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Page 9 of 13

  1. Past and recent findings on tumor heterogeneity have led clinicians and researchers to broadly define cancer development as an evolving process. This evolutionary model of tumorigenesis has largely been shaped...

    Authors: Victoria R Zellmer and Siyuan Zhang

    Citation: Cell & Bioscience 2014 4:69

    Content type: Review

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  2. 2-Ethyl-3-O-sulphamoyl-estra-1,3,5(10)16-tetraene (ESE-16) is a unique, in silico-designed compound with possible anticancer properties, which were identified in our laboratory. This compound is capable of interf...

    Authors: Elize Wolmarans, Katherine Sippel, Robert McKenna and Annie Joubert

    Citation: Cell & Bioscience 2014 4:68

    Content type: Research

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  3. Patients with Kawasaki disease (KD), a pediatric systemic vasculitis, may develop coronary artery aneurysm (CAA) as a complication. To investigate the role of glutamate receptors in KD and its CAA development,...

    Authors: Ying-Ju Lin, Jeng-Sheng Chang, Xiang Liu, Hsinyi Tsang, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Wen-Kuei Chien, Jin-Hua Chen, Jer-Yuarn Wu, Chien-Hsiun Chen, Li-Ching Chang, Cheng-Wen Lin, Tsung-Jung Ho and Fuu-Jen Tsai

    Citation: Cell & Bioscience 2014 4:67

    Content type: Research

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  4. Mounting evidence supports the role of hydrogen peroxide (H2O2) in physiological signaling as well as pathological conditions. However, the subtleties of peroxide-mediated signaling are not well understood, in pa...

    Authors: Hengchang Guo, Hossein Aleyasin, Bryan C Dickinson, Renée E Haskew-Layton and Rajiv R Ratan

    Citation: Cell & Bioscience 2014 4:64

    Content type: Review

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  5. Drosophila melanogaster has been a classic model organism for the studies of genetics. More than 15,000 Drosophila genes have been annotated since the entire genome was sequenced; however, many of them still lack...

    Authors: Shih-Ching Lin, Yu-Yun Chang and Chih-Chiang Chan

    Citation: Cell & Bioscience 2014 4:63

    Content type: Review

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  6. MicroRNAs (miRNAs) are endogenous, small non-coding RNAs that play important roles in multiple biological processes. MiR-20b has been reported to participate in breast cancer tumorigenic progression, however, ...

    Authors: Weidong Zhou, Guixiu Shi, Qiuyan Zhang, Qiuwan Wu, Boan Li and Zhiming Zhang

    Citation: Cell & Bioscience 2014 4:62

    Content type: Research

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  7. The transactivator of transcription (Tat) protein of human immunodeficiency virus type 1 (HIV-1) is known to undergo ubiquitination. However, the roles of ubiquitination in regulating Tat stability and activit...

    Authors: Linlin Zhang, Juan Qin, Yuanyuan Li, Jian Wang, Qianqian He, Jun Zhou, Min Liu and Dengwen Li

    Citation: Cell & Bioscience 2014 4:61

    Content type: Research

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  8. The adapter proteins Appl1 (adaptor protein containing pleckstrin homology domain, phosphotyrosine domain, and leucine zipper motif 1) and Appl2 are highly homologous and involved in several signaling pathways...

    Authors: Liufeng Mao, Wanhua Lin, Tao Nie, Xiaoyan Hui, Xuefei Gao, Kuai Li, Mengxiao Ding, Xiaofeng Tang, Peng Li, Yu Wang, Aimin Xu, Pentao Liu and Donghai Wu

    Citation: Cell & Bioscience 2014 4:60

    Content type: Research

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  9. Akt regulates critical cellular processes including cell survival and proliferation, glucose metabolism, cell migration, cancer progression and metastasis through phosphorylation of a variety of downstream tar...

    Authors: Chia-Hsin Chan, Ukhyun Jo, Abraham Kohrman, Abdol Hossein Rezaeian, Ping-Chieh Chou, Christopher Logothetis and Hui-Kuan Lin

    Citation: Cell & Bioscience 2014 4:59

    Content type: Review

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  10. Glucose and oxygen deprivation during ischemia is known to affect the homeostasis of the endoplasmic reticulum (ER) in ways predicted to activate the unfolded protein response (UPR). Activation of UPR signalli...

