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  1. For decades, cancer metastasis has been a heated topic for its high mortality. Previous research has shown that pre-metastatic niche and metastatic niche are the 2 crucial steps in cancer metastasis, assisting...

    Authors: Jianan Zhuyan, Mingyu Chen, Tianhao Zhu, Xunxia Bao, Timing Zhen, Kaichen Xing, Qiubo Wang and Sibo Zhu

    Citation: Cell & Bioscience 2020 10:89

    Content type: Review

    Published on:

  2. Mesenchymal stem/stromal cells (MSCs) and macrophages are critical components in many tissue microenvironments, including that in adipose tissue. The close interaction between MSCs and macrophages modulates va...

    Authors: Hui Ma, Ya-nan Li, Lin Song, Rui Liu, Xiaolei Li, Qianwen Shang, Ying Wang, Changshun Shao and Yufang Shi

    Citation: Cell & Bioscience 2020 10:88

    Content type: Research

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  3. The correct folding is a key process for a protein to acquire its functional structure and conformation. Prefoldin is a well-known chaperone protein that regulates the correct folding of proteins. Prefoldin pl...

    Authors: Jiaxin Liang, Longzheng Xia, Linda Oyang, Jinguan Lin, Shiming Tan, Pin Yi, Yaqian Han, Xia Luo, Hui Wang, Lu Tang, Qing Pan, Yutong Tian, Shan Rao, Min Su, Yingrui Shi, Deliang Cao…

    Citation: Cell & Bioscience 2020 10:87

    Content type: Review

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  4. With the acceleration of urbanization and aging and the change of lifestyle, inflammatory diseases have become one of the important threats to the health of the global population. Matrix metalloproteinases (MM...

    Authors: Jie He, Man Qin, Yingyi Chen, Ziqi Hu, Fei Xie, Ling Ye and Tianqian Hui

    Citation: Cell & Bioscience 2020 10:86

    Content type: Review

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  5. The chemokine receptor CCR5 is one of the co-receptor of HIV-1 infection. People with homozygous CCR5Δ32 deletion resist HIV-1 infection, which makes the CCR5 an important target for HIV-1 gene therapy. Although ...

    Authors: Zhepeng Liu, Jin Liang, Shuliang Chen, Kewu Wang, Xianhao Liu, Beibei Liu, Yang Xia, Mingxiong Guo, Xiaoshi Zhang, Guihong Sun and Geng Tian

    Citation: Cell & Bioscience 2020 10:85

    Content type: Research

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  7. Hepatocellular carcinoma (HCC) is one of the most malignant tumor types and has a high incidence and mortality. Many miRNAs play important roles in the development of HCC. Identification of these miRNAs and th...

    Authors: Li Hui, Fang Zheng, Yuan Bo, Ma Sen-lin, Li Ai-jun, Zhou Wei-ping, Zhang Yong-jie and Yin Lei

    Citation: Cell & Bioscience 2020 10:83

    Content type: Research

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  8. Long intergenic noncoding RNA p21 was mapped on the human chromosome 6p21.2. Accordingly, it was firstly described by promoting the p53-dependent apoptosis in the mouse. Also, it is a new lncRNA playing some v...

    Authors: Roya Amirinejad, Mina Rezaei and Zeinab Shirvani-Farsani

    Citation: Cell & Bioscience 2020 10:82

    Content type: Review

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  10. Recent evidences demonstrate that dysregulated expression of microRNA-320d (miR-320d) has been associated with several cancer development and progression. However the effect of miR-320d on gastric cardiac aden...

    Authors: Xiaojie Chen, Shegan Gao, Zhiwei Zhao, Gaofeng Liang, Jinyu Kong and Xiaoshan Feng

    Citation: Cell & Bioscience 2020 10:80

    Content type: Research

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  11. Ischemic stroke poses a severe risk to human health worldwide, and currently, clinical therapies for the disease are limited. Delta opioid receptor (DOR)-mediated neuroprotective effects against ischemia have ...

    Authors: Zelin Lai, Lingling Gu, Lu Yu, Huifen Chen, Zhenhua Yu, Cheng Zhang, Xiaoqing Xu, Mutian Zhang, Min Zhang, Mingliang Ma, Zheng Zhao and Jun Zhang

    Citation: Cell & Bioscience 2020 10:79

    Content type: Research

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  12. The X-linked inhibitor of apoptosis protein (XIAP) is the most potent caspase inhibitor of the IAP family in apoptosis pathway. This study aims to identify the molecular targets of XIAP in human breast cancer ...

