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  1. Alzheimer’s disease (AD) is a neurodegenerative disease that leads to progressive loss of memory and dementia. The pathological hallmarks of AD include extracellular accumulation of amyloid-β peptides forming ...

    Authors: Hariharakrishnan Chidambaram, Rashmi Das and Subashchandrabose Chinnathambi

    Citation: Cell & Bioscience 2020 10:109

    Content type: Review

    Published on:

  3. Fear is an adaptive response across species in the face of threatening cues. It can be either innate or learned through postnatal experience. We have previously shown that genetic deletion of both Rap1a and Ra...

    Authors: Wen-Bing Chen, Han-Qing Pan, Ye He, Xue-Hui Wang, Wen-Hua Zhang and Bing-Xing Pan

    Citation: Cell & Bioscience 2020 10:107

    Content type: Research

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  4. Huntington’s disease (HD) is a neurodegenerative disease that involves a complex combination of psychiatric, cognitive and motor impairments. Synaptic dysfunction has been implicated in HD pathogenesis. Howeve...

    Authors: Li Niu, Li Li, Shiming Yang, Weixi Wang, Cuifang Ye and He Li

    Citation: Cell & Bioscience 2020 10:106

    Content type: Research

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  5. Shwachman-Diamond syndrome (SDS) is a congenital disease that affects the bone marrow, skeletal system, and pancreas. The majority of patients with SDS have mutations in the SBDS gene, involved in ribosome biogen...

    Authors: Ayushi Jain, Phubed Nilatawong, Narinrat Mamak, Laran T. Jensen and Amornrat Naranuntarat Jensen

    Citation: Cell & Bioscience 2020 10:105

    Content type: Research

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  6. Mesenchymal stem cells (MSCs), also referred to as multipotent stromal cells or mesenchymal stromal cells, are present in multiple tissues and capable of differentiating into diverse cell lineages, holding a g...

    Authors: Yizhen Sima and Yisong Chen

    Citation: Cell & Bioscience 2020 10:104

    Content type: Review

    Published on:

  7. Long bones of limbs are formed through endochondral bone formation, which depends on the coordinated development of growth plates. Our previous studies have demonstrated that dysfunction of mitogen-activated p...

    Authors: Xiaoming Yang, Dongmei Zhong, Wenjie Gao, Zhiheng Liao, Yuyu Chen, Shun Zhang, Hang Zhou, Peiqiang Su and Caixia Xu

    Citation: Cell & Bioscience 2020 10:103

    Content type: Research

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  8. Patients with type 2 diabetes mellitus (T2DM), especially those with poor glycemic control, are characterized by low bone mass and destruction of bone microstructure. Nowadays, autologous mesenchymal stem cell...

    Authors: Lei Wang, Shaojie Shi, Ruiping Bai, Yue Wang, Zhao Guo and Doudou Li

    Citation: Cell & Bioscience 2020 10:102

    Content type: Research

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  9. Autophagy has a crucial role in the defense against parasites. The interplay existing between host autophagy and parasites has varied outcomes due to the kind of host cell and microorganism. The presence of au...

    Authors: George Ghartey-Kwansah, Frank Adu-Nti, Benjamin Aboagye, Amandus Ankobil, Edward Eyipe Essuman, Yeboah Kwaku Opoku, Samuel Abokyi, Emmanuel Kwasi Abu and Johnson Nyarko Boampong

    Citation: Cell & Bioscience 2020 10:101

    Content type: Review

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  10. Ribosomal protein 34 (RPL34) is a highly conserved protein belonging to the 60S large subunit of mammalian ribosomes that has been found to be dysregulated in a variety of human tumors. However, there are limi...

    Authors: Jianxin Qian, Lin Xu, Wenlong Yu, Xiaoqiang Gu, Yongjun Zuo, Ying Chen, Feng Xie and Lixin Wei

    Citation: Cell & Bioscience 2020 10:100

    Content type: Research

    Published on:

  12. Schwann cells (SCs) play a crucial role in Wallerian degeneration after peripheral nerve injury. The expression of genes in SCs undergo a series of changes, which greatly affect the proliferation and apoptosis...

