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  1. Content type: Review

    When hepatocytes are damaged severely, a variety of signaling pathways will be triggered by inflammatory factors and cytokines involving in the process of hepatic fibrosis. The microRNA (miRNA) family consists...

    Authors: Xue-Ping Jiang, Wen-Bing Ai, Lin-Yan Wan, Yan-Qiong Zhang and Jiang-Feng Wu

    Citation: Cell & Bioscience 2017 7:34

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  2. Content type: Research

    Disruption of blood–brain barrier (BBB) and subsequent infiltration of auto-reactive T lymphocytes are major characteristics of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). Kv1....

    Authors: Jie Huang, Song Han, Qi Sun, Yipeng Zhao, Junchen Liu, Xiaolu Yuan, Wenqian Mao, Biwen Peng, Wanhong Liu, Jun Yin and Xiaohua He

    Citation: Cell & Bioscience 2017 7:31

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  3. Content type: Review

    Human cancers results in large part from the accumulation of multiple mutations. The progression of premalignant cells is an evolutionary process in which mutations provide the fundamental driving force for ge...

    Authors: Jun Zou, Chen Wang, Xiangyi Ma, Edward Wang and Guang Peng

    Citation: Cell & Bioscience 2017 7:29

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  4. Content type: Research highlight

    Induced pluripotent stem cells (iPSCs) hold great promises in cell therapy. However, the potential safety issues have dampened the enthusiasm of their clinical development. One of the biggest concerns came fro...

    Authors: Hualong Yan, Yun-Bo Shi and Jing Huang

    Citation: Cell & Bioscience 2017 7:30

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  5. Content type: Research

    Bone degenerative disorders like osteoporosis may be initiated by age-related shifts in anabolic and catabolic responses that control bone homeostasis. Although there are studies suggesting that metabolic chan...

    Authors: Min Ling, Peixin Huang, Shamima Islam, Daniel P. Heruth, Xuanan Li, Li Qin Zhang, Ding-You Li, Zhaohui Hu and Shui Qing Ye

    Citation: Cell & Bioscience 2017 7:27

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  6. Content type: Research

    Chloroquine, a bitter tastant, inhibits Ca2+ signaling, resulting in suppression of B cell activation; however, the inhibitory mechanism remains unclear.

    Authors: Yi-Fan Wu, Ping Zhao, Xi Luo, Jin-Chao Xu, Lu Xue, Qi Zhou, Mingrui Xiong, Jinhua Shen, Yong-Bo Peng, Meng-Fei Yu, Weiwei Chen, Liqun Ma and Qing-Hua Liu

    Citation: Cell & Bioscience 2017 7:28

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  7. Content type: Research

    Natural killer (NK)T cells and conventional T cells share phenotypic characteristic however they differ in transcription factor requirements and functional properties. The role of histone modifying enzymes in ...

    Authors: Daniel Northrup, Ryoji Yagi, Kairong Cui, William R. Proctor, Chaochen Wang, Katarzyna Placek, Lance R. Pohl, Rongfu Wang, Kai Ge, Jinfang Zhu and Keji Zhao

    Citation: Cell & Bioscience 2017 7:25

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  8. Content type: Review

    Regulation of lineage specification and differentiation in embryonic stem (ES) cells can be achieved through the activation of endogenous signaling, an avenue for potential application in regenerative medicine...

    Authors: Katherine Dixon, Jihong Chen and Qiao Li

    Citation: Cell & Bioscience 2017 7:23

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  9. Content type: Research

    Oculocutaneous albinism (OCA) is an autosomal recessive disorder. A significant portion of OCA patients has been found with a single pathogenic variant either in the TYR or the OCA2 gene. Diagnostic sequencing of...

    Authors: Jackson Gao, Leera D’Souza, Keith Wetherby, Christian Antolik, Melissa Reeves, David R. Adams, Santa Tumminia and Xinjing Wang

    Citation: Cell & Bioscience 2017 7:22

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  10. Content type: Review

    Genome editing promises giant leaps forward in advancing biotechnology, agriculture, and basic research. The process relies on the use of sequence specific nucleases (SSNs) to make DNA double stranded breaks a...

