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  1. Content type: Research

    Myocardium regeneration in adult mammals is very limited, but has enormous therapeutic potentials. However, we are far from complete understanding the cellular and molecular mechanisms by which heart tissue ca...

    Authors: Souqi Liao, Wenyan Dong, Luocheng Lv, Hongyan Guo, Jifeng Yang, Hui Zhao, Ruijin Huang, Ziqiang Yuan, Yilin Chen, Shanshan Feng, Xin Zheng, Junqi Huang, Weihuan Huang, Xufeng Qi and Dongqing Cai

    Citation: Cell & Bioscience 2017 7:70

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  2. Content type: Research

    Neural stem cells (NSCs) are able to differentiate into neurons and astroglia. miRNAs have been demonstrated to be involved in NSC self-renewal, proliferation and differentiation. However, the exact role of mi...

    Authors: Shujie Jiao, Yaling Liu, Yaobing Yao and Junfang Teng

    Citation: Cell & Bioscience 2017 7:68

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  3. Content type: Research

    A gasotransmitter hydrogen sulfide (H2S) plays an important physiological and pathological role in cardiovascular system. Ischemic post-conditioning (PC) provides cardioprotection in the young hearts but not in t...

    Authors: Weiming Sun, Jinxia Yang, Yuanzhou Zhang, Yuxin Xi, Xin Wen, Di Yuan, Yuehong Wang, Can Wei, Rui Wang, Lingyun Wu, Hongzhu Li and Changqing Xu

    Citation: Cell & Bioscience 2017 7:67

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  4. Content type: Research

    Defects of the growth arrest DNA damage-inducible gene 45β (Gadd45β) play an important role in the progression of tumor and confer resistance to chemotherapy. However, the role of Gadd45β in the apoptosis of h...

    Authors: Xiao-Juan Hou, Qiu-Dong Zhao, Ying-Ying Jing, Zhi-Peng Han, Xue Yang, Li-Xin Wei, Yu-Ting Zheng, Feng Xie and Bai-He Zhang

    Citation: Cell & Bioscience 2017 7:63

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  5. Content type: Research

    Long non-coding RNA growth arrest-specific transcript 5 (lncRNA GAS5) is a well-known tumor suppressor in the pathogenesis of a variety of human cancers. The precise role of GAS5 in pancreatic cancer (PC) prog...

    Authors: Zhi-Qiang Gao, Jun-feng Wang, De-Hua Chen, Xue-Song Ma, Yang Wu, Zhe Tang and Xiao-Wei Dang

    Citation: Cell & Bioscience 2017 7:66

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  6. Content type: Research

    Numerous recent studies indicate that the long non-coding RNAs (lncRNAs) are frequently abnormal expressed and take critical roles in many cancers. Renal cell carcinoma is the secondary malignant tumors in the...

    Authors: Haowei He, Nana Wang, Xiaoming Yi, Chaopeng Tang and Dong Wang

    Citation: Cell & Bioscience 2017 7:65

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  7. Content type: Review

    Cancer, the main cause of human deaths in the modern world is a group of diseases. Anticancer drug discovery is a challenge for scientists because of involvement of multiple survival pathways of cancer cells. ...

    Authors: Davinder Singh, Rohit Arora, Pardeep Kaur, Balbir Singh, Rahul Mannan and Saroj Arora

    Citation: Cell & Bioscience 2017 7:62

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  8. Content type: Research

    Specific and selective peptidic blockers of Kv1.3 channels can serve as a valuable drug lead for treating T cell-mediated autoimmune diseases, and scorpion venom is an important source of kv1.3 channel inhibit...

    Authors: Yan Zou, Feng Zhang, Yaxian Li, Yuanfang Wang, Yi Li, Zhengtao Long, Shujuan Shi, Li Shuai, Jiukai Liu, Zhiyong Di and Shijin Yin

    Citation: Cell & Bioscience 2017 7:60

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  9. Content type: Research

    Multiple sclerosis (MS) is a severe neurological disorder, characterized by demyelination of the central nervous system (CNS), and with a prevalence of greater than 2 million people worldwide. In terms of rese...

    Authors: Qili Yu, Ryan Hui, Jiyoung Park, Yangyang Huang, Alexander W. Kusnecov, Cheryl F. Dreyfus and Renping Zhou

    Citation: Cell & Bioscience 2017 7:59

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  10. Content type: Research

    The 14-3-3 family of proteins have been reported to play an important role in development in various mouse models, but the context specific developmental functions of 14-3-3ζ remain to be determined. In this s...

    Authors: Jun Yang, Sonali Joshi, Qingfei Wang, Ping Li, Hai Wang, Yan Xiong, Yi Xiao, Jinyang Wang, Jan Parker-Thornburg, Richard R. Behringer and Dihua Yu

    Citation: Cell & Bioscience 2017 7:58

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  11. Content type: Letter to the Editor

    Interferonε (IFNε) is a unique type I IFN that has distinct functions from IFNα/β. IFNε is constitutively expressed at mucosal tissues, including the female genital mucosa, and is reported to be modulated by e...

