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  1. Lung cancer is a complex and heterogeneous disease characterized by abnormal growth and proliferation of lung cells. It is the leading cause of cancer-related deaths worldwide, accounting for approximately 18%...

    Authors: Ying Zou, Hongmei Zheng, Yue Ning, Yang Yang, Qiuyuan Wen and Songqing Fan
    Citation: Cell & Bioscience 2023 13:150
  2. N6-methyladenosine (m6A) modification is the most abundant reversible methylation modification in eukaryotes, and it is reportedly closely associated with a variety of cancers progression, including colorectal...

    Authors: Mujie Ye, Jinhao Chen, Feiyu Lu, Minghui Zhao, Suwen Wu, Chunhua Hu, Ping Yu, Jingbao Kan, Jianan Bai, Ye Tian and Qiyun Tang
    Citation: Cell & Bioscience 2023 13:148
  3. Pancreatic ductal adenocarcinoma (PDA) is a pernicious disease characterized by an immunosuppressive milieu that is unresponsive to current immunotherapies. Interleukin-1 receptor antagonist (IL-1Ra) is a natu...

    Authors: Yu-Ching Fan, Yu-Cin Fong, Chun-Tse Kuo, Chia-Wei Li, Wei-Yu Chen, Jian-Da Lin, Florian Bürtin, Michael Linnebacher, Quoc Thang Bui, Kuan-Der Lee and Yuan-Chin Tsai
    Citation: Cell & Bioscience 2023 13:147
  4. The oncoprotein KAI1 C-terminal interacting tetraspanin (KITENIN; vang-like 1) promotes cell metastasis, invasion, and angiogenesis, resulting in shorter survival times in cancer patients. Here, we aimed to de...

    Authors: Mücahit Varlı, Sung Jin Kim, Myung-Giun Noh, Yoon Gyoon Kim, Hyung-Ho Ha, Kyung Keun Kim and Hangun Kim
    Citation: Cell & Bioscience 2023 13:146
  5. Mouse embryonic stem cells (mESCs) not only retain the property of self-renewal but also have the ability to develop into primordial germ cell-like cells (PGCLCs). However, knowledge about the mechanisms of tr...

    Authors: Xiaofeng Li, Peng Chen, Junxiang Ji, Quanchao Duan, Jianjian Cao, Ru Huang and Shou-Dong Ye
    Citation: Cell & Bioscience 2023 13:145
  6. Standard neuropathologic analysis of Alzheimer’s brain relies on traditional fluorescence microscopy, which suffers from limited spatial resolution due to light diffraction. As a result, it fails to reveal int...

    Authors: Björn Johansson, Sho Oasa, Aida Muntsant Soria, Ann Tiiman, Linda Söderberg, Ebba Amandius, Christer Möller, Lars Lannfelt, Lars Terenius, Lydia Giménez-Llort and Vladana Vukojević
    Citation: Cell & Bioscience 2023 13:142
  7. The amyloid precursor protein (APP), a key player in Alzheimer’s disease (AD), is part of a larger gene family, including the APP like proteins APLP1 and APLP2. They share similar structures, form homo- and he...

    Authors: Sandra Schilling, Alexander August, Mathieu Meleux, Carolin Conradt, Luisa M. Tremmel, Sandra Teigler, Virginie Adam, Ulrike C. Müller, Edward H. Koo, Stefan Kins and Simone Eggert
    Citation: Cell & Bioscience 2023 13:141
  8. Parkinson’s disease (PD), a highly prevalent neuro-motor disorder is caused due to progressive loss of dopaminergic (DAergic) neurons at substantia nigra region of brain. This leads to depleted dopamine (DA) c...

    Authors: Rupsha Mondal, Chayan Banerjee, Sumangal Nandy, Moumita Roy and Joy Chakraborty
    Citation: Cell & Bioscience 2023 13:140
  9. The two most prevalent subtypes of epithelial ovarian carcinoma (EOC) are ovarian clear cell carcinoma (OCCC) and high-grade serous ovarian carcinoma (HGSC). Patients with OCCC have a poor prognosis than those...

    Authors: Dan Guo, Sumei Zhang, Yike Gao, Jinghua Shi, Xiaoxi Wang, Zixin Zhang, Yaran Zhang, Yuming Wang, Kun Zhao, Mei Li, Anqi Wang, Pan Wang, Yanqin Gou, Miao Zhang, Meiyu Liu, Yuhan Zhang…
    Citation: Cell & Bioscience 2023 13:139
  10. Gamma sensory stimulation may reduce AD-specific pathology. Yet, the efficacy of alternating electrical current stimulation in animal models of AD is unknown, and prior research has not addressed intensity-dep...

