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  1. Adipose tissue is essential for maintaining systemic metabolic homeostasis through traditional metabolic regulation, endocrine crosstalk, and extracellular vesicle production. Adipose dysfunction is a risk fac...

    Authors: Songling Tang, Ruixin Li, Wen Ma, Liu Lian, Jiuyu Gao, Yu Cao and Lu Gan
    Citation: Cell & Bioscience 2023 13:161
  2. The emergence of SARS-CoV-2 becomes life-threatening for the older and immunocompromised individuals, whereas limited treatment is available on these populations. Mesenchymal stromal cells (MSCs) have been rep...

    Authors: Yanning Wang, Tianyun Gao, WanTing Li, Chenxu Tai, Yuanyuan Xie, Dong Chen, Shuo Liu, Feifei Huang, Wenqing Wang, Yuxin Chen and Bin Wang
    Citation: Cell & Bioscience 2023 13:160
  3. Sex determining region Y related high-mobility group box protein 9 (Sox9) is expressed in a subset of hepatocytes, and it is important for chronic liver injury. However, the roles of Sox9+ hepatocytes in response...

    Authors: Dan Qin, Rui Wang, Jinwei Ji, Duo Wang, Yuanyuan Lu, Shiyao Cao, Yaqing Chen, Liqiang Wang, Xiangmei Chen and Lisheng Zhang
    Citation: Cell & Bioscience 2023 13:159
  4. Mitophagy, mitochondrial selective autophagy, plays a pivotal role in the maintenance of cellular homeostasis in response to cellular stress. However, the role of mitophagy in macrophages during infection has ...

    Authors: Junghwan Lee, Seong-Ahn Lee, Sang-Hun Son, Ji-Ae Choi, Tam Doan Nguyen, Jaewhan Kim, Doyi Son and Chang-Hwa Song
    Citation: Cell & Bioscience 2023 13:158
  5. Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder characterized by widespread intranuclear inclusions in the nervous system as well as multiple visceral organs. In 2019, expan...

    Authors: Yongcheng Pan, Ying Jiang, Juan Wan, Zhengmao Hu, Hong Jiang, Lu Shen, Beisha Tang, Yun Tian and Qiong Liu
    Citation: Cell & Bioscience 2023 13:157
  6. Type 1 diabetes (T1D) is a chronic, progressive autoinflammatory disorder resulting from the breakdown of self-tolerance and unrestrained β cell-reactive immune response. Activation of immune cells is initiate...

    Authors: Fei Sun, Chun-Liang Yang, Fa-Xi Wang, Shan-Jie Rong, Jia-Hui Luo, Wan-Ying Lu, Tian-Tian Yue, Cong-Yi Wang and Shi-Wei Liu
    Citation: Cell & Bioscience 2023 13:156
  7. Pain in early life may impact on development and risk of chronic pain. We developed an optogenetic Cre/loxP mouse model of “early-life-pain” (ELP) using mice with transgenic expression of channelrhodopsin-2 (C...

    Authors: Alexandra Vogel, Timo Ueberbach, Annett Wilken-Schmitz, Lisa Hahnefeld, Luisa Franck, Marc-Philipp Weyer, Tassilo Jungenitz, Tobias Schmid, Giulia Buchmann, Florian Freudenberg, Ralf P. Brandes, Robert Gurke, Stephan W. Schwarzacher, Gerd Geisslinger, Thomas Mittmann and Irmgard Tegeder
    Citation: Cell & Bioscience 2023 13:155
  8. Phosphoglycerate mutase 5 (PGAM5), a phosphatase involved in mitochondrial homeostasis, is reported to be closely related to the metabolic stress induced by high-fat diet (HFD) or cold. In this study, we aimed...

    Authors: Li Li, Chengcheng Guo, Yue Yu, Lu Tie, Guotao Lu, Feng Liu, Xueyao Han, Linong Ji and Xiantong Zou
    Citation: Cell & Bioscience 2023 13:154
  9. Renal cell carcinoma (RCC) is characterized by a high rate of distant metastasis, which leads to poor prognosis in patients with advanced RCC. PUS10 has been recognized as a member of the pseudouridine synthas...

