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  1. Profiling and comparing the performance of current widely used DNA targeting CRISPR systems provide the basic information for the gene-editing toolkit and can be a useful resource for this field. In the curren...

    Authors: Hongxin Huang, Weiqi Lv, Jinhe Li, Guanjie Huang, Zhihong Tan, Yongfei Hu, Shufeng Ma, Xin Zhang, Linxuan Huang and Ying Lin
    Citation: Cell & Bioscience 2023 13:11
  2. The dynamic changes in chromatin conformation alter the organization and structure of the genome and further regulate gene transcription. Basically, the chromatin structure is controlled by reversible, enzyme-...

    Authors: Dongfang Jiang, Tingting Li, Caixia Guo, Tie-Shan Tang and Hongmei Liu
    Citation: Cell & Bioscience 2023 13:10
  3. Vector-borne flaviviruses, including tick-borne encephalitis virus (TBEV), Zika virus (ZIKV), West Nile virus (WNV), yellow fever virus (YFV), dengue virus (DENV), and Japanese encephalitis virus (JEV), pose a...

    Authors: Liyan Sui, Yinghua Zhao, Wenfang Wang, Hongmiao Chi, Tian Tian, Ping Wu, Jinlong Zhang, Yicheng Zhao, Zheng-Kai Wei, Zhijun Hou, Guoqiang Zhou, Guoqing Wang, Zedong Wang and Quan Liu
    Citation: Cell & Bioscience 2023 13:9
  4. Temporal lobe epilepsy (TLE) remains one of the most drug-resistant focal epilepsies. Glutamate excitotoxicity and neuroinflammation which leads to loss of synaptic proteins and neuronal death appear to repres...

    Authors: Namgue Hong, Hee Jung Kim, Keunsoo Kang, Ji On Park, Seyoung Mun, Hyung-Gun Kim, Bong Hui Kang, Phil-Sang Chung, Min Young Lee and Jin-Chul Ahn
    Citation: Cell & Bioscience 2023 13:8
  5. Our recent studies found that intestinal mechanical signals can regulate mucus synthesis and secretion of intestinal goblet cells through piezo type mechanosensitive ion channel component 1 (Piezo1), but the d...

    Authors: Yan Xu, Yilin Xiong, Ying Liu, Gangping Li, Tao Bai, Gen Zheng, Xiaohua Hou and Jun Song
    Citation: Cell & Bioscience 2023 13:7
  6. Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a rare acquired immune-mediated neuropathy. Although microbial infection is potentially a contributing factor, a causative link between CIDP ...

    Authors: Jiafang Fu, Jingli Shan, Yazhou Cui, Chuanzhu Yan, Qinzhou Wang, Jinxiang Han and Guangxiang Cao
    Citation: Cell & Bioscience 2023 13:6
  7. Alcohol-related liver disease (ALD) is characterized by ductular reaction (DR), liver inflammation, steatosis, fibrosis, and cirrhosis. The secretin (Sct)/secretin receptor (SR) axis (expressed only by cholang...

    Authors: Konstantina Kyritsi, Nan Wu, Tianhao Zhou, Guido Carpino, Leonardo Baiocchi, Lindsey Kennedy, Lixian Chen, Ludovica Ceci, Alison Ann Meyer, Nipuni Barupala, Antonio Franchitto, Paolo Onori, Burcin Ekser, Eugenio Gaudio, Chaodong Wu, Corinn Marakovits…
    Citation: Cell & Bioscience 2023 13:5
  8. Neural stem cells (NSCs) are considered as candidates for cell replacement therapy in many neurological disorders. However, the propensity for their differentiation to proceed more glial rather than neuronal p...

    Authors: Qian Liu, Vsevolod Telezhkin, Wenkai Jiang, Yu Gu, Yan Wang, Wei Hong, Weiming Tian, Polina Yarova, Gaofeng Zhang, Simon Ming-yuen Lee, Peng Zhang, Min Zhao, Nicholas D. Allen, Emilio Hirsch, Josef Penninger and Bing Song
    Citation: Cell & Bioscience 2023 13:4
  9. Drug resistance is a particular problem in patients with temporal lobe epilepsy, where seizures originate mainly from the hippocampus. Many of these epilepsies are acquired conditions following an insult to th...

    Authors: Sereen Sandouka, Aseel Saadi, Prince Kumar Singh, Rhoda Olowe and Tawfeeq Shekh-Ahmad
    Citation: Cell & Bioscience 2023 13:3
  10. DNA methylation is a critical molecular mark involved in cellular differentiation and cell-specific processes. Single-cell whole genome DNA methylation profiling methods hold great potential to resolve the DNA...