    Authors: Qian Liu, Adam Contreras, Muhammad Shan Afaq, Weijian Yang, Daniel K. Hsu, Michael Russell, Bruce Lyeth, Theodore P. Zanto and Min Zhao
    Citation: Cell & Bioscience 2023 13:138
  11. The blood–brain barrier (BBB) is a sophisticated structure whose full functionality is required for maintaining the executive functions of the central nervous system (CNS). Tight control of transport across th...

    Authors: Amit Sharma, Diogo C. Fernandes, Rui L. Reis, Dominika Gołubczyk, Silke Neumann, Barbara Lukomska, Miroslaw Janowski, Marcin Kortylewski, Piotr Walczak, J. Miguel Oliveira and Jarek Maciaczyk
    Citation: Cell & Bioscience 2023 13:137
  12. The absence of prominent, actionable genetic alternations in osteosarcomas (OS) implies that transcriptional and epigenetic mechanisms significantly contribute to the progression of this life-threatening form ...

    Authors: Young-Im Kim, Yu-Chou Tseng, Gamze Ayaz, Shasha Wang, Hualong Yan, Wendy du Bois, Howard Yang, Tao Zhen, Maxwell P. Lee, Paul Liu, Rosandra N. Kaplan and Jing Huang
    Citation: Cell & Bioscience 2023 13:136
  13. Genetics evidences have long linked mosaic loss of Y-chromosome (mLOY) in peripheral leukocytes with a wide range of male age-associated diseases. However, a lack of cellular and molecular mechanistic explanat...

    Authors: Xuehong Xu, Rong Zhou, Qinchun Duan, Yuanlin Miao, Tingting Zhang, Mofei Wang, Odell D. Jones and MengMeng Xu
    Citation: Cell & Bioscience 2023 13:135
  14. Dendritic spines are the sites of excitatory synapses on pyramidal neurons, and their development is crucial for neural circuits and brain functions. The spine shape, size, or number alterations are associated...

    Authors: Dongyan Ren, Bin Luo, Peng Chen, Lulu Yu, Mingtao Xiong, Zhiqiang Fu, Tian Zhou, Wen-Bing Chen and Erkang Fei
    Citation: Cell & Bioscience 2023 13:134
  15. Metastatic cancer cells exploit Epithelial-mesenchymal-transition (EMT) to enhance their migration, invasion, and resistance to treatments. Recent studies highlight that elevated levels of copper are implicate...

    Authors: Ensieh M. Poursani, Daniele Mercatelli, Prahlad Raninga, Jessica L. Bell, Federica Saletta, Felix V. Kohane, Daniel P. Neumann, Ye Zheng, Jourdin R. C. Rouaen, Toni Rose Jue, Filip T. Michniewicz, Piper Schadel, Erin Kasiou, Maria Tsoli, Giuseppe Cirillo, Shafagh Waters…
    Citation: Cell & Bioscience 2023 13:132
  16. Thoracic aortic aneurysm (TAA) is a serious condition that affects the aorta, characterized by the dilation of its first segment. The causes of TAA (e.g., age, hypertension, genetic syndromes) are heterogeneous a...

    Authors: Sara Rega, Floriana Farina, Silvia Bouhuis, Silvia de Donato, Mattia Chiesa, Paolo Poggio, Laura Cavallotti, Giorgia Bonalumi, Ilaria Giambuzzi, Giulio Pompilio and Gianluca L. Perrucci
    Citation: Cell & Bioscience 2023 13:131
  17. The temporomandibular joint (TMJ) is a complex joint consisting of the condyle, the temporal articular surface, and the articular disc. Functions such as mastication, swallowing and articulation are accomplish...

    Authors: Qianqi Zhu, Miaoying Tan, Chengniu Wang, Yufei Chen, Chenfei Wang, Junqi Zhang, Yijun Gu, Yuqi Guo, Jianpeng Han, Lei Li, Rongrong Jiang, Xudong Fan, Huimin Xie, Liang Wang, Zhifeng Gu, Dong Liu…
    Citation: Cell & Bioscience 2023 13:130
  18. How transcription factors (TFs) down-regulate gene expression remains ill-understood, especially when they bind to multiple enhancers contacting the same gene promoter. In particular, it is not known whether t...

