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  1. The discovery of novel biomarkers of stroke etiology would be most helpful in management of acute ischemic stroke patients. Recently, circular RNAs (circRNAs) have been proposed as candidate biomarkers of neur...

    Authors: Aiora Ostolaza, Idoia Blanco-Luquin, Amaya Urdánoz-Casado, Idoya Rubio, Alberto Labarga, Beatriz Zandio, Miren Roldán, Judith Martínez-Cascales, Sergio Mayor, María Herrera, Nuria Aymerich, Jaime Gallego, Roberto Muñoz and Maite Mendioroz

    Citation: Cell & Bioscience 2020 10:34

    Content type: Research

    Published on:

  3. Ovarian cancer is known as a serious malignancy that affects women’s reproductive tract and can considerably threat their health. A wide range of molecular mechanisms and genetic modifications have been involv...

    Authors: Asma Vafadar, Zahra Shabaninejad, Ahmad Movahedpour, Farzaneh Fallahi, Mona Taghavipour, Younes Ghasemi, Maryam Akbari, Alimohammad Shafiee, Sarah Hajighadimi, Sanaz Moradizarmehri, Ebrahim Razi, Amir Savardashtaki and Hamed Mirzaei

    Citation: Cell & Bioscience 2020 10:32

    Content type: Review

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  6. Common fragile sites (CFSs) are large chromosomal regions that exhibit breakage on metaphase chromosomes upon replication stress. They become preferentially unstable at the early stage of cancer development an...

    Authors: Shibo Li and Xiaohua Wu

    Citation: Cell & Bioscience 2020 10:29

    Content type: Review

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  7. The increasing prevalence of depression and diabetes mellitus has become a major public health problem worldwide. Studies have shown that people with diabetes are at a high risk of being diagnosed with depress...

    Authors: Danwen Wang, Hui Wang, Haixia Gao, Heng Zhang, Hua Zhang, Qiuling Wang and Zhiling Sun

    Citation: Cell & Bioscience 2020 10:28

    Content type: Review

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  8. Glutamate (Glu) is the predominant excitatory neurotransmitter in the central nervous system (CNS). Glutamatergic transmission is critical for controlling neuronal activity. In presynaptic neurons, Glu is stor...

    Authors: Xianchao Du, Jiashuo Li, Minghui Li, Xinxin Yang, Zhipeng Qi, Bin Xu, Wei Liu, Zhaofa Xu and Yu Deng

    Citation: Cell & Bioscience 2020 10:26

    Content type: Review

    Published on:

  9. Persistent infection with hepatitis B virus (HBV) accounts for the majority of hepatocellular carcinoma (HCC), but the molecular mechanisms underlying liver carcinogenesis are still not completely understood. ...

    Authors: Xiaoming Dai, Ruixue Huang, Sai Hu, Yao Zhou, Xiaoya Sun, Pucheng Gui, Zijian Yu and Pingkun Zhou

    Citation: Cell & Bioscience 2020 10:24

    Content type: Research

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  10. Mesenchymal stem cells (MSCs) have been extensively studied and implicated for the cell-based therapy in several diseases due to theirs immunomodulatory properties. Embryonic stem cells and induced-pluripotent...

    Authors: Shyam Kishor Sah, Gaurav Agrahari and Tae-Yoon Kim

    Citation: Cell & Bioscience 2020 10:22

    Content type: Review

    Published on:

  11. Cardiovascular diseases are currently the leading cause of death in humans. The high mortality of cardiac diseases is associated with myocardial ischemia and reperfusion (I/R). Recent studies have reported tha...

    Authors: Bifeng Yao, Xiaoya Wan, Xinbin Zheng, Ting Zhong, Jia Hu, Yu Zhou, Anna Qin, Yeshuo Ma and Deling Yin

    Citation: Cell & Bioscience 2020 10:20

    Content type: Research

    Published on:

  13. KIT mutations are the predominant driver mutations in gastrointestinal stromal tumors (GISTs), and targeted therapy against KIT has improved treatment outcome dramatically. However, gaining secondary mutation ...

    Authors: Guangrong Zhu, Jun Shi, Shaoting Zhang, Yue Guo, Ling Huang, Hui Zhao, Yideng Jiang and Jianmin Sun

    Citation: Cell & Bioscience 2020 10:16

    Content type: Research

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  14. γδ T cells are an important subset of T lymphocytes that play important roles in innate and adaptive immunity via the secretion of various cytokines. Previous studies have found that long noncoding RNAs (lncRN...

