Gingras AC, Raught B, Sonenberg N. Regulation of translation initiation by FRAP/mTOR. Genes Dev. 2001;15(7):807–26.
Article
CAS
PubMed
Google Scholar
Raught B, Peiretti F, Gingras AC, et al. Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases. EMBO J. 2004;23(8):1761–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ruggero D, Pandolfi PP. Does the ribosome translate cancer?. Nat Rev Cancer. 2003;3(3):179–92.
Ruggero D, Sonenberg N. The Akt of translational control. Oncogene. 2005;24(50):7426–34.
Article
CAS
PubMed
Google Scholar
Hu H, Juvekar A, Lyssiotis CA, et al. Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton. Cell. 2016;164(3):433–46.
Article
CAS
PubMed
PubMed Central
Google Scholar
Rathmell JC, Fox CJ, Plas DR, et al. Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Mol Cell Biol. 2003;23(20):7315–28.
Article
CAS
PubMed
PubMed Central
Google Scholar
Cantley LC. The phosphoinositide 3-kinase pathway. Science. 2002;296(5573):1655–7.
Article
CAS
PubMed
Google Scholar
Jimenez C, Portela RA, Mellado M, et al. Role of the PI3K regulatory subunit in the control of actin organization and cell migration. J Cell Biol. 2000;151(2):249–62.
Article
CAS
PubMed
PubMed Central
Google Scholar
Jope RS, Roh MS. Glycogen synthase kinase-3 (GSK3) in psychiatric diseases and therapeutic interventions. Curr Drug Targets. 2006;7(11):1421–34.
Article
CAS
PubMed
PubMed Central
Google Scholar
Cross DA, Alessi DR, Cohen P, et al. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature. 1995;378(6559):785–9.
Article
CAS
PubMed
Google Scholar
Paraskevopoulou MD, Tsichlis PN. A perspective on AKT 25-plus years after its discovery. Sci Signal. 2017;10:486.
Article
CAS
Google Scholar
Manning BD, Toker A. AKT/PKB Signaling: Navigating the Network. Cell. 2017;169(3):381–405.
Article
CAS
PubMed
PubMed Central
Google Scholar
Franke TF, Yang SI, Chan TO, et al. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell. 1995;81(5):727–36.
Article
CAS
PubMed
Google Scholar
Beaulieu JM. A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health. J Psychiatry Neurosci. 2012;37(1):7–16.
Article
PubMed
PubMed Central
Google Scholar
Law AJ, Wang Y, Sei Y, et al. Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110delta inhibition as a potential therapeutic strategy. Proc Natl Acad Sci U S A. 2012;109(30):12165–70.
Article
CAS
PubMed
PubMed Central
Google Scholar
Goldman-Rakic PS, Castner SA, Svensson TH, et al. Targeting the dopamine D1 receptor in schizophrenia: insights for cognitive dysfunction. Psychopharmacology. 2004;174(1):3–16.
Article
CAS
PubMed
Google Scholar
Sotnikova TD, Beaulieu JM, Barak LS, et al. Dopamine-independent locomotor actions of amphetamines in a novel acute mouse model of Parkinson disease. PLoS Biol. 2005;3(8): e271.
Article
PubMed
PubMed Central
CAS
Google Scholar
Balu DT, Carlson GC, Talbot K, et al. Akt1 deficiency in schizophrenia and impairment of hippocampal plasticity and function. Hippocampus. 2012;22(2):230–40.
Article
CAS
PubMed
Google Scholar
Karege F, Perroud N, Burkhardt S, et al. Alteration in kinase activity but not in protein levels of protein kinase B and glycogen synthase kinase-3beta in ventral prefrontal cortex of depressed suicide victims. Biol Psychiatry. 2007;61(2):240–5.
Article
CAS
PubMed
Google Scholar
Emamian ES, Hall D, Birnbaum MJ, et al. Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia. Nat Genet. 2004;36(2):131–7.
Article
CAS
PubMed
Google Scholar
Leibrock C, Ackermann TF, Hierlmeier M, et al. Akt2 deficiency is associated with anxiety and depressive behavior in mice. Cell Physiol Biochem. 2013;32(3):766–77.
Article
CAS
PubMed
Google Scholar
Howell KR, Floyd K, Law AJ. PKBgamma/AKT3 loss-of-function causes learning and memory deficits and deregulation of AKT/mTORC2 signaling: Relevance for schizophrenia. PLoS ONE. 2017;12(5): e0175993.