    Authors: Fabienne Bejjani, Emilie Evanno, Samantha Mahfoud, Claire Tolza, Kazem Zibara, Marc Piechaczyk and Isabelle Jariel-Encontre
    Citation: Cell & Bioscience 2023 13:129
  19. Ectodysplasin-A (EDA), a skin-specific TNF ligand, interacts with its membrane receptor EDAR to trigger EDA signaling in skin appendage formation. Gene mutations in EDA signaling cause Anhidrotic/Hypohidrotic ...

    Authors: Yuyuan Yao, Ruihan Yang, Jian Zhu, David Schlessinger and Jian Sima
    Citation: Cell & Bioscience 2023 13:128
  20. Hepatic sinusoidal obstruction syndrome (HSOS) is caused by toxic injury, such as pyrrolizidine alkaloids, to the liver sinusoidal endothelial cells, and the gut microbiota may be involved. However, the specif...

    Authors: Haitao Shang, Chao Huang, Zhuanglong Xiao, Pengcheng Yang, Shengyan Zhang, Xiaohua Hou and Lei Zhang
    Citation: Cell & Bioscience 2023 13:127
  21. Hepatic fibrosis (HF) is a pathological process caused by excessive accumulation of extracellular matrix caused by a series of causes, leading to the formation of fiber scar. RNA methylation is a newly discove...

    Authors: Chenglong Cheng, Yajie Wu, Xin Wang, Qiuyun Xue, Yurong Huang, Faxue Liao, Xiao Wang, Qiangjun Duan and Chenggui Miao
    Citation: Cell & Bioscience 2023 13:126
  22. Cancer/testis (CT) antigens/genes are usually overexpressed in cancers and exhibit high immunogenicity, making them promising targets for immunotherapy and cancer vaccines. The role of serine protease PRSS56 i...

    Authors: Dandan Li, Lingyun Xia, Pan Huang, Zidi Wang, Qiwei Guo, Congcong Huang, Weidong Leng and Shanshan Qin
    Citation: Cell & Bioscience 2023 13:124
  23. Maintaining homeostasis of Ca2+ stores in the endoplasmic reticulum (ER) is crucial for proper Ca2+ signaling and key cellular functions. Although Ca2+ depletion has been known to cause ER stress which in turn ac...

    Authors: Song Zhao, Haiping Feng, Dongfang Jiang, Keyan Yang, Si-Tong Wang, Yu-Xin Zhang, Yun Wang, Hongmei Liu, Caixia Guo and Tie-Shan Tang
    Citation: Cell & Bioscience 2023 13:123
  24. Salivary carcinoma ex pleomorphic adenoma (CXPA) is defined as a carcinoma that develops from benign pleomorphic adenoma (PA). Abnormally activated Androgen signaling pathway and amplification of HER-2/neu(ERBB-2...

    Authors: Wanling Chen, Ting Gu, Qianqian Chen, Chuxiang Qu, Chunye Zhang, Yuhua Hu, Ronghui Xia, Ying Zhang, Min Wang, Xinyi Huang, Jiang Li, Chaoji Shi and Zhen Tian
    Citation: Cell & Bioscience 2023 13:122
  25. BRAFV600E comes as two main splicing variants. The well-studied ref isoform and the recently discovered X1 isoform are co-expressed in cancer cells and differ in terms of 3’UTR length and sequence, as well as ...

    Authors: Raffaella De Paolo, Samanta Sarti, Sara Bernardi, Francesco Cucco, Andrea Tavosanis, Letizia Pitto and Laura Poliseno
    Citation: Cell & Bioscience 2023 13:121
  26. Immune checkpoint inhibitors (ICIs) targeting CTLA-4 and PD-1/PD-L1 to boost tumor-specific T lymphocyte immunity have opened up new avenues for the treatment of various histological types of malignancies, wit...

    Authors: Bin Wang, Yin Han, Yuyu Zhang, Qin Zhao, Huanhuan Wang, Jinlong Wei, Lingbin Meng, Ying Xin and Xin Jiang
    Citation: Cell & Bioscience 2023 13:120
  27. Cones are essential for color recognition, high resolution, and central vision; therefore cone death causes blindness. Understanding the pathophysiology of each cell type in the retina is key to developing the...