    Authors: Jiang-Bo Wang, Zhan Zhang, Jian-Nan Li, Tuo Yang, Shuang Du, Rang-Juan Cao and Shu-Sen Cui

    Citation: Cell & Bioscience 2020 10:98

    Content type: Research

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  13. Sex differences are prevalent in normal development, physiology and disease pathogeneses. Recent studies have demonstrated that mosaic loss of Y chromosome and aberrant activation of its genes could modify the...

    Authors: Yun-Fai Chris Lau

    Citation: Cell & Bioscience 2020 10:97

    Content type: Review

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  14. Openers of mitochondrial adenosine triphosphate-dependent potassium (mKATP) channels like diazoxide increase reactive oxygen species (ROS) production in cardiac cells and reduce Ca2+ elevations produced by ischem...

    Authors: Joice T. Gavali, Elba D. Carrillo, María C. García and Jorge A. Sánchez

    Citation: Cell & Bioscience 2020 10:96

    Content type: Research

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  15. Human pyruvate dehydrogenase phosphatase 1 (PDP1) plays an important physiological role in energy metabolism; however, its expression and function in human pancreatic adenocarcinoma (PDAC) remain unknown. This...

    Authors: Ye Li, Jia Shen, Chien-shan Cheng, HuiFeng Gao, Jiangang Zhao and Lianyu Chen

    Citation: Cell & Bioscience 2020 10:95

    Content type: Research

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  16. Gastric cancer (GC) is a malignancy with high morbidity/mortality, partly due to a lack of reliable biomarkers for early diagnosis. It is important to develop reliable biomarker(s) with specificity, sensitivit...

    Authors: Qinghua Liu, Ying Zhang, Jiwei Zhang, Kun Tao, Brett D. Hambly and Shisan Bao

    Citation: Cell & Bioscience 2020 10:94

    Content type: Research

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  17. Cancer stem cells are the main reason of relapse, metastasis and resistance to anti-cancer therapies of Hepatocellular carcinoma (HCC). Mesenchymal stem cells (MSCs) are an important part of the tumor microenv...

    Authors: Jing Hou, Naping Zhao, Pengxi Zhu, Jun Chang, Yan Du and Wei Shen

    Citation: Cell & Bioscience 2020 10:93

    Content type: Research

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  18. Vesicular system of mammalian cells is composed of two intracellular and extracellular vesicles systems, which contributes to the intra/intercellular communication and cellular homeostasis. These systems media...

    Authors: Mehdi Hassanpour, Aysa Rezabakhsh, Jafar Rezaie, Mohammad Nouri and Reza Rahbarghazi

    Citation: Cell & Bioscience 2020 10:92

    Content type: Review

    Published on:

  19. Arsenic exposure has become a matter of worldwide concern, which is associated with immune-related diseases. However, little is known about its effect on inflammatory immune-related homeostasis. The purpose of...

    Authors: Nan Yan, Guowei Xu, Chenchen Zhang, Xuping Liu, Xin Li, Lin Sun, Da Wang, Xiaoxu Duan and Bing Li

    Citation: Cell & Bioscience 2020 10:91

    Content type: Research

    Published on:

  20. NF-E2-related factor 2 (Nrf2) is involved in the radiation resistance of esophageal squamous cell carcinoma (ESCC), but the underlying molecular mechanism is unclear. The purpose of our study was to explore th...

    Authors: Di Xia, Xiao-Ran Zhang, Yan-Li Ma, Zhi-Jun Zhao, Ren Zhao and Yan-Yang Wang

    Citation: Cell & Bioscience 2020 10:90

    Content type: Research

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  21. For decades, cancer metastasis has been a heated topic for its high mortality. Previous research has shown that pre-metastatic niche and metastatic niche are the 2 crucial steps in cancer metastasis, assisting...

