Articles
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Citation: Cell & Bioscience 2013 3:14
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Erratum to: the MTA family proteins as novel histone H3 binding proteins
Citation: Cell & Bioscience 2013 3:12 -
The role of BRCA1 in homologous recombination repair in response to replication stress: significance in tumorigenesis and cancer therapy
Germ line mutations in breast cancer gene 1 (BRCA1) predispose women to breast and ovarian cancers. Although BRCA1 is involved in many important biological processes, the function of BRCA1 in homologous recomb...
Citation: Cell & Bioscience 2013 3:11 -
The role and clinical significance of DNA damage response and repair pathways in primary brain tumors
Primary brain tumors, in particular, glioblastoma multiforme (GBM), continue to have dismal survivability despite advances in treating other neoplasms. The goal of new anti-glioma therapy development is to inc...
Citation: Cell & Bioscience 2013 3:10 -
The regulation of cellular metabolism by tumor suppressor p53
As a hallmark of tumor cells, metabolic alterations play a critical role in tumor development and could be targeted for tumor therapy. Tumor suppressor p53 plays a central role in tumor prevention. As a transc...
Citation: Cell & Bioscience 2013 3:9 -
Non-steroid anti-inflammatory drugs, prostaglandins, and cancer
Fatty acids are involved in multiple pathways and play a pivotal role in health. Eicosanoids, derived from arachidonic acid, have received extensive attention in the field of cancer research. Following release...
Citation: Cell & Bioscience 2013 3:8 -
Complex roles of filamin-A mediated cytoskeleton network in cancer progression
Filamin-A (FLNA), also called actin-binding protein 280 (ABP-280), was originally identified as a non-muscle actin binding protein, which organizes filamentous actin into orthogonal networks and stress fibers....
Citation: Cell & Bioscience 2013 3:7 -
Cancer biomarkers and targeted therapies
Citation: Cell & Bioscience 2013 3:6 -
One cell, multiple roles: contribution of mesenchymal stem cells to tumor development in tumor microenvironment
The discovery of tissue reparative and immunosuppressive abilities of mesenchymal stem cells (MSCs) has drawn more attention to tumor microenvironment and its role in providing the soil for the tumor cell grow...
Citation: Cell & Bioscience 2013 3:5 -
TGF-beta1 on osteoimmunology and the bone component cells
TGF-β1 is an immunoregulatory cytokine that regulates immune cell proliferation, survival, differentiation, and migration. Compelling evidence has demonstrated a strong association between the immune and skele...
Citation: Cell & Bioscience 2013 3:4 -
Thanking Cell & Bioscience reviewers
The editors of Cell & Bioscience would like to thank all the reviewers who contributed to the journal in Volume 2 (2012).
Citation: Cell & Bioscience 2013 3:3 -
One step closer to an experimental infection system for Hepatitis B Virus? --- the identification of sodium taurocholate cotransporting peptide as a viral receptor
Following the successful cloning of receptor for SARS coronavirus a few years ago, Dr. Wenhui Li and colleagues raised attention again by publishing a possible receptor for hepatitis B virus in eLife. We will bri...
Citation: Cell & Bioscience 2013 3:2 -
The MTA family proteins as novel histone H3 binding proteins
The nucleosome remodeling and histone deacetylase complex (Mi2/NRD/NuRD/NURD) has a broad role in regulation of transcription, DNA repair and cell cycle. Previous studies have revealed a specific interaction b...
Citation: Cell & Bioscience 2013 3:1 -
RNA-seq analysis of synovial fibroblasts brings new insights into rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune-disease of unknown origin that primarily affects the joints and ultimately leads to their destruction. Growing evidence suggests that synvovial fibroblasts pla...
Citation: Cell & Bioscience 2012 2:43 -
Thyroid hormone receptor actions on transcription in amphibia: The roles of histone modification and chromatin disruption
Thyroid hormone (T3) plays diverse roles in adult organ function and during vertebrate development. The most important stage of mammalian development affected by T3 is the perinatal period when plasma T3 level...
Citation: Cell & Bioscience 2012 2:42 -
Tombusvirus P19 RNA silencing suppressor (RSS) activity in mammalian cells correlates with charged amino acids that contribute to direct RNA-binding
Tombusvirus P19 is a protein encoded by tomato bushy stunt virus and related tombusviruses. Earlier studies have demonstrated that P19 is an RNA silencing suppressor (RSS) in plant cells. However, it has not b...
Citation: Cell & Bioscience 2012 2:41 -
Anti-oxidative stress regulator NF-E2-related factor 2 mediates the adaptive induction of antioxidant and detoxifying enzymes by lipid peroxidation metabolite 4-hydroxynonenal
NF-E2-related factor 2 (NRF2) regulates a battery of antioxidative and phase II drug metabolizing/detoxifying genes through binding to the antioxidant response elements (ARE). NRF2-ARE signaling plays a central r...
