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  1. Deamination of adenine can occur spontaneously under physiological conditions generating the highly mutagenic lesion, hypoxanthine. This process is enhanced by ROS from exposure of DNA to ionizing radiation, U...

    Authors: Chia-Chia Lee, Ya-Chien Yang, Steven D. Goodman, Shi Chen, Teng-Yung Huang, Wern-Cherng Cheng, Liang-In Lin and Woei-horng Fang

    Citation: Cell & Bioscience 2015 5:52

    Content type: Research

    Published on:

  2. Preclinical evaluations of chemotherapies depend on clinically relevant animal models for pancreatic cancer. The injection of syngeneic murine adenocarcinoma cells is one efficient option to generate carcinoma...

    Authors: Dietmar Zechner, Florian Bürtin, Jonas Amme, Tobias Lindner, Tobias Radecke, Stefan Hadlich, Jens-Peter Kühn and Brigitte Vollmar

    Citation: Cell & Bioscience 2015 5:51

    Content type: Research

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  3. Human DNA topoisomerase II-binding protein 1 (hTopBP1) plays an important role in DNA replication and the DNA damage checkpoint pathway. The human mutY homolog (hMYH) is a base excision repair DNA glycosylase ...

    Authors: Se Hee Han, Soo-Hyun Hahm, An Hue Vy Tran, Ji Hyung Chung, Myoung-Ki Hong, Hyun-Dong Paik, Key-Sun Kim and Ye Sun Han

    Citation: Cell & Bioscience 2015 5:50

    Content type: Research

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  4. The overall goal of this study was to demonstrate potential chemopreventive effects of ferulic acid (FA), an antioxidant, combined with aspirin (ASP), a commonly used anti-inflammatory drug for pancreatic canc...

    Authors: Arvind Thakkar, Sushma Chenreddy, Jeffrey Wang and Sunil Prabhu

    Citation: Cell & Bioscience 2015 5:46

    Content type: Research

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  5. Acute kidney injury (AKI) is a severe disease with high morbidity and mortality. Methods that promote repair of the injured kidney have been extensively investigated. Cell-based therapy with mesenchymal stem c...

    Authors: Qing Li, Shou-fu Tian, Ye Guo, Xin Niu, Bin Hu, Shang-chun Guo, Nian-song Wang and Yang Wang

    Citation: Cell & Bioscience 2015 5:45

    Content type: Research

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  6. Mutations in the Alpha-actinin-4 gene (ACTN4) cause a rare form of familial focal segmental glomerulosclerosis in humans. Individuals with kidney disease-associated ACTN4 mutations tend to have mild to moderat...

    Authors: Di Feng, Clark DuMontier and Martin R Pollak

    Citation: Cell & Bioscience 2015 5:44

    Content type: Review

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  7. The physiological and pathological roles of hydrogen sulfide (H2S) in the regulation of cardiovascular functions have been recognized. H2S protects against the hypoxia/reoxygenation (H/R)-induced injury and apopt...

    Authors: Hongzhu Li, Chao Zhang, Weiming Sun, Lina Li, Bo Wu, Shuzhi Bai, Hongxia Li, Xin Zhong, Rui Wang, Lingyun Wu and Changqing Xu

    Citation: Cell & Bioscience 2015 5:43

    Content type: Research

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  8. Pten plays a crucial role in the stem cell maintenance in a few organs. Pten defect also causes the premature oocytes and ovary aging. We and other groups have found that the phosphati...

    Authors: Wei Zhou, Hongfang Shao, Di Zhang, Jian Dong, Wei Cheng, Lu Wang, Yincheng Teng and Zhuo Yu

    Citation: Cell & Bioscience 2015 5:42

    Content type: Research

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  9. Adult hematopoietic stem cells (HSCs) are maintained in a microenvironment, known as niche in the endosteal regions of the bone marrow. This stem cell niche with low oxygen tension requires HSCs to adopt a uni...

    Authors: Fatih Kocabas, Li Xie, Jingjing Xie, Zhuo Yu, Ralph J. DeBerardinis, Wataru Kimura, SuWannee Thet, Ahmed F. Elshamy, Hesham Abouellail, Shalini Muralidhar, Xiaoye Liu, Chiqi Chen, Hesham A. Sadek, Cheng Cheng Zhang and Junke Zheng

    Citation: Cell & Bioscience 2015 5:39

    Content type: Research

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  10. Prostate cancer (PCa) is the most commonly diagnosed solid tumor and the second leading cancer death in the United States, and also one of the major cancer-related deaths in Chinese. Androgen deprivation thera...

