Articles
Page 6 of 31
-
Citation: Cell & Bioscience 2023 13:104
-
The genomic signature of resistance to platinum-containing neoadjuvant therapy based on single-cell data
Neoadjuvant chemotherapy (NACT) becomes the first-line option for advanced tumors, while patients who are not sensitive to it may not benefit. Therefore, it is important to screen patients suitable for NACT.
Citation: Cell & Bioscience 2023 13:103 -
FFAR2 antagonizes TLR2- and TLR3-induced lung cancer progression via the inhibition of AMPK-TAK1 signaling axis for the activation of NF-κB
Free fatty acid receptors (FFARs) and toll-like receptors (TLRs) recognize microbial metabolites and conserved microbial products, respectively, and are functionally implicated in inflammation and cancer. Howe...
Citation: Cell & Bioscience 2023 13:102 -
Amelioration of olfactory dysfunction in a mouse model of Parkinson’s disease via enhancing GABAergic signaling
Olfactory dysfunction is among the earliest non-motor symptoms of Parkinson’s disease (PD). As the foremost pathological hallmark, α-synuclein initiates the pathology in the olfactory pathway at the early stag...
Citation: Cell & Bioscience 2023 13:101 -
Structural basis of human PRPS2 filaments
PRPP synthase (PRPS) transfers the pyrophosphate groups from ATP to ribose-5-phosphate to produce 5-phosphate ribose-1-pyrophosphate (PRPP), a key intermediate in the biosynthesis of several metabolites includ...
Citation: Cell & Bioscience 2023 13:100 -
TRIM67 alleviates cerebral ischemia‒reperfusion injury by protecting neurons and inhibiting neuroinflammation via targeting IκBα for K63-linked polyubiquitination
Excessive and unresolved neuroinflammation plays an important role in the pathophysiology of many neurological disorders, such as ischemic stroke, yet there are no effective treatments. Tripartite motif-contai...
Citation: Cell & Bioscience 2023 13:99 -
Suppression of TGFβR-Smad3 pathway alleviates the syrinx induced by syringomyelia
Syringomyelia is a cerebrospinal fluid (CSF) disorder resulted in separation of pain and temperature, dilation of central canal and formation of syrinx in central canal. It is unclear about mechanisms of the d...
Citation: Cell & Bioscience 2023 13:98 -
TSA-PACT: a method for tissue clearing and immunofluorescence staining on zebrafish brain with improved sensitivity, specificity and stability
For comprehensive studies of the brain structure and function, fluorescence imaging of the whole brain is essential. It requires large-scale volumetric imaging in cellular or molecular resolution, which could ...
Citation: Cell & Bioscience 2023 13:97 -
Timely expression of PGAM5 and its cleavage control mitochondrial homeostasis during neurite re-growth after traumatic brain injury
Patients suffered from severe traumatic brain injury (TBI) have twice the risk of developing into neurodegenerative diseases later in their life. Thus, early intervention is needed not only to treat TBI but al...
Citation: Cell & Bioscience 2023 13:96 -
Microglia degrade Tau oligomers deposit via purinergic P2Y12-associated podosome and filopodia formation and induce chemotaxis
Tau protein forms neurofibrillary tangles and becomes deposited in the brain during Alzheimer’s disease (AD). Tau oligomers are the most reactive species, mediating neurotoxic and inflammatory activity. Microg...
Citation: Cell & Bioscience 2023 13:95 -
Identification and validation of CCL2 as a potential biomarker relevant to mast cell infiltration in the testicular immune microenvironment of spermatogenic dysfunction
Spermatogenic dysfunction is an important cause of azoospermia. Numerous studies have focused on germ-cell-related genes that lead to spermatogenic impairment. However, based on the immune-privileged character...
Citation: Cell & Bioscience 2023 13:94 -
The applications of CRISPR/Cas-mediated genome editing in genetic hearing loss
Hearing loss (HL) can be caused by a number of different genetic factors. Non-syndromic HL refers that HL occurs as an isolated symptom in an individual, whereas syndromic HL refers that HL is associated with ...
Citation: Cell & Bioscience 2023 13:93 -
Integrated single-nucleus sequencing and spatial architecture analysis identified distinct injured-proximal tubular types in calculi rats
Urolithiasis with high prevalence and recurrence rate, has impacts on kidney injury in patients, becomes a socioeconomic and healthcare problem in worldwide. However, the biology of kidney with crystal formati...
