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Research
Oculocutaneous albinism (OCA) is an autosomal recessive disorder. A significant portion of OCA patients has been found with a single pathogenic variant either in the TYR or the OCA2 gene. Diagnostic sequencing of...
Cell & Bioscience 2017 7:22
Published on: 26 April 2017
Review
Genome editing promises giant leaps forward in advancing biotechnology, agriculture, and basic research. The process relies on the use of sequence specific nucleases (SSNs) to make DNA double stranded breaks a...
Cell & Bioscience 2017 7:21
Published on: 24 April 2017
Research
Curcumin is a major constituent of rhizomes of Curcuma longa that elicits beneficial effects for oxidative damage. The aim of this study was to investigate whether curcumin could attenuate hydrogen peroxide (H2O2
Cell & Bioscience 2017 7:20
Published on: 21 April 2017
Research
Parkinson disease (PD) is the most common movement disturbance characterized by the loss of dopaminergic (DA) neurons in midbrain. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is aberrantly ...
Cell & Bioscience 2017 7:19
Published on: 21 April 2017
Research
Persistent fetal vasculature (PFV) is a congenital developmental anomaly of the eye that accounts for about 5% of childhood blindness. The molecular mechanism of PFV remains unclear. As a glycosyltransferase o...
Cell & Bioscience 2017 7:18
Published on: 17 April 2017
Research
Colorectal cancer is a leading cause of cancer-related mortality worldwide, with Fluorouracil (5-FU)-based chemotherapy as the major treatment for advanced disease. Many patients with advanced colorectal cance...
Cell & Bioscience 2017 7:17
Published on: 13 April 2017
Research
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide, and infection with hepatitis B virus (HBV) is a leading cause of HCC. Previous studies have demonstrated that expre...
Cell & Bioscience 2017 7:16
Published on: 12 April 2017
Research
Lysine-specific histone demethylase 1 (LSD1) modulates chromatin status through demethylation of H3K4 and H3K9. It has been demonstrated that LSD1 is hyperphosphorylated and dissociates from chromatin during m...
Cell & Bioscience 2017 7:15
Published on: 23 March 2017
Review
Thyroid hormone (TH) signaling plays critical roles in the differentiation, growth, metabolism, and physiological function of all organs or tissues, including heart and skeletal muscle. Due to the significant ...
Cell & Bioscience 2017 7:14
Published on: 21 March 2017
Review
Thyroid hormone (T3) has been suggested to participate in the regulation of herpesvirus replication during reactivation. Clinical observations and in vivo experiments suggest that T3 are involved in the suppressi...
Cell & Bioscience 2017 7:13
Published on: 21 March 2017
Review
Persistent dysregulation of the DNA damage response and repair in cells causes genomic instability. The resulting genetic changes permit alterations in growth and proliferation observed in virtually all cancer...
Cell & Bioscience 2017 7:8
Published on: 22 February 2017
Review
As a key enzyme for gene expression, RNA polymerase II (pol II) reads along the DNA template and catalyzes accurate mRNA synthesis during transcription. On the other hand, genomic DNA is under constant attack ...
Cell & Bioscience 2017 7:9
Published on: 22 February 2017
Research highlight
Accumulating evidence implicates Zika virus (ZIKV) in pathogenesis of microcephaly in newborns and Guillain-Barré syndrome in adults. However, it remains unclear which viral proteins are responsible for these ...
Cell & Bioscience 2017 7:12
Published on: 20 February 2017
Research
The cereal cyst nematode (CCN, Heterodera avenae) is a devastating pathogen of wheat and barley crops in many countries. We aimed to prioritize genetic and molecular targets for H. avenae control via the powerful...
Cell & Bioscience 2017 7:11
Published on: 14 February 2017
Editorial
Cell & Bioscience 2017 7:10
Published on: 31 January 2017
Research
Human enterovirus 71 (EV71) causes severe hand, foot and mouse disease, accompanied by neurological complications. During the interaction between EV71 and the host, the virus subverts host cell machinery for i...
Cell & Bioscience 2017 7:7
Published on: 14 January 2017
Review
DNA double-strand breaks (DSBs) are the most deleterious type of DNA damage in cells arising from endogenous and exogenous attacks on the genomic DNA. Timely and properly repair of DSBs is important for genomi...
Cell & Bioscience 2017 7:6
Published on: 13 January 2017
Research
HIV-1 protease (PR) is an essential enzyme for viral production. Thus, PR inhibitors (PIs) are the most effective class of anti-HIV drugs. However, the main challenge to the successful use of PI drugs in patie...
Cell & Bioscience 2017 7:5
Published on: 11 January 2017
Research
Osteogenic differentiation of mesenchymal stem cells has been extensively investigated with regards to different aspects, including the analysis of cell intracellular and extracellular proteome, cell gene expr...
Cell & Bioscience 2017 7:2
Published on: 3 January 2017
Research
Zfp819, a member of the Krüppel-associated box (KRAB) family, encodes a spermatogenic cell-specific transcription factor. Zfp819-overexpression induces apoptosis and inhibits prolifera...
Cell & Bioscience 2017 7:4
Published on: 3 January 2017
Letter to the Editor
Antimicrotubule agent vincristine (VCR) has long been known as an alternative treatment for frequent relapse nephrotic syndrome and steroid-dependent nephrotic syndrome (SDNS). However, the mechanism is unknow...
Cell & Bioscience 2017 7:1
Published on: 3 January 2017
Letter to the Editor
Massive liquid crystal droplets have been found during embryonic development in more than twenty different tissues and organs, including the liver, brain and kidney. Liquid crystal deposits have also been iden...
Cell & Bioscience 2017 7:3
Published on: 3 January 2017
Review
The addition of mono-ubiquitin or poly-ubiquitin chain to signaling proteins in response to DNA damage signal is thought to be a critical event that facilitates the recognition of DNA damage lesion site, the a...
Cell & Bioscience 2016 6:62
Published on: 20 December 2016
Research
Rhabdomyosarcoma (RMS) originates from skeletal muscle precursors that fail to differentiate. Hedgehog (Hh) signaling and primary cilia contribute to the pathobiology of RMS.
Cell & Bioscience 2016 6:61
Published on: 12 December 2016
Review
The generation of mutants and transgenes are indispensible for biomedical research. In the nematode Caenorhabditis elegans, a series of methods have been developed to introduce genome modifications, including ran...
Cell & Bioscience 2016 6:60
Published on: 8 December 2016