    Authors: Nan-Kai Wang, Pei-Kang Liu, Yang Kong, Yun-Ju Tseng, Laura A. Jenny, Nicholas D. Nolan, Nelson Chen, Hung-Hsi Wang, Chun Wei Hsu, Wan-Chun Huang, Janet R. Sparrow, Chyuan-Sheng Lin and Stephen H. Tsang
    Citation: Cell & Bioscience 2023 13:119
  28. Artemisia argyi (A. argyi), also called Chinese mugwort, has been widely used to control pandemic diseases for thousands of years since ancient China due to its anti-microbial infection, anti-allergy, and anti-in...

    Authors: Fang-Ju Cheng, Chien-Yi Ho, Tzong-Shiun Li, Yeh Chen, Yi-Lun Yeh, Ya-Ling Wei, Thanh Kieu Huynh, Bo-Rong Chen, Hung-Yu Ko, Chen-Si Hsueh, Ming Tan, Yang-Chang Wu, Hui-Chi Huang, Chih-Hsin Tang, Chia-Hung Chen, Chih-Yen Tu…
    Citation: Cell & Bioscience 2023 13:118
  29. Hepatic liver disease, including primary sclerosing cholangitis (PSC), is a serious extraintestinal manifestations of colonic inflammation. Cyclic adenosine monophosphate (cAMP)-responsive element-binding prot...

    Authors: Sang-Hee Lee, Sung-Je Moon, Seung Hee Woo, Gwangsook Ahn, Won Kon Kim, Chul-Ho Lee and Jung Hwan Hwang
    Citation: Cell & Bioscience 2023 13:116
  30. Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) niche, which includes bone-forming and bone-resorbing cells, i.e., osteoblasts (OBs) and osteoclasts (OCs). OBs originate from mesenchymal progeni...

    Authors: Alessia Oppezzo, Lovely Monney, Henri Kilian, Lofti Slimani, Frédérique Maczkowiak-Chartois and Filippo Rosselli
    Citation: Cell & Bioscience 2023 13:115
  31. Transcription factor FOXM1 is a potential target for anti-cancer drug development. An interfering peptide M1-21, targeting FOXM1 and FOXM1-interacting proteins, is developed and its anti-cancer efficacy is eva...

    Authors: Haojie Cheng, Jie Yuan, Chaozhu Pei, Min Ouyang, Huitong Bu, Yan Chen, Xiaoqin Huang, Zhenwang Zhang, Li Yu and Yongjun Tan
    Citation: Cell & Bioscience 2023 13:114
  32. Acne is a chronic inflammatory skin disorder that profoundly impacts the quality of life of patients worldwide. While it is predominantly observed in adolescents, it can affect individuals across all age group...

    Authors: Cong Huang, Fan Zhuo, Baoquan Han, Wenting Li, Bin Jiang, Kaoyuan Zhang, Xingling Jian, Zhenzhen Chen, Hui Li, Haiyan Huang, Xia Dou and Bo Yu
    Citation: Cell & Bioscience 2023 13:113
  33. Pulmonary vein stenosis (PVS), one of the most challenging clinical problems in congenital heart disease, leads to secondary pulmonary arterial hypertension (PAH) and right ventricular (RV) hypertrophy. Due to...

    Authors: Debao Li, Lisheng Qiu, Haifa Hong, Hao Chen, Peibin Zhao, Yingying Xiao, Hao Zhang, Qi Sun and Lincai Ye
    Citation: Cell & Bioscience 2023 13:112
  34. The early accurate diagnoses for autoimmune encephalitis (AE) and infectious encephalitis (IE) are essential since the treatments for them are different. This study aims to discover some specific and sensitive...

    Authors: Siyuan Fan, Xiangyan He, Zhongyi Zhu, Lu Chen, Yijun Zou, Zhonglin Chen, Jialin Yu, Weijun Chen, Hongzhi Guan and Jinmin Ma
    Citation: Cell & Bioscience 2023 13:111
  35. Angiotensin II type 1 receptor (AT1R) is a promising therapeutic target for cardiovascular diseases. Compared with orthosteric ligands, allosteric modulators attract considerable attention for drug development...

    Authors: Xi Zhang, Suli Zhang, Meili Wang, Hao Chen and Huirong Liu
    Citation: Cell & Bioscience 2023 13:110
  36. Gene editing has emerged as an exciting therapeutic development platform for numerous genetic and nongenetic diseases. Targeting lipid-modulating genes such as angiopoietin-related protein 3 (ANGPTL3) with gene e...