    Authors: Zac Chatterton, Praves Lamichhane, Diba Ahmadi Rastegar, Lauren Fitzpatrick, Hélène Lebhar, Christopher Marquis, Glenda Halliday and John B. Kwok
    Citation: Cell & Bioscience 2023 13:2
  11. Bmal1 (Brain and muscle arnt-like, or Arntl) is a bHLH/PAS domain transcription factor central to the transcription/translation feedback loop of the biologic clock. Although Bmal1 is well-established as a major r...

    Authors: Yuanjia Zheng, Lingyun Pan, Feixue Wang, Jinglan Yan, Taiyi Wang, Yucen Xia, Lin Yao, Kelin Deng, Yuqi Zheng, Xiaoye Xia, Zhikai Su, Hongjie Chen, Jie Lin, Zhenwei Ding, Kaitong Zhang, Meng Zhang…
    Citation: Cell & Bioscience 2023 13:1
  12. Pathogenic mutations in WRN are a cause of premature aging disease Werner syndrome (WS). Besides accelerated aging phenotypes and cancer predisposition, patients with WS also display underdevelopment in the skele...

    Authors: Adrian On-Wah Leung, Tsz-Ching Yiu, Lingxiao Liu, Hei-Yin Tam, Shen Gu, Jiajie Tu, Duanqing Pei and Hoi-Hung Cheung
    Citation: Cell & Bioscience 2022 12:212
  13. The gene encoding the E3 ubiquitin ligase substrate-binding adapter Speckle-type BTB/POZ protein (SPOP) is frequently mutated in prostate cancer (PCa) and endometrial cancer (EC); however, the molecular mechanism...

    Authors: Kai Feng, Qing Shi, Dongyue Jiao, Yingji Chen, Wanqi Yang, Ke Su, Yalan Wang, Yan Huang, Pingzhao Zhang, Yao Li and Chenji Wang
    Citation: Cell & Bioscience 2022 12:211
  14. In neuroblastoma, hyperactivation of the PI3K signaling pathway has been correlated with aggressive neuroblastomas, suggesting PI3Ks as promising targets for the treatment of neuroblastoma. However, the oncoge...

    Authors: Yue Guo, Donghao Guo, Shaoting Zhang, Yuan Zhang, Xiaoyan He, Xiaohua Jiang, Andrew Man-Lok Chan, Lin Zou, Jianmin Sun and Hui Zhao
    Citation: Cell & Bioscience 2022 12:210
  15. Recent research has indicated that cuprotosis, or copper induced cell death, is a novel type of cell death that could be utilized as a new weapon for cancer management. However, the characteristics and implica...

    Authors: Aimin Jiang, Peng Luo, Ming Chen, Yu Fang, Bing Liu, Zhenjie Wu, Le Qu, Anbang Wang, Linhui Wang and Chen Cai
    Citation: Cell & Bioscience 2022 12:209
  16. Colorectal cancer (CRC), a commonly diagnosed cancer often develops slowly from benign polyps called adenoma to carcinoma. Altered gut microbiota is implicated in colorectal carcinogenesis. It is warranted to ...

    Authors: Junfeng Xu, Zhijun Zheng, Lang Yang, Ruoran Li, Xianzong Ma, Jie Zhang, Fumei Yin, Lin Liu, Qian Xu, Qiujing Shen, Xiuping Shen, Chunyan Wu, Jing Liu, Nan Qin, Jianqiu Sheng and Peng Jin
    Citation: Cell & Bioscience 2022 12:208
  17. N6-methyladenosine is the most abundant eukaryotic mRNA modification and alters a wide range of cellular processes in cancer. Therefore, defining the molecular details are critical for understanding the regulato....

    Authors: Tao Yu, Fuxia Wu, Yan Jia, Xue Zhang, Xiaozhen Qi, Zeyuan Jin, Tongxin Hao, Jianing Zhao, Ziyu Liu, Chaokun Wang, Minmin Niu, Qin Yue, Min Li and Yankun Liu
    Citation: Cell & Bioscience 2022 12:207
  18. Cysteine protease ATG4B, a key autophagy protein, is an attractive target for colorectal cancer therapy. However, ATG4B inhibitors with higher efficiency, safety, and clear mechanism are still limited. In this...

    Authors: Huazhong Xie, Pengfei Qiang, Yao Wang, Fan Xia, Peiqing Liu and Min Li
    Citation: Cell & Bioscience 2022 12:206
  19. ADD1 (adducin-1) and TPX2 (targeting protein for Xklp2) are centrosomal proteins and regulate mitotic spindle assembly. Mammalian oocytes that segregate homologous chromosomes in Meiosis I and sister chromatid...

