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  1. Thyroid hormone (T3) plays an important role in vertebrate development. Compared to the postembryonic development of uterus-enclosed mammalian embryos, T3-dependent amphibian metamorphosis is advantageous for ...

    Authors: Wonho Na, Liezhen Fu, Nga Luu and Yun-Bo Shi

    Citation: Cell & Bioscience 2020 10:60

    Content type: Research

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  2. The benefit of inducing cellular senescence as a tumor suppressive strategy remains questionable due to the senescence-associated secretory phenotype. Hence, studies and development of senolytic compounds that...

    Authors: Thanakorn Pungsrinont, Malika Franziska Sutter, Maren C. C. M. Ertingshausen, Gopinath Lakshmana, Miriam Kokal, Amir Saeed Khan and Aria Baniahmad

    Citation: Cell & Bioscience 2020 10:59

    Content type: Research

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  3. The freshwater snail Oncomelania hupensis is the obligate intermediate host for Schistosoma japonicum in China. Transcriptomic examination of snail–schistosome interactions can provide valuable information of hos...

    Authors: Xinyu Feng, Lingqian Zhu, Zhiqiang Qin, Xiaojin Mo, Yuwan Hao, Ying Jiang, Wei Hu and Shizhu Li

    Citation: Cell & Bioscience 2020 10:58

    Content type: Research

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  4. Forced polyploidization is an effective strategy for acute megakaryoblastic leukemia (AMKL) therapy and factors controlling polyploidization are potential targets for drug development. Although bone morphology...

    Authors: Manman Wang, Tan Zhang, Xuechun Zhang, Zhou Jiang, Min Peng and Zan Huang

    Citation: Cell & Bioscience 2020 10:57

    Content type: Research

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  5. Radiation damage to normal tissues is a serious concern. P53 is a well-known transcription factor which is closely associated with radiation-induced cell damage. Increasing evidence has indicated that regulati...

    Authors: Ruixue Huang, Xiaodan Liu, He Li, Yao Zhou and Ping-Kun Zhou

    Citation: Cell & Bioscience 2020 10:56

    Content type: Research

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  6. In the past 30 years, incidences of non-alcoholic fatty liver disease (NAFLD) has risen by 30%. However, there is still no clear mechanism or accurate method of anticipating liver failure. Here we reveal the p...

    Authors: Liyang Wang, MengMeng Xu, Odell D. Jones, Zhongguang Li, Yu Liang, Qiuxia Yu, Jiali Li, Yajun Wu, Xinjuan Lei, Boling He, Huimin Yue, Liqin Xiao, Rong Zhou, Wei Zhang, Xin Zhou, Yuhui Zhang…

    Citation: Cell & Bioscience 2020 10:55

    Content type: Research

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  7. Exocytosis is a process by which vesicles are transported to and fused with specific areas of the plasma membrane. Although several studies have shown that sphingolipids are the main components of exocytic com...

    Authors: Qingguo Guo, Tianrui Zhang, Na Meng, Yuran Duan, Yuan Meng, Dong Sun, Ying Liu and Guangzuo Luo

    Citation: Cell & Bioscience 2020 10:53

    Content type: Research

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  8. Thanks to the advancement in science and technology and a significant number of cancer research programs being carried out throughout the world, the prevention, prognosis and treatment of breast cancer are imp...

    Authors: Debparna Nandy, Sruthy Manuraj Rajam and Debasree Dutta

    Citation: Cell & Bioscience 2020 10:52

    Content type: Review

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  9. Fndc5, a well-defined myokine and also identified as an adipokine, has a critical role in modulation of metabolism and protection against obesity. These important functions are mediated by irisin, a secretory ...

    Authors: Farzaneh Rabiee, Liana Lachinani, Sarvenaz Ghaedi, Mohammad Hossein Nasr-Esfahani, Timothy L. Megraw and Kamran Ghaedi

    Citation: Cell & Bioscience 2020 10:51

    Content type: Review

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  10. OTUB1 (ovarian tumor domain protease domain-containing ubiquitin aldehyde-binding proteins)-mediated deubiquitination of FOXM1 (Forkhead box M1) participates in carcinogenesis of various tumors. We aim to inve...

    Authors: Kai Zhou, Haixing Mai, Song Zheng, Weizhong Cai, Xu Yang, Zhenlin Chen and Bin Zhan

    Citation: Cell & Bioscience 2020 10:50

    Content type: Research

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  11. Switching microglial polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype represents a novel therapeutic strategy for neuropathic pain (NP). This study aims to investigate ...

    Authors: Xianwei Gui, Hansen Wang, Lanxiang Wu, Sheng Tian, Xuan Wang, Heqing Zheng and Wei Wu

    Citation: Cell & Bioscience 2020 10:45

    Content type: Research

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  12. Induction of biliary epithelial cell apoptosis by toxic bile acids is involved in the development of cholestatic disease, but the underlying molecular mechanism is not clear. The purpose of this study was to i...