    Authors: Mehdi Agha Gholizadeh, Fatemeh T. Shamsabadi, Ahad Yamchi, Masoud Golalipour, Gagan Deep Jhingan and Majid Shahbazi

    Citation: Cell & Bioscience 2020 10:78

    Content type: Research

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  13. MicroRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression at the post-transcriptional level and play critical roles in regulating physiological function, and are becoming worldwide ...

    Authors: Juanjuan Zhao, Ya Zhou, Mengmeng Guo, Dongxu Yue, Chao Chen, Guiyou Liang and Lin Xu

    Citation: Cell & Bioscience 2020 10:77

    Content type: Review

    Published on:

  14. Colorectal cancer (CRC) is the fourth most deadly malignancy throughout the world. Extensive studies have shown that Krüppel-like factors (KLFs) play essential roles in cancer development. However, the functio...

    Authors: Weilong Yao, Yue Jiao, Yanhua Zhou and Xiaoya Luo

    Citation: Cell & Bioscience 2020 10:76

    Content type: Research

    Published on:

  15. Stem cell-based regenerative medicine is a promising approach for tissue reconstruction. However, a large number of cells are needed in a typical clinical study, where conventional monolayer cultures might pos...

    Authors: Benson Koh, Nadiah Sulaiman, Mh Busra Fauzi, Jia Xian Law, Min Hwei Ng, Ruszymah Bt Hj Idrus and Muhammad Dain Yazid

    Citation: Cell & Bioscience 2020 10:75

    Content type: Review

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  17. Interleukin-17A (IL-17) is an evolutionary conserved cytokine and best known for its role in boosting immune response. However, recent clinical researches showed that abundant IL-17 in tumor microenvironment w...

    Authors: Shijia Wang, Guan Wang, Liying Zhang, Fengying Li, Keli Liu, Ying Wang, Yufang Shi and Kai Cao

    Citation: Cell & Bioscience 2020 10:73

    Content type: Research

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  18. Arginine vasopressin (AVP) is elevated in patients with heart failure, and the increase in the AVP concentration in plasma is positively correlated with disease severity and mortality. Metoprolol (Met) is a be...

    Authors: Jieqiong Zhao, Yonghong Lei, Yanping Yang, Haibo Gao, Zhongchao Gai and Xue Li

    Citation: Cell & Bioscience 2020 10:72

    Content type: Research

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  19. Acute Liver failure (ALF) is a life-threatening disease and is determined by coagulopathy (with INR ≥ 1.5) and hepatic encephalopathy as a result of severe liver injury in patients without preexisting liver di...

    Authors: Mahshid Saleh, Mohammad Taher, Amir Ali Sohrabpour, Amir Abbas Vaezi, Mohsen Nasiri Toosi, Maria Kavianpour, Zeinab Ghazvinian, Shahrokh Abdolahi and Javad Verdi

    Citation: Cell & Bioscience 2020 10:71

    Content type: Review

    Published on:

  20. Herpesvirus is ranked as one of the grand old members of all pathogens. Of all the viruses in the superfamily, Herpes simplex virus type 1 (HSV-1) is considered as a model virus for a variety of reasons. In a ...

    Authors: Qiaojuan Zhang, Miguel Martin-Caraballo and Shaochung V. Hsia

    Citation: Cell & Bioscience 2020 10:70

    Content type: Review

    Published on:

  21. Mesenchymal stem cells (MSCs) were known to have excellent properties in cell therapy. However, the risk of immune rejection associated with cell transplant therapy hampers its use. Extracellular vesicles secr...

    Authors: Jiaxin Cai, Junyong Wu, Jiemin Wang, Yongjiang Li, Xiongbin Hu, Shifu Luo and Daxiong Xiang

    Citation: Cell & Bioscience 2020 10:69

    Content type: Review

    Published on:

  23. Teleost fishes account for over half of extant vertebrate species. A core question in biology is how genomic changes drive phenotypic diversity that relates to the origin of teleost fishes.