    Authors: Yuanbojiao Zuo, Chen Zhang, Yuan Zhou, Haiwen Li, Weidong Xiao, Roland W. Herzog, Jie Xu, Jifeng Zhang, Y. Eugene Chen and Renzhi Han
    Citation: Cell & Bioscience 2023 13:109
  37. Various renal abnormalities, including hydronephrosis, polycystic kidney disease, and hydroureter, have been reported, and these abnormalities are present in DiGeorge syndrome, renal dysplasia, and acute kidne...

    Authors: Jong-Min Lee, Tae-Yang Lim, Sang-Bin Oh, Seung-Jun Lee, Yun Soo Bae and Han-Sung Jung
    Citation: Cell & Bioscience 2023 13:108
  38. Cisplatin is commonly used to treat cervical cancer while drug resistance limits its effectiveness. There is an urgent need to identify strategies that increase cisplatin sensitivity and improve the outcomes o...

    Authors: Xin Wang, Chen Cao, Xiangyu Tan, Xueyao Liao, Xiaofang Du, Xueqian Wang, Ting Liu, Danni Gong, Zheng Hu and Xun Tian
    Citation: Cell & Bioscience 2023 13:107
  39. Bile acids (BA) are important physiological molecules not only mediating nutrients absorption and metabolism in peripheral tissues, but exerting neuromodulation effect in the central nerve system (CNS). The ca...

    Authors: Chen Xing, Xin Huang, Dongxue Wang, Dengjun Yu, Shaojun Hou, Haoran Cui and Lung Song
    Citation: Cell & Bioscience 2023 13:106

    The Correction to this article has been published in Cell & Bioscience 2023 13:125

  40. Mesenchymal progenitors (MPs) are considered to play vital roles in bone development, growth, bone turnover, and repair. In recent years, benefiting from advanced approaches such as single-cell sequence, linea...

    Authors: Fangyuan Shen, Xiaobin Huang, Guangxu He and Yu Shi
    Citation: Cell & Bioscience 2023 13:105
  41. Neoadjuvant chemotherapy (NACT) becomes the first-line option for advanced tumors, while patients who are not sensitive to it may not benefit. Therefore, it is important to screen patients suitable for NACT.

    Authors: Qihai Sui, Zhengyang Hu, Xing Jin, Yunyi Bian, Jiaqi Liang, Huan Zhang, Huiqiang Yang, Zongwu Lin, Qun Wang, Cheng Zhan and Zhencong Chen
    Citation: Cell & Bioscience 2023 13:103

    The Correction to this article has been published in Cell & Bioscience 2023 13:133

  42. Free fatty acid receptors (FFARs) and toll-like receptors (TLRs) recognize microbial metabolites and conserved microbial products, respectively, and are functionally implicated in inflammation and cancer. Howe...

    Authors: Mi-Jeong Kim, Ji Young Kim, Ji Hye Shin, Yeeun Kang, Ji Su Lee, Juhee Son, Soo-Kyung Jeong, Daesik Kim, Duk-Hwan Kim, Eunyoung Chun and Ki-Young Lee
    Citation: Cell & Bioscience 2023 13:102
  43. Olfactory dysfunction is among the earliest non-motor symptoms of Parkinson’s disease (PD). As the foremost pathological hallmark, α-synuclein initiates the pathology in the olfactory pathway at the early stag...

    Authors: Xing-Yang Liu, Ke Wang, Xian-Hua Deng, Yi-Hua Wei, Rui Guo, Sui-Feng Liu, Yi-Fan Zhu, Jia-Jun Zhong, Jing-Yuan Zheng, Meng-Dan Wang, Qiu-Hong Ye, Jian-Quan He, Kai-Hang Guo, Jun-Rong Zhu, Shu-Qiong Huang, Ze-Xu Chen…
    Citation: Cell & Bioscience 2023 13:101
  44. PRPP synthase (PRPS) transfers the pyrophosphate groups from ATP to ribose-5-phosphate to produce 5-phosphate ribose-1-pyrophosphate (PRPP), a key intermediate in the biosynthesis of several metabolites includ...

    Authors: Guang-Ming Lu, Huan-Huan Hu, Chia-Chun Chang, Jiale Zhong, Xian Zhou, Chen-Jun Guo, Tianyi Zhang, Yi-Lan Li, Boqi Yin and Ji-Long Liu
    Citation: Cell & Bioscience 2023 13:100