    Authors: Jiye Li, Dongsheng Yu, Sanyang Chen, Yifan Liu, Jihua Shi, Jiakai Zhang, Peihao Wen, Zhihui Wang, Jie Li, Wenzhi Guo and Shuijun Zhang

    Citation: Cell & Bioscience 2020 10:43

    Content type: Research

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  13. Microglia-mediated neuroinflammation is associated with epilepsy. Switching microglial polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype represents a novel therapeutic s...

    Authors: Lin Liu, Yingtong Xu, Hongmei Dai, Shan Tan, Xiao Mao and Zhiheng Chen

    Citation: Cell & Bioscience 2020 10:42

    Content type: Research

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  14. Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an ongoing global health emergency. Here we highlight nine most important research questions concer...

    Authors: Kit-San Yuen, Zi -Wei Ye, Sin-Yee Fung, Chi-Ping Chan and Dong-Yan Jin

    Citation: Cell & Bioscience 2020 10:40

    Content type: Research Highlight

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  15. Fanconi anemia (FA) is a recessive genetic disorder caused by biallelic mutations in at least one of 22 FA genes. Beyond its pathological presentation of bone marrow failure and congenital abnormalities, FA is...

    Authors: Wenjun Liu, Anna Palovcak, Fang Li, Alyan Zafar, Fenghua Yuan and Yanbin Zhang

    Citation: Cell & Bioscience 2020 10:39

    Content type: Review

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  16. Kawasaki disease (KD) is one of the major causes of heart disease and vasculitis in children under 5 years old in the world. Clinical evidence has shown that coronary artery calcification may develop in KD pat...

    Authors: Shun-Fu Chang, Shih-Feng Liu, Cheng-Nan Chen and Ho-Chang Kuo

    Citation: Cell & Bioscience 2020 10:36

    Content type: Research

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  17. Poly(ADP-ribose) polymerase (PARP) inhibitors represent one of the successful novel approaches to targeted cancer treatment. Indeed, the US Food and Drug Administration (FDA) has recently approved PARP inhibit...

    Authors: Mausam Patel, Somaira Nowsheen, Sanjay Maraboyina and Fen Xia

    Citation: Cell & Bioscience 2020 10:35

    Content type: Review

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  18. The discovery of novel biomarkers of stroke etiology would be most helpful in management of acute ischemic stroke patients. Recently, circular RNAs (circRNAs) have been proposed as candidate biomarkers of neur...

    Authors: Aiora Ostolaza, Idoia Blanco-Luquin, Amaya Urdánoz-Casado, Idoya Rubio, Alberto Labarga, Beatriz Zandio, Miren Roldán, Judith Martínez-Cascales, Sergio Mayor, María Herrera, Nuria Aymerich, Jaime Gallego, Roberto Muñoz and Maite Mendioroz

    Citation: Cell & Bioscience 2020 10:34

    Content type: Research

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  19. Ovarian cancer is known as a serious malignancy that affects women’s reproductive tract and can considerably threat their health. A wide range of molecular mechanisms and genetic modifications have been involv...

    Authors: Asma Vafadar, Zahra Shabaninejad, Ahmad Movahedpour, Farzaneh Fallahi, Mona Taghavipour, Younes Ghasemi, Maryam Akbari, Alimohammad Shafiee, Sarah Hajighadimi, Sanaz Moradizarmehri, Ebrahim Razi, Amir Savardashtaki and Hamed Mirzaei

    Citation: Cell & Bioscience 2020 10:32

    Content type: Review

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  20. Common fragile sites (CFSs) are large chromosomal regions that exhibit breakage on metaphase chromosomes upon replication stress. They become preferentially unstable at the early stage of cancer development an...

    Authors: Shibo Li and Xiaohua Wu

    Citation: Cell & Bioscience 2020 10:29

    Content type: Review

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  21. The increasing prevalence of depression and diabetes mellitus has become a major public health problem worldwide. Studies have shown that people with diabetes are at a high risk of being diagnosed with depress...

    Authors: Danwen Wang, Hui Wang, Haixia Gao, Heng Zhang, Hua Zhang, Qiuling Wang and Zhiling Sun

    Citation: Cell & Bioscience 2020 10:28

    Content type: Review

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  22. Glutamate (Glu) is the predominant excitatory neurotransmitter in the central nervous system (CNS). Glutamatergic transmission is critical for controlling neuronal activity. In presynaptic neurons, Glu is stor...

