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  1. Content type: Research

    Histamine releasing factor (HRF) is a unique cytokine known to regulate a variety of immune cells in late allergic reactions. In the previous study, we revealed that the biologically active form of HRF is the ...

    Authors: Heewon Lee and Kyunglim Lee

    Citation: Cell & Bioscience 2018 8:13

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  2. Content type: Research

    Chronic hepatitis B (CHB) remains a global health dilemma with high morbidity and mortality. Human males absent on the first (hMOF) (a histone acetyltransferase) is responsible for DNA damage repair, tumorigen...

    Authors: Liwen Chen, Chuanwu Zhu, Fengdi Li, Yun Wang, Rebecca Bao, Zhujun Cao, Xiaogang Xiang, Lei Yan, Lanyi Lin, Gangde Zhao, Qing Xie, Shisan Bao and Hui Wang

    Citation: Cell & Bioscience 2018 8:14

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  3. Content type: Research

    Precise genome editing is essential for both basic and translational research. The recently developed CRISPR/Cas9 system can specifically cleave a designated site of target gene to create a DNA double-strand b...

    Authors: Zheng Hu, Zhaoying Shi, Xiaogang Guo, Baishan Jiang, Guo Wang, Dixian Luo, Yonglong Chen and Yuan-Shan Zhu

    Citation: Cell & Bioscience 2018 8:12

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  4. Content type: Research

    Rheumatoid arthritis (RA) is an auto-immune disease characterized by chronic inflammation of multiple joints. Hypoxia is a constant feature of synovial microenvironment in RA. Fibroblast-like synoviocytes (FLS...

    Authors: Ru Yang, Yanhua Yao and Panjun Wang

    Citation: Cell & Bioscience 2018 8:11

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  5. Content type: Review

    Sepsis is a common cause of death in intensive care units worldwide. Due to the high complexity of this immunological syndrome development of novel therapeutic strategies is urgent. Promising drug targets or b...

    Authors: Katharina Rump and Michael Adamzik

    Citation: Cell & Bioscience 2018 8:10

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  6. Content type: Research

    ATP-binding cassette transporter super-family including ABCC1 and MDR-1 were involved in multi-drug resistance (MDR) of renal cell carcinoma (RCC) patients. Several miRNAs were confirmed to promote the MDR and...

    Authors: Songchao Li, Jinjian Yang, Jun Wang, Wansheng Gao, Yafei Ding, Yinghui Ding and Zhankui Jia

    Citation: Cell & Bioscience 2018 8:9

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  7. Content type: Review

    Long noncoding RNAs (lncRNAs) are a class of non-protein-coding transcripts with the length longer than 200 nucleotides. Growing evidence suggests that lncRNAs, which were initially thought to be merely transc...

    Authors: Yuyu Li, Jiawei Zhang, Jie Pan, Xu Feng, Peipei Duan, Xing Yin, Yang Xu, Xin Wang and Shujuan Zou

    Citation: Cell & Bioscience 2018 8:8

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  8. Content type: Research

    MAPT-AS1, a long non-coding RNA, has not been reported in any previous research about its function in cancers. In this study, we investigated the role of MAPT-AS1 in the progression and paclitaxel resistance i...

    Authors: Yiyuan Pan, Yiqi Pan, Yue Cheng, Fan Yang, Zhihan Yao and Ouchen Wang

    Citation: Cell & Bioscience 2018 8:7

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  9. Content type: Review

    There have been enough cell death modes delineated in the biomedical literature to befuddle all cell death researchers. Mulling over cell death from the viewpoints of the host tissue or organ and of the host a...

    Authors: Xingde Liu, Wenxiu Yang, Zhizhong Guan, Wenfeng Yu, Bin Fan, Ningzhi Xu and D. Joshua Liao

    Citation: Cell & Bioscience 2018 8:6

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  10. Content type: Review

    Promyelocytic leukemia protein (PML) was originally identified as a fusion partner of retinoic acid receptor alpha in acute promyelocytic leukemia patients with the (15;17) chromosomal translocation, giving ri...