Article
PubMed
PubMed Central
CAS
Google Scholar
Riviere JB, Mirzaa GM, O’Roak BJ, et al. De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes. Nat Genet. 2012;44(8):934–40.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hobert JA, Embacher R, Mester JL, et al. Biochemical screening and PTEN mutation analysis in individuals with autism spectrum disorders and macrocephaly. Eur J Hum Genet. 2014;22(2):273–6.
Article
CAS
PubMed
Google Scholar
Fricker M, Tolkovsky AM, Borutaite V, et al. Neuronal Cell Death. Physiol Rev. 2018;98(2):813–80.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mishra R, Barthwal MK, Sondarva G, et al. Glycogen synthase kinase-3beta induces neuronal cell death via direct phosphorylation of mixed lineage kinase 3. J Biol Chem. 2007;282(42):30393–405.
Article
CAS
PubMed
Google Scholar
Boland E, Clayton-Smith J, Woo VG, et al. Mapping of deletion and translocation breakpoints in 1q44 implicates the serine/threonine kinase AKT3 in postnatal microcephaly and agenesis of the corpus callosum. Am J Hum Genet. 2007;81(2):292–303.
Article
CAS
PubMed
PubMed Central
Google Scholar
Schizophrenia Working Group of the Psychiatric Genomics. Biological insights from 108 schizophrenia-associated genetic loci. Nature. 2014;511(7510):421–7.
Article
CAS
Google Scholar
Consortium TSW, Ripke S, Walters JT, et al. Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia. medRxiv. 2020:2020.09.12.20192922.
Singh T, Poterba T, Curtis D, et al. Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia. medRxiv. 2020:2020.09.18.20192815.
Polytarchou C, Hatziapostolou M, Yau TO, et al. Akt3 induces oxidative stress and DNA damage by activating the NADPH oxidase via phosphorylation of p47(phox). Proc Natl Acad Sci U S A. 2020;117(46):28806–15.
Article
CAS
PubMed
PubMed Central
Google Scholar
Iliopoulos D, Polytarchou C, Hatziapostolou M, et al. MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells. Sci Signal. 2009;2(92):62.
Article
Google Scholar
Sanidas I, Polytarchou C, Hatziapostolou M, et al. Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer. Mol Cell. 2014;53(4):577–90.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tsimberidou AM, Shaw JV, Juric D, et al. Phase 1 study of M2698, a p70S6K/AKT dual inhibitor, in patients with advanced cancer. J Hematol Oncol. 2021;14(1):127.
Article
CAS
PubMed
PubMed Central
Google Scholar
Li X, Dai D, Chen B, et al. Efficacy of PI3K/AKT/mTOR pathway inhibitors for the treatment of advanced solid cancers: A literature-based meta-analysis of 46 randomised control trials. PLoS ONE. 2018;13(2): e0192464.
Article
PubMed
PubMed Central
CAS
Google Scholar
Machl A, Wilker EW, Tian H, et al. M2698 is a potent dual-inhibitor of p70S6K and Akt that affects tumor growth in mouse models of cancer and crosses the blood-brain barrier. Am J Cancer Res. 2016;6(4):806–18.
CAS
PubMed
PubMed Central
Google Scholar
Baselga J, Im SA, Iwata H, et al. Buparlisib plus fulvestrant versus placebo plus fulvestrant in postmenopausal, hormone receptor-positive, HER2-negative, advanced breast cancer (BELLE-2): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Oncol. 2017;18(7):904–16.
Article
CAS
PubMed
PubMed Central
Google Scholar
Di Leo A, Johnston S, Lee KS, et al. Buparlisib plus fulvestrant in postmenopausal women with hormone-receptor-positive, HER2-negative, advanced breast cancer progressing on or after mTOR inhibition (BELLE-3): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Oncol. 2018;19(1):87–100.
Article
PubMed
Google Scholar
Shalimova A, Babasieva V, Chubarev VN, et al. Therapy response prediction in major depressive disorder: current and novel genomic markers influencing pharmacokinetics and pharmacodynamics. Pharmacogenomics. 2021;22(8):485–503.
Article
CAS
PubMed
Google Scholar
Chadha R, Meador-Woodruff JH. Downregulated AKT-mTOR signaling pathway proteins in dorsolateral prefrontal cortex in Schizophrenia. Neuropsychopharmacology. 2020;45(6):1059–67.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kitagishi Y, Kobayashi M, Kikuta K, et al. Roles of PI3K/AKT/GSK3/mTOR Pathway in Cell Signaling of Mental Illnesses. Depress Res Treat. 2012;2012: 752563.
