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  1. The Wnt signaling pathway was initially discovered for its role in tumorigenesis and the development of Drosophila and other eukaryotic organisms. The key effector of this pathway, the bipartite transcription fac...

    Authors: Wilfred Ip, Yu-ting Alex Chiang and Tianru Jin
    Citation: Cell & Bioscience 2012 2:28
  2. During normal development primordial germ cells (PGCs) derived from the epiblast are the precursors of spermatogonia and oogonia. In culture, PGCs can be induced to dedifferentiate to pluripotent embryonic ger...

    Authors: Lu Wang, Jinping Cao, Ping Ji, Di Zhang, Lianghong Ma, Martin Dym, Zhuo Yu and Lixin Feng
    Citation: Cell & Bioscience 2012 2:27
  3. Thyroid hormone (T3) is important for adult organ function and vertebrate development. Amphibian metamorphosis is totally dependent on T3 and offers a unique opportunity to study how T3 controls postembryonic ...

    Authors: Kazuo Matsuura, Kenta Fujimoto, Biswajit Das, Liezhen Fu, Christopher D Lu and Yun-Bo Shi
    Citation: Cell & Bioscience 2012 2:25
  4. Phosphatases are important regulators of intracellular signaling events, and their functions have been implicated in many biological processes. Dual-specificity phosphatases (DUSPs), whose family currently con...

    Authors: Ching-Yu Huang and Tse-Hua Tan
    Citation: Cell & Bioscience 2012 2:24
  5. PDLIM2 is essential for the termination of the inflammatory transcription factors NF-κB and STAT but is dispensable for the development of immune cells and immune tissues/organs. Currently, it remains unknown ...

    Authors: Zhaoxia Qu, Jing Fu, Huihui Ma, Jingjiao Zhou, Meihua Jin, Markus Y Mapara, Michael J Grusby and Gutian Xiao
    Citation: Cell & Bioscience 2012 2:23
  6. Mutations in LMNA encoding lamins A and C are associated with at least 10 different degenerative disorders affecting diverse tissues, collectively called laminopathies. A recent study showed that mis-accumulation...

    Authors: Baohua Liu, Dong-Yan Jin and Zhongjun Zhou
    Citation: Cell & Bioscience 2012 2:21
  7. Wounding following whole-body γ-irradiation (radiation combined injury, RCI) increases mortality. Wounding-induced increases in radiation mortality are triggered by sustained activation of inducible nitric oxi...

    Authors: Juliann G Kiang, Bradley R Garrison, True M Burns, Min Zhai, Ian C Dews, Patrick H Ney, Lynnette H Cary, Risaku Fukumoto, Thomas B Elliott and G David Ledney
    Citation: Cell & Bioscience 2012 2:20
  8. Glucocorticoids are steroid hormones that play critical and complex roles in the regulation of triglyceride (TG) homeostasis. Depending on physiological states, glucocorticoids can modulate both TG synthesis a...

    Authors: Jen-Chywan Wang, Nora E Gray, Taiyi Kuo and Charles A Harris
    Citation: Cell & Bioscience 2012 2:19
  9. Caenorhabditis elegans sarcomeres have been studied extensively utilizing both forward and reverse genetic techniques to provide insight into muscle development and the mechanisms behind muscle contraction. A pre...

    Authors: Qian Liu, Takako I Jones, Rebecca A Bachmann, Mitchell Meghpara, Lauren Rogowski, Benjamin D Williams and Peter L Jones
    Citation: Cell & Bioscience 2012 2:18
  10. Cell signaling mediated by morphogens is essential to coordinate growth and patterning, two key processes that govern the formation of a complex multi-cellular organism. During growth and patterning, cells are...

    Authors: Yingzi Yang
    Citation: Cell & Bioscience 2012 2:14
  11. A novel, cancer-fighting function was recently discovered for Sm ad u biquitination r egulatory f actor 2 (Smurf2).

    Authors: Keji Zhao and Yun-Bo Shi
    Citation: Cell & Bioscience 2012 2:10
  12. TGF-β signaling regulates diverse cellular processes, including cell proliferation, differentiation, apoptosis, cell plasticity and migration. Its dysfunctions can result in various kinds of diseases, such as ...

    Authors: Fei Huang and Ye-Guang Chen
    Citation: Cell & Bioscience 2012 2:9
  13. Germline mutations of the BRCA1 tumor suppressor gene are a major cause of familial breast and ovarian cancer. BRCA1 plays critical roles in the DNA damage response that regulates activities of multiple repair an...

    Authors: Bin Wang
    Citation: Cell & Bioscience 2012 2:6
  14. The structural maintenance of chromosomes (Smc) proteins regulate nearly all aspects of chromosome biology and are critical for genomic stability. In eukaryotes, six Smc proteins form three heterodimers--Smc1/...