    Authors: Kuo-Sheng Hsu and Hung-Ying Kao

    Citation: Cell & Bioscience 2018 8:5

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    The Correction to this article has been published in Cell & Bioscience 2018 8:18

  11. Content type: Research

    We investigated the genomic DNA methylation profile of prostate cancer in transgenic adenocarcinoma of the mouse prostate (TRAMP) cancer model and to analyze the crosstalk among targeted genes and the related ...

    Authors: Wenji Li, Ying Huang, Davit Sargsyan, Tin Oo Khor, Yue Guo, Limin Shu, Anne Yuqing Yang, Chengyue Zhang, Ximena Paredes-Gonzalez, Michael Verzi, Ronald P. Hart and Ah-Ng Kong

    Citation: Cell & Bioscience 2018 8:3

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  12. Content type: Research

    Extracellular vesicles (EVs) play important roles in intercellular communication through the delivery of their cargoes, which include proteins, lipids, and RNAs. Increasingly, multiple studies have reported th...

    Authors: Chuang Li, Fang Qin, Fen Hu, Hui Xu, Guihong Sun, Guang Han, Tao Wang and Mingxiong Guo

    Citation: Cell & Bioscience 2018 8:2

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  13. Content type: Research

    The metastasis of colorectal cancer frequently tends to liver, which is one of the three leading causes of cancer-related deaths worldwide. Growing evidence showed that aspirin could effectively inhibit liver ...

    Authors: Jun Ying, Hai-yang Zhou, Peng Liu, Qing You, Fei Kuang, Yi-nan Shen and Zhi-qian Hu

    Citation: Cell & Bioscience 2018 8:1

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  14. Content type: Research

    The aim of this study is to determine the effect of hypoxia on axitinib and sorafenib-treated renal cell carcinoma (RCC) cells. Hypoxia is a crucial factor influencing transcription process via protein modulat...

    Authors: Zofia F. Bielecka, Agata Malinowska, Klaudia K. Brodaczewska, Aleksandra Klemba, Claudine Kieda, Paweł Krasowski, Elżbieta Grzesiuk, Jan Piwowarski, Anna M. Czarnecka and Cezary Szczylik

    Citation: Cell & Bioscience 2017 7:71

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  15. Content type: Research

    Myocardium regeneration in adult mammals is very limited, but has enormous therapeutic potentials. However, we are far from complete understanding the cellular and molecular mechanisms by which heart tissue ca...

    Authors: Souqi Liao, Wenyan Dong, Luocheng Lv, Hongyan Guo, Jifeng Yang, Hui Zhao, Ruijin Huang, Ziqiang Yuan, Yilin Chen, Shanshan Feng, Xin Zheng, Junqi Huang, Weihuan Huang, Xufeng Qi and Dongqing Cai

    Citation: Cell & Bioscience 2017 7:70

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  16. Content type: Research

    A gasotransmitter hydrogen sulfide (H2S) plays an important physiological and pathological role in cardiovascular system. Ischemic post-conditioning (PC) provides cardioprotection in the young hearts but not in t...

    Authors: Weiming Sun, Jinxia Yang, Yuanzhou Zhang, Yuxin Xi, Xin Wen, Di Yuan, Yuehong Wang, Can Wei, Rui Wang, Lingyun Wu, Hongzhu Li and Changqing Xu

    Citation: Cell & Bioscience 2017 7:67

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  17. Content type: Research

    Neural stem cells (NSCs) are able to differentiate into neurons and astroglia. miRNAs have been demonstrated to be involved in NSC self-renewal, proliferation and differentiation. However, the exact role of mi...

    Authors: Shujie Jiao, Yaling Liu, Yaobing Yao and Junfang Teng

    Citation: Cell & Bioscience 2017 7:68

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  18. Content type: Research

    Defects of the growth arrest DNA damage-inducible gene 45β (Gadd45β) play an important role in the progression of tumor and confer resistance to chemotherapy. However, the role of Gadd45β in the apoptosis of h...

