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  1. Cancer is a disease arising from both genetic and epigenetic modifications of DNA that contribute to changes in gene expression in the cell. Genetic modifications include loss or amplification of DNA, loss of ...

    Authors: Eva Baxter, Karolina Windloch, Frank Gannon and Jason S Lee

    Citation: Cell & Bioscience 2014 4:45

    Content type: Review

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  2. Cells regulate gene expression at multiple levels leading to a balance between robustness and complexity within their proteome. One core molecular step contributing to this important balance during metazoan ge...

    Authors: Hsuan Liu, Chung-Pei Ma, Yi-Tung Chen, Scott C Schuyler, Kai-Ping Chang and Bertrand Chin-Ming Tan

    Citation: Cell & Bioscience 2014 4:44

    Content type: Review

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  3. Pinocembrin is the most abundant flavonoid in propolis. In this study, we investigated the antimetastatic effect of pinocembrin on TGF-β1-induced epithelial-mesenchymal transition (EMT) and metastasis of human...

    Authors: Kun-Shiang Chen, Ming-Der Shi, Chi-Sheng Chien and Yuan-Wei Shih

    Citation: Cell & Bioscience 2014 4:41

    Content type: Research

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  4. The human immunodeficiency virus (HIV-1) exploits host proteins to complete its life cycle. Genome-wide siRNA approaches suggested that host proteins affect HIV-1 replication. However, the results barely overl...

    Authors: Ying-Ju Lin, Chia-Yen Chen, Kuan-Teh Jeang, Xiang Liu, Jen-Hsien Wang, Chien-Hui Hung, Hsinyi Tsang, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Cheng-Wen Lin, Mao-Wang Ho, Wen-Kuei Chien, Jin-Hua Chen, Tsung-Jung Ho and Fuu-Jen Tsai

    Citation: Cell & Bioscience 2014 4:40

    Content type: Research

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  5. Nrf2 plays a critical role in defending against oxidative stress and inflammation. We previously reported that Nrf2 confers protection against ultraviolet-B (UVB)-induced inflammation, sunburn reaction, and is...

    Authors: Constance Lay Lay Saw, Anne Yuqing Yang, Mou-Tuan Huang, Yue Liu, Jong Hun Lee, Tin Oo Khor, Zheng-Yuan Su, Limin Shu, Yaoping Lu, Allan H Conney and Ah-Ng Tony Kong

    Citation: Cell & Bioscience 2014 4:39

    Content type: Research

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  6. Thyroid hormones (THs) are potent hormones modulating liver lipid homeostasis. The perturbation of lipid homeostasis is a hallmark of non-alcoholic fatty liver disease (NAFLD), a very common liver disorder. It...

    Authors: Xuan Yao, Sarina Hou, Duo Zhang, Hongfeng Xia, Yu-Cheng Wang, Jingjing Jiang, Huiyong Yin and Hao Ying

    Citation: Cell & Bioscience 2014 4:38

    Content type: Research

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  7. Processing of homologous recombination intermediates is tightly coordinated to ensure that chromosomal integrity is maintained and tumorigenesis avoided. Decatenation of double Holliday junctions, for example,...

    Authors: Paolo Swuec and Alessandro Costa

    Citation: Cell & Bioscience 2014 4:36

    Content type: Review

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  8. miRNAs play key regulatory roles in cellular pathological processes. We aimed to identify clinically meaningful biomarkers in pulmonary carcinoid tumors (PCTs), a member of neuroendocrine neoplasms, via profil...

    Authors: Bo Deng, Julian Molina, Marie C Aubry, Zhifu Sun, Liang Wang, Bruce W Eckloff, George Vasmatzis, Ming You, Eric D Wieben, Jin Jen, Dennis A Wigle and Ping Yang

    Citation: Cell & Bioscience 2014 4:35

    Content type: Research

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  9. A team of scientists led by Professor DW Pang at Wuhan University have developed a new class of fluorescence probes based on bacterial cells. These microbial factories manufacture semiconductor nanocrystals in...

