-Young Kim, Kyunggon Kim, Dong-Hou Kim and Seung-Yong Yoon
    Citation: Cell & Bioscience 2023 13:181
  40. Metastases within liver or the brain are the most common causes of mortality from lung cancer (LC). Predicting liver or brain metastases before having evidence from imaging of the tumors is challenging but imp...

    Authors: Sini Li, Yan Qu, Lihui Liu, Xue Zhang, Yan He, Chao Wang, Yufeng Guo, Li Yuan, Zixiao Ma, Hua Bai and Jie Wang
    Citation: Cell & Bioscience 2023 13:180
  41. Although the clinical application of PARP inhibitors has brought hope to ovarian cancer, the problem of its resistance has become increasingly prominent. Therefore, clinical experts have been focused on findin...

    Authors: Xucui Zhuang, Rourou Xiao, Yu Fu, Bin Yang, Junpeng Fan, Funian Lu, Tianyu Qin, Xiaohang Yang, Xingyuan Hu, Jingjing Yin, Wenting Li, Xiaoyan Kang, Gang Chen, Dianxing Hu and Chaoyang Sun
    Citation: Cell & Bioscience 2023 13:178
  42. Spermatogonial stem cells (SSCs) provide a foundation for robust and continual spermatogenesis in mammals. SSCs self-renew to maintain a functional stem cell pool and differentiate to supply committed progenit...

    Authors: Rong-Ge Yan, Zhen He, Fei-Chen Wang, Shuang Li, Qin-Bang Shang and Qi-En Yang
    Citation: Cell & Bioscience 2023 13:177
  43. Pancreatic cancer stem cells (CSCs) promote pancreatic ductal adenocarcinoma (PDAC) tumorigenesis and chemoresistance. Cyclin-dependent kinase 1 (CDK1) plays an important role in tumor initiation in other tumo...

    Authors: Xiaodong Xu, Yimin Ding, Junbin Jin, Chengjie Xu, Wenyi Hu, Songtao Wu, Guoping Ding, Rui Cheng, Liping Cao and Shengnan Jia
    Citation: Cell & Bioscience 2023 13:176