    Authors: Xiao-Juan Hou, Qiu-Dong Zhao, Ying-Ying Jing, Zhi-Peng Han, Xue Yang, Li-Xin Wei, Yu-Ting Zheng, Feng Xie and Bai-He Zhang

    Citation: Cell & Bioscience 2017 7:63

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  19. Content type: Research

    Long non-coding RNA growth arrest-specific transcript 5 (lncRNA GAS5) is a well-known tumor suppressor in the pathogenesis of a variety of human cancers. The precise role of GAS5 in pancreatic cancer (PC) prog...

    Authors: Zhi-Qiang Gao, Jun-feng Wang, De-Hua Chen, Xue-Song Ma, Yang Wu, Zhe Tang and Xiao-Wei Dang

    Citation: Cell & Bioscience 2017 7:66

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  20. Content type: Research

    Numerous recent studies indicate that the long non-coding RNAs (lncRNAs) are frequently abnormal expressed and take critical roles in many cancers. Renal cell carcinoma is the secondary malignant tumors in the...

    Authors: Haowei He, Nana Wang, Xiaoming Yi, Chaopeng Tang and Dong Wang

    Citation: Cell & Bioscience 2017 7:65

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  21. Content type: Review

    Cancer, the main cause of human deaths in the modern world is a group of diseases. Anticancer drug discovery is a challenge for scientists because of involvement of multiple survival pathways of cancer cells. ...

    Authors: Davinder Singh, Rohit Arora, Pardeep Kaur, Balbir Singh, Rahul Mannan and Saroj Arora

    Citation: Cell & Bioscience 2017 7:62

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  22. Content type: Research

    Specific and selective peptidic blockers of Kv1.3 channels can serve as a valuable drug lead for treating T cell-mediated autoimmune diseases, and scorpion venom is an important source of kv1.3 channel inhibit...

    Authors: Yan Zou, Feng Zhang, Yaxian Li, Yuanfang Wang, Yi Li, Zhengtao Long, Shujuan Shi, Li Shuai, Jiukai Liu, Zhiyong Di and Shijin Yin

    Citation: Cell & Bioscience 2017 7:60

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  23. Content type: Research

    Multiple sclerosis (MS) is a severe neurological disorder, characterized by demyelination of the central nervous system (CNS), and with a prevalence of greater than 2 million people worldwide. In terms of rese...

    Authors: Qili Yu, Ryan Hui, Jiyoung Park, Yangyang Huang, Alexander W. Kusnecov, Cheryl F. Dreyfus and Renping Zhou

    Citation: Cell & Bioscience 2017 7:59

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  24. Content type: Research

    The 14-3-3 family of proteins have been reported to play an important role in development in various mouse models, but the context specific developmental functions of 14-3-3ζ remain to be determined. In this s...

    Authors: Jun Yang, Sonali Joshi, Qingfei Wang, Ping Li, Hai Wang, Yan Xiong, Yi Xiao, Jinyang Wang, Jan Parker-Thornburg, Richard R. Behringer and Dihua Yu

    Citation: Cell & Bioscience 2017 7:58

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  25. Content type: Letter to the Editor

    Interferonε (IFNε) is a unique type I IFN that has distinct functions from IFNα/β. IFNε is constitutively expressed at mucosal tissues, including the female genital mucosa, and is reported to be modulated by e...

    Authors: Jennifer Couret, Carley Tasker, Jaeha Kim, Tiina Sihvonen, Saahil Fruitwala, Alison J. Quayle, Pierre Lespinasse, Debra S. Heller and Theresa L. Chang

    Citation: Cell & Bioscience 2017 7:57

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  26. Content type: Research

    Diffuse intrinsic pontine glioma is an infiltrative, often high-grade glioma of the brainstem that is not amenable to surgical resection. The current treatment of DIPG by radiation therapy showed dramatically ...

    Authors: Yaqin Zhang, Weijie Dong, Junying Zhu, Lizhu Wang, Xinjian Wu and Hong Shan

    Citation: Cell & Bioscience 2017 7:56

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  27. Content type: Research

    Current immunosuppressive medications used after transplantation induce significant toxicity , and a new medication regimen is needed. Based on recent research, Sirt1 exerts a proinflammatory effect on the imm...