    Authors: Jing Shang and Xiaohu Gao

    Citation: Cell & Bioscience 2014 4:34

    Content type: Commentary

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  10. The potential biodiesel plant castor bean (Ricinus communis) has been in the limelight for bioenergy research due to the availability of its genome which raises the bar for genome-wide studies claiming advances t...

    Authors: Umashankar Chandrasekaran, Wei Xu and Aizhong Liu

    Citation: Cell & Bioscience 2014 4:33

    Content type: Research

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  11. Double-stranded DNA translocation is ubiquitous in living systems. Cell mitosis, bacterial binary fission, DNA replication or repair, homologous recombination, Holliday junction resolution, viral genome packag...

    Authors: Gian Marco De-Donatis, Zhengyi Zhao, Shaoying Wang, Lisa P Huang, Chad Schwartz, Oleg V Tsodikov, Hui Zhang, Farzin Haque and Peixuan Guo

    Citation: Cell & Bioscience 2014 4:30

    Content type: Research

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  12. Non-alcoholic fatty liver disease, one of the most common liver diseases, has obtained increasing attention. Palmitate (PA)-induced liver injury is considered a risk factor for the development of non-alcoholic...

    Authors: Ning Cai, Xue Zhao, Yingying Jing, Kai Sun, Shufan Jiao, Xiaojing Chen, Haozheng Yang, Yan Zhou and Lixin Wei

    Citation: Cell & Bioscience 2014 4:28

    Content type: Research

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  13. Protein phosphates 4 (PP4), encoded by the ppp4c gene, is a ubiquitously expressed phosphatase that has been implicated in the regulation of cytokine signaling and lymphocyte survival; recent reports suggest that...

    Authors: Fang-Hsuean Liao, Jr-Wen Shui, En-Wei Hsing, Wan-Yi Hsiao, Yu-Chun Lin, Yi-Chiao Chan, Tse-Hua Tan and Ching-Yu Huang

    Citation: Cell & Bioscience 2014 4:25

    Content type: Research

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  14. Gastric cancer is one of the leading causes of cancer death world-wide and carries a high rate of metastatic risk. In addition to other protein-coding oncogenes and tumor suppressor genes, microRNAs play an im...

    Authors: Jun Ren, Hui-jie Huang, Yu Gong, Shen Yue, Li-ming Tang and Steven Y Cheng

    Citation: Cell & Bioscience 2014 4:26

    Content type: Research

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  15. It is well established that adipose-derived stem cells (ADSCs) produce and secrete cytokines/growth factors that antagonize UV-induced photoaging of skin. However, the exact molecular basis underlying the anti...

    Authors: Xiao Xu, Hong-yi Wang, Yu Zhang, Yang Liu, Yan-qi Li, Kai Tao, Chu-Tse Wu, Ji-de Jin and Xiao-yan Liu

    Citation: Cell & Bioscience 2014 4:24

    Content type: Research

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  16. Both eukaryotic translation initiation factor 4E (eIF4E) and integrin αvβ6 play an important role in the development and progression of cancer. The aim of this study was to investigate the expression of eIF4E ...

    Authors: Zhengchuan Niu, Jiayong Wang, Shahbaz Muhammad, Weibo Niu, Enyu Liu, Cheng Peng, Benjia Liang, Qi Sun, Shinichi Obo, Zhaobin He, Song Liu, Xueqing Zou and Jun Niu

    Citation: Cell & Bioscience 2014 4:23

    Content type: Research

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  17. Mesenchymal stem cells (MSCs) have been reported to play an important role in tumor growth. Inflammation is an important feature of hepatocellular carcinoma (HCC). Certain inflammatory cytokines produced in tu...

    Authors: Zhipeng Han, Yingying Jing, Yong Xia, Shanshan Zhang, Jing Hou, Yan Meng, Fenghai Yu, Xiaoqing Liu, Mengchao Wu, Ping Zhang and Lixin Wei

    Citation: Cell & Bioscience 2014 4:22

    Content type: Research

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  18. Steroid receptor coactivator 3 (SRC-3) is a multifunctional protein that plays an important role in malignancy of several cancers and in regulation of bacterial LPS-induced inflammation. However, the involveme...