    Authors: Wenqin Luo, Zhehao Xu, Huan Wang, Zeyi Lu, Lifeng Ding, Ruyue Wang, Haiyun Xie, Qiming Zheng, Yudong Lin, Zhenwei Zhou, Yang Li, Xianjiong Chen, Gonghui Li and Liqun Xia
    Citation: Cell & Bioscience 2023 13:153
  10. Chronic obstructive pulmonary disease (COPD) is a frequent and common disease in clinical respiratory medicine and its mechanism is unclear. The purpose of this study was to find the new biomarkers of COPD and...

    Authors: Chunhua Ma, Kexi Liao, Jing Wang, Tao Li and Liangming Liu
    Citation: Cell & Bioscience 2023 13:152
  11. Cardiac fibroblasts (CFs) and cardiomyocytes are the major cell populations in the heart. CFs not only support cardiomyocytes by producing extracellular matrix (ECM) but also assimilate myocardial nutrient met...

    Authors: Tong Wei, Yuetong Guo, Chenglin Huang, Mengwei Sun, Bin Zhou, Jing Gao and Weili Shen
    Citation: Cell & Bioscience 2023 13:151
  12. Lung cancer is a complex and heterogeneous disease characterized by abnormal growth and proliferation of lung cells. It is the leading cause of cancer-related deaths worldwide, accounting for approximately 18%...

    Authors: Ying Zou, Hongmei Zheng, Yue Ning, Yang Yang, Qiuyuan Wen and Songqing Fan
    Citation: Cell & Bioscience 2023 13:150
  13. N6-methyladenosine (m6A) modification is the most abundant reversible methylation modification in eukaryotes, and it is reportedly closely associated with a variety of cancers progression, including colorectal...

    Authors: Mujie Ye, Jinhao Chen, Feiyu Lu, Minghui Zhao, Suwen Wu, Chunhua Hu, Ping Yu, Jingbao Kan, Jianan Bai, Ye Tian and Qiyun Tang
    Citation: Cell & Bioscience 2023 13:148
  14. Pancreatic ductal adenocarcinoma (PDA) is a pernicious disease characterized by an immunosuppressive milieu that is unresponsive to current immunotherapies. Interleukin-1 receptor antagonist (IL-1Ra) is a natu...

    Authors: Yu-Ching Fan, Yu-Cin Fong, Chun-Tse Kuo, Chia-Wei Li, Wei-Yu Chen, Jian-Da Lin, Florian Bürtin, Michael Linnebacher, Quoc Thang Bui, Kuan-Der Lee and Yuan-Chin Tsai
    Citation: Cell & Bioscience 2023 13:147
  15. The oncoprotein KAI1 C-terminal interacting tetraspanin (KITENIN; vang-like 1) promotes cell metastasis, invasion, and angiogenesis, resulting in shorter survival times in cancer patients. Here, we aimed to de...

    Authors: Mücahit Varlı, Sung Jin Kim, Myung-Giun Noh, Yoon Gyoon Kim, Hyung-Ho Ha, Kyung Keun Kim and Hangun Kim
    Citation: Cell & Bioscience 2023 13:146
  16. Mouse embryonic stem cells (mESCs) not only retain the property of self-renewal but also have the ability to develop into primordial germ cell-like cells (PGCLCs). However, knowledge about the mechanisms of tr...

    Authors: Xiaofeng Li, Peng Chen, Junxiang Ji, Quanchao Duan, Jianjian Cao, Ru Huang and Shou-Dong Ye
    Citation: Cell & Bioscience 2023 13:145
  17. Standard neuropathologic analysis of Alzheimer’s brain relies on traditional fluorescence microscopy, which suffers from limited spatial resolution due to light diffraction. As a result, it fails to reveal int...

    Authors: Björn Johansson, Sho Oasa, Aida Muntsant Soria, Ann Tiiman, Linda Söderberg, Ebba Amandius, Christer Möller, Lars Lannfelt, Lars Terenius, Lydia Giménez-Llort and Vladana Vukojević
    Citation: Cell & Bioscience 2023 13:142
  18. The amyloid precursor protein (APP), a key player in Alzheimer’s disease (AD), is part of a larger gene family, including the APP like proteins APLP1 and APLP2. They share similar structures, form homo- and he...

    Authors: Sandra Schilling, Alexander August, Mathieu Meleux, Carolin Conradt, Luisa M. Tremmel, Sandra Teigler, Virginie Adam, Ulrike C. Müller, Edward H. Koo, Stefan Kins and Simone Eggert
    Citation: Cell & Bioscience 2023 13:141
  19. Parkinson’s disease (PD), a highly prevalent neuro-motor disorder is caused due to progressive loss of dopaminergic (DAergic) neurons at substantia nigra region of brain. This leads to depleted dopamine (DA) c...