    Authors: Ying Zhang, Bingfeng Fan, Xiaoxia Li, Yu Tang, Jing Shao, Lixiang Liu, Yuhe Ren, Yifeng Yang and Baozeng Xu
    Citation: Cell & Bioscience 2022 12:205
  20. Sustained cardiac hypertrophy often develops maladaptive myocardial remodeling, and eventually progresses to heart failure and sudden death. Therefore, maladaptive hypertrophy is considered as a critical thera...

    Authors: Teng Sun, Yu Han, Jia-Lei Li, Xiang-Ying Jiao, Lin Zuo, Jin Wang, Hai-Xiong Wang, Jun-Li Yang, Ji-Min Cao and Jian-Xun Wang
    Citation: Cell & Bioscience 2022 12:204
  21. Renal fibrosis is the pathological foundation of various chronic kidney diseases progressing to end stage renal failure. However, there are currently no nephroprotective drugs targeted to the fibrotic process ...

    Authors: Jiayi Yang, Yuyi Ruan, Dan Wang, Jinjin Fan, Ning Luo, Huiting Chen, Xiaoyan Li, Wei Chen and Xin Wang
    Citation: Cell & Bioscience 2022 12:203
  22. In the aging process and central nervous system (CNS) diseases, the functions of the meningeal lymphatic vessels (MLVs) are impaired. Alterations in MLVs have been observed in aging-related neurodegenerative d...

    Authors: Huimin Jiang, Huimin Wei, Yifan Zhou, Xuechun Xiao, Chen Zhou and Xunming Ji
    Citation: Cell & Bioscience 2022 12:202
  23. Authors: Qian Zhu, Min Qin, Zixian Wang, Yonglin Wu, Xiaoping Chen, Chen Liu, Qilin Ma, Yibin Liu, Weihua Lai, Hui Chen, Jingjing Cai, Yemao Liu, Fang Lei, Bin Zhang, Shuyao Zhang, Guodong He…
    Citation: Cell & Bioscience 2022 12:201

    The original article was published in Cell & Bioscience 2022 12:173

  24. Prostate cancer (PCa) is an age-related malignancy in men with a high incidence rate. PCa treatments face many obstacles due to cancer cell resistance and many bypassing mechanisms to escape therapy. According...

    Authors: Julia Kallenbach, Golnaz Atri Roozbahani, Mehdi Heidari Horestani and Aria Baniahmad
    Citation: Cell & Bioscience 2022 12:200
  25. The guanine-rich RNA sequence binding factor 1 (GRSF1) is an RNA-binding protein of the heterogenous nuclear ribonucleoprotein H/F (hnRNP H/F) family that binds to guanine-rich RNA sequences forming G-quadrupl...

    Authors: Bernhard Dumoulin, Dagmar Heydeck, Desiree Jähn, Moritz Lassé, Sajad Sofi, Christoph Ufer and Hartmut Kuhn
    Citation: Cell & Bioscience 2022 12:199
  26. Disordered lipid metabolism plays an essential role in both the initiation and progression of alcoholic fatty liver disease (AFLD), and fatty acid β-oxidation is increasingly considered as a crucial factor for...

    Authors: Mei-fei Wu, Guo-dong Zhang, Tong-tong Liu, Jun-hao Shen, Jie-ling Cheng, Jie Shen, Tian-yu Yang, Cheng Huang and Lei Zhang
    Citation: Cell & Bioscience 2022 12:198
  27. The synthesis and secretion of renin in juxtaglomerular (JG) cells are closely regulated by the blood pressure. To date, however, the molecular identity through which JG cells respond to the blood pressure rem...

    Authors: Xiaoqiang Yang, Honghui Zeng, Le Wang, Siweier Luo and Yiming Zhou
    Citation: Cell & Bioscience 2022 12:197
  28. Despite current intervention measures/therapies are able to ameliorate neuronal death following retinal injuries/diseases, the recovery of visual function remains unsatisfactory. Previous studies revealed that...

    Authors: Tu Hu, Shuhan Meng, Qianyue Zhang, Shuang Song, Cheng Tan, Jufang Huang and Dan Chen
    Citation: Cell & Bioscience 2022 12:196
  29. Treatment failure is the main cause of death from papillary thyroid carcinoma (PTC). It is urgent to look for new intervention targets and to develop new therapies for treating PTC. Aurora-A kinase (AURKA) fun...