    Authors: Aimee Malzahn, Levi Lowder and Yiping Qi

    Citation: Cell & Bioscience 2017 7:21

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  11. Content type: Research

    Curcumin is a major constituent of rhizomes of Curcuma longa that elicits beneficial effects for oxidative damage. The aim of this study was to investigate whether curcumin could attenuate hydrogen peroxide (H2O2

    Authors: Xiaobo Yang, Hong Jiang and Yao Shi

    Citation: Cell & Bioscience 2017 7:20

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  12. Content type: Research

    Parkinson disease (PD) is the most common movement disturbance characterized by the loss of dopaminergic (DA) neurons in midbrain. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is aberrantly ...

    Authors: Wei Liu, Qishun Zhang, Jianlei Zhang, Wujun Pan, Jingya Zhao and Yuming Xu

    Citation: Cell & Bioscience 2017 7:19

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  13. Content type: Research

    Colorectal cancer is a leading cause of cancer-related mortality worldwide, with Fluorouracil (5-FU)-based chemotherapy as the major treatment for advanced disease. Many patients with advanced colorectal cance...

    Authors: Lining Zhang, Ruolan Song, Dongsheng Gu, Xiaoli Zhang, Beiqin Yu, Bingya Liu and Jingwu Xie

    Citation: Cell & Bioscience 2017 7:17

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  14. Content type: Research

    Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide, and infection with hepatitis B virus (HBV) is a leading cause of HCC. Previous studies have demonstrated that expre...

    Authors: Qiushuang Xiong, Shaoshuai Wu, Jingwen Wang, Xianhuang Zeng, Jianwen Chen, Mingcong Wei, Haotong Guan, Chengpeng Fan, Lang Chen, Deyin Guo and Guihong Sun

    Citation: Cell & Bioscience 2017 7:16

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  15. Content type: Research

    Lysine-specific histone demethylase 1 (LSD1) modulates chromatin status through demethylation of H3K4 and H3K9. It has been demonstrated that LSD1 is hyperphosphorylated and dissociates from chromatin during m...

    Authors: Bin Peng, Ruifeng Shi, Weiwei Jiang, Yue-He Ding, Meng-Qiu Dong, Wei-Guo Zhu and Xingzhi Xu

    Citation: Cell & Bioscience 2017 7:15

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  16. Content type: Review

    Thyroid hormone (TH) signaling plays critical roles in the differentiation, growth, metabolism, and physiological function of all organs or tissues, including heart and skeletal muscle. Due to the significant ...

    Authors: Duo Zhang, Yan Li, Shengnan Liu, Yu-cheng Wang, Feifan Guo, Qiwei Zhai, Jingjing Jiang and Hao Ying

    Citation: Cell & Bioscience 2017 7:14

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  17. Content type: Review

    Persistent dysregulation of the DNA damage response and repair in cells causes genomic instability. The resulting genetic changes permit alterations in growth and proliferation observed in virtually all cancer...

    Authors: Anna Palovcak, Wenjun Liu, Fenghua Yuan and Yanbin Zhang

    Citation: Cell & Bioscience 2017 7:8

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  18. Content type: Research highlight

    Accumulating evidence implicates Zika virus (ZIKV) in pathogenesis of microcephaly in newborns and Guillain-Barré syndrome in adults. However, it remains unclear which viral proteins are responsible for these ...

    Authors: Michael Bukrinsky

    Citation: Cell & Bioscience 2017 7:12

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  19. Content type: Research

    The cereal cyst nematode (CCN, Heterodera avenae) is a devastating pathogen of wheat and barley crops in many countries. We aimed to prioritize genetic and molecular targets for H. avenae control via the powerful...

    Authors: Dan Yang, Changlong Chen, Qian Liu and Heng Jian

    Citation: Cell & Bioscience 2017 7:11

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  20. Content type: Research

    Human enterovirus 71 (EV71) causes severe hand, foot and mouse disease, accompanied by neurological complications. During the interaction between EV71 and the host, the virus subverts host cell machinery for i...