    Authors: Nan Wu and Hongtao Yu
    Citation: Cell & Bioscience 2012 2:5
  15. The TGFβ and Ras-MAPK pathways play critical roles in cell development and cell cycle regulation, as well as in tumor formation and metastasis. In the absence of cellular transformation, these pathways operate...

    Authors: Douglas A Chapnick, Lisa Warner, Jennifer Bernet, Timsi Rao and Xuedong Liu
    Citation: Cell & Bioscience 2011 1:42
  16. Smad proteins are classified in different groups based on their functions in mediating transforming growth factor β (TGFβ) superfamily components. Smad1/5/8 mainly mediate bone morphogenetic proteins (BMP) pat...

    Authors: Gangwen Han and Xiao-Jing Wang
    Citation: Cell & Bioscience 2011 1:41
  17. It remains unclear whether retroviruses can encode and express an intragenomic microRNA (miRNA). Some have suggested that processing by the Drosha and Dicer enzymes might preclude the viability of a replicatin...

    Authors: Zachary Klase, Laurent Houzet and Kuan-Teh Jeang
    Citation: Cell & Bioscience 2011 1:38
  18. Brown adipose tissue in mammals plays a critical role in maintaining energy balance by thermogenesis, which means dissipating energy in the form of heat. It is held that in mammals, long-term surplus food inta...

    Authors: Xuan Yao, Shifang Shan, Ying Zhang and Hao Ying
    Citation: Cell & Bioscience 2011 1:35
  19. Cancer cells possess unique metabolic phenotypes that are determined by their underlying oncogenic pathways. Activation of the PI3K/Akt/mTOR signaling cascade promotes glycolysis and leads to glucose-dependenc...

    Authors: Xiuyun Jiang, Heidi L Kenerson and Raymond S Yeung
    Citation: Cell & Bioscience 2011 1:34
  20. Despite detailed in vivo knowledge of glycolytic enolases and many bacterial non-enolase members of the superfamily, little is known about the in vivo function of vertebrate non-enolase enolase superfamily member...

    Authors: Steve Finckbeiner, Pin-Joe Ko, Blake Carrington, Raman Sood, Kenneth Gross, Bruce Dolnick, Janice Sufrin and Paul Liu
    Citation: Cell & Bioscience 2011 1:32
  21. Adult organ-specific stem cells are essential for organ homeostasis and repair in adult vertebrates. The intestine is one of the best-studied organs in this regard. The intestinal epithelium undergoes constant...

    Authors: Yun-Bo Shi, Takashi Hasebe, Liezhen Fu, Kenta Fujimoto and Atsuko Ishizuya-Oka
    Citation: Cell & Bioscience 2011 1:30
  22. The epithelial to mesenchymal transition (EMT) plays crucial roles in the formation of the body plan and also in the tumor invasion process. In addition, EMT also causes disruption of cell-cell adherence, loss...

    Authors: Yingying Jing, Zhipeng Han, Shanshan Zhang, Yan Liu and Lixin Wei
    Citation: Cell & Bioscience 2011 1:29
  23. Laribacter hongkongensis is a Gram-negative, sea gull-shaped rod associated with community-acquired gastroenteritis. The bacterium has been found in diverse freshwater environments including fish, frogs and drink...

    Authors: Susanna KP Lau, Rachel YY Fan, Gilman KM Wong, Jade LL Teng, Kong-Hung Sze, Herman Tse, Kwok-Yung Yuen and Patrick CY Woo
    Citation: Cell & Bioscience 2011 1:28
  24. Human papillomavirus (HPV) pseudovirions have recently been shown to deliver DNA efficiently in vivo, resulting in the priming of antigen-specific CD8+ T cells in vaccinated mice. In the current study, we compare...

    Authors: Shiwen Peng, Barbara Ma, Shu-Hsia Chen, Chien-Fu Hung and TC Wu
    Citation: Cell & Bioscience 2011 1:26
  25. The Inhibitor of Growth (ING) proteins represent a type II tumor suppressor family comprising five conserved genes, ING1 to ING5. While ING1, ING2 and ING3 proteins are stable components of the mSIN3a-HDAC comple...

    Authors: Susann Ludwig, Alexandra Klitzsch and Aria Baniahmad
    Citation: Cell & Bioscience 2011 1:25
  26. Thyroid hormone (TH) is involved in many biological functions such as animal development, cell differentiation, etc. Variation and/or disruption of plasma TH level often led to abnormalities and physiological ...

    Authors: Shao-Chung Hsia, Gautam R Bedadala and Matthew D Balish
    Citation: Cell & Bioscience 2011 1:24