    Authors: Jianan Zhuyan, Mingyu Chen, Tianhao Zhu, Xunxia Bao, Timing Zhen, Kaichen Xing, Qiubo Wang and Sibo Zhu

    Citation: Cell & Bioscience 2020 10:89

    Content type: Review

    Published on:

  22. Mesenchymal stem/stromal cells (MSCs) and macrophages are critical components in many tissue microenvironments, including that in adipose tissue. The close interaction between MSCs and macrophages modulates va...

    Authors: Hui Ma, Ya-nan Li, Lin Song, Rui Liu, Xiaolei Li, Qianwen Shang, Ying Wang, Changshun Shao and Yufang Shi

    Citation: Cell & Bioscience 2020 10:88

    Content type: Research

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  23. The correct folding is a key process for a protein to acquire its functional structure and conformation. Prefoldin is a well-known chaperone protein that regulates the correct folding of proteins. Prefoldin pl...

    Authors: Jiaxin Liang, Longzheng Xia, Linda Oyang, Jinguan Lin, Shiming Tan, Pin Yi, Yaqian Han, Xia Luo, Hui Wang, Lu Tang, Qing Pan, Yutong Tian, Shan Rao, Min Su, Yingrui Shi, Deliang Cao…

    Citation: Cell & Bioscience 2020 10:87

    Content type: Review

    Published on:

  24. With the acceleration of urbanization and aging and the change of lifestyle, inflammatory diseases have become one of the important threats to the health of the global population. Matrix metalloproteinases (MM...

    Authors: Jie He, Man Qin, Yingyi Chen, Ziqi Hu, Fei Xie, Ling Ye and Tianqian Hui

    Citation: Cell & Bioscience 2020 10:86

    Content type: Review

    Published on:

  25. The chemokine receptor CCR5 is one of the co-receptor of HIV-1 infection. People with homozygous CCR5Δ32 deletion resist HIV-1 infection, which makes the CCR5 an important target for HIV-1 gene therapy. Although ...

    Authors: Zhepeng Liu, Jin Liang, Shuliang Chen, Kewu Wang, Xianhao Liu, Beibei Liu, Yang Xia, Mingxiong Guo, Xiaoshi Zhang, Guihong Sun and Geng Tian

    Citation: Cell & Bioscience 2020 10:85

    Content type: Research

    Published on:

  27. Hepatocellular carcinoma (HCC) is one of the most malignant tumor types and has a high incidence and mortality. Many miRNAs play important roles in the development of HCC. Identification of these miRNAs and th...

    Authors: Li Hui, Fang Zheng, Yuan Bo, Ma Sen-lin, Li Ai-jun, Zhou Wei-ping, Zhang Yong-jie and Yin Lei

    Citation: Cell & Bioscience 2020 10:83

    Content type: Research

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  28. Long intergenic noncoding RNA p21 was mapped on the human chromosome 6p21.2. Accordingly, it was firstly described by promoting the p53-dependent apoptosis in the mouse. Also, it is a new lncRNA playing some v...

    Authors: Roya Amirinejad, Mina Rezaei and Zeinab Shirvani-Farsani

    Citation: Cell & Bioscience 2020 10:82

    Content type: Review

    Published on:

  30. Recent evidences demonstrate that dysregulated expression of microRNA-320d (miR-320d) has been associated with several cancer development and progression. However the effect of miR-320d on gastric cardiac aden...

    Authors: Xiaojie Chen, Shegan Gao, Zhiwei Zhao, Gaofeng Liang, Jinyu Kong and Xiaoshan Feng

    Citation: Cell & Bioscience 2020 10:80

    Content type: Research

    Published on:

  31. Ischemic stroke poses a severe risk to human health worldwide, and currently, clinical therapies for the disease are limited. Delta opioid receptor (DOR)-mediated neuroprotective effects against ischemia have ...