    Authors: Yu-Wei Chou, Fen-Fen Lin, Sakthivel Muniyan, Frank C Lin, Ching-Shih Chen, Jue Wang, Chao-Cheng Huang and Ming-Fong Lin

    Citation: Cell & Bioscience 2015 5:38

    Content type: Research

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  11. Due to their high proliferative requirements, tumorigenic cells possess altered metabolic systems whereby cells utilize higher quantities of glutamine and glucose. These altered metabolic requirements make it ...

    Authors: Michelle Helen Visagie, Thandi Vuyelwa Mqoco, Leon Liebenberg, Edward Henry Mathews, George Edward Mathews and Anna Margaretha Joubert

    Citation: Cell & Bioscience 2015 5:37

    Content type: Research

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  12. DNA vaccines have emerged as attractive candidates for the control of human papillomavirus (HPV)-associated malignancies. However, DNA vaccines suffer from limited immunogenicity and thus strategies to enhance...

    Authors: Benjamin Yang, Andrew Yang, Shiwen Peng, Xiaowu Pang, Richard B.S. Roden, T.-C. Wu and Chien-Fu Hung

    Citation: Cell & Bioscience 2015 5:35

    Content type: Research

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  13. The Clustered Regions of Interspersed Palindromic Repeats-Cas9 (CRISPR/Cas9), a viral defense system found in bacteria and archaea, has emerged as a tour de force genome editing tool. The CRISPR/Cas9 system is mu...

    Authors: Sean M. Riordan, Daniel P. Heruth, Li Q. Zhang and Shui Qing Ye

    Citation: Cell & Bioscience 2015 5:33

    Content type: Review

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  14. MicroRNAs (miRNAs) are small noncoding regulatory RNAs that regulate gene expression post-transcriptionally by either inhibiting protein translation or degrading target mRNAs. The differential expression profi...

    Authors: Lei Zhou, Fan Liu, Xiaomin Wang and Gaoliang Ouyang

    Citation: Cell & Bioscience 2015 5:32

    Content type: Review

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  15. Leishmaniases are caused by obligate intracellular protozoan parasites of the genus Leishmania. They cause a spectrum of diseases, most notably visceral (VL), cutaneous (CL), and mucosal (ML) leishmaniasis, which...

    Authors: Milena de Paiva-Cavalcanti, Rayana Carla Silva de Morais, Rômulo Pessoa-e-Silva, Lays Adrianne Mendonça Trajano-Silva, Suênia da Cunha Gonçalves-de-Albuquerque, Diego de Hollanda Cavalcanti Tavares, Maria Carolina Accioly Brelaz-de-Castro, Rafael de Freitas e Silva and Valéria Rêgo Alves Pereira

    Citation: Cell & Bioscience 2015 5:31

    Content type: Review

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  16. One major challenge in gene therapy is the host immune responses against viral vectors. Previous studies indicate the involvement of NK cells in stunted gene expression in viral vector mediated gene therapy. T...

    Authors: Manjunatha Ankathatti Munegowda and Jim Hu

    Citation: Cell & Bioscience 2015 5:29

    Content type: Research

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  17. Adipogenesis is tightly controlled by a complex network of transcription factors acting at different stages of differentiation. Kruppel-like factors (KLFs) as a family of zinc-finger transcription factors play...

    Authors: Shuzhong Jiang, Hongkui Wei, Tongxing Song, Yang Yang, Feng Zhang, Yuanfei Zhou, Jian Peng and Siwen Jiang

    Citation: Cell & Bioscience 2015 5:28

    Content type: Research

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  18. Burkholderia pseudomallei is an emerging pathogen that causes melioidosis, a serious and potentially fatal disease which requires prolonged antibiotics to prevent relapse. However, diagnosis of...