Citation: Cell & Bioscience 2023 13:92 -
Overview of multifunctional cysteinyl cathepsins in atherosclerosis-based cardiovascular disease: from insights into molecular functions to clinical implications
Cysteinyl cathepsins (CTSs) are widely known to have a proteolysis function that mediates recycling of unwanted proteins in endosomes and lysosomes, and investigation of CTSs has greatly improved with advances...
Citation: Cell & Bioscience 2023 13:91 -
Circuit- and laminar-specific regulation of medial prefrontal neurons by chronic stress
Chronic stress exposure increases the risk of mental health problems such as anxiety and depression. The medial prefrontal cortex (mPFC) is a hub for controlling stress responses through communicating with mul...
Citation: Cell & Bioscience 2023 13:90 -
miR-210-3p enriched extracellular vesicles from hypoxic neuroblastoma cells stimulate migration and invasion of target cells
Tumor hypoxia stimulates release of extracellular vesicles (EVs) that facilitate short- and long-range intercellular communication and metastatization. Albeit hypoxia and EVs release are known features of Neur...
Citation: Cell & Bioscience 2023 13:89 -
Establishing extended pluripotent stem cells from human urine cells
Extended pluripotent stem cells (EPSCs) can contribute to both embryonic and trophectoderm-derived extraembryonic tissues. Therefore, EPSCs have great application significance for both research and industry. H...
Citation: Cell & Bioscience 2023 13:88 -
Hinokitiol-iron complex is a ferroptosis inducer to inhibit triple-negative breast tumor growth
Ferroptosis is a unique cell death, dependent on iron and phospholipid peroxidation, involved in massive processes of physiopathology. Tremendous attention has been caught in oncology, particularly for those t...
Citation: Cell & Bioscience 2023 13:87 -
Stress granules: functions and mechanisms in cancer
Stress granules (SGs) are non-enveloped structures formed primarily via protein and RNA aggregation under various stress conditions, including hypoxia and viral infection, as well as oxidative, osmotic, and he...
Citation: Cell & Bioscience 2023 13:86 -
Modulating AHR function offers exciting therapeutic potential in gut immunity and inflammation
Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a classical exogenous synthetic ligand of AHR that has significant immunotoxic effects....
Citation: Cell & Bioscience 2023 13:85 -
ISG15 suppresses ovulation and female fertility by ISGylating ADAMTS1
ISGylation is a post-translational protein modification that regulates many life activities, including immunomodulation, antiviral responses, and embryo implantation. The exact contribution of ISGylation to fo...
Citation: Cell & Bioscience 2023 13:84 -
Competitive PCR with dual fluorescent primers enhances the specificity and reproducibility of genotyping animals generated from genome editing
Targeted genome editing is a powerful tool for studying gene function in almost every aspect of biological and pathological processes. The most widely used genome editing approach is to introduce engineered en...
Citation: Cell & Bioscience 2023 13:83 -
Dual roles of R-loops in the formation and processing of programmed DNA double-strand breaks during meiosis
Meiotic recombination is initiated by Spo11-dependent programmed DNA double-strand breaks (DSBs) that are preferentially concentrated within genomic regions called hotspots; however, the factor(s) that specify...
Citation: Cell & Bioscience 2023 13:82 -
NAD+ metabolism-based immunoregulation and therapeutic potential
Nicotinamide adenine dinucleotide (NAD+) is a critical metabolite that acts as a cofactor in energy metabolism, and serves as a cosubstrate for non-redox NAD+-dependent enzymes, including sirtuins, CD38 and poly(...
Citation: Cell & Bioscience 2023 13:81 -
Interaction of TAGLN and USP1 promotes ZEB1 ubiquitination degradation in UV-induced skin photoaging
Ultraviolet A (UVA) irradiation can lead to skin damage and premature skin aging known as photoaging. This work found that UVA irradiation caused an imbalance between dermal matrix synthesis and degradation th...
Citation: Cell & Bioscience 2023 13:80 -
Genetic labeling reveals spatial and cellular expression pattern of neuregulin 1 in mouse brain
Where the gene is expressed determines the function of the gene. Neuregulin 1 (Nrg1) encodes a tropic factor and is genetically linked with several neuropsychiatry diseases such as schizophrenia, bipolar disor...