    Authors: Zewei Zhao, Huijuan Wang, Ning Kang, Zhongyu Wang, Xiukun Hou, Linfei Hu, Shuo Qie, Jianping Guo, Songfeng Wei, Xianhui Ruan and Xiangqian Zheng
    Citation: Cell & Bioscience 2022 12:195
  30. Neurocognitive disorders and psychosocial difficulties are common in patients with Turner syndrome and multiple neurodegenerative diseases, yet there is no effective cure. Human primordial germ cells (hPGCs) a...

    Authors: Dantong Shang, Tian Lan, Yue Wang, Xuanyu Li, Quanyi Liu, Huimin Dong, Bo Xu, Hanhua Cheng and Rongjia Zhou
    Citation: Cell & Bioscience 2022 12:194
  31. Systemic identification of tumor suppressor genes (TSGs) and elucidation of their signaling provide a new angle for understanding of tumorigenesis, which is important for developing successful treatment for lu...

    Authors: Lu Liu, Yuxi Lei, Wensheng Chen, Qian Zhou, Zongyao Zheng, Guandi Zeng, Wanting Liu, Pengju Feng, Zhiyi Zhang, Lei Yu and Liang Chen
    Citation: Cell & Bioscience 2022 12:193
  32. Inhibitors of ornithine decarboxylase (ODC) are effective at preventing colorectal cancer (CRC). However, their high toxicity limits their clinical application. This study was aimed to explore the potential of...

    Authors: Ningning Liu, Tianpeng Zhang, Clifford J. Steer and Guisheng Song
    Citation: Cell & Bioscience 2022 12:192
  33. Mechanical loading promotes bone formation and osteocytes are a major mechanosensory cell in the bone. Both Piezo1 channels and connexin 43 hemichannels (Cx43 HCs) in osteocytes are important players in mechan...

    Authors: Yan Zeng, Manuel A. Riquelme, Rui Hua, Jingruo Zhang, Francisca M. Acosta, Sumin Gu and Jean X. Jiang
    Citation: Cell & Bioscience 2022 12:191
  34. Pregnenolone (P5) is a neurosteroid that promotes microtubule polymerization. It also reduces stress and negative symptoms of schizophrenia, promotes memory, as well as recovery from spinal cord injury. P5 is ...

    Authors: Viktoryia Kolas, Jose Sandino A. Bandonil, Niaz Wali, Kuo-Chiang Hsia, Jiun-Jie Shie and Bon-chu Chung
    Citation: Cell & Bioscience 2022 12:190
  35. Schizophrenia is a complex and severe neuropsychiatric disorder, with a wide range of debilitating symptoms. Several aspects of its multifactorial complexity are still unknown, and some are accepted to be an e...

    Authors: Juliana Minardi Nascimento, Verônica M. Saia-Cereda, Giuliana S. Zuccoli, Guilherme Reis-de-Oliveira, Victor Corasolla Carregari, Bradley J. Smith, Stevens K. Rehen and Daniel Martins-de-Souza
    Citation: Cell & Bioscience 2022 12:189
  36. Acute liver failure caused by drug overdose is a significant clinical problem in developed countries. Acetaminophen (APAP), a widely used analgesic and antipyretic drug, but its overdose can cause acute liver ...

    Authors: Qianhui Li, Feng Chen and Fei Wang
    Citation: Cell & Bioscience 2022 12:187
  37. Diabetic retinopathy (DR), a specific neuron-vascular complication of diabetes, is a major cause of vision loss among middle-aged people worldwide, and the number of DR patients will increase with the increasi...

    Authors: Chunyang Cai, Chunren Meng, Shuai He, Chufeng Gu, Thashi Lhamo, Deji Draga, Dawei Luo and Qinghua Qiu
    Citation: Cell & Bioscience 2022 12:186
  38. Early studies indicated that the androgen receptor (AR) could promote renal cell carcinoma (RCC) development and metastasis, but its linkage to RCC progression under hypoxia, remains unclear.

    Authors: Changcheng Guo, Yin Sun, Wei Zhai, Xudong Yao, Dongkui Gong, Bosen You, Chi-Ping Huang, Junhua Zheng and Chawnshang Chang
    Citation: Cell & Bioscience 2022 12:185
  39. Exploiting cancer metabolism during nutrient availability holds immense potential for the clinical and therapeutic benefits of hepatocellular carcinoma (HCC) patients. Dietary methionine is a metabolic depende...