    Authors: Susanna K. P. Lau, Ching-Wan Lam, Shirly O. T. Curreem, Kim-Chung Lee, Wang-Ngai Chow, Candy C. Y. Lau, Siddharth Sridhar, Sally C. Y. Wong, Paolo Martelli, Suk-Wai Hui, Kwok-Yung Yuen and Patrick C. Y. Woo

    Citation: Cell & Bioscience 2015 5:26

    Content type: Research

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  19. Interleukin-22 (IL-22), a cytokine with important functions in anti-microbial defense and tissue repair, has been recently suggested to have beneficial effects in obesity and metabolic syndrome in some but not...

    Authors: Ogyi Park, Sung Hwan Ki, Mingjiang Xu, Hua Wang, Dechun Feng, Joseph Tam, Douglas Osei-Hyiaman, George Kunos and Bin Gao

    Citation: Cell & Bioscience 2015 5:25

    Content type: Research

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  20. Aberrant DNA methylation at the 5-carbon on cytosine residues (5mC) in CpG dinucleotides is probably the most extensively characterized epigenetic modification in colon cancer. It has been suggested that the l...

    Authors: Yue Guo, Jong Hun Lee, Limin Shu, Ying Huang, Wenji Li, Chengyue Zhang, Anne Yuqing Yang, Sarandeep SS Boyanapalli, Ansu Perekatt, Ronald P Hart, Michael Verzi and Ah-Ng Tony Kong

    Citation: Cell & Bioscience 2015 5:24

    Content type: Research

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  21. Mycoepoxydiene (MED) is a polyketide that can be isolated from a marine fungus and is associated with various activities, including antitumor and anti-inflammatory functions. However, its effects on atheroscle...

    Authors: Xiaochun Xia, Yang Li, Qiang Su, Zhengrong Huang, Yuemao Shen, Weihua Li and Chundong Yu

    Citation: Cell & Bioscience 2015 5:23

    Content type: Research

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  22. Cellular senescence is linked to aging and tumorigenesis. The senescence of mesenchymal stem cells (MSCs) may influence the tumor growth, metastasis, and angiogenesis by secreting a variety of cytokines and gr...

    Authors: Yanju Li, Xiao Xu, Lihua Wang, Guangjin Liu, Yanqi Li, Xiaobing Wu, Yongguang Jing, Haiyan Li and Guihua Wang

    Citation: Cell & Bioscience 2015 5:21

    Content type: Research

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  23. Whilst there have been a number of insights into the subsets of CD4+ T cells induced by pathogenic Bacillus anthracis infections in animal models, how these findings relate to responses generated in naturally inf...

    Authors: Rebecca J Ingram, Stephanie Ascough, Catherine J Reynolds, Gökhan Metan, Mehmet Doganay, Les Baillie, Diane E Williamson, John H Robinson, Bernard Maillere, Rosemary J Boyton and Daniel M Altmann

    Citation: Cell & Bioscience 2015 5:20

    Content type: Short report

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  24. Research involving antimitotic compounds identified 2-methoxyestradiol (2ME2), as a promising anticancer endogenous metabolite. Owing to its low bioavailability, several in silico-designed 2ME2 analogues were syn...

    Authors: Michelle Helen Visagie, Lyn-Marie Birkholtz and Anna Margaretha Joubert

    Citation: Cell & Bioscience 2015 5:19

    Content type: Research

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  25. Cellular antiviral activities are critically controlled by transcriptional activation of interferon-inducible genes, involving interferon regulatory factors (IRFs). Previous data suggested that IRF1 is an acti...

    Authors: Gang Ren, Kairong Cui, Zhiying Zhang and Keji Zhao

    Citation: Cell & Bioscience 2015 5:17

    Content type: Research

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  26. Aedes albopictus is an important vector of Dengue virus (DENV) and it has quickly invaded the tropical and temperate environments worldwide. A few studies have shown that, microRNAs (miRNAs) re...

    Authors: Yanxia Liu, Yanhe Zhou, Jinya Wu, Peiming Zheng, Yiji Li, Xiaoying Zheng, Santhosh Puthiyakunnon, Zhijian Tu and Xiao-Guang Chen

    Citation: Cell & Bioscience 2015 5:16

    Content type: Research

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  27. Development of a tumor is a very complex process, and invasion and metastasis of malignant tumors are hallmarks and are difficult problems to overcome. The tumor microenvironment plays an important role in con...