    Authors: Chuan Yang, Ting Feng, Fang Lin, Tinxiang Gong, Shuo Yang, Yuhong Tao and Hong Li

    Citation: Cell & Bioscience 2020 10:15

    Content type: Research

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  16. MicroRNAs or miRNAs are a component of the non-coding RNAs family which is engaged in many cellular functions such as cell proliferation, apoptosis, gene expression, signaling pathways, angiogenesis, and etc. ...

    Authors: Mona Taghavipour, Fatemeh Sadoughi, Hamed Mirzaei, Bahman Yousefi, Bahram Moazzami, Shahla Chaichian, Mohammad Ali Mansournia and Zatollah Asemi

    Citation: Cell & Bioscience 2020 10:12

    Content type: Review

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  17. Mesenchymal stem cells (MSCs) are considered the most promising seed cells for regenerative medicine because of their considerable therapeutic properties and accessibility. Fine-tuning of cell biological proce...

    Authors: Jianhan Ren, Delan Huang, Runze Li, Weicai Wang and Chen Zhou

    Citation: Cell & Bioscience 2020 10:11

    Content type: Review

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  19. Histone marks control many cellular processes including DNA damage repair. This review will focus primarily on the active histone mark H3K36me3 in the regulation of DNA damage repair and the maintenance of gen...

    Authors: Zhongxing Sun, Yanjun Zhang, Junqi Jia, Yuan Fang, Yin Tang, Hongfei Wu and Dong Fang

    Citation: Cell & Bioscience 2020 10:9

    Content type: Review

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  21. Poly(ADP-ribosyl)ation (PARylation) mediated by poly ADP-ribose polymerases (PARPs) plays a key role in DNA damage repair. Suppression of PARylation by PARP inhibitors impairs DNA damage repair and induces apo...

    Authors: Muzaffer Ahmad Kassab, Lily L. Yu and Xiaochun Yu

    Citation: Cell & Bioscience 2020 10:7

    Content type: Review

    Published on:

  23. Vascular calcification is the major reason for high mortality of cardiovascular complications for diabetes. Interleukin (IL)-1β has been implicated in this pathogenesis, but its precise role and clinical evide...

    Authors: Te-Chuan Chen, Chia-Kung Yen, Ying-Chen Lu, Chung-Sheng Shi, Rong-Ze Hsieh, Shun-Fu Chang and Cheng-Nan Chen

    Citation: Cell & Bioscience 2020 10:5

    Content type: Research

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  24. Plenty of long non-coding RNAs (lncRNAs) play vital roles in the progression of atherosclerosis. Small nucleolar RNA host gene 6 (SNHG6) is a well known lncRNA that is aberrantly high expressed in atherosclero...

    Authors: Haiyan Shan, Dawei Guo, Siyang Zhang, Huimeng Qi, Shen Liu, Yanmei Du, Yini He, Bofu Wang, Ming Xu and Xiaosong Yu

    Citation: Cell & Bioscience 2020 10:4

    Content type: Research

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  25. When a protein is covalently and irreversibly bound to DNA (i.e., a DNA–protein cross-link [DPC]), it may obstruct any DNA-based transaction, such as transcription and replication. DPC formation is very common...

    Authors: Huimin Zhang, Yun Xiong and Junjie Chen

    Citation: Cell & Bioscience 2020 10:3

    Content type: Review

    Published on:

  26. A two-stage method of obtaining viable human amniotic stem cells (hAMSCs) in large-scale is described. First, human amniotic stem cells are isolated via dual enzyme (collagenase II and DNAase I) digestion. Nex...

    Authors: Bi Foua Claude Alain Gohi, Xue-Ying Liu, Hong-Yan Zeng, Sheng Xu, Kouassi Marius Honore Ake, Xiao-Ju Cao, Kai-Min Zou and Sheila Namulondo

    Citation: Cell & Bioscience 2020 10:2

    Content type: Research

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  27. miRNAs, the smallest nucleotide molecules able to regulate gene expression at post transcriptional level, are found in both animals and plants being involved in fundamental processes for growth and development...

