Antibody blockade of the PD-1/PD-L1 pathway has elicited durable antitumor responses in the therapy of a broad spectrum of cancers. PD-L1 is constitutively expressed in certain tumors and host immune cells, an...
Previous studies have shown that inhibition of inducible NO synthase (NOS2 or iNOS) with an inhibitor can selectively protect several normal tissues against radiation during radiotherapy. However, the role of ...
Authors: Chengcheng Li, Yi Luo, Lijian Shao, Aimin Meng and Daohong Zhou
Two studies have recently focused on adult heart regeneration in Xenopus. While we reported on cardiac myogenic regeneration in Xenopus tropicalis after injury, Marshall and colleagues found no regeneration in an...
Authors: Souqi Liao, Wenyan Dong, Hui Zhao, Ruijin Huang, Xufeng Qi and Dongqing Cai
We recently used an endoscopy-based resection method to explore the consequences of cardiac injury in adult Xenopus laevis, obtaining the result that the adult Xenopus heart is unable to regenerate. At 11 months ...
Authors: Lindsey Marshall, Fabrice Girardot, Barbara A. Demeneix and Laurent Coen
Antibodies to human CTLA-4 have been shown to induce long-lasting protection against melanoma. It is assumed that these antibodies cause tumor rejection by blocking negative signaling from the B7-CTLA-4 intera...
Authors: Fei Tang, Xuexiang Du, Mingyue Liu, Pan Zheng and Yang Liu
microRNAs (miRNAs) are one kind of small non-coding RNAs widely distributed in insects. Many studies have shown that miRNAs play critical roles in development, differentiation, apoptosis, and innate immunity. ...
Authors: Xinyu Feng, Jiatong Wu, Shuisen Zhou, Jingwen Wang and Wei Hu
Organ preservation solutions are designed to minimize organ damage during transplantation. A novel preservation solution, WMO-II, was developed to have a low viscosity and to improve microvasculature perfusion...
Authors: Sheng Wang, Kristyn Gumpper, Tao Tan, Xianzhang Luo, Hui Guo, Changsheng Ming, Hanying Jiang, Jiangguo Fang, Guang Du, Hua Zhu, Jianjie Ma, Zhishui Chen and Nianqiao Gong
Radiation injury combined wound (CI) enhances acute radiation syndrome and subsequently mortality as compared to radiation injury alone (RI). We previously reported that ghrelin (a 28-amino-acid-peptide secret...
Authors: Juliann G. Kiang, Marsha N. Anderson and Joan T. Smith
Innate immunity activator (INAVA) has been shown to be elevated in lung adenocarcinoma. However, its expression pattern and function in papillary thyroid cancer (PTC) are unknown. This study aimed to identify ...
Authors: Hongyu Guan, Yan Guo, Liehua Liu, Runyi Ye, Weiwei Liang, Hai Li, Haipeng Xiao and Yanbing Li
Although the study of calcium (Ca2+) is classically associated with excitable cells such as myocytes or neurons, the ubiquity of this essential element in all cellular processes has led to interest in other cell ...
Authors: MengMeng Xu, Andreas Seas, Musa Kiyani, Keven S. Y. Ji and Hannah N. Bell
Macrophages are traditionally viewed as a key component of the immunity defense system. Recent studies have identified resident macrophages in multiple organs including the heart, in which the cells perform th...
Authors: Xin Zhou, Zhongguang Li, Zefan Wang, Eda Chen, Juan Wang, Frederic Chen, Odell Jones, Tao Tan, Shawn Chen, Hiroshi Takeshima, Joseph Bryant, Jianjie Ma and Xuehong Xu
The acquisition of drug resistance has been considered as a main obstacle for cancer chemotherapy. Tumor protein 53 target gene 1 (TP53TG1), a p53-induced lncRNA, plays a vital role in the progression of human...