    Authors: Xianchao Du, Jiashuo Li, Minghui Li, Xinxin Yang, Zhipeng Qi, Bin Xu, Wei Liu, Zhaofa Xu and Yu Deng

    Citation: Cell & Bioscience 2020 10:26

    Content type: Review

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  23. Persistent infection with hepatitis B virus (HBV) accounts for the majority of hepatocellular carcinoma (HCC), but the molecular mechanisms underlying liver carcinogenesis are still not completely understood. ...

    Authors: Xiaoming Dai, Ruixue Huang, Sai Hu, Yao Zhou, Xiaoya Sun, Pucheng Gui, Zijian Yu and Pingkun Zhou

    Citation: Cell & Bioscience 2020 10:24

    Content type: Research

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  24. Mesenchymal stem cells (MSCs) have been extensively studied and implicated for the cell-based therapy in several diseases due to theirs immunomodulatory properties. Embryonic stem cells and induced-pluripotent...

    Authors: Shyam Kishor Sah, Gaurav Agrahari and Tae-Yoon Kim

    Citation: Cell & Bioscience 2020 10:22

    Content type: Review

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  25. Cardiovascular diseases are currently the leading cause of death in humans. The high mortality of cardiac diseases is associated with myocardial ischemia and reperfusion (I/R). Recent studies have reported tha...

    Authors: Bifeng Yao, Xiaoya Wan, Xinbin Zheng, Ting Zhong, Jia Hu, Yu Zhou, Anna Qin, Yeshuo Ma and Deling Yin

    Citation: Cell & Bioscience 2020 10:20

    Content type: Research

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  26. KIT mutations are the predominant driver mutations in gastrointestinal stromal tumors (GISTs), and targeted therapy against KIT has improved treatment outcome dramatically. However, gaining secondary mutation ...

    Authors: Guangrong Zhu, Jun Shi, Shaoting Zhang, Yue Guo, Ling Huang, Hui Zhao, Yideng Jiang and Jianmin Sun

    Citation: Cell & Bioscience 2020 10:16

    Content type: Research

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  27. γδ T cells are an important subset of T lymphocytes that play important roles in innate and adaptive immunity via the secretion of various cytokines. Previous studies have found that long noncoding RNAs (lncRN...

    Authors: Chuan Yang, Ting Feng, Fang Lin, Tinxiang Gong, Shuo Yang, Yuhong Tao and Hong Li

    Citation: Cell & Bioscience 2020 10:15

    Content type: Research

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  28. MicroRNAs or miRNAs are a component of the non-coding RNAs family which is engaged in many cellular functions such as cell proliferation, apoptosis, gene expression, signaling pathways, angiogenesis, and etc. ...

    Authors: Mona Taghavipour, Fatemeh Sadoughi, Hamed Mirzaei, Bahman Yousefi, Bahram Moazzami, Shahla Chaichian, Mohammad Ali Mansournia and Zatollah Asemi

    Citation: Cell & Bioscience 2020 10:12

    Content type: Review

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  29. Mesenchymal stem cells (MSCs) are considered the most promising seed cells for regenerative medicine because of their considerable therapeutic properties and accessibility. Fine-tuning of cell biological proce...

    Authors: Jianhan Ren, Delan Huang, Runze Li, Weicai Wang and Chen Zhou

    Citation: Cell & Bioscience 2020 10:11

    Content type: Review

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  30. Histone marks control many cellular processes including DNA damage repair. This review will focus primarily on the active histone mark H3K36me3 in the regulation of DNA damage repair and the maintenance of gen...

    Authors: Zhongxing Sun, Yanjun Zhang, Junqi Jia, Yuan Fang, Yin Tang, Hongfei Wu and Dong Fang

    Citation: Cell & Bioscience 2020 10:9

    Content type: Review

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  31. Poly(ADP-ribosyl)ation (PARylation) mediated by poly ADP-ribose polymerases (PARPs) plays a key role in DNA damage repair. Suppression of PARylation by PARP inhibitors impairs DNA damage repair and induces apo...

    Authors: Muzaffer Ahmad Kassab, Lily L. Yu and Xiaochun Yu

    Citation: Cell & Bioscience 2020 10:7

    Content type: Review

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  32. Vascular calcification is the major reason for high mortality of cardiovascular complications for diabetes. Interleukin (IL)-1β has been implicated in this pathogenesis, but its precise role and clinical evide...

    Authors: Te-Chuan Chen, Chia-Kung Yen, Ying-Chen Lu, Chung-Sheng Shi, Rong-Ze Hsieh, Shun-Fu Chang and Cheng-Nan Chen

    Citation: Cell & Bioscience 2020 10:5

    Content type: Research

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  33. When a protein is covalently and irreversibly bound to DNA (i.e., a DNA–protein cross-link [DPC]), it may obstruct any DNA-based transaction, such as transcription and replication. DPC formation is very common...

    Authors: Huimin Zhang, Yun Xiong and Junjie Chen

    Citation: Cell & Bioscience 2020 10:3

    Content type: Review

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