Citation: Cell & Bioscience 2023 13:79 -
Impacts of plasma microbial lipopolysaccharide translocation on B cell perturbations and anti-CD4 autoantibody production in people with HIV on suppressive antiretroviral therapy
. Up to 20% of people with HIV (PWH) who undergo virologically suppressed antiretroviral therapy (ART) fail to experience complete immune restoration. We recently reported that plasma anti-CD4 IgG (antiCD4IgG)...
Citation: Cell & Bioscience 2023 13:78 -
Bile acid-mediated signaling in cholestatic liver diseases
Chronic cholestatic liver diseases, such as primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), are associated with bile stasis and gradually progress to fibrosis, cirrhosis, and liver ...
Citation: Cell & Bioscience 2023 13:77 -
Meloxicam inhibits STING phosphorylation and alleviates intracellular DNA-mediated autoimmune responses
Cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is critical for cytosolic DNA-sensing and the subsequent immune responses. The inappropriate activation of this pathway leads to DN...
Citation: Cell & Bioscience 2023 13:76 -
Loss of Stat3 in Osterix+ cells impairs dental hard tissues development
Mutations in the signal transducers and activators of transcription 3 (STAT3) gene result in hyper-IgE syndrome(HIES), a rare immunodeficiency that causes abnormalities in immune system, bones and teeth. However,...
Citation: Cell & Bioscience 2023 13:75 -
FACI is a novel clathrin adaptor protein 2-binding protein that facilitates low-density lipoprotein endocytosis
Cholesterol plays a vital role in multiple physiological processes. Cellular uptake of cholesterol is mediated primarily through endocytosis of low-density lipoprotein (LDL) receptor. New modifiers of this pro...
Citation: Cell & Bioscience 2023 13:74 -
The malignancy suppression and ferroptosis facilitation of BCL6 in gastric cancer mediated by FZD7 repression are strengthened by RNF180/RhoC pathway
B-cell lymphoma 6 (BCL6) is a transcription repressor that plays a tumor suppressor or promoting role in various tumors. However, its function and molecular mechanism in gastric cancer (GC) remain unclear. Fer...
Citation: Cell & Bioscience 2023 13:73 -
Improving the response to oxaliplatin by targeting chemotherapy-induced CLDN1 in resistant metastatic colorectal cancer cells
Tumor resistance is a frequent cause of therapy failure and remains a major challenge for the long-term management of colorectal cancer (CRC). The aim of this study was to determine the implication of the tigh...
Citation: Cell & Bioscience 2023 13:72 -
RNF20 is required for male fertility through regulation of H2B ubiquitination in the Sertoli cells
Spermatogenesis depends on the supporting of the Sertoli cells and their communications with germ cells. However, the regulation of crosstalk between the Sertoli cells and germ cells remains unclear.
Citation: Cell & Bioscience 2023 13:71 -
Slit-Robo expression in the leech nervous system: insights into eyespot evolution
Slit and Robo are evolutionarily conserved ligand and receptor proteins, respectively, but the number of slit and robo gene paralogs varies across recent bilaterian genomes. Previous studies indicate that this li...
Citation: Cell & Bioscience 2023 13:70 -
N-methyl-d-aspartate receptors induce M1 polarization of macrophages: Feasibility of targeted imaging in inflammatory response in vivo
N-methyl-d-aspartate receptors (NMDARs) are considered to be involved in several physiological and pathophysiological processes in addition to the progression of neurological disorders. However, how NMDARs are in...
Citation: Cell & Bioscience 2023 13:69 -
Correction: ANGPTL2 binds MAG to efficiently enhance oligodendrocyte differentiation
Citation: Cell & Bioscience 2023 13:68 -
PSMD2 contributes to the progression of esophageal squamous cell carcinoma by repressing autophagy
The ubiquitin–proteasome and autophagy-lysosomal systems collaborate in regulating the levels of intracellular proteins. Dysregulation of protein homeostasis is a central feature of malignancy. The gene encodi...
Citation: Cell & Bioscience 2023 13:67 -
H3K27me3-H3K4me1 transition at bivalent promoters instructs lineage specification in development
Bivalent genes, of which promoters are marked by both H3K4me3 (trimethylation of histone H3 on lysine 4) and H3K27me3 (trimethylation of histone H3 on lysine 27), play critical roles in development and tumorig...