    Authors: Danielle E Read, Ananya Gupta, Yury Ladilov, Afshin Samali and Sanjeev Gupta

    Citation: Cell & Bioscience 2014 4:56

    Content type: Research

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  11. Herpes simplex virus (HSV) type 1 has a 152 kb double-stranded DNA genome that may encode more than 80 gene products, many of which remain uncharacterized. The HSV-1 triplex is a complex of three protein subun...

    Authors: You Li, Dongwei Mao, Guoda Ma, Lili Cui, Hua Tao, Haihong Zhou, Wandong Liang, Bin Zhao and Keshen Li

    Citation: Cell & Bioscience 2014 4:55

    Content type: Short report

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  12. Both transcriptional factor Ets-1 and integrin αvβ6 play an important role in the development and progression of cancer. The aim of our study was to investigate the expression of Integrin αvβ6 and Ets-1, two p...

    Authors: Cheng Peng, Huijie Gao, Zhengchuan Niu, Ben Wang, Zhen Tan, Weibo Niu, Enyu Liu, Jiayong Wang, Jiuzheng Sun, Muhammad Shahbaz, Michael Agrez and Jun Niu

    Citation: Cell & Bioscience 2014 4:53

    Content type: Research

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  13. Dihydroneopterin aldolase (DHNA) catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and also the epimerization of DHNP to 7,8-dihydromonapterin. Previously, we determined the...

    Authors: Jaroslaw Blaszczyk, Zhenwei Lu, Yue Li, Honggao Yan and Xinhua Ji

    Citation: Cell & Bioscience 2014 4:52

    Content type: Research

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  14. Ductular reactions (DRs) are well documented in many acute and chronic liver disease. The DRs are thought to be the transit amplifying cells deriving from activation of the stem/progenitor cell compartments of...

    Authors: Fei Ye, Ying-Ying Jing, Shi-Wei Guo, Guo-Feng Yu, Qing-Min Fan, Fang-Fang Qu, Lu Gao, Yang Yang, Dong Wu, Yan Meng, Feng-Hai Yu and Li-Xin Wei

    Citation: Cell & Bioscience 2014 4:50

    Content type: Research

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  15. Peptidylarginine deiminase IV (PADI4) is widely distributed in several tissues and the expression is correlated with many pathological processes. Chemotherapy remains a major treatment alternatively to surgery...

    Authors: Tingting Fan, Changsong Zhang, Ming Zong, Qiudong Zhao, Xue Yang, Chong Hao, Hui Zhang, Shanshan Yu, Jinhu Guo, Ruhan Gong, Shasha Fan, Lixin Wei and Lieying Fan

    Citation: Cell & Bioscience 2014 4:49

    Content type: Research

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  16. Sirtuin1 (SIRT1) is an NAD+-dependent type III histone deacetylase (HDAC). This research investigated the prevalence of SIRT1 protein expression and its prognostic influence with the aim of validating its potenti...

    Authors: Guan-qing Chen, Hui Tian, Wei-ming Yue, Lin Li, Shu-hai Li, Lei Qi, Cun Gao, Li-bo Si, Ming Lu and Fei Feng

    Citation: Cell & Bioscience 2014 4:48

    Content type: Research

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  17. Cholestasis is characterized by an abnormal accumulation of bile acids and causes hepatocellular injury. Recent studies show that autophagy is involved in the pathophysiology of many liver diseases. The potent...

    Authors: Lu Gao, Gang Lv, Xianling Guo, Yingying Jing, Zhipeng Han, Shanshan Zhang, Kai Sun, Rong Li, Yang Yang and Lixin Wei

    Citation: Cell & Bioscience 2014 4:47

    Content type: Research

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  18. Cancer is a disease arising from both genetic and epigenetic modifications of DNA that contribute to changes in gene expression in the cell. Genetic modifications include loss or amplification of DNA, loss of ...

    Authors: Eva Baxter, Karolina Windloch, Frank Gannon and Jason S Lee

    Citation: Cell & Bioscience 2014 4:45

    Content type: Review

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  19. Cells regulate gene expression at multiple levels leading to a balance between robustness and complexity within their proteome. One core molecular step contributing to this important balance during metazoan ge...