    Authors: Qing Ye, Mingjian Zhang, Yang Wang, Shangxi Fu, Shu Han, Liming Wang and Quanxing Wang

    Citation: Cell & Bioscience 2017 7:55

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  28. Content type: Research

    A vital property of eukaryotic cells physiology is their rather quick response to variation of oxygen tension, mainly by a transcription factor known as hypoxia-inducible factor-1 (HIF-1). Aside from its trans...

    Authors: Elham Parandavar and Razieh Yazdanparast

    Citation: Cell & Bioscience 2017 7:52

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  29. Content type: Research Highlight

    Histone proteins and transcription factors (TFs) play critical roles in gene transcription and development of multicellular organisms. Although antibody mediated protein isolation couple with mass spectrometry...

    Authors: Yi Qiu and Suming Huang

    Citation: Cell & Bioscience 2017 7:49

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  30. Content type: Research highlight

    It is well known that too much sugar uptake causes many health problems, including diabetes and obesity (Lustig et al. in Nature 482:27–29, 2012). However, a team of researchers led by Dr. Wanjun Chen of the Nati...

    Authors: Yun-Bo Shi and Deling Yin

    Citation: Cell & Bioscience 2017 7:48

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  31. Content type: Research

    The main approach to treat HIV-1 infection is combination antiretroviral therapy (cART). Although cART is effective in reducing HIV-1 viral load and controlling disease progression, it has many side effects, a...

    Authors: Zhepeng Liu, Shuliang Chen, Xu Jin, Qiankun Wang, Kongxiang Yang, Chenlin Li, Qiaoqiao Xiao, Panpan Hou, Shuai Liu, Shaoshuai Wu, Wei Hou, Yong Xiong, Chunyan Kong, Xixian Zhao, Li Wu, Chunmei Li…

    Citation: Cell & Bioscience 2017 7:47

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  32. Content type: Research

    Human papillomavirus (HPV) has been identified as the primary etiologic factor of cervical cancer, the fourth leading cause of cancer death in females worldwide. We have previously shown that coadministration ...

    Authors: Andrew Yang, Shiwen Peng, Emily Farmer, Qi Zeng, Max A. Cheng, Xiaowu Pang, T. -C. Wu and Chien-Fu Hung

    Citation: Cell & Bioscience 2017 7:46

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  33. Content type: Research

    Burkholderia pseudomallei is an intracellular bacteria causing Melioidosis, the disease widely disseminates in Southeast Asia and Northern Australia. B. pseudomallei has ability to inv...

    Authors: Pattamaporn Joompa, Saranyoo Ponnikorn, Sittiruk Roytrakul and Sumalee Tungpradabkul

    Citation: Cell & Bioscience 2017 7:45

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  34. Content type: Research

    Ginkgetin aglycone (GA), a novel Ginkgo biloba extract (GBE) by acid hydrolysis and recrystallization, is characterized by higher liposolubility and antioxidation than classical GBEs. There is no study depicting ...

    Authors: Junwei Zhang, Suxia Yang, Fang Chen, Huicong Li and Baoping Chen

    Citation: Cell & Bioscience 2017 7:44

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  35. Content type: Letter to the Editor

    Current techniques for cell culture routinely use animal-derived components. Fetal bovine serum (FBS) is the most widely applied supplement, but it often displays significant batch-to-batch variations and is g...

    Authors: C. Castells-Sala, J. Martorell and M. Balcells

    Citation: Cell & Bioscience 2017 7:41

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  36. Content type: Research

    Mammalian folliculogenesis, maturation of the ovarian follicles, require both growth factors derived from oocyte and surrounding cells, including stromal cells. However, the mechanism by which stromal cells an...

    Authors: Shu Tan, Boya Feng, Mingzhu Yin, Huanjiao Jenny Zhou, Ge Lou, Weidong Ji, Yonghao Li and Wang Min

    Citation: Cell & Bioscience 2017 7:36

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