    Authors: Rupsha Mondal, Chayan Banerjee, Sumangal Nandy, Moumita Roy and Joy Chakraborty
    Citation: Cell & Bioscience 2023 13:140
  20. The two most prevalent subtypes of epithelial ovarian carcinoma (EOC) are ovarian clear cell carcinoma (OCCC) and high-grade serous ovarian carcinoma (HGSC). Patients with OCCC have a poor prognosis than those...

    Authors: Dan Guo, Sumei Zhang, Yike Gao, Jinghua Shi, Xiaoxi Wang, Zixin Zhang, Yaran Zhang, Yuming Wang, Kun Zhao, Mei Li, Anqi Wang, Pan Wang, Yanqin Gou, Miao Zhang, Meiyu Liu, Yuhan Zhang…
    Citation: Cell & Bioscience 2023 13:139
  21. Gamma sensory stimulation may reduce AD-specific pathology. Yet, the efficacy of alternating electrical current stimulation in animal models of AD is unknown, and prior research has not addressed intensity-dep...

    Authors: Qian Liu, Adam Contreras, Muhammad Shan Afaq, Weijian Yang, Daniel K. Hsu, Michael Russell, Bruce Lyeth, Theodore P. Zanto and Min Zhao
    Citation: Cell & Bioscience 2023 13:138
  22. The blood–brain barrier (BBB) is a sophisticated structure whose full functionality is required for maintaining the executive functions of the central nervous system (CNS). Tight control of transport across th...

    Authors: Amit Sharma, Diogo C. Fernandes, Rui L. Reis, Dominika Gołubczyk, Silke Neumann, Barbara Lukomska, Miroslaw Janowski, Marcin Kortylewski, Piotr Walczak, J. Miguel Oliveira and Jarek Maciaczyk
    Citation: Cell & Bioscience 2023 13:137
  23. The absence of prominent, actionable genetic alternations in osteosarcomas (OS) implies that transcriptional and epigenetic mechanisms significantly contribute to the progression of this life-threatening form ...

    Authors: Young-Im Kim, Yu-Chou Tseng, Gamze Ayaz, Shasha Wang, Hualong Yan, Wendy du Bois, Howard Yang, Tao Zhen, Maxwell P. Lee, Paul Liu, Rosandra N. Kaplan and Jing Huang
    Citation: Cell & Bioscience 2023 13:136
  24. Genetics evidences have long linked mosaic loss of Y-chromosome (mLOY) in peripheral leukocytes with a wide range of male age-associated diseases. However, a lack of cellular and molecular mechanistic explanat...

    Authors: Xuehong Xu, Rong Zhou, Qinchun Duan, Yuanlin Miao, Tingting Zhang, Mofei Wang, Odell D. Jones and MengMeng Xu
    Citation: Cell & Bioscience 2023 13:135
  25. Dendritic spines are the sites of excitatory synapses on pyramidal neurons, and their development is crucial for neural circuits and brain functions. The spine shape, size, or number alterations are associated...

    Authors: Dongyan Ren, Bin Luo, Peng Chen, Lulu Yu, Mingtao Xiong, Zhiqiang Fu, Tian Zhou, Wen-Bing Chen and Erkang Fei
    Citation: Cell & Bioscience 2023 13:134
  26. Metastatic cancer cells exploit Epithelial-mesenchymal-transition (EMT) to enhance their migration, invasion, and resistance to treatments. Recent studies highlight that elevated levels of copper are implicate...

    Authors: Ensieh M. Poursani, Daniele Mercatelli, Prahlad Raninga, Jessica L. Bell, Federica Saletta, Felix V. Kohane, Daniel P. Neumann, Ye Zheng, Jourdin R. C. Rouaen, Toni Rose Jue, Filip T. Michniewicz, Piper Schadel, Erin Kasiou, Maria Tsoli, Giuseppe Cirillo, Shafagh Waters…
    Citation: Cell & Bioscience 2023 13:132
  27. Thoracic aortic aneurysm (TAA) is a serious condition that affects the aorta, characterized by the dilation of its first segment. The causes of TAA (e.g., age, hypertension, genetic syndromes) are heterogeneous a...