    Authors: Zelin Lai, Lingling Gu, Lu Yu, Huifen Chen, Zhenhua Yu, Cheng Zhang, Xiaoqing Xu, Mutian Zhang, Min Zhang, Mingliang Ma, Zheng Zhao and Jun Zhang

    Citation: Cell & Bioscience 2020 10:79

    Content type: Research

    Published on:

  32. The X-linked inhibitor of apoptosis protein (XIAP) is the most potent caspase inhibitor of the IAP family in apoptosis pathway. This study aims to identify the molecular targets of XIAP in human breast cancer ...

    Authors: Mehdi Agha Gholizadeh, Fatemeh T. Shamsabadi, Ahad Yamchi, Masoud Golalipour, Gagan Deep Jhingan and Majid Shahbazi

    Citation: Cell & Bioscience 2020 10:78

    Content type: Research

    Published on:

  33. MicroRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression at the post-transcriptional level and play critical roles in regulating physiological function, and are becoming worldwide ...

    Authors: Juanjuan Zhao, Ya Zhou, Mengmeng Guo, Dongxu Yue, Chao Chen, Guiyou Liang and Lin Xu

    Citation: Cell & Bioscience 2020 10:77

    Content type: Review

    Published on:

  34. Colorectal cancer (CRC) is the fourth most deadly malignancy throughout the world. Extensive studies have shown that Krüppel-like factors (KLFs) play essential roles in cancer development. However, the functio...

    Authors: Weilong Yao, Yue Jiao, Yanhua Zhou and Xiaoya Luo

    Citation: Cell & Bioscience 2020 10:76

    Content type: Research

    Published on:

  35. Stem cell-based regenerative medicine is a promising approach for tissue reconstruction. However, a large number of cells are needed in a typical clinical study, where conventional monolayer cultures might pos...

    Authors: Benson Koh, Nadiah Sulaiman, Mh Busra Fauzi, Jia Xian Law, Min Hwei Ng, Ruszymah Bt Hj Idrus and Muhammad Dain Yazid

    Citation: Cell & Bioscience 2020 10:75

    Content type: Review

    Published on:

  37. Interleukin-17A (IL-17) is an evolutionary conserved cytokine and best known for its role in boosting immune response. However, recent clinical researches showed that abundant IL-17 in tumor microenvironment w...

    Authors: Shijia Wang, Guan Wang, Liying Zhang, Fengying Li, Keli Liu, Ying Wang, Yufang Shi and Kai Cao

    Citation: Cell & Bioscience 2020 10:73

    Content type: Research

    Published on:

  38. Arginine vasopressin (AVP) is elevated in patients with heart failure, and the increase in the AVP concentration in plasma is positively correlated with disease severity and mortality. Metoprolol (Met) is a be...

    Authors: Jieqiong Zhao, Yonghong Lei, Yanping Yang, Haibo Gao, Zhongchao Gai and Xue Li

    Citation: Cell & Bioscience 2020 10:72

    Content type: Research

    Published on:

  39. Acute Liver failure (ALF) is a life-threatening disease and is determined by coagulopathy (with INR ≥ 1.5) and hepatic encephalopathy as a result of severe liver injury in patients without preexisting liver di...

    Authors: Mahshid Saleh, Mohammad Taher, Amir Ali Sohrabpour, Amir Abbas Vaezi, Mohsen Nasiri Toosi, Maria Kavianpour, Zeinab Ghazvinian, Shahrokh Abdolahi and Javad Verdi

    Citation: Cell & Bioscience 2020 10:71

    Content type: Review

    Published on:

  40. Herpesvirus is ranked as one of the grand old members of all pathogens. Of all the viruses in the superfamily, Herpes simplex virus type 1 (HSV-1) is considered as a model virus for a variety of reasons. In a ...

