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  1. Content type: Research

    A vital property of eukaryotic cells physiology is their rather quick response to variation of oxygen tension, mainly by a transcription factor known as hypoxia-inducible factor-1 (HIF-1). Aside from its trans...

    Authors: Elham Parandavar and Razieh Yazdanparast

    Citation: Cell & Bioscience 2017 7:52

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  2. Content type: Research Highlight

    Histone proteins and transcription factors (TFs) play critical roles in gene transcription and development of multicellular organisms. Although antibody mediated protein isolation couple with mass spectrometry...

    Authors: Yi Qiu and Suming Huang

    Citation: Cell & Bioscience 2017 7:49

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  3. Content type: Research highlight

    It is well known that too much sugar uptake causes many health problems, including diabetes and obesity (Lustig et al. in Nature 482:27–29, 2012). However, a team of researchers led by Dr. Wanjun Chen of the Nati...

    Authors: Yun-Bo Shi and Deling Yin

    Citation: Cell & Bioscience 2017 7:48

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  4. Content type: Research

    The main approach to treat HIV-1 infection is combination antiretroviral therapy (cART). Although cART is effective in reducing HIV-1 viral load and controlling disease progression, it has many side effects, a...

    Authors: Zhepeng Liu, Shuliang Chen, Xu Jin, Qiankun Wang, Kongxiang Yang, Chenlin Li, Qiaoqiao Xiao, Panpan Hou, Shuai Liu, Shaoshuai Wu, Wei Hou, Yong Xiong, Chunyan Kong, Xixian Zhao, Li Wu, Chunmei Li…

    Citation: Cell & Bioscience 2017 7:47

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  5. Content type: Research

    Human papillomavirus (HPV) has been identified as the primary etiologic factor of cervical cancer, the fourth leading cause of cancer death in females worldwide. We have previously shown that coadministration ...

    Authors: Andrew Yang, Shiwen Peng, Emily Farmer, Qi Zeng, Max A. Cheng, Xiaowu Pang, T. -C. Wu and Chien-Fu Hung

    Citation: Cell & Bioscience 2017 7:46

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  6. Content type: Research

    Burkholderia pseudomallei is an intracellular bacteria causing Melioidosis, the disease widely disseminates in Southeast Asia and Northern Australia. B. pseudomallei has ability to inv...

    Authors: Pattamaporn Joompa, Saranyoo Ponnikorn, Sittiruk Roytrakul and Sumalee Tungpradabkul

    Citation: Cell & Bioscience 2017 7:45

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  7. Content type: Research

    Ginkgetin aglycone (GA), a novel Ginkgo biloba extract (GBE) by acid hydrolysis and recrystallization, is characterized by higher liposolubility and antioxidation than classical GBEs. There is no study depicting ...

    Authors: Junwei Zhang, Suxia Yang, Fang Chen, Huicong Li and Baoping Chen

    Citation: Cell & Bioscience 2017 7:44

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  8. Content type: Letter to the Editor

    Current techniques for cell culture routinely use animal-derived components. Fetal bovine serum (FBS) is the most widely applied supplement, but it often displays significant batch-to-batch variations and is g...

    Authors: C. Castells-Sala, J. Martorell and M. Balcells

    Citation: Cell & Bioscience 2017 7:41

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  9. Content type: Research

    Mammalian folliculogenesis, maturation of the ovarian follicles, require both growth factors derived from oocyte and surrounding cells, including stromal cells. However, the mechanism by which stromal cells an...

    Authors: Shu Tan, Boya Feng, Mingzhu Yin, Huanjiao Jenny Zhou, Ge Lou, Weidong Ji, Yonghao Li and Wang Min

    Citation: Cell & Bioscience 2017 7:36

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  10. Content type: Review

    When hepatocytes are damaged severely, a variety of signaling pathways will be triggered by inflammatory factors and cytokines involving in the process of hepatic fibrosis. The microRNA (miRNA) family consists...

    Authors: Xue-Ping Jiang, Wen-Bing Ai, Lin-Yan Wan, Yan-Qiong Zhang and Jiang-Feng Wu

    Citation: Cell & Bioscience 2017 7:34

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  11. Content type: Research

    Disruption of blood–brain barrier (BBB) and subsequent infiltration of auto-reactive T lymphocytes are major characteristics of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). Kv1....