    Authors: Xiaochun Xia, Wei Wan, Qiang Chen, Kun Liu, Sidra Majaz, Pingli Mo, Jianming Xu and Chundong Yu

    Citation: Cell & Bioscience 2014 4:21

    Content type: Research

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  19. PKM2 is an attractive target for cancer therapy, however, for many cancer cells, PKM2 knockdown only leads to a modest impairment of survival and proliferation. It is not known whether PKM2 knockdown rewires c...

    Authors: Xiaodong Qin, Yuping Du, Xing Chen, Wuyan Li, Jinghong Zhang and Jinbo Yang

    Citation: Cell & Bioscience 2014 4:20

    Content type: Short report

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  20. Iron is an important mineral element used by the body in a variety of metabolic and physiologic processes. These processes are highly active when the body is undergoing physical exercises. Prevalence of exerci...

    Authors: Wei-Na Kong, Guofen Gao and Yan-Zhong Chang

    Citation: Cell & Bioscience 2014 4:19

    Content type: Review

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  21. The human ether-a-go-go-related gene potassium channel (hERG) has an unusual long turret, whose role in recognizing scorpion toxins remains controversial. Here, BmKKx2, the first specific blocker of hERG chann...

    Authors: You-Tian Hu, Jun Hu, Tian Li, Jing-Jing Wei, Jing Feng, Yi-Mei Du, Zhi-Jian Cao, Wen-Xin Li and Ying-Liang Wu

    Citation: Cell & Bioscience 2014 4:18

    Content type: Research

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  22. Autophagy (macroautophagy), a cellular process of “self-eating”, segregates damaged/aged organelles into vesicles, fuses with lysosomes, and enables recycling of the digested materials. The precise origin(s) o...

    Authors: Katherine L Cook, David R Soto-Pantoja, Mones Abu-Asab, Pamela AG Clarke, David D Roberts and Robert Clarke

    Citation: Cell & Bioscience 2014 4:16

    Content type: Short report

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  23. To clone and express a truncated, soluble vascular endothelial growth factor receptor 2 (sVEGFR2) possessing the combined-functional domains 1–3 and 5 in eukaryotic cells and to test the inhibitory effects of ...

    Authors: Wei Liu, Xinyuan Zhang, Ching Song, Shisan Bao, Donna Lai, Jianqiu Mou, Tao Jiang and Ningli Wang

    Citation: Cell & Bioscience 2014 4:14

    Content type: Research

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  24. Human papillomavirus (HPV) infections are particularly problematic for HIV + and solid organ transplant patients with compromised CD4+ T cell-dependent immunity as they produce more severe and progressive dise...

    Authors: Shiwen Peng, Liwen Song, Jayne Knoff, Joshua W Wang, Yung-Nien Chang, Drew Hannaman, T-C Wu, Ronald D Alvarez, Richard BS Roden and Chien-Fu Hung

    Citation: Cell & Bioscience 2014 4:11

    Content type: Research

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  25. Autophagy1 is a complex of adaptive cellular response that enhances cancer cell survival in the face of cellular stresses such as chemothery. Here we show that in human gallbladder carcinoma (GBC) cells lines,...

    Authors: Xiao Liang, JiaCheng Tang, YueLong Liang, RenAn Jin and XiuJun Cai

    Citation: Cell & Bioscience 2014 4:10

    Content type: Research

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  26. The human TSPY is the putative gene for the gonadoblastoma locus on the Y chromosome (GBY). Various molecular, pathological and transgenic mouse studies suggest that TSPY is a Y-located proto-oncogene contributin...

    Authors: Tatsuo Kido, Stephanie Schubert, Shingo Hatakeyama, Chikara Ohyama, Jörg Schmidtke and Yun-Fai Chris Lau

    Citation: Cell & Bioscience 2014 4:9

    Content type: Research

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  27. Induction of Nrf2-mediated detoxifying/antioxidant genes has been recognized as an effective strategy for cancer chemoprevention. Si-Wu-Tang (SWT), comprising the combination of four herbs, Paeoniae, Angelicae...