    Authors: Bingfei Zhou, Min Chu, Shanshan Xu, Xiong Chen, Yongjuan Liu, Zhihao Wang, Fengfeng Zhang, Song Han, Jun Yin, Biwen Peng, Xiaohua He and Wanhong Liu

    Citation: Cell & Bioscience 2017 7:7

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  21. Content type: Research

    HIV-1 protease (PR) is an essential enzyme for viral production. Thus, PR inhibitors (PIs) are the most effective class of anti-HIV drugs. However, the main challenge to the successful use of PI drugs in patie...

    Authors: Zsigmond Benko, Dong Liang, Ge Li, Robert T. Elder, Anindya Sarkar, Jun Takayama, Arun K. Ghosh and Richard Y. Zhao

    Citation: Cell & Bioscience 2017 7:5

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  22. Content type: Research

    Osteogenic differentiation of mesenchymal stem cells has been extensively investigated with regards to different aspects, including the analysis of cell intracellular and extracellular proteome, cell gene expr...

    Authors: Jakub Grzesiak, Agnieszka Śmieszek and Krzysztof Marycz

    Citation: Cell & Bioscience 2017 7:2

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  23. Content type: Research

    Zfp819, a member of the Krüppel-associated box (KRAB) family, encodes a spermatogenic cell-specific transcription factor. Zfp819-overexpression induces apoptosis and inhibits prolifera...

    Authors: Sora Jin, Heejin Choi, Jun Tae Kwon, Jihye Kim, Juri Jeong, Jaehwan Kim, Seong Hyeon Hong and Chunghee Cho

    Citation: Cell & Bioscience 2017 7:4

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  24. Content type: Letter to the Editor

    Antimicrotubule agent vincristine (VCR) has long been known as an alternative treatment for frequent relapse nephrotic syndrome and steroid-dependent nephrotic syndrome (SDNS). However, the mechanism is unknow...

    Authors: Lei Yin, Youying Mao, Hejie Song, Ye Wang, Wei Zhou and Zhen Zhang

    Citation: Cell & Bioscience 2017 7:1

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  25. Content type: Letter to the Editor

    Massive liquid crystal droplets have been found during embryonic development in more than twenty different tissues and organs, including the liver, brain and kidney. Liquid crystal deposits have also been iden...

    Authors: MengMeng Xu, Odell D. Jones, Liyang Wang, Xin Zhou, Harry G. Davis, Joseph L. Bryant, Jianjie Ma, Willian B. Isaacs and Xuehong Xu

    Citation: Cell & Bioscience 2017 7:3

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  26. Content type: Review

    The addition of mono-ubiquitin or poly-ubiquitin chain to signaling proteins in response to DNA damage signal is thought to be a critical event that facilitates the recognition of DNA damage lesion site, the a...

    Authors: Mingjing He, Zhuan Zhou, Anil A. Shah, Haojing Zou, Jin Tao, Qianming Chen and Yong Wan

    Citation: Cell & Bioscience 2016 6:62

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  27. Content type: Research

    Rhabdomyosarcoma (RMS) originates from skeletal muscle precursors that fail to differentiate. Hedgehog (Hh) signaling and primary cilia contribute to the pathobiology of RMS.

    Authors: Xiaotong Liu, Qiuhong Shen, Tingting Yu, Huijie Huang, Ziyu Zhang, Jie Ding, Ying Tang, Ning Xu and Shen Yue

    Citation: Cell & Bioscience 2016 6:61

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  28. Content type: Review

    The generation of mutants and transgenes are indispensible for biomedical research. In the nematode Caenorhabditis elegans, a series of methods have been developed to introduce genome modifications, including ran...

    Authors: Xiangyang Chen, Xuezhu Feng and Shouhong Guang

    Citation: Cell & Bioscience 2016 6:60

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  29. Content type: Review

    One of the two common hallmark lesions of Alzheimer’s disease (AD) brains is neurofibrillary tangles (NFTs), which are composed of hyperphosphorylated tau protein (p-tau). NFTs are also a defining feature of o...