    Authors: Jennifer Couret, Carley Tasker, Jaeha Kim, Tiina Sihvonen, Saahil Fruitwala, Alison J. Quayle, Pierre Lespinasse, Debra S. Heller and Theresa L. Chang

    Citation: Cell & Bioscience 2017 7:57

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  12. Content type: Research

    Diffuse intrinsic pontine glioma is an infiltrative, often high-grade glioma of the brainstem that is not amenable to surgical resection. The current treatment of DIPG by radiation therapy showed dramatically ...

    Authors: Yaqin Zhang, Weijie Dong, Junying Zhu, Lizhu Wang, Xinjian Wu and Hong Shan

    Citation: Cell & Bioscience 2017 7:56

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  13. Content type: Research

    Current immunosuppressive medications used after transplantation induce significant toxicity , and a new medication regimen is needed. Based on recent research, Sirt1 exerts a proinflammatory effect on the imm...

    Authors: Qing Ye, Mingjian Zhang, Yang Wang, Shangxi Fu, Shu Han, Liming Wang and Quanxing Wang

    Citation: Cell & Bioscience 2017 7:55

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  14. Content type: Research

    A vital property of eukaryotic cells physiology is their rather quick response to variation of oxygen tension, mainly by a transcription factor known as hypoxia-inducible factor-1 (HIF-1). Aside from its trans...

    Authors: Elham Parandavar and Razieh Yazdanparast

    Citation: Cell & Bioscience 2017 7:52

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  15. Content type: Research Highlight

    Histone proteins and transcription factors (TFs) play critical roles in gene transcription and development of multicellular organisms. Although antibody mediated protein isolation couple with mass spectrometry...

    Authors: Yi Qiu and Suming Huang

    Citation: Cell & Bioscience 2017 7:49

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  16. Content type: Research highlight

    It is well known that too much sugar uptake causes many health problems, including diabetes and obesity (Lustig et al. in Nature 482:27–29, 2012). However, a team of researchers led by Dr. Wanjun Chen of the Nati...

    Authors: Yun-Bo Shi and Deling Yin

    Citation: Cell & Bioscience 2017 7:48

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  17. Content type: Research

    The main approach to treat HIV-1 infection is combination antiretroviral therapy (cART). Although cART is effective in reducing HIV-1 viral load and controlling disease progression, it has many side effects, a...

    Authors: Zhepeng Liu, Shuliang Chen, Xu Jin, Qiankun Wang, Kongxiang Yang, Chenlin Li, Qiaoqiao Xiao, Panpan Hou, Shuai Liu, Shaoshuai Wu, Wei Hou, Yong Xiong, Chunyan Kong, Xixian Zhao, Li Wu, Chunmei Li…

    Citation: Cell & Bioscience 2017 7:47

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  18. Content type: Research

    Human papillomavirus (HPV) has been identified as the primary etiologic factor of cervical cancer, the fourth leading cause of cancer death in females worldwide. We have previously shown that coadministration ...

    Authors: Andrew Yang, Shiwen Peng, Emily Farmer, Qi Zeng, Max A. Cheng, Xiaowu Pang, T. -C. Wu and Chien-Fu Hung

    Citation: Cell & Bioscience 2017 7:46

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  19. Content type: Research

    Burkholderia pseudomallei is an intracellular bacteria causing Melioidosis, the disease widely disseminates in Southeast Asia and Northern Australia. B. pseudomallei has ability to inv...

    Authors: Pattamaporn Joompa, Saranyoo Ponnikorn, Sittiruk Roytrakul and Sumalee Tungpradabkul

    Citation: Cell & Bioscience 2017 7:45

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  20. Content type: Research

    Ginkgetin aglycone (GA), a novel Ginkgo biloba extract (GBE) by acid hydrolysis and recrystallization, is characterized by higher liposolubility and antioxidation than classical GBEs. There is no study depicting ...

    Authors: Junwei Zhang, Suxia Yang, Fang Chen, Huicong Li and Baoping Chen

    Citation: Cell & Bioscience 2017 7:44

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  21. Content type: Letter to the Editor

    Current techniques for cell culture routinely use animal-derived components. Fetal bovine serum (FBS) is the most widely applied supplement, but it often displays significant batch-to-batch variations and is g...

    Authors: C. Castells-Sala, J. Martorell and M. Balcells

    Citation: Cell & Bioscience 2017 7:41

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  22. Content type: Research

    Mammalian folliculogenesis, maturation of the ovarian follicles, require both growth factors derived from oocyte and surrounding cells, including stromal cells. However, the mechanism by which stromal cells an...