    Authors: Liang Zhao, Huizhao Su, Xiaomeng Liu, Hongquan Wang, Yukuan Feng, Yan Wang, Haiqiang Chen, Luo Dai, Shihui Lai, Siqi Xu, Chong Li, Jihui Hao and Bo Tang
    Citation: Cell & Bioscience 2022 12:183
  40. Semaphorins (Sema) belong to a large family of repellent guidance cues instrumental in guiding axons during development. In particular, Class 3 Sema (Sema 3) is among the best characterized Sema family members...

    Authors: Gabriella Ferretti, Alessia Romano, Rossana Sirabella, Sara Serafini, Thorsten Jürgen Maier and Carmela Matrone
    Citation: Cell & Bioscience 2022 12:182
  41. Human primordial germ cells (hPGCs) initiate from the early post-implantation embryo at week 2–3 and undergo epigenetic reprogramming during development. However, the regulatory mechanism of DNA methylation du...

    Authors: Zili Li, Fang Fang, Yuting Long, Qian Zhao, Xiaotong Wang, Zhen Ye, Tianqing Meng, Xiuli Gu, Wenpei Xiang, Chengliang Xiong and Honggang Li
    Citation: Cell & Bioscience 2022 12:181
  42. Neurite dystrophy is a pathologic hallmark of Alzheimer’s disease (AD). However, drug discovery targeting neurite protection in AD remains largely unexplored.

    Authors: Yuyuan Yao, Zhichu Ren, Ruihan Yang, Yilan Mei, Yuying Dai, Qian Cheng, Chong Xu, Xiaogang Xu, Sanying Wang, Kyoung Mi Kim, Ji Heon Noh, Jian Zhu, Ningwei Zhao, Yong U. Liu, Genxiang Mao and Jian Sima
    Citation: Cell & Bioscience 2022 12:180
  43. Retinoic acid(RA), an embryonic morphogen, regulates cell differentiation. Endocytosis regulates receptor signaling that governs such RA-directed cellular processes. Vacuolin-1 is a small molecule that disrupt...

    Authors: Kaiyuan Zhu, Noor Kazim, Jianbo Yue and Andrew Yen
    Citation: Cell & Bioscience 2022 12:179

    The Correction to this article has been published in Cell & Bioscience 2023 13:22

  44. Central nervous system (CNS) control of metabolism plays a pivotal role in maintaining energy balance. In the brain, Glucagon-like peptide 1 (GLP-1), encoded by the proglucagon ‘Gcg gene, produced in a distinct ...

    Authors: Ishnoor Singh, Le Wang, Baijuan Xia, Ji Liu, Azeddine Tahiri, Abdelfattah El Ouaamari, Michael B. Wheeler and Zhiping P. Pang
    Citation: Cell & Bioscience 2022 12:178
  45. Corpora amylacea of human brain, recently renamed as wasteosomes, are granular structures that appear during aging and also accumulate in specific areas of the brain in neurodegenerative conditions. Acting as was...

    Authors: Marta Riba, Joan Campo-Sabariz, Iraida Tena, Laura Molina-Porcel, Teresa Ximelis, Maria Calvo, Ruth Ferrer, Raquel Martín-Venegas, Jaume del Valle, Jordi Vilaplana and Carme Pelegrí
    Citation: Cell & Bioscience 2022 12:177
  46. DNMT1 has been shown to be highly expressed in a variety of cancers, including breast cancer. However, the mechanism is not very clear. Therefore, we aim to reveal the mechanism of DNMT1 highly express in brea...

    Authors: Zhongwei Li, Pengfei Wang, Wenjie Cui, Hongmei Yong, Diandian Wang, Tiesuo Zhao, Wenwen Wang, Ming Shi, Junnian Zheng and Jin Bai
    Citation: Cell & Bioscience 2022 12:176
  47. The human endometrium is a highly regenerative tissue that is believed to have two main types of stem cells: endometrial mesenchymal/stromal stem cells (eMSCs) and endometrial epithelial stem cells (eESCs). So...

    Authors: Wen He, Xuejing Zhu, Aijie Xin, Hongdan Zhang, Yiming Sun, Hua Xu, He Li, Tianying Yang, Dan Zhou, Hexin Yan and Xiaoxi Sun
    Citation: Cell & Bioscience 2022 12:175
  48. The kidneys require vast amounts of mitochondria to provide ample energy to reabsorb nutrients and regulate electrolyte, fluid, and blood pressure homeostasis. The lack of the human model hinders the investiga...

    Authors: Yapei Yuan, Huan Chen, Sihua Ou, Baomei Cai, Ruifang Zhang, Yue Qin, Mengjie Pan, Shangtao Cao, Duanqing Pei and Fan Fan Hou
    Citation: Cell & Bioscience 2022 12:174