Authors: Huijuan Xiao, Yihe Liu, Pan Liang, Bo Wang, Hongna Tan, Yonggao Zhang, Xianzheng Gao and Jianbo Gao
Biomaterial modifications—chemical and topographical—are of particular importance for the integration of materials in biosystems. Cells are known to sense these biomaterial characteristics, but it has remained...
Authors: Susanne Staehlke, Henrike Rebl, Birgit Finke, Petra Mueller, Martina Gruening and J. Barbara Nebe
Paraquat (PQ) presents with high toxicity for humans and animals, and the lungs become the main target organ by the poisoning of PQ leading to acute lung injury. Endothelial progenitor cells (EPCs) were proved...
Authors: Yan Jin, Wei Liu, Xiaowei Liu, Tao Ma, Chen Yang, Quan Cai and Zhi Liu
Chronic inflammatory is involved in the development of salt-sensitive hypertension and other cardiovascular diseases. PSGL-1 plays an important role in the inflammatory response.
Authors: Yuhui Yang, Xue Liu, Yunpeng Liu, Hui Fu, Ying Gao, Xing Liu and Xiaoliang Jiang
Resveratrol (RSV) has been reported to stimulate osteoblast differentiation in which Wnt/β-catenin signaling pathway played a crucial role. However, whether and how RSV activated Wnt/β-catenin pathway in osteo...
Authors: Xuren Gao, Jian Ge, Weiyi Li, Wangchen Zhou and Lei Xu
In the publication of this article [1], there is an error in Table 3. The position of the black arrow and the terms CBP, Cdk1/2 and STAT3 of Table 3 were placed incorrectly in the online version while these we...
MicroRNAs have emerged as critical modulators of carcinogenesis and tumor progression including renal cell carcinoma (RCC). MiR-622 plays as a tumor inhibitor in some types of cancer, however, its role in kidn...
Prostate cancer (PrCa) progression and mortality are associated with calcium metabolism, parathyroid hormone level, and vitamin D level. However, the lack of comprehensive understanding on the molecular ration...
Authors: Liyang Wang, MengMeng Xu, Zhongguang Li, Mengting Shi, Xin Zhou, Xinnong Jiang, Joseph Bryant, Steven Balk, Jianjie Ma, William Isaacs and Xuehong Xu
Apoptosis of lung epithelial cell is implicated in the pathogenesis of acute lung injury (ALI). To study the protective effect and mechanism of cancer susceptibility candidate 2 (CASC2) on reducing lung epithe...
Authors: Hongbin Li, Huijuan Shi, Min Gao, Ning Ma and Rongqing Sun
Chronic hepatitis B (CHB) remains a global health dilemma with high morbidity and mortality. Human males absent on the first (hMOF) (a histone acetyltransferase) is responsible for DNA damage repair, tumorigen...
Authors: Liwen Chen, Chuanwu Zhu, Fengdi Li, Yun Wang, Rebecca Bao, Zhujun Cao, Xiaogang Xiang, Lei Yan, Lanyi Lin, Gangde Zhao, Qing Xie, Shisan Bao and Hui Wang
Histamine releasing factor (HRF) is a unique cytokine known to regulate a variety of immune cells in late allergic reactions. In the previous study, we revealed that the biologically active form of HRF is the ...
Precise genome editing is essential for both basic and translational research. The recently developed CRISPR/Cas9 system can specifically cleave a designated site of target gene to create a DNA double-strand b...
Rheumatoid arthritis (RA) is an auto-immune disease characterized by chronic inflammation of multiple joints. Hypoxia is a constant feature of synovial microenvironment in RA. Fibroblast-like synoviocytes (FLS...
Sepsis is a common cause of death in intensive care units worldwide. Due to the high complexity of this immunological syndrome development of novel therapeutic strategies is urgent. Promising drug targets or b...
ATP-binding cassette transporter super-family including ABCC1 and MDR-1 were involved in multi-drug resistance (MDR) of renal cell carcinoma (RCC) patients. Several miRNAs were confirmed to promote the MDR and...