    Authors: Xue Yang, Dan-Dan Yu, Fei Yan, Ying-Ying Jing, Zhi-Peng Han, Kai Sun, Lei Liang, Jing Hou and Li-Xin Wei

    Citation: Cell & Bioscience 2015 5:14

    Content type: Review

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  28. Intestinal remodeling during amphibian metamorphosis has long been studied as a model for the formation of the adult organs in vertebrates, especially the formation of adult organ-specific stem cells. Like all...

    Authors: Luan Wen, Takashi Hasebe, Thomas C Miller, Atsuko Ishizuya-Oka and Yun-Bo Shi

    Citation: Cell & Bioscience 2015 5:13

    Content type: Research

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  29. Growth hormone secretagogue receptor (GHSR) and its ligand, ghrelin, are important modulators in weight control and energy homeostasis. Recently, ghrelin is also involved in experimental colitis, but the role ...

    Authors: Zhen-ze Liu, Wei-gang Wang, Qing Li, Miao Tang, Jun Li, Wen-ting Wu, Ying-han Wan, Zhu-gang Wang, Shi-san Bao and Jian Fei

    Citation: Cell & Bioscience 2015 5:12

    Content type: Research

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  30. The physiological and pathological roles of hydrogen sulfide (H2S) in the regulation of cardiovascular functions have been recognized. Cystathionine gamma-lyase (CSE) is a major H2S-producing enzyme in cardiovasc...

    Authors: Hongzhu Li, Yuehong Wang, Can Wei, Shuzhi Bai, Yajun Zhao, Hongxia Li, Bo Wu, Rui Wang, Lingyun Wu and Changqing Xu

    Citation: Cell & Bioscience 2015 5:11

    Content type: Research

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  31. The INT6 gene was first discovered as a site of integration in mouse mammary tumors by the mouse mammary tumor virus; however, INT6’s role in the development of human breast cancer remains largely unknown. By gen...

    Authors: Jinfeng Suo, Daniel Medina, Sabrina Herrera, Ze-Yi Zheng, Lei Jin, Gary C Chamness, Alejandro Contreras, Carolina Gutierrez, Susan Hilsenbeck, Arzu Umar, John A Foekens, Samir Hanash, Rachel Schiff, Xiang H-F Zhang and Eric C Chang

    Citation: Cell & Bioscience 2015 5:10

    Content type: Research

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  32. The T790M mutation of epithelial growth factor receptor (EGFR) is a major cause of the acquired resistance to EGFR tyrosine kinase inhibitor (EGFR-TKIs) treatment for lung cancer patients. The Hippo pathway ef...

    Authors: Wei Xu, Yunyan Wei, Shuangshuang Wu, Yun Wang, Zhen Wang, Yu Sun, Steven Y Cheng and Jianqing Wu

    Citation: Cell & Bioscience 2015 5:7

    Content type: Research

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  33. Radiotherapy is widely used to treat cancer alone or in combination with surgery, chemotherapy, and immunotherapy. However, damage to normal tissues and radioresistance of tumor cells are major obstacles to su...

    Authors: Mi-Hyoung Kim, Seung-Youn Jung, Jiyeon Ahn, Sang-Gu Hwang, Hee-Jong Woo, Sungkwan An, Seon Young Nam, Dae-Seog Lim and Jie-Young Song

    Citation: Cell & Bioscience 2015 5:2

    Content type: Research

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  34. Skin tissue homeostasis is maintained by a balance between the proliferation and differentiation of epidermal stem cells (EpSCs). EpSC proliferation and differentiation are complex processes regulated by many ...

    Authors: Peng Cheng, Xuying Sun, Delong Yin, Fei Xu, Kaixiang Yang, Liang Qin, Yonghui Dong, Fengjing Guo, Anmin Chen, Weikai Zhang and Hui Huang

    Citation: Cell & Bioscience 2015 5:5

    Content type: Research

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  35. Both apoptosis and caspase-3 activity in adipose tissue-derived stem cells play an important role in the therapeutic process of diabetes patients. The purpose of this study was to investigate the effect of adv...

    Authors: Zhe Wang, Hongqiu Li, Dianbao Zhang, Xiaoyu Liu, Feng Zhao, Xining Pang and Qiushi Wang

    Citation: Cell & Bioscience 2015 5:3

    Content type: Research

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