    Authors: Jie Huang, Song Han, Qi Sun, Yipeng Zhao, Junchen Liu, Xiaolu Yuan, Wenqian Mao, Biwen Peng, Wanhong Liu, Jun Yin and Xiaohua He

    Citation: Cell & Bioscience 2017 7:31

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  12. Content type: Research highlight

    Induced pluripotent stem cells (iPSCs) hold great promises in cell therapy. However, the potential safety issues have dampened the enthusiasm of their clinical development. One of the biggest concerns came fro...

    Authors: Hualong Yan, Yun-Bo Shi and Jing Huang

    Citation: Cell & Bioscience 2017 7:30

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  13. Content type: Review

    Human cancers results in large part from the accumulation of multiple mutations. The progression of premalignant cells is an evolutionary process in which mutations provide the fundamental driving force for ge...

    Authors: Jun Zou, Chen Wang, Xiangyi Ma, Edward Wang and Guang Peng

    Citation: Cell & Bioscience 2017 7:29

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  14. Content type: Research

    Chloroquine, a bitter tastant, inhibits Ca2+ signaling, resulting in suppression of B cell activation; however, the inhibitory mechanism remains unclear.

    Authors: Yi-Fan Wu, Ping Zhao, Xi Luo, Jin-Chao Xu, Lu Xue, Qi Zhou, Mingrui Xiong, Jinhua Shen, Yong-Bo Peng, Meng-Fei Yu, Weiwei Chen, Liqun Ma and Qing-Hua Liu

    Citation: Cell & Bioscience 2017 7:28

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  15. Content type: Research

    Bone degenerative disorders like osteoporosis may be initiated by age-related shifts in anabolic and catabolic responses that control bone homeostasis. Although there are studies suggesting that metabolic chan...

    Authors: Min Ling, Peixin Huang, Shamima Islam, Daniel P. Heruth, Xuanan Li, Li Qin Zhang, Ding-You Li, Zhaohui Hu and Shui Qing Ye

    Citation: Cell & Bioscience 2017 7:27

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  16. Content type: Research

    Natural killer (NK)T cells and conventional T cells share phenotypic characteristic however they differ in transcription factor requirements and functional properties. The role of histone modifying enzymes in ...

    Authors: Daniel Northrup, Ryoji Yagi, Kairong Cui, William R. Proctor, Chaochen Wang, Katarzyna Placek, Lance R. Pohl, Rongfu Wang, Kai Ge, Jinfang Zhu and Keji Zhao

    Citation: Cell & Bioscience 2017 7:25

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  17. Content type: Review

    Regulation of lineage specification and differentiation in embryonic stem (ES) cells can be achieved through the activation of endogenous signaling, an avenue for potential application in regenerative medicine...

    Authors: Katherine Dixon, Jihong Chen and Qiao Li

    Citation: Cell & Bioscience 2017 7:23

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  18. Content type: Research

    Oculocutaneous albinism (OCA) is an autosomal recessive disorder. A significant portion of OCA patients has been found with a single pathogenic variant either in the TYR or the OCA2 gene. Diagnostic sequencing of...

    Authors: Jackson Gao, Leera D’Souza, Keith Wetherby, Christian Antolik, Melissa Reeves, David R. Adams, Santa Tumminia and Xinjing Wang

    Citation: Cell & Bioscience 2017 7:22

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  19. Content type: Review

    Genome editing promises giant leaps forward in advancing biotechnology, agriculture, and basic research. The process relies on the use of sequence specific nucleases (SSNs) to make DNA double stranded breaks a...

    Authors: Aimee Malzahn, Levi Lowder and Yiping Qi

    Citation: Cell & Bioscience 2017 7:21

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  20. Content type: Research

    Curcumin is a major constituent of rhizomes of Curcuma longa that elicits beneficial effects for oxidative damage. The aim of this study was to investigate whether curcumin could attenuate hydrogen peroxide (H2O2

    Authors: Xiaobo Yang, Hong Jiang and Yao Shi

    Citation: Cell & Bioscience 2017 7:20

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  21. Content type: Research

    Parkinson disease (PD) is the most common movement disturbance characterized by the loss of dopaminergic (DA) neurons in midbrain. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is aberrantly ...

    Authors: Wei Liu, Qishun Zhang, Jianlei Zhang, Wujun Pan, Jingya Zhao and Yuming Xu

    Citation: Cell & Bioscience 2017 7:19

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  22. Content type: Research

    Colorectal cancer is a leading cause of cancer-related mortality worldwide, with Fluorouracil (5-FU)-based chemotherapy as the major treatment for advanced disease. Many patients with advanced colorectal cance...