    Authors: Sara Rega, Floriana Farina, Silvia Bouhuis, Silvia de Donato, Mattia Chiesa, Paolo Poggio, Laura Cavallotti, Giorgia Bonalumi, Ilaria Giambuzzi, Giulio Pompilio and Gianluca L. Perrucci
    Citation: Cell & Bioscience 2023 13:131
  28. The temporomandibular joint (TMJ) is a complex joint consisting of the condyle, the temporal articular surface, and the articular disc. Functions such as mastication, swallowing and articulation are accomplish...

    Authors: Qianqi Zhu, Miaoying Tan, Chengniu Wang, Yufei Chen, Chenfei Wang, Junqi Zhang, Yijun Gu, Yuqi Guo, Jianpeng Han, Lei Li, Rongrong Jiang, Xudong Fan, Huimin Xie, Liang Wang, Zhifeng Gu, Dong Liu…
    Citation: Cell & Bioscience 2023 13:130
  29. How transcription factors (TFs) down-regulate gene expression remains ill-understood, especially when they bind to multiple enhancers contacting the same gene promoter. In particular, it is not known whether t...

    Authors: Fabienne Bejjani, Emilie Evanno, Samantha Mahfoud, Claire Tolza, Kazem Zibara, Marc Piechaczyk and Isabelle Jariel-Encontre
    Citation: Cell & Bioscience 2023 13:129
  30. Ectodysplasin-A (EDA), a skin-specific TNF ligand, interacts with its membrane receptor EDAR to trigger EDA signaling in skin appendage formation. Gene mutations in EDA signaling cause Anhidrotic/Hypohidrotic ...

    Authors: Yuyuan Yao, Ruihan Yang, Jian Zhu, David Schlessinger and Jian Sima
    Citation: Cell & Bioscience 2023 13:128
  31. Hepatic sinusoidal obstruction syndrome (HSOS) is caused by toxic injury, such as pyrrolizidine alkaloids, to the liver sinusoidal endothelial cells, and the gut microbiota may be involved. However, the specif...

    Authors: Haitao Shang, Chao Huang, Zhuanglong Xiao, Pengcheng Yang, Shengyan Zhang, Xiaohua Hou and Lei Zhang
    Citation: Cell & Bioscience 2023 13:127
  32. Hepatic fibrosis (HF) is a pathological process caused by excessive accumulation of extracellular matrix caused by a series of causes, leading to the formation of fiber scar. RNA methylation is a newly discove...

    Authors: Chenglong Cheng, Yajie Wu, Xin Wang, Qiuyun Xue, Yurong Huang, Faxue Liao, Xiao Wang, Qiangjun Duan and Chenggui Miao
    Citation: Cell & Bioscience 2023 13:126
  33. Cancer/testis (CT) antigens/genes are usually overexpressed in cancers and exhibit high immunogenicity, making them promising targets for immunotherapy and cancer vaccines. The role of serine protease PRSS56 i...

    Authors: Dandan Li, Lingyun Xia, Pan Huang, Zidi Wang, Qiwei Guo, Congcong Huang, Weidong Leng and Shanshan Qin
    Citation: Cell & Bioscience 2023 13:124
  34. Maintaining homeostasis of Ca2+ stores in the endoplasmic reticulum (ER) is crucial for proper Ca2+ signaling and key cellular functions. Although Ca2+ depletion has been known to cause ER stress which in turn ac...

    Authors: Song Zhao, Haiping Feng, Dongfang Jiang, Keyan Yang, Si-Tong Wang, Yu-Xin Zhang, Yun Wang, Hongmei Liu, Caixia Guo and Tie-Shan Tang
    Citation: Cell & Bioscience 2023 13:123
  35. Salivary carcinoma ex pleomorphic adenoma (CXPA) is defined as a carcinoma that develops from benign pleomorphic adenoma (PA). Abnormally activated Androgen signaling pathway and amplification of HER-2/neu(ERBB-2...

    Authors: Wanling Chen, Ting Gu, Qianqian Chen, Chuxiang Qu, Chunye Zhang, Yuhua Hu, Ronghui Xia, Ying Zhang, Min Wang, Xinyi Huang, Jiang Li, Chaoji Shi and Zhen Tian
    Citation: Cell & Bioscience 2023 13:122
  36. BRAFV600E comes as two main splicing variants. The well-studied ref isoform and the recently discovered X1 isoform are co-expressed in cancer cells and differ in terms of 3’UTR length and sequence, as well as ...