Citation: Cell & Bioscience 2012 2:40 -
Phylogenetic identification of bacterial MazF toxin protein motifs among probiotic strains and foodborne pathogens and potential implications of engineered probiotic intervention in food
Toxin-antitoxin (TA) systems are commonly found in bacteria and Archaea, and it is the most common mechanism involved in bacterial programmed cell death or apoptosis. Recently, MazF, the toxin component of the...
Citation: Cell & Bioscience 2012 2:39 -
Uncovering the link between malfunctions in Drosophila neuroblast asymmetric cell division and tumorigenesis
Asymmetric cell division is a developmental process utilized by several organisms. On the most basic level, an asymmetric division produces two daughter cells, each possessing a different identity or fate. Drosop...
Citation: Cell & Bioscience 2012 2:38 -
Strategies to identify long noncoding RNAs involved in gene regulation
Long noncoding RNAs (lncRNAs) have been detected in nearly every cell type and found to be fundamentally involved in many biological processes. The characterization of lncRNAs has immense potential to advance ...
Citation: Cell & Bioscience 2012 2:37 -
Strategy for eliciting antigen-specific CD8+ T cell-mediated immune response against a cryptic CTL epitope of merkel cell polyomavirus large T antigen
Merkel cell carcinoma (MCC) is a relatively new addition to the expanding category of oncovirus-induced cancers. Although still comparably rare, the number of cases has risen dramatically in recent years. Furt...
Citation: Cell & Bioscience 2012 2:36 -
A measure of success
Cell and Bioscience is on track to receive its first Impact Factor in mid-2013. What is the role of the Impact Factor as a measure of a journal’s success?
Citation: Cell & Bioscience 2012 2:35 -
GW501516-activated PPARβ/δ promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferation
After liver injury, the repair process comprises activation and proliferation of hepatic stellate cells (HSCs), which produce extracellular matrix (ECM) proteins. Peroxisome proliferator-activated receptor bet...
Citation: Cell & Bioscience 2012 2:34 -
Nuclear hormone receptors in podocytes
Nuclear receptors are a family of ligand-activated, DNA sequence-specific transcription factors that regulate various aspects of animal development, cell proliferation, differentiation, and homeostasis. The ph...
Citation: Cell & Bioscience 2012 2:33 -
Effects of HIV-1 protease on cellular functions and their potential applications in antiretroviral therapy
Human Immunodeficiency Virus Type 1 (HIV-1) protease inhibitors (PIs) are the most potent class of drugs in antiretroviral therapies. However, viral drug resistance to PIs could emerge rapidly thus reducing th...
Citation: Cell & Bioscience 2012 2:32 -
Golgi phosphoprotein 2 in physiology and in diseases
Golgi phosphoprotein 2 (GOLPH2, also termed GP73 and GOLM1) is a type II transmembrane protein residing in the cis and medial-Golgi cisternae. GOLPH2 is predominantly expressed in the epithelial cells of many ...
Citation: Cell & Bioscience 2012 2:31 -
The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation
Hypoxia is associated with many disease conditions in humans, such as cancer, stroke and traumatic injuries. Hypoxia elicits broad molecular and cellular changes in diverse eukaryotes. Our recent studies sugge...
Citation: Cell & Bioscience 2012 2:30 -
Breaking through a phylogenetic impasse: a pair of associated archaea might have played host in the endosymbiotic origin of eukaryotes
For over a century, the origin of eukaryotes has been a topic of intense debate among scientists. Although it has become widely accepted that organelles such as the mitochondria and chloroplasts arose via endo...
Citation: Cell & Bioscience 2012 2:29 -
The involvement of the wnt signaling pathway and TCF7L2 in diabetes mellitus: The current understanding, dispute, and perspective
The Wnt signaling pathway was initially discovered for its role in tumorigenesis and the development of Drosophila and other eukaryotic organisms. The key effector of this pathway, the bipartite transcription fac...
Citation: Cell & Bioscience 2012 2:28 -
Oocyte-like cells induced from mouse spermatogonial stem cells
During normal development primordial germ cells (PGCs) derived from the epiblast are the precursors of spermatogonia and oogonia. In culture, PGCs can be induced to dedifferentiate to pluripotent embryonic ger...
Citation: Cell & Bioscience 2012 2:27 -
Statistical methods for identifying differentially expressed genes in RNA-Seq experiments
RNA sequencing (RNA-Seq) is rapidly replacing microarrays for profiling gene expression with much improved accuracy and sensitivity. One of the most common questions in a typical gene profiling experiment is h...
Citation: Cell & Bioscience 2012 2:26 -
Histone H3K79 methyltransferase Dot1L is directly activated by thyroid hormone receptor during Xenopus metamorphosis
Thyroid hormone (T3) is important for adult organ function and vertebrate development. Amphibian metamorphosis is totally dependent on T3 and offers a unique opportunity to study how T3 controls postembryonic ...
Citation: Cell & Bioscience 2012 2:25 -
DUSPs, to MAP kinases and beyond
Phosphatases are important regulators of intracellular signaling events, and their functions have been implicated in many biological processes. Dual-specificity phosphatases (DUSPs), whose family currently con...