    Authors: Shu Tan, Boya Feng, Mingzhu Yin, Huanjiao Jenny Zhou, Ge Lou, Weidong Ji, Yonghao Li and Wang Min

    Citation: Cell & Bioscience 2017 7:36

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  23. Content type: Review

    When hepatocytes are damaged severely, a variety of signaling pathways will be triggered by inflammatory factors and cytokines involving in the process of hepatic fibrosis. The microRNA (miRNA) family consists...

    Authors: Xue-Ping Jiang, Wen-Bing Ai, Lin-Yan Wan, Yan-Qiong Zhang and Jiang-Feng Wu

    Citation: Cell & Bioscience 2017 7:34

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  24. Content type: Research

    Disruption of blood–brain barrier (BBB) and subsequent infiltration of auto-reactive T lymphocytes are major characteristics of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). Kv1....

    Authors: Jie Huang, Song Han, Qi Sun, Yipeng Zhao, Junchen Liu, Xiaolu Yuan, Wenqian Mao, Biwen Peng, Wanhong Liu, Jun Yin and Xiaohua He

    Citation: Cell & Bioscience 2017 7:31

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  25. Content type: Research highlight

    Induced pluripotent stem cells (iPSCs) hold great promises in cell therapy. However, the potential safety issues have dampened the enthusiasm of their clinical development. One of the biggest concerns came fro...

    Authors: Hualong Yan, Yun-Bo Shi and Jing Huang

    Citation: Cell & Bioscience 2017 7:30

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  26. Content type: Review

    Human cancers results in large part from the accumulation of multiple mutations. The progression of premalignant cells is an evolutionary process in which mutations provide the fundamental driving force for ge...

    Authors: Jun Zou, Chen Wang, Xiangyi Ma, Edward Wang and Guang Peng

    Citation: Cell & Bioscience 2017 7:29

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  27. Content type: Research

    Chloroquine, a bitter tastant, inhibits Ca2+ signaling, resulting in suppression of B cell activation; however, the inhibitory mechanism remains unclear.

    Authors: Yi-Fan Wu, Ping Zhao, Xi Luo, Jin-Chao Xu, Lu Xue, Qi Zhou, Mingrui Xiong, Jinhua Shen, Yong-Bo Peng, Meng-Fei Yu, Weiwei Chen, Liqun Ma and Qing-Hua Liu

    Citation: Cell & Bioscience 2017 7:28

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  28. Content type: Research

    Bone degenerative disorders like osteoporosis may be initiated by age-related shifts in anabolic and catabolic responses that control bone homeostasis. Although there are studies suggesting that metabolic chan...

    Authors: Min Ling, Peixin Huang, Shamima Islam, Daniel P. Heruth, Xuanan Li, Li Qin Zhang, Ding-You Li, Zhaohui Hu and Shui Qing Ye

    Citation: Cell & Bioscience 2017 7:27

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  29. Content type: Research

    Natural killer (NK)T cells and conventional T cells share phenotypic characteristic however they differ in transcription factor requirements and functional properties. The role of histone modifying enzymes in ...

    Authors: Daniel Northrup, Ryoji Yagi, Kairong Cui, William R. Proctor, Chaochen Wang, Katarzyna Placek, Lance R. Pohl, Rongfu Wang, Kai Ge, Jinfang Zhu and Keji Zhao

    Citation: Cell & Bioscience 2017 7:25

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  30. Content type: Review

    Regulation of lineage specification and differentiation in embryonic stem (ES) cells can be achieved through the activation of endogenous signaling, an avenue for potential application in regenerative medicine...

    Authors: Katherine Dixon, Jihong Chen and Qiao Li

    Citation: Cell & Bioscience 2017 7:23

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  31. Content type: Research

    Oculocutaneous albinism (OCA) is an autosomal recessive disorder. A significant portion of OCA patients has been found with a single pathogenic variant either in the TYR or the OCA2 gene. Diagnostic sequencing of...

    Authors: Jackson Gao, Leera D’Souza, Keith Wetherby, Christian Antolik, Melissa Reeves, David R. Adams, Santa Tumminia and Xinjing Wang

    Citation: Cell & Bioscience 2017 7:22

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  32. Content type: Review

    Genome editing promises giant leaps forward in advancing biotechnology, agriculture, and basic research. The process relies on the use of sequence specific nucleases (SSNs) to make DNA double stranded breaks a...

    Authors: Aimee Malzahn, Levi Lowder and Yiping Qi

    Citation: Cell & Bioscience 2017 7:21

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  33. Content type: Research

    Parkinson disease (PD) is the most common movement disturbance characterized by the loss of dopaminergic (DA) neurons in midbrain. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is aberrantly ...

    Authors: Wei Liu, Qishun Zhang, Jianlei Zhang, Wujun Pan, Jingya Zhao and Yuming Xu

    Citation: Cell & Bioscience 2017 7:19

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