Citation: Cell & Bioscience 2023 13:66 -
TMED3 promotes the development of malignant melanoma by targeting CDCA8 and regulating PI3K/Akt pathway
Transmembrane emp24 domain containing (TMED) proteins are known to play pivotal roles in normal development, but have been reported to be implicated in pancreatic disease, immune system disorders, and cancers....
Citation: Cell & Bioscience 2023 13:65 -
Overexpression of HSF2 binding protein suppresses endoplasmic reticulum stress via regulating subcellular localization of CDC73 in hepatocytes
Endoplasmic reticulum (ER) stress plays an important role in the occurrence and development of various liver diseases. However, there are no effective prevention and treatment strategies. We aimed to determine...
Citation: Cell & Bioscience 2023 13:64 -
SEPT2 crotonylation promotes metastasis and recurrence in hepatocellular carcinoma and is associated with poor survival
Hepatocellular carcinoma (HCC) metastasis and recurrence lead to therapy failure, which are closely associated with the proteome. However, the role of post-translational modification (PTM) in HCC, especially f...
Citation: Cell & Bioscience 2023 13:63 -
Single-cell transcriptomic analysis of normal and pathological tissues from the same patient uncovers colon cancer progression
The aim of the present study was to elucidate the evolutionary trajectory of colon cells from normal colon mucosa, to adenoma, then to carcinoma in the same microenvironment. Normal colon, adenoma and carcinom...
Citation: Cell & Bioscience 2023 13:62 -
Aging aggravates acetaminophen-induced acute liver injury and inflammation through inordinate C/EBPα-BMP9 crosstalk
Previous studies have shown that bone morphogenetic protein 9 (BMP9) is almost exclusively produced in the liver and reaches tissues throughout the body as a secreted protein. However, the mechanism of BMP9 ac...
Citation: Cell & Bioscience 2023 13:61 -
The nerve growth factor-delivered signals in prostate cancer and its associated microenvironment: when the dialogue replaces the monologue
Prostate cancer (PC) represents the most diagnosed and the second most lethal cancer in men worldwide. Its development and progression occur in concert with alterations in the surrounding tumor microenvironmen...
Citation: Cell & Bioscience 2023 13:60 -
The versatile roles of testrapanins in cancer from intracellular signaling to cell–cell communication: cell membrane proteins without ligands
The tetraspanins (TSPANs) are a family of four-transmembrane proteins with 33 members in mammals. They are variably expressed on the cell surface, various intracellular organelles and vesicles in nearly all ce...
Citation: Cell & Bioscience 2023 13:59 -
Fetal hypoxia results in sex- and cell type-specific alterations in neonatal transcription in rat oligodendrocyte precursor cells, microglia, neurons, and oligodendrocytes
Fetal hypoxia causes vital, systemic, developmental malformations in the fetus, particularly in the brain, and increases the risk of diseases in later life. We previously demonstrated that fetal hypoxia exposu...
Citation: Cell & Bioscience 2023 13:58 -
Remote ischemic preconditioning protects against spinal cord ischemia–reperfusion injury in mice by activating NMDAR/AMPK/PGC-1α/SIRT3 signaling
To study the protective effects of delayed remote ischemic preconditioning (RIPC) against spinal cord ischemia–reperfusion injury (SCIRI) in mice and determine whether SIRT3 is involved in this protection and ...
Citation: Cell & Bioscience 2023 13:57 -
Stem cell therapy combined with controlled release of growth factors for the treatment of sphincter dysfunction
Sphincter dysfunction often occurs at the end of tubule organs such as the urethra, anus, or gastroesophageal sphincters. It is the primary consequence of neuromuscular impairment caused by trauma, inflammatio...
Citation: Cell & Bioscience 2023 13:56 -
Exosomal USP13 derived from microvascular endothelial cells regulates immune microenvironment and improves functional recovery after spinal cord injury by stabilizing IκBα
Spinal cord injury (SCI) can result in irreversible sensory and motor disability with no effective treatment currently. After SCI, infiltrated macrophages accumulate in epicenter through destructed blood-spina...
Citation: Cell & Bioscience 2023 13:55
Follow
- ISSN: 2045-3701 (electronic)