    Authors: Bernardetta Ledda, Laura Ottaggio, Alberto Izzotti, Samir G. Sukkar and Mariangela Miele

    Citation: Cell & Bioscience 2020 10:1

    Content type: Review

    Published on:

  28. Breast cancer is a most common type of cancer in women. Circular RNAs (circRNAs) are involved in cancer development and progression, but their roles and regulatory mechanisms are unclear in breast cancer. Our ...

    Authors: Zhongli Geng, Wei Wang, Hui Chen, Jianya Mao, Zhenguo Li and Jing Zhou

    Citation: Cell & Bioscience 2019 9:104

    Content type: Research

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  29. The failure of remodeling process that constantly regenerates effete, aged bone is highly associated with bone nonunion and degenerative bone diseases. Numerous studies have demonstrated that aspirin and other...

    Authors: Yong Xie, Meng Pan, Yanpan Gao, Licheng Zhang, Wei Ge and Peifu Tang

    Citation: Cell & Bioscience 2019 9:103

    Content type: Review

    Published on:

  30. Lung cancer is one of very important malignancies which are related to high mobility and mortality in the world. Despite several efforts for improving diagnosis and treatment strategies of lung cancer, finding...

    Authors: Hadis Fathizadeh and Zatollah Asemi

    Citation: Cell & Bioscience 2019 9:102

    Content type: Review

    Published on:

  31. Drosophila Prominin-like is a homolog of mammalian CD133, which is recognized as a biomarker for stem cells. The interacting proteins of CD133 and their biological functions remain elusive.

    Authors: Xuexiang Wang, Huimei Zheng, Zexiao Jia, Zhaoying Lei, Mengyao Li, Qianqian Zhuang, Hui Zhou, Yue Qiu, Yong Fu, Xiaohang Yang, Yongmei Xi and Qingfeng Yan

    Citation: Cell & Bioscience 2019 9:101

    Content type: Research

    Published on:

  32. PRC1 (Protein regulator of cytokinesis 1) regulates microtubules organization and functions as a novel regulator in Wnt/β-catenin signaling pathway. Wnt/β-catenin is involved in development of liver fibrosis (...

    Authors: Shenzong Rao, Jie Xiang, Jingsong Huang, Shangang Zhang, Min Zhang, Haoran Sun and Jian Li

    Citation: Cell & Bioscience 2019 9:100

    Content type: Research

    Published on:

  33. The cDNA Library of venomous animals could provide abundant bioactive peptides coding information and is an important resource for screening bioactive peptides that target and regulate disease-related ion chan...

    Authors: Yubiao Zhang, Feng Zhang, Shujuan Shi, Xinqiao Liu, Weisong Cai, Guangtao Han, Caihua Ke, Siru Long, Zhiyong Di, Shijin Yin and Haohuan Li

    Citation: Cell & Bioscience 2019 9:99

    Content type: Research

    Published on:

  35. Colorectal cancer (CRC) is the fourth leading cause of the worldwide cancer mortality. Different molecular mechanisms have been attributed to the development and progress of CRC. In this review, we will focus ...

    Authors: Zahra Koveitypour, Farnoush Panahi, Mehrdad Vakilian, Maryam Peymani, Farzad Seyed Forootan, Mohammad Hossein Nasr Esfahani and Kamran Ghaedi

    Citation: Cell & Bioscience 2019 9:97

    Content type: Review

    Published on:

  36. High levels of ROS cause oxidative stress, which plays a critical role in cell death. As a ROS effector protein, PRL2 senses ROS and controls phagocyte bactericidal activity during infection. Here we report PR...

    Authors: Xinyue Du, Yang Zhang, Xiao Li, Qi Li, Chenyun Wu, Guangjie Chen, XiaoKui Guo, Yongqiang Weng and Zhaojun Wang

    Citation: Cell & Bioscience 2019 9:96

    Content type: Research

    Published on:

  37. Along with the decline in oocyte quality, numerous defects such as mitochondrial insufficiency and the increase of mutation and deletion have been reported in oocyte mitochondrial DNA (mtDNA) following aging. ...

    Authors: Halimeh Mobarak, Mohammad Heidarpour, Pei-Shiue Jason Tsai, Aysa Rezabakhsh, Reza Rahbarghazi, Mohammad Nouri and Mahdi Mahdipour

    Citation: Cell & Bioscience 2019 9:95

    Content type: Review

    Published on:

  39. Forkhead box P3+ (FOXP3+) regulatory T cells (Tregs) are a subset of lymphocytes, critical for the maintenance of immune homeostasis. Loss-of-function mutations of the FOXP3 gene in animal models and humans resul...