    Authors: Onder Albayram, Megan K. Herbert, Asami Kondo, Cheng-Yu Tsai, Sean Baxley, Xiaolan Lian, Madison Hansen, Xiao Zhen Zhou and Kun Ping Lu

    Citation: Cell & Bioscience 2016 6:59

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  30. Content type: Research

    Regulating cardiac differentiation to maintain normal heart development and function is very important. At present, biological functions of H19 in cardiac differentiation is not completely clear.

    Authors: Yu Han, Hongdang Xu, Jiangtao Cheng, Yanwei Zhang, Chuanyu Gao, Taibing Fan, Bangtian Peng, Bin Li, Lin Liu and Zhaoyun Cheng

    Citation: Cell & Bioscience 2016 6:58

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  31. Content type: Methodology

    The ability to transform normal human cells into cancer cells with the introduction of defined genetic alterations is a valuable method for understanding the mechanisms of oncogenesis. Easy establishment of im...

    Authors: Jordan L. Smith, Liam C. Lee, Abigail Read, Qiuning Li, Bing Yu, Chih-Shia Lee and Ji Luo

    Citation: Cell & Bioscience 2016 6:57

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  32. Content type: Review

    The serine/threonine kinase MAP4K4 is a member of the Ste20p (sterile 20 protein) family. MAP4K4 was initially discovered in 1995 as a key kinase in the mating pathway in Saccharomyces cerevisiae and was later fo...

    Authors: Xuan Gao, Chenxi Gao, Guoxiang Liu and Jing Hu

    Citation: Cell & Bioscience 2016 6:56

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  33. Content type: Research

    3-Nitro-4-hydroxy phenyl arsenic acid, roxarsone, is widely used as an organic arsenic feed additive for livestock and poultry, which may increase the level of arsenic in the environment and the risk of exposu...

    Authors: Yujing Wang, Donglai Yin, Chao Xu, Kai Wang, Lingmin Zheng and Yumei Zhang

    Citation: Cell & Bioscience 2016 6:54

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  34. Content type: Review

    Enzyme catalysis has been studied for over a century. How it actually occurs has not been visualized until recently. By combining in crystallo reaction and X-ray diffraction analysis of reaction intermediates,...

    Authors: Wei Yang, Peter J. Weng and Yang Gao

    Citation: Cell & Bioscience 2016 6:51

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    The Erratum to this article has been published in Cell & Bioscience 2017 7:32

  35. Content type: Research

    Aside from its importance in reproduction, estrogen (E2) is known to regulate the proliferation and differentiation of hematopoietic stem cells in rodents. However, the regulatory role of E2 in human hematopoi...

    Authors: Hye-Ryun Kim, Jong-Hee Lee, Hye-Ryeon Heo, Se-Ran Yang, Kwon-Soo Ha, Won Sun Park, Eun-Taek Han, Haengseok Song and Seok-Ho Hong

    Citation: Cell & Bioscience 2016 6:50

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  36. Content type: Letter to the Editor

    The involvement of Wnt in carcinogenesis and progression of pancreatic cancer is currently intensely discussed. We evaluated activation of the Wnt signaling pathway by using a Wnt reporter mouse strain express...

    Authors: Dietmar Zechner, Tim Kroemer, Ann-Christin Albert, Maria Schönrogge, Tobias Radecke and Brigitte Vollmar

    Citation: Cell & Bioscience 2016 6:49

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  37. Content type: Research

    General control non-depressible 5 (GCN5) is a crucial catalytic component of a transcriptional regulatory complex that plays important roles in cellular functions from cell cycle regulation to DNA damage repai...

    Authors: Sidra Majaz, Zhangwei Tong, Kesong Peng, Wei Wang, Wenjing Ren, Ming Li, Kun Liu, Pingli Mo, Wengang Li and Chundong Yu

    Citation: Cell & Bioscience 2016 6:47

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