    Authors: Raffaella De Paolo, Samanta Sarti, Sara Bernardi, Francesco Cucco, Andrea Tavosanis, Letizia Pitto and Laura Poliseno
    Citation: Cell & Bioscience 2023 13:121
  37. Immune checkpoint inhibitors (ICIs) targeting CTLA-4 and PD-1/PD-L1 to boost tumor-specific T lymphocyte immunity have opened up new avenues for the treatment of various histological types of malignancies, wit...

    Authors: Bin Wang, Yin Han, Yuyu Zhang, Qin Zhao, Huanhuan Wang, Jinlong Wei, Lingbin Meng, Ying Xin and Xin Jiang
    Citation: Cell & Bioscience 2023 13:120
  38. Cones are essential for color recognition, high resolution, and central vision; therefore cone death causes blindness. Understanding the pathophysiology of each cell type in the retina is key to developing the...

    Authors: Nan-Kai Wang, Pei-Kang Liu, Yang Kong, Yun-Ju Tseng, Laura A. Jenny, Nicholas D. Nolan, Nelson Chen, Hung-Hsi Wang, Chun Wei Hsu, Wan-Chun Huang, Janet R. Sparrow, Chyuan-Sheng Lin and Stephen H. Tsang
    Citation: Cell & Bioscience 2023 13:119
  39. Artemisia argyi (A. argyi), also called Chinese mugwort, has been widely used to control pandemic diseases for thousands of years since ancient China due to its anti-microbial infection, anti-allergy, and anti-in...

    Authors: Fang-Ju Cheng, Chien-Yi Ho, Tzong-Shiun Li, Yeh Chen, Yi-Lun Yeh, Ya-Ling Wei, Thanh Kieu Huynh, Bo-Rong Chen, Hung-Yu Ko, Chen-Si Hsueh, Ming Tan, Yang-Chang Wu, Hui-Chi Huang, Chih-Hsin Tang, Chia-Hung Chen, Chih-Yen Tu…
    Citation: Cell & Bioscience 2023 13:118
  40. Hepatic liver disease, including primary sclerosing cholangitis (PSC), is a serious extraintestinal manifestations of colonic inflammation. Cyclic adenosine monophosphate (cAMP)-responsive element-binding prot...

    Authors: Sang-Hee Lee, Sung-Je Moon, Seung Hee Woo, Gwangsook Ahn, Won Kon Kim, Chul-Ho Lee and Jung Hwan Hwang
    Citation: Cell & Bioscience 2023 13:116
  41. Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) niche, which includes bone-forming and bone-resorbing cells, i.e., osteoblasts (OBs) and osteoclasts (OCs). OBs originate from mesenchymal progeni...

    Authors: Alessia Oppezzo, Lovely Monney, Henri Kilian, Lofti Slimani, Frédérique Maczkowiak-Chartois and Filippo Rosselli
    Citation: Cell & Bioscience 2023 13:115
  42. Transcription factor FOXM1 is a potential target for anti-cancer drug development. An interfering peptide M1-21, targeting FOXM1 and FOXM1-interacting proteins, is developed and its anti-cancer efficacy is eva...

    Authors: Haojie Cheng, Jie Yuan, Chaozhu Pei, Min Ouyang, Huitong Bu, Yan Chen, Xiaoqin Huang, Zhenwang Zhang, Li Yu and Yongjun Tan
    Citation: Cell & Bioscience 2023 13:114
  43. Acne is a chronic inflammatory skin disorder that profoundly impacts the quality of life of patients worldwide. While it is predominantly observed in adolescents, it can affect individuals across all age group...

    Authors: Cong Huang, Fan Zhuo, Baoquan Han, Wenting Li, Bin Jiang, Kaoyuan Zhang, Xingling Jian, Zhenzhen Chen, Hui Li, Haiyan Huang, Xia Dou and Bo Yu
    Citation: Cell & Bioscience 2023 13:113
  44. Pulmonary vein stenosis (PVS), one of the most challenging clinical problems in congenital heart disease, leads to secondary pulmonary arterial hypertension (PAH) and right ventricular (RV) hypertrophy. Due to...

    Authors: Debao Li, Lisheng Qiu, Haifa Hong, Hao Chen, Peibin Zhao, Yingying Xiao, Hao Zhang, Qi Sun and Lincai Ye
    Citation: Cell & Bioscience 2023 13:112