    Authors: Qiaojuan Zhang, Miguel Martin-Caraballo and Shaochung V. Hsia

    Citation: Cell & Bioscience 2020 10:70

    Content type: Review

    Published on:

  41. Mesenchymal stem cells (MSCs) were known to have excellent properties in cell therapy. However, the risk of immune rejection associated with cell transplant therapy hampers its use. Extracellular vesicles secr...

    Authors: Jiaxin Cai, Junyong Wu, Jiemin Wang, Yongjiang Li, Xiongbin Hu, Shifu Luo and Daxiong Xiang

    Citation: Cell & Bioscience 2020 10:69

    Content type: Review

    Published on:

  43. Teleost fishes account for over half of extant vertebrate species. A core question in biology is how genomic changes drive phenotypic diversity that relates to the origin of teleost fishes.

    Authors: Yibin Cheng, Dantong Shang, Majing Luo, Chunhua Huang, Fengling Lai, Xin Wang, Xu Xu, Ruhong Ying, Lingling Wang, Yu Zhao, Li Zhang, Manyuan Long, Hanhua Cheng and Rongjia Zhou

    Citation: Cell & Bioscience 2020 10:67

    Content type: Research

    Published on:

  45. Mesenchymal stromal cells (MSCs) are multiple stromal cells existing in various tissues and have already been employed in animal models and clinical trials to treat immune disorders through potent immunosuppre...

    Authors: Menghui Jiang, Jiayin Ye, Xuefeng Wang, Na Li, Ying Wang and Yufang Shi

    Citation: Cell & Bioscience 2020 10:65

    Content type: Research

    Published on:

  46. Eukaryotic cells demonstrate two tightly linked vesicular transport systems, comprising intracellular vesicle transport and extracellular vesicle transport system. Intracellular transport vesicles can transloc...

    Authors: Leila Salimi, Ali Akbari, Nassrollah Jabbari, Behnam Mojarad, Ali Vahhabi, Sławomir Szafert, Sadegh Asghari Kalashani, Hamid Soraya, Muhammad Nawaz and Jafar Rezaie

    Citation: Cell & Bioscience 2020 10:64

    Content type: Review

    Published on:

  47. Compared to radiation injury alone (RI), radiation injury combined wound (CI) further enhances acute radiation syndrome and subsequently mortality. We previously reported that therapy with Ghrelin, the 28-amin...

    Authors: Juliann G. Kiang, Joan T. Smith, Georgetta Cannon, Marsha N. Anderson, Connie Ho, Min Zhai, Wanchang Cui and Mang Xiao

    Citation: Cell & Bioscience 2020 10:63

    Content type: Research

    Published on:

  48. Following publication of the original article [1], one of the funding was missing in the Funding section.

    Authors: Sheng Wang, Kristyn Gumpper, Tao Tan, Xianzhang Luo, Hui Guo, Changsheng Ming, Hanying Jiang, Jiangguo Fang, Guang Du, Hua Zhu, Jianjie Ma, Zhishui Chen and Nianqiao Gong

    Citation: Cell & Bioscience 2020 10:62

    Content type: Correction

    Published on:

    The original article was published in Cell & Bioscience 2018 8:28

  49. Following publication of the original article [1], the authors identified an error in Figs. 1b, 5b.

    Authors: Yi Wang, Zhiheng Guo, Yongmei Gao, Ping Liang, Yanhong Shan and Jin He

    Citation: Cell & Bioscience 2020 10:61

    Content type: Correction

    Published on:

    The original article was published in Cell & Bioscience 2019 9:86

  50. Thyroid hormone (T3) plays an important role in vertebrate development. Compared to the postembryonic development of uterus-enclosed mammalian embryos, T3-dependent amphibian metamorphosis is advantageous for ...

    Authors: Wonho Na, Liezhen Fu, Nga Luu and Yun-Bo Shi

    Citation: Cell & Bioscience 2020 10:60

    Content type: Research

    Published on:

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