    Authors: Hsuan Liu, Chung-Pei Ma, Yi-Tung Chen, Scott C Schuyler, Kai-Ping Chang and Bertrand Chin-Ming Tan

    Citation: Cell & Bioscience 2014 4:44

    Content type: Review

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  20. Pinocembrin is the most abundant flavonoid in propolis. In this study, we investigated the antimetastatic effect of pinocembrin on TGF-β1-induced epithelial-mesenchymal transition (EMT) and metastasis of human...

    Authors: Kun-Shiang Chen, Ming-Der Shi, Chi-Sheng Chien and Yuan-Wei Shih

    Citation: Cell & Bioscience 2014 4:41

    Content type: Research

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  21. The human immunodeficiency virus (HIV-1) exploits host proteins to complete its life cycle. Genome-wide siRNA approaches suggested that host proteins affect HIV-1 replication. However, the results barely overl...

    Authors: Ying-Ju Lin, Chia-Yen Chen, Kuan-Teh Jeang, Xiang Liu, Jen-Hsien Wang, Chien-Hui Hung, Hsinyi Tsang, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Cheng-Wen Lin, Mao-Wang Ho, Wen-Kuei Chien, Jin-Hua Chen, Tsung-Jung Ho and Fuu-Jen Tsai

    Citation: Cell & Bioscience 2014 4:40

    Content type: Research

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  22. Nrf2 plays a critical role in defending against oxidative stress and inflammation. We previously reported that Nrf2 confers protection against ultraviolet-B (UVB)-induced inflammation, sunburn reaction, and is...

    Authors: Constance Lay Lay Saw, Anne Yuqing Yang, Mou-Tuan Huang, Yue Liu, Jong Hun Lee, Tin Oo Khor, Zheng-Yuan Su, Limin Shu, Yaoping Lu, Allan H Conney and Ah-Ng Tony Kong

    Citation: Cell & Bioscience 2014 4:39

    Content type: Research

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  23. Thyroid hormones (THs) are potent hormones modulating liver lipid homeostasis. The perturbation of lipid homeostasis is a hallmark of non-alcoholic fatty liver disease (NAFLD), a very common liver disorder. It...

    Authors: Xuan Yao, Sarina Hou, Duo Zhang, Hongfeng Xia, Yu-Cheng Wang, Jingjing Jiang, Huiyong Yin and Hao Ying

    Citation: Cell & Bioscience 2014 4:38

    Content type: Research

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  24. Processing of homologous recombination intermediates is tightly coordinated to ensure that chromosomal integrity is maintained and tumorigenesis avoided. Decatenation of double Holliday junctions, for example,...

    Authors: Paolo Swuec and Alessandro Costa

    Citation: Cell & Bioscience 2014 4:36

    Content type: Review

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  25. miRNAs play key regulatory roles in cellular pathological processes. We aimed to identify clinically meaningful biomarkers in pulmonary carcinoid tumors (PCTs), a member of neuroendocrine neoplasms, via profil...

    Authors: Bo Deng, Julian Molina, Marie C Aubry, Zhifu Sun, Liang Wang, Bruce W Eckloff, George Vasmatzis, Ming You, Eric D Wieben, Jin Jen, Dennis A Wigle and Ping Yang

    Citation: Cell & Bioscience 2014 4:35

    Content type: Research

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  26. A team of scientists led by Professor DW Pang at Wuhan University have developed a new class of fluorescence probes based on bacterial cells. These microbial factories manufacture semiconductor nanocrystals in...

    Authors: Jing Shang and Xiaohu Gao

    Citation: Cell & Bioscience 2014 4:34

    Content type: Commentary

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  27. The potential biodiesel plant castor bean (Ricinus communis) has been in the limelight for bioenergy research due to the availability of its genome which raises the bar for genome-wide studies claiming advances t...

    Authors: Umashankar Chandrasekaran, Wei Xu and Aizhong Liu

    Citation: Cell & Bioscience 2014 4:33

    Content type: Research

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  28. Double-stranded DNA translocation is ubiquitous in living systems. Cell mitosis, bacterial binary fission, DNA replication or repair, homologous recombination, Holliday junction resolution, viral genome packag...