Authors: Songchao Li, Jinjian Yang, Jun Wang, Wansheng Gao, Yafei Ding, Yinghui Ding and Zhankui Jia
Long noncoding RNAs (lncRNAs) are a class of non-protein-coding transcripts with the length longer than 200 nucleotides. Growing evidence suggests that lncRNAs, which were initially thought to be merely transc...
Authors: Yuyu Li, Jiawei Zhang, Jie Pan, Xu Feng, Peipei Duan, Xing Yin, Yang Xu, Xin Wang and Shujuan Zou
MAPT-AS1, a long non-coding RNA, has not been reported in any previous research about its function in cancers. In this study, we investigated the role of MAPT-AS1 in the progression and paclitaxel resistance i...
Authors: Yiyuan Pan, Yiqi Pan, Yue Cheng, Fan Yang, Zhihan Yao and Ouchen Wang
There have been enough cell death modes delineated in the biomedical literature to befuddle all cell death researchers. Mulling over cell death from the viewpoints of the host tissue or organ and of the host a...
Authors: Xingde Liu, Wenxiu Yang, Zhizhong Guan, Wenfeng Yu, Bin Fan, Ningzhi Xu and D. Joshua Liao
Promyelocytic leukemia protein (PML) was originally identified as a fusion partner of retinoic acid receptor alpha in acute promyelocytic leukemia patients with the (15;17) chromosomal translocation, giving ri...
Atherosclerosis, a chronic multi-factorial vascular disease, has become a predominant cause of a variety of cardiovascular disorders. miR-26a was previously reported to be involved in atherosclerosis progressi...
We investigated the genomic DNA methylation profile of prostate cancer in transgenic adenocarcinoma of the mouse prostate (TRAMP) cancer model and to analyze the crosstalk among targeted genes and the related ...
Authors: Wenji Li, Ying Huang, Davit Sargsyan, Tin Oo Khor, Yue Guo, Limin Shu, Anne Yuqing Yang, Chengyue Zhang, Ximena Paredes-Gonzalez, Michael Verzi, Ronald P. Hart and Ah-Ng Kong
Extracellular vesicles (EVs) play important roles in intercellular communication through the delivery of their cargoes, which include proteins, lipids, and RNAs. Increasingly, multiple studies have reported th...
Authors: Chuang Li, Fang Qin, Fen Hu, Hui Xu, Guihong Sun, Guang Han, Tao Wang and Mingxiong Guo
The metastasis of colorectal cancer frequently tends to liver, which is one of the three leading causes of cancer-related deaths worldwide. Growing evidence showed that aspirin could effectively inhibit liver ...
Authors: Jun Ying, Hai-yang Zhou, Peng Liu, Qing You, Fei Kuang, Yi-nan Shen and Zhi-qian Hu
The aim of this study is to determine the effect of hypoxia on axitinib and sorafenib-treated renal cell carcinoma (RCC) cells. Hypoxia is a crucial factor influencing transcription process via protein modulat...
Authors: Zofia F. Bielecka, Agata Malinowska, Klaudia K. Brodaczewska, Aleksandra Klemba, Claudine Kieda, Paweł Krasowski, Elżbieta Grzesiuk, Jan Piwowarski, Anna M. Czarnecka and Cezary Szczylik
Myocardium regeneration in adult mammals is very limited, but has enormous therapeutic potentials. However, we are far from complete understanding the cellular and molecular mechanisms by which heart tissue ca...
Osteoarthritis (OA) is a chronic joint disease and there is no a definitive cure at present. Long non-coding RNAs (lncRNAs) have been confirmed to play important roles in the development of OA. However, the un...
Neural stem cells (NSCs) are able to differentiate into neurons and astroglia. miRNAs have been demonstrated to be involved in NSC self-renewal, proliferation and differentiation. However, the exact role of mi...
Authors: Shujie Jiao, Yaling Liu, Yaobing Yao and Junfang Teng
A gasotransmitter hydrogen sulfide (H2S) plays an important physiological and pathological role in cardiovascular system. Ischemic post-conditioning (PC) provides cardioprotection in the young hearts but not in t...