    Authors: Vida Forstnerič, Irena Oven, Jernej Ogorevc, Duško Lainšček, Arne Praznik, Tina Lebar, Roman Jerala and Simon Horvat

    Citation: Cell & Bioscience 2019 9:93

    Content type: Research

    Published on:

  41. Imbalance between amyloid-beta (Aβ) peptide synthesis and clearance results in Aβ deregulation. Failure to clear these peptides appears to cause the development of Alzheimer’s disease (AD). In recent years, mi...

    Authors: Soheil Madadi, Heidi Schwarzenbach, Massoud Saidijam, Reza Mahjub and Meysam Soleimani

    Citation: Cell & Bioscience 2019 9:91

    Content type: Review

    Published on:

  43. Schizophrenia is a common psychiatric disease with high hereditary. The identification of schizophrenia risk genes (SRG) has shed light on its pathophysiological mechanisms. Mouse genetic models have been wide...

    Authors: Hai-Long Zhang, Jia-Wen Long, Wei Han, Jiuzhou Wang, Weichen Song, Guan Ning Lin and Dong-Min Yin

    Citation: Cell & Bioscience 2019 9:89

    Content type: Research

    Published on:

  44. Imatinib shows limited efficacy in patients with gastrointestinal stromal tumors (GISTs) carrying secondary KIT mutations. HQP1351, an orally bioavailable multikinase BCR-ABL inhibitor, is currently in clinica...

    Authors: Xuechao Liu, Guangfeng Wang, Xianglei Yan, Haibo Qiu, Ping Min, Miaoyi Wu, Chunyang Tang, Fei Zhang, Qiuqiong Tang, Saijie Zhu, Miaozhen Qiu, Wei Zhuang, Douglas D. Fang, Zhiwei Zhou, Dajun Yang and Yifan Zhai

    Citation: Cell & Bioscience 2019 9:88

    Content type: Research

    Published on:

  45. Overlap extension polymerase chain reaction (PCR) is a powerful technology for DNA assembly. Based on this technology, we synthesized DNA templates, which were transcribed into sgRNA in vitro, and further dete...

    Authors: Zheng Hu, Li Wang, Zhaoying Shi, Jing Jiang, Xiangning Li, Yonglong Chen, Kai Li and Dixian Luo

    Citation: Cell & Bioscience 2019 9:87

    Content type: Letter to the Editor

    Published on:

  46. Pregnancy-associated cardiomyopathy (PAH) represents a pregnancy-associated myocardial disease that is characterized by the progression of heart failure due to marked left ventricular systolic dysfunction. Com...

    Authors: Yi Wang, Zhiheng Guo, Yongmei Gao, Ping Liang, Yanhong Shan and Jin He

    Citation: Cell & Bioscience 2019 9:86

    Content type: Research

    Published on:

    The Correction to this article has been published in Cell & Bioscience 2020 10:61

  47. The growth plate is a special region of the cartilage that drives longitudinal growth of long bones. Proliferating chondrocytes in the growth plate, arranged in columns, divide perpendicular to the long axis o...

    Authors: Huiyan Gan, Wenqian Xue, Ya Gao, Guixia Zhu, Danny Chan, Kathryn S. E. Cheah and Jiandong Huang

    Citation: Cell & Bioscience 2019 9:85

    Content type: Research

    Published on:

  48. To investigate the mechanism of LncRNA H19 in Th17 cell differentiation and endometrial stromal cells (ESCs) proliferation in endometriosis (EMS).

    Authors: Zheying Liu, Liya Liu, Yun Zhong, Mingbo Cai, Junbi Gao, Chaoyue Tan, Xiaoxiao Han, Ruixia Guo and Liping Han

    Citation: Cell & Bioscience 2019 9:84

    Content type: Research

    Published on:

  49. Cellular heterogeneity, which was initially defined for tumor cells, is a fundamental property of all cellular systems, ranging from genetic diversity to cell-to-cell variation driven by stochastic molecular i...

    Authors: Gang Ren and Keji Zhao

    Citation: Cell & Bioscience 2019 9:83

    Content type: Review

    Published on:

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Cell & Bioscience

ISSN: 2045-3701

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