    Authors: Yibin Cheng, Dantong Shang, Majing Luo, Chunhua Huang, Fengling Lai, Xin Wang, Xu Xu, Ruhong Ying, Lingling Wang, Yu Zhao, Li Zhang, Manyuan Long, Hanhua Cheng and Rongjia Zhou

    Citation: Cell & Bioscience 2020 10:67

    Content type: Research

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  25. Mesenchymal stromal cells (MSCs) are multiple stromal cells existing in various tissues and have already been employed in animal models and clinical trials to treat immune disorders through potent immunosuppre...

    Authors: Menghui Jiang, Jiayin Ye, Xuefeng Wang, Na Li, Ying Wang and Yufang Shi

    Citation: Cell & Bioscience 2020 10:65

    Content type: Research

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  26. Eukaryotic cells demonstrate two tightly linked vesicular transport systems, comprising intracellular vesicle transport and extracellular vesicle transport system. Intracellular transport vesicles can transloc...

    Authors: Leila Salimi, Ali Akbari, Nassrollah Jabbari, Behnam Mojarad, Ali Vahhabi, Sławomir Szafert, Sadegh Asghari Kalashani, Hamid Soraya, Muhammad Nawaz and Jafar Rezaie

    Citation: Cell & Bioscience 2020 10:64

    Content type: Review

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  27. Compared to radiation injury alone (RI), radiation injury combined wound (CI) further enhances acute radiation syndrome and subsequently mortality. We previously reported that therapy with Ghrelin, the 28-amin...

    Authors: Juliann G. Kiang, Joan T. Smith, Georgetta Cannon, Marsha N. Anderson, Connie Ho, Min Zhai, Wanchang Cui and Mang Xiao

    Citation: Cell & Bioscience 2020 10:63

    Content type: Research

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  28. Following publication of the original article [1], one of the funding was missing in the Funding section.

    Authors: Sheng Wang, Kristyn Gumpper, Tao Tan, Xianzhang Luo, Hui Guo, Changsheng Ming, Hanying Jiang, Jiangguo Fang, Guang Du, Hua Zhu, Jianjie Ma, Zhishui Chen and Nianqiao Gong

    Citation: Cell & Bioscience 2020 10:62

    Content type: Correction

    Published on:

    The original article was published in Cell & Bioscience 2018 8:28

  29. Following publication of the original article [1], the authors identified an error in Figs. 1b, 5b.

    Authors: Yi Wang, Zhiheng Guo, Yongmei Gao, Ping Liang, Yanhong Shan and Jin He

    Citation: Cell & Bioscience 2020 10:61

    Content type: Correction

    Published on:

    The original article was published in Cell & Bioscience 2019 9:86

  30. Thyroid hormone (T3) plays an important role in vertebrate development. Compared to the postembryonic development of uterus-enclosed mammalian embryos, T3-dependent amphibian metamorphosis is advantageous for ...

    Authors: Wonho Na, Liezhen Fu, Nga Luu and Yun-Bo Shi

    Citation: Cell & Bioscience 2020 10:60

    Content type: Research

    Published on:

  31. The benefit of inducing cellular senescence as a tumor suppressive strategy remains questionable due to the senescence-associated secretory phenotype. Hence, studies and development of senolytic compounds that...

    Authors: Thanakorn Pungsrinont, Malika Franziska Sutter, Maren C. C. M. Ertingshausen, Gopinath Lakshmana, Miriam Kokal, Amir Saeed Khan and Aria Baniahmad

    Citation: Cell & Bioscience 2020 10:59

    Content type: Research

    Published on:

  32. The freshwater snail Oncomelania hupensis is the obligate intermediate host for Schistosoma japonicum in China. Transcriptomic examination of snail–schistosome interactions can provide valuable information of hos...

    Authors: Xinyu Feng, Lingqian Zhu, Zhiqiang Qin, Xiaojin Mo, Yuwan Hao, Ying Jiang, Wei Hu and Shizhu Li

    Citation: Cell & Bioscience 2020 10:58

    Content type: Research

    Published on:

  33. Forced polyploidization is an effective strategy for acute megakaryoblastic leukemia (AMKL) therapy and factors controlling polyploidization are potential targets for drug development. Although bone morphology...

    Authors: Manman Wang, Tan Zhang, Xuechun Zhang, Zhou Jiang, Min Peng and Zan Huang

    Citation: Cell & Bioscience 2020 10:57

    Content type: Research

    Published on:

  34. Radiation damage to normal tissues is a serious concern. P53 is a well-known transcription factor which is closely associated with radiation-induced cell damage. Increasing evidence has indicated that regulati...