    Authors: Gian Marco De-Donatis, Zhengyi Zhao, Shaoying Wang, Lisa P Huang, Chad Schwartz, Oleg V Tsodikov, Hui Zhang, Farzin Haque and Peixuan Guo

    Citation: Cell & Bioscience 2014 4:30

    Content type: Research

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  29. Non-alcoholic fatty liver disease, one of the most common liver diseases, has obtained increasing attention. Palmitate (PA)-induced liver injury is considered a risk factor for the development of non-alcoholic...

    Authors: Ning Cai, Xue Zhao, Yingying Jing, Kai Sun, Shufan Jiao, Xiaojing Chen, Haozheng Yang, Yan Zhou and Lixin Wei

    Citation: Cell & Bioscience 2014 4:28

    Content type: Research

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  30. Protein phosphates 4 (PP4), encoded by the ppp4c gene, is a ubiquitously expressed phosphatase that has been implicated in the regulation of cytokine signaling and lymphocyte survival; recent reports suggest that...

    Authors: Fang-Hsuean Liao, Jr-Wen Shui, En-Wei Hsing, Wan-Yi Hsiao, Yu-Chun Lin, Yi-Chiao Chan, Tse-Hua Tan and Ching-Yu Huang

    Citation: Cell & Bioscience 2014 4:25

    Content type: Research

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  31. Gastric cancer is one of the leading causes of cancer death world-wide and carries a high rate of metastatic risk. In addition to other protein-coding oncogenes and tumor suppressor genes, microRNAs play an im...

    Authors: Jun Ren, Hui-jie Huang, Yu Gong, Shen Yue, Li-ming Tang and Steven Y Cheng

    Citation: Cell & Bioscience 2014 4:26

    Content type: Research

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  32. It is well established that adipose-derived stem cells (ADSCs) produce and secrete cytokines/growth factors that antagonize UV-induced photoaging of skin. However, the exact molecular basis underlying the anti...

    Authors: Xiao Xu, Hong-yi Wang, Yu Zhang, Yang Liu, Yan-qi Li, Kai Tao, Chu-Tse Wu, Ji-de Jin and Xiao-yan Liu

    Citation: Cell & Bioscience 2014 4:24

    Content type: Research

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  33. Both eukaryotic translation initiation factor 4E (eIF4E) and integrin αvβ6 play an important role in the development and progression of cancer. The aim of this study was to investigate the expression of eIF4E ...

    Authors: Zhengchuan Niu, Jiayong Wang, Shahbaz Muhammad, Weibo Niu, Enyu Liu, Cheng Peng, Benjia Liang, Qi Sun, Shinichi Obo, Zhaobin He, Song Liu, Xueqing Zou and Jun Niu

    Citation: Cell & Bioscience 2014 4:23

    Content type: Research

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  34. Mesenchymal stem cells (MSCs) have been reported to play an important role in tumor growth. Inflammation is an important feature of hepatocellular carcinoma (HCC). Certain inflammatory cytokines produced in tu...

    Authors: Zhipeng Han, Yingying Jing, Yong Xia, Shanshan Zhang, Jing Hou, Yan Meng, Fenghai Yu, Xiaoqing Liu, Mengchao Wu, Ping Zhang and Lixin Wei

    Citation: Cell & Bioscience 2014 4:22

    Content type: Research

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  35. Steroid receptor coactivator 3 (SRC-3) is a multifunctional protein that plays an important role in malignancy of several cancers and in regulation of bacterial LPS-induced inflammation. However, the involveme...

    Authors: Xiaochun Xia, Wei Wan, Qiang Chen, Kun Liu, Sidra Majaz, Pingli Mo, Jianming Xu and Chundong Yu

    Citation: Cell & Bioscience 2014 4:21

    Content type: Research

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  36. PKM2 is an attractive target for cancer therapy, however, for many cancer cells, PKM2 knockdown only leads to a modest impairment of survival and proliferation. It is not known whether PKM2 knockdown rewires c...

    Authors: Xiaodong Qin, Yuping Du, Xing Chen, Wuyan Li, Jinghong Zhang and Jinbo Yang

    Citation: Cell & Bioscience 2014 4:20

    Content type: Short report

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