Authors: Weiming Sun, Jinxia Yang, Yuanzhou Zhang, Yuxin Xi, Xin Wen, Di Yuan, Yuehong Wang, Can Wei, Rui Wang, Lingyun Wu, Hongzhu Li and Changqing Xu
Defects of the growth arrest DNA damage-inducible gene 45β (Gadd45β) play an important role in the progression of tumor and confer resistance to chemotherapy. However, the role of Gadd45β in the apoptosis of h...
Long non-coding RNA growth arrest-specific transcript 5 (lncRNA GAS5) is a well-known tumor suppressor in the pathogenesis of a variety of human cancers. The precise role of GAS5 in pancreatic cancer (PC) prog...
Authors: Zhi-Qiang Gao, Jun-feng Wang, De-Hua Chen, Xue-Song Ma, Yang Wu, Zhe Tang and Xiao-Wei Dang
Numerous recent studies indicate that the long non-coding RNAs (lncRNAs) are frequently abnormal expressed and take critical roles in many cancers. Renal cell carcinoma is the secondary malignant tumors in the...
Authors: Haowei He, Nana Wang, Xiaoming Yi, Chaopeng Tang and Dong Wang
S100A4, an important member of the S100 family of proteins, is best known for its significant role in promoting cancer progression and metastasis. In addition to its expression in tumors, upregulation of S100A...
Authors: Fei Fei, Jie Qu, Chunyuan Li, Xinlu Wang, Yuwei Li and Shiwu Zhang
Cancer, the main cause of human deaths in the modern world is a group of diseases. Anticancer drug discovery is a challenge for scientists because of involvement of multiple survival pathways of cancer cells. ...
Cancer is a complex disease without a unified explanation for its cause so far. Our recent work demonstrates that cancer cells share similar regulatory networks and characteristics with embryonic neural cells....
Specific and selective peptidic blockers of Kv1.3 channels can serve as a valuable drug lead for treating T cell-mediated autoimmune diseases, and scorpion venom is an important source of kv1.3 channel inhibit...
Authors: Yan Zou, Feng Zhang, Yaxian Li, Yuanfang Wang, Yi Li, Zhengtao Long, Shujuan Shi, Li Shuai, Jiukai Liu, Zhiyong Di and Shijin Yin
Multiple sclerosis (MS) is a severe neurological disorder, characterized by demyelination of the central nervous system (CNS), and with a prevalence of greater than 2 million people worldwide. In terms of rese...
Authors: Qili Yu, Ryan Hui, Jiyoung Park, Yangyang Huang, Alexander W. Kusnecov, Cheryl F. Dreyfus and Renping Zhou
The 14-3-3 family of proteins have been reported to play an important role in development in various mouse models, but the context specific developmental functions of 14-3-3ζ remain to be determined. In this s...
Authors: Jun Yang, Sonali Joshi, Qingfei Wang, Ping Li, Hai Wang, Yan Xiong, Yi Xiao, Jinyang Wang, Jan Parker-Thornburg, Richard R. Behringer and Dihua Yu
Interferonε (IFNε) is a unique type I IFN that has distinct functions from IFNα/β. IFNε is constitutively expressed at mucosal tissues, including the female genital mucosa, and is reported to be modulated by e...
Authors: Jennifer Couret, Carley Tasker, Jaeha Kim, Tiina Sihvonen, Saahil Fruitwala, Alison J. Quayle, Pierre Lespinasse, Debra S. Heller and Theresa L. Chang
Diffuse intrinsic pontine glioma is an infiltrative, often high-grade glioma of the brainstem that is not amenable to surgical resection. The current treatment of DIPG by radiation therapy showed dramatically ...
Authors: Yaqin Zhang, Weijie Dong, Junying Zhu, Lizhu Wang, Xinjian Wu and Hong Shan