Citation: Cell & Bioscience 2012 2:24 -
PDLIM2 restricts Th1 and Th17 differentiation and prevents autoimmune disease
PDLIM2 is essential for the termination of the inflammatory transcription factors NF-κB and STAT but is dispensable for the development of immune cells and immune tissues/organs. Currently, it remains unknown ...
Citation: Cell & Bioscience 2012 2:23 -
The protective effect of peroxiredoxin II on oxidative stress induced apoptosis in pancreatic β-cells
Excessive loss of pancreatic β-cells, mainly through apoptosis, contributes to the development of diabetic hyperglycemia. Oxidative stress plays a major role in the process of β-cell apoptosis due to low expre...
Citation: Cell & Bioscience 2012 2:22 -
From loss to gain: role for SUN1 in laminopathies
Mutations in LMNA encoding lamins A and C are associated with at least 10 different degenerative disorders affecting diverse tissues, collectively called laminopathies. A recent study showed that mis-accumulation...
Citation: Cell & Bioscience 2012 2:21 -
Wound trauma alters ionizing radiation dose assessment
Wounding following whole-body γ-irradiation (radiation combined injury, RCI) increases mortality. Wounding-induced increases in radiation mortality are triggered by sustained activation of inducible nitric oxi...
Citation: Cell & Bioscience 2012 2:20 -
Regulation of triglyceride metabolism by glucocorticoid receptor
Glucocorticoids are steroid hormones that play critical and complex roles in the regulation of triglyceride (TG) homeostasis. Depending on physiological states, glucocorticoids can modulate both TG synthesis a...
Citation: Cell & Bioscience 2012 2:19 -
C. elegans PAT-9 is a nuclear zinc finger protein critical for the assembly of muscle attachments
Caenorhabditis elegans sarcomeres have been studied extensively utilizing both forward and reverse genetic techniques to provide insight into muscle development and the mechanisms behind muscle contraction. A pre...
Citation: Cell & Bioscience 2012 2:18 -
Human papillomavirus type 58: the unique role in cervical cancers in East Asia
About 15 types of human papillomavirus (HPV) are classified as high-risk based on their epidemiological link with cervical cancer. These HPV types have deferent degrees of oncogenicity and their distribution a...
Citation: Cell & Bioscience 2012 2:17 -
The 2011 Ming K Jeang Award for Excellence in Cell & Bioscience
Two research groups led by Dr T.C. Wu of Johns Hopkins Medical Institutions and Dr P. Liu of National Human Genome Research Institute, National Institutes of Health, respectively, have won the 2011 Ming K Jean...
Citation: Cell & Bioscience 2012 2:16 -
Unstabilized DNA breaks in HTLV-1 Tax expressing cells correlate with functional targeting of Ku80, not PKcs, XRCC4, or H2AX
Expression of the human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein rapidily induces a significant increase of micronuclei (MN) and unstabilized DNA breaks in cells. Unstabilized DNA breaks can have ...
Citation: Cell & Bioscience 2012 2:15 -
Wnt signaling in development and disease
Cell signaling mediated by morphogens is essential to coordinate growth and patterning, two key processes that govern the formation of a complex multi-cellular organism. During growth and patterning, cells are...
Citation: Cell & Bioscience 2012 2:14 -
Nuclear functions and subcellular trafficking mechanisms of the epidermal growth factor receptor family
Accumulating evidence suggests that various diseases, including many types of cancer, result from alteration of subcellular protein localization and compartmentalization. Therefore, it is worthwhile to expand ...
Citation: Cell & Bioscience 2012 2:13 -
Epidermal growth factor receptor (EGFR) biology and Wnt developmental signaling highlight research endeavors of SCBA award winners
This months Cell and Bioscience highlights review articles by Mien-Chie Hung on EGFR biology and Yingzi Yang on Wnt signaling. Dr. Hung was the 2011 Society of Chinese Bioscientists in America (SCBA) Presidential...
Citation: Cell & Bioscience 2012 2:12 -
Retinoic acid synthesis and functions in early embryonic development
Retinoic acid (RA) is a morphogen derived from retinol (vitamin A) that plays important roles in cell growth, differentiation, and organogenesis. The production of RA from retinol requires two consecutive enzy...
Citation: Cell & Bioscience 2012 2:11 -
An anti-cancer Smurf
A novel, cancer-fighting function was recently discovered for Sm ad u biquitination r egulatory f actor 2 (Smurf2).
Citation: Cell & Bioscience 2012 2:10 -
Regulation of TGF-β receptor activity
TGF-β signaling regulates diverse cellular processes, including cell proliferation, differentiation, apoptosis, cell plasticity and migration. Its dysfunctions can result in various kinds of diseases, such as ...
Citation: Cell & Bioscience 2012 2:9 -
The role of immunosuppression of mesenchymal stem cells in tissue repair and tumor growth
Mesenchymal stem cells (MSCs) have acquired great interests for their potential use in the clinical therapy of many diseases because of their functions including multiple lineage differentiation, low immunogen...
Citation: Cell & Bioscience 2012 2:8 -
A special issue on DNA damage response and genome stability
Citation: Cell & Bioscience 2012 2:4
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- ISSN: 2045-3701 (electronic)