    Authors: Ruixue Huang, Xiaodan Liu, He Li, Yao Zhou and Ping-Kun Zhou

    Citation: Cell & Bioscience 2020 10:56

    Content type: Research

    Published on:

  35. In the past 30 years, incidences of non-alcoholic fatty liver disease (NAFLD) has risen by 30%. However, there is still no clear mechanism or accurate method of anticipating liver failure. Here we reveal the p...

    Authors: Liyang Wang, MengMeng Xu, Odell D. Jones, Zhongguang Li, Yu Liang, Qiuxia Yu, Jiali Li, Yajun Wu, Xinjuan Lei, Boling He, Huimin Yue, Liqin Xiao, Rong Zhou, Wei Zhang, Xin Zhou, Yuhui Zhang…

    Citation: Cell & Bioscience 2020 10:55

    Content type: Research

    Published on:

  37. Exocytosis is a process by which vesicles are transported to and fused with specific areas of the plasma membrane. Although several studies have shown that sphingolipids are the main components of exocytic com...

    Authors: Qingguo Guo, Tianrui Zhang, Na Meng, Yuran Duan, Yuan Meng, Dong Sun, Ying Liu and Guangzuo Luo

    Citation: Cell & Bioscience 2020 10:53

    Content type: Research

    Published on:

  38. Thanks to the advancement in science and technology and a significant number of cancer research programs being carried out throughout the world, the prevention, prognosis and treatment of breast cancer are imp...

    Authors: Debparna Nandy, Sruthy Manuraj Rajam and Debasree Dutta

    Citation: Cell & Bioscience 2020 10:52

    Content type: Review

    Published on:

  39. Fndc5, a well-defined myokine and also identified as an adipokine, has a critical role in modulation of metabolism and protection against obesity. These important functions are mediated by irisin, a secretory ...

    Authors: Farzaneh Rabiee, Liana Lachinani, Sarvenaz Ghaedi, Mohammad Hossein Nasr-Esfahani, Timothy L. Megraw and Kamran Ghaedi

    Citation: Cell & Bioscience 2020 10:51

    Content type: Review

    Published on:

  40. OTUB1 (ovarian tumor domain protease domain-containing ubiquitin aldehyde-binding proteins)-mediated deubiquitination of FOXM1 (Forkhead box M1) participates in carcinogenesis of various tumors. We aim to inve...

    Authors: Kai Zhou, Haixing Mai, Song Zheng, Weizhong Cai, Xu Yang, Zhenlin Chen and Bin Zhan

    Citation: Cell & Bioscience 2020 10:50

    Content type: Research

    Published on:

  45. Switching microglial polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype represents a novel therapeutic strategy for neuropathic pain (NP). This study aims to investigate ...

    Authors: Xianwei Gui, Hansen Wang, Lanxiang Wu, Sheng Tian, Xuan Wang, Heqing Zheng and Wei Wu

    Citation: Cell & Bioscience 2020 10:45

    Content type: Research

    Published on:

  47. Induction of biliary epithelial cell apoptosis by toxic bile acids is involved in the development of cholestatic disease, but the underlying molecular mechanism is not clear. The purpose of this study was to i...

    Authors: Jiye Li, Dongsheng Yu, Sanyang Chen, Yifan Liu, Jihua Shi, Jiakai Zhang, Peihao Wen, Zhihui Wang, Jie Li, Wenzhi Guo and Shuijun Zhang

    Citation: Cell & Bioscience 2020 10:43

    Content type: Research

    Published on:

  48. Microglia-mediated neuroinflammation is associated with epilepsy. Switching microglial polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype represents a novel therapeutic s...

    Authors: Lin Liu, Yingtong Xu, Hongmei Dai, Shan Tan, Xiao Mao and Zhiheng Chen

    Citation: Cell & Bioscience 2020 10:42

    Content type: Research

    Published on:

  50. Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an ongoing global health emergency. Here we highlight nine most important research questions concer...

    Authors: Kit-San Yuen, Zi -Wei Ye, Sin-Yee Fung, Chi-Ping Chan and Dong-Yan Jin

    Citation: Cell & Bioscience 2020 10:40

    Content type: Research Highlight

    Published on:

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