PubMed
PubMed Central
Google Scholar
Roh MS, Seo MS, Kim Y, et al. Haloperidol and clozapine differentially regulate signals upstream of glycogen synthase kinase 3 in the rat frontal cortex. Exp Mol Med. 2007;39(3):353–60.
Article
CAS
PubMed
Google Scholar
Pan B, Huang XF, Deng C. Aripiprazole and Haloperidol Activate GSK3beta-Dependent Signalling Pathway Differentially in Various Brain Regions of Rats. Int J Mol Sci. 2016;17(4):459.
Article
PubMed
PubMed Central
CAS
Google Scholar
Duda P, Hajka D, Wojcicka O, et al. GSK3beta: A Master Player in Depressive Disorder Pathogenesis and Treatment Responsiveness. Cells. 2020;9:3.
Google Scholar
Krishnan V, Han MH, Mazei-Robison M, et al. AKT signaling within the ventral tegmental area regulates cellular and behavioral responses to stressful stimuli. Biol Psychiatry. 2008;64(8):691–700.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wong H, Levenga J, LaPlante L, et al. Isoform-specific roles for AKT in affective behavior, spatial memory, and extinction related to psychiatric disorders. Elife. 2020;9:897.
Google Scholar
Ikeda M, Iwata N, Suzuki T, et al. Association of AKT1 with schizophrenia confirmed in a Japanese population. Biol Psychiatry. 2004;56(9):698–700.
Article
CAS
PubMed
Google Scholar
Schwab SG, Hoefgen B, Hanses C, et al. Further evidence for association of variants in the AKT1 gene with schizophrenia in a sample of European sib-pair families. Biol Psychiatry. 2005;58(6):446–50.
Article
CAS
PubMed
Google Scholar
Xu MQ, Xing QH, Zheng YL, et al. Association of AKT1 gene polymorphisms with risk of schizophrenia and with response to antipsychotics in the Chinese population. J Clin Psychiatry. 2007;68(9):1358–67.
Article
CAS
PubMed
Google Scholar
Magno LA, Miranda DM, Neves FS, et al. Association between AKT1 but not AKTIP genetic variants and increased risk for suicidal behavior in bipolar patients. Genes Brain Behav. 2010;9(4):411–8.
Article
CAS
PubMed
Google Scholar
Pereira PA, Bicalho MA, de Moraes EN, et al. Genetic variant of AKT1 and AKTIP associated with late-onset depression in a Brazilian population. Int J Geriatr Psychiatry. 2014;29(4):399–405.
Article
PubMed
Google Scholar
Losenkov IS, Vyalova NM, Simutkin GG, et al. An association of AKT1 gene polymorphism with antidepressant treatment response. World J Biol Psychiatry. 2016;17(3):239–42.
Article
PubMed
Google Scholar
Bergeron Y, Bureau G, Laurier-Laurin ME, et al. Genetic Deletion of Akt3 Induces an Endophenotype Reminiscent of Psychiatric Manifestations in Mice. Front Mol Neurosci. 2017;10:102.
Article
PubMed
PubMed Central
CAS
Google Scholar
Chia S, Gandhi S, Joy AA, et al. Novel agents and associated toxicities of inhibitors of the pi3k/Akt/mtor pathway for the treatment of breast cancer. Curr Oncol. 2015;22(1):33–48.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ezell SA, Polytarchou C, Hatziapostolou M, et al. The protein kinase Akt1 regulates the interferon response through phosphorylation of the transcriptional repressor EMSY. Proc Natl Acad Sci U S A. 2012;109(10):E613–21.
Article
PubMed
PubMed Central
Google Scholar
Thomas CC, Deak M, Alessi DR, et al. High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate. Curr Biol. 2002;12(14):1256–62.
Article
CAS
PubMed
Google Scholar
Lee MS, Feig M, Salsbury FR Jr, et al. New analytic approximation to the standard molecular volume definition and its application to generalized Born calculations. J Comput Chem. 2003;24(11):1348–56.
Article
CAS
PubMed
Google Scholar
Feig M, Onufriev A, Lee MS, et al. Performance comparison of generalized born and Poisson methods in the calculation of electrostatic solvation energies for protein structures. J Comput Chem. 2004;25(2):265–84.
Article
CAS
PubMed
Google Scholar