    Authors: Mandy Liu, Ranadheer Ravula, Zhijun Wang, Zhong Zuo, Moses SS Chow, Arvind Thakkar, Sunil Prabhu, Bradley Andresen and Ying Huang

    Citation: Cell & Bioscience 2014 4:8

    Content type: Research

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  28. A great challenge of cancer chemotherapy is to eliminate cancer cells and concurrently maintain the quality of life (QOL) for cancer patients. Previously, we identified a novel anti-cancer bioactive peptide (A...

    Authors: Xiulan Su, Chao Dong, Jialing Zhang, Liya Su, Xuemei Wang, Hongwei Cui and Zhong Chen

    Citation: Cell & Bioscience 2014 4:7

    Content type: Research

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  29. Interleukin-6 (IL-6) has been shown to be vital for liver regeneration, however the specific mechanisms and factors involved remain incompletely defined. The present study aimed to investigate whether IL-6 exe...

    Authors: Shingo Tachibana, Xiuying Zhang, Kazushige Ito, Yoshihiro Ota, Andrew M Cameron, George Melville Williams and Zhaoli Sun

    Citation: Cell & Bioscience 2014 4:6

    Content type: Research

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  30. The editors of Cell & Bioscience would like to thank all the reviewers who contributed to the journal in Volume 3 (2013).

    Authors: Yun-Bo Shi

    Citation: Cell & Bioscience 2014 4:4

    Content type: Reviewer acknowledgement

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  31. Genome variations in human papillomaviruses (HPVs) are common and have been widely investigated in the past two decades. HPV genotyping depends on the finding of the viral genome variations in the L1 ORF. Othe...

    Authors: Xiaohong Wang, Yang Li, Ting Ni, Xing Xie, Jun Zhu and Zhi-Ming Zheng

    Citation: Cell & Bioscience 2014 4:5

    Content type: Research

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  32. Whereas severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) is associated with severe disease, human coronavirus HKU1 (HCoV-HKU1) commonly circulates in the human populations causing generally mild...

    Authors: Kam-Leung Siu, Ching-Ping Chan, Kin-Hang Kok, Patrick C-Y Woo and Dong-Yan Jin

    Citation: Cell & Bioscience 2014 4:3

    Content type: Research

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  33. Abnormal and uncontrolled proliferation of lung fibroblasts may contribute to pulmonary fibrosis. Lipopolysaccharide (LPS) can induce fibroblast proliferation and differentiation through activation of phosphoi...

    Authors: Zhengyu He, Yuxiao Deng, Wen Li, Yongming Chen, Shunpeng Xing, Xianyuan Zhao, Jia Ding, Yuan Gao and Xiangrui Wang

    Citation: Cell & Bioscience 2014 4:2

    Content type: Research

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  34. There is an urgent need to develop targeted therapies for the control of advanced stage ovarian cancer because it is the most deadly gynecologic cancer. Antigen-specific immunotherapy is a promising approach b...

    Authors: Tae Heung Kang, Jayne Knoff, Benjamin Yang, Ya-Chea Tsai, Liangmei He, Chien-Fu Hung and T-C Wu

    Citation: Cell & Bioscience 2013 3:48

    Content type: Research

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  35. Type 1 and type 2 diabetes are characterized by loss of β-cells; therefore, β-cell regeneration has become one of the primary approaches to diabetes therapy. Resveratrol, a naturally occurring polyphenolic com...

    Authors: Sherwin Xie, Rohit Anthony Sinha, Brijesh K Singh, Guo Dong Li, Weiping Han and Paul M Yen

    Citation: Cell & Bioscience 2013 3:47

    Content type: Short report

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  36. Accumulating evidences have identified the immunoregulatory features of stem cells. In this study, the immunoregulation of bone marrow-derived stem cells (BMSCs) transplanted into patients with HBV-related dec...

    Authors: Linhua Zheng, Jindong Chu, Yongquan Shi, Xinmin Zhou, Ling Tan, Qiang Li, Lina Cui, Zheyi Han, Ying Han and Daiming Fan

    Citation: Cell & Bioscience 2013 3:46

    Content type: Research

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