    Authors: Lining Zhang, Ruolan Song, Dongsheng Gu, Xiaoli Zhang, Beiqin Yu, Bingya Liu and Jingwu Xie

    Citation: Cell & Bioscience 2017 7:17

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  23. Content type: Research

    Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide, and infection with hepatitis B virus (HBV) is a leading cause of HCC. Previous studies have demonstrated that expre...

    Authors: Qiushuang Xiong, Shaoshuai Wu, Jingwen Wang, Xianhuang Zeng, Jianwen Chen, Mingcong Wei, Haotong Guan, Chengpeng Fan, Lang Chen, Deyin Guo and Guihong Sun

    Citation: Cell & Bioscience 2017 7:16

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  24. Content type: Research

    Lysine-specific histone demethylase 1 (LSD1) modulates chromatin status through demethylation of H3K4 and H3K9. It has been demonstrated that LSD1 is hyperphosphorylated and dissociates from chromatin during m...

    Authors: Bin Peng, Ruifeng Shi, Weiwei Jiang, Yue-He Ding, Meng-Qiu Dong, Wei-Guo Zhu and Xingzhi Xu

    Citation: Cell & Bioscience 2017 7:15

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  25. Content type: Review

    Thyroid hormone (TH) signaling plays critical roles in the differentiation, growth, metabolism, and physiological function of all organs or tissues, including heart and skeletal muscle. Due to the significant ...

    Authors: Duo Zhang, Yan Li, Shengnan Liu, Yu-cheng Wang, Feifan Guo, Qiwei Zhai, Jingjing Jiang and Hao Ying

    Citation: Cell & Bioscience 2017 7:14

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  26. Content type: Review

    Persistent dysregulation of the DNA damage response and repair in cells causes genomic instability. The resulting genetic changes permit alterations in growth and proliferation observed in virtually all cancer...

    Authors: Anna Palovcak, Wenjun Liu, Fenghua Yuan and Yanbin Zhang

    Citation: Cell & Bioscience 2017 7:8

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  27. Content type: Research highlight

    Accumulating evidence implicates Zika virus (ZIKV) in pathogenesis of microcephaly in newborns and Guillain-Barré syndrome in adults. However, it remains unclear which viral proteins are responsible for these ...

    Authors: Michael Bukrinsky

    Citation: Cell & Bioscience 2017 7:12

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  28. Content type: Research

    The cereal cyst nematode (CCN, Heterodera avenae) is a devastating pathogen of wheat and barley crops in many countries. We aimed to prioritize genetic and molecular targets for H. avenae control via the powerful...

    Authors: Dan Yang, Changlong Chen, Qian Liu and Heng Jian

    Citation: Cell & Bioscience 2017 7:11

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  29. Content type: Research

    Human enterovirus 71 (EV71) causes severe hand, foot and mouse disease, accompanied by neurological complications. During the interaction between EV71 and the host, the virus subverts host cell machinery for i...

    Authors: Bingfei Zhou, Min Chu, Shanshan Xu, Xiong Chen, Yongjuan Liu, Zhihao Wang, Fengfeng Zhang, Song Han, Jun Yin, Biwen Peng, Xiaohua He and Wanhong Liu

    Citation: Cell & Bioscience 2017 7:7

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  30. Content type: Research

    HIV-1 protease (PR) is an essential enzyme for viral production. Thus, PR inhibitors (PIs) are the most effective class of anti-HIV drugs. However, the main challenge to the successful use of PI drugs in patie...

    Authors: Zsigmond Benko, Dong Liang, Ge Li, Robert T. Elder, Anindya Sarkar, Jun Takayama, Arun K. Ghosh and Richard Y. Zhao

    Citation: Cell & Bioscience 2017 7:5

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  31. Content type: Letter to the Editor

    Massive liquid crystal droplets have been found during embryonic development in more than twenty different tissues and organs, including the liver, brain and kidney. Liquid crystal deposits have also been iden...

    Authors: MengMeng Xu, Odell D. Jones, Liyang Wang, Xin Zhou, Harry G. Davis, Joseph L. Bryant, Jianjie Ma, Willian B. Isaacs and Xuehong Xu

    Citation: Cell & Bioscience 2017 7:3

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  32. Content type: Letter to the Editor

    Antimicrotubule agent vincristine (VCR) has long been known as an alternative treatment for frequent relapse nephrotic syndrome and steroid-dependent nephrotic syndrome (SDNS). However, the mechanism is unknow...

    Authors: Lei Yin, Youying Mao, Hejie Song, Ye Wang, Wei Zhou and Zhen Zhang

    Citation: Cell & Bioscience 2017 7:1

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