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  1. Colorectal cancer (CRC) is the fourth leading cause of the worldwide cancer mortality. Different molecular mechanisms have been attributed to the development and progress of CRC. In this review, we will focus ...

    Authors: Zahra Koveitypour, Farnoush Panahi, Mehrdad Vakilian, Maryam Peymani, Farzad Seyed Forootan, Mohammad Hossein Nasr Esfahani and Kamran Ghaedi

    Citation: Cell & Bioscience 2019 9:97

    Content type: Review

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  2. High levels of ROS cause oxidative stress, which plays a critical role in cell death. As a ROS effector protein, PRL2 senses ROS and controls phagocyte bactericidal activity during infection. Here we report PR...

    Authors: Xinyue Du, Yang Zhang, Xiao Li, Qi Li, Chenyun Wu, Guangjie Chen, XiaoKui Guo, Yongqiang Weng and Zhaojun Wang

    Citation: Cell & Bioscience 2019 9:96

    Content type: Research

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  3. Along with the decline in oocyte quality, numerous defects such as mitochondrial insufficiency and the increase of mutation and deletion have been reported in oocyte mitochondrial DNA (mtDNA) following aging. ...

    Authors: Halimeh Mobarak, Mohammad Heidarpour, Pei-Shiue Jason Tsai, Aysa Rezabakhsh, Reza Rahbarghazi, Mohammad Nouri and Mahdi Mahdipour

    Citation: Cell & Bioscience 2019 9:95

    Content type: Review

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  5. Forkhead box P3+ (FOXP3+) regulatory T cells (Tregs) are a subset of lymphocytes, critical for the maintenance of immune homeostasis. Loss-of-function mutations of the FOXP3 gene in animal models and humans resul...

    Authors: Vida Forstnerič, Irena Oven, Jernej Ogorevc, Duško Lainšček, Arne Praznik, Tina Lebar, Roman Jerala and Simon Horvat

    Citation: Cell & Bioscience 2019 9:93

    Content type: Research

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  7. Imbalance between amyloid-beta (Aβ) peptide synthesis and clearance results in Aβ deregulation. Failure to clear these peptides appears to cause the development of Alzheimer’s disease (AD). In recent years, mi...

    Authors: Soheil Madadi, Heidi Schwarzenbach, Massoud Saidijam, Reza Mahjub and Meysam Soleimani

    Citation: Cell & Bioscience 2019 9:91

    Content type: Review

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  9. Schizophrenia is a common psychiatric disease with high hereditary. The identification of schizophrenia risk genes (SRG) has shed light on its pathophysiological mechanisms. Mouse genetic models have been wide...

    Authors: Hai-Long Zhang, Jia-Wen Long, Wei Han, Jiuzhou Wang, Weichen Song, Guan Ning Lin and Dong-Min Yin

    Citation: Cell & Bioscience 2019 9:89

    Content type: Research

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  10. Imatinib shows limited efficacy in patients with gastrointestinal stromal tumors (GISTs) carrying secondary KIT mutations. HQP1351, an orally bioavailable multikinase BCR-ABL inhibitor, is currently in clinica...

    Authors: Xuechao Liu, Guangfeng Wang, Xianglei Yan, Haibo Qiu, Ping Min, Miaoyi Wu, Chunyang Tang, Fei Zhang, Qiuqiong Tang, Saijie Zhu, Miaozhen Qiu, Wei Zhuang, Douglas D. Fang, Zhiwei Zhou, Dajun Yang and Yifan Zhai

    Citation: Cell & Bioscience 2019 9:88

    Content type: Research

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  11. Overlap extension polymerase chain reaction (PCR) is a powerful technology for DNA assembly. Based on this technology, we synthesized DNA templates, which were transcribed into sgRNA in vitro, and further dete...

    Authors: Zheng Hu, Li Wang, Zhaoying Shi, Jing Jiang, Xiangning Li, Yonglong Chen, Kai Li and Dixian Luo

    Citation: Cell & Bioscience 2019 9:87

    Content type: Letter to the Editor

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  12. Pregnancy-associated cardiomyopathy (PAH) represents a pregnancy-associated myocardial disease that is characterized by the progression of heart failure due to marked left ventricular systolic dysfunction. Com...

    Authors: Yi Wang, Zhiheng Guo, Yongmei Gao, Ping Liang, Yanhong Shan and Jin He

    Citation: Cell & Bioscience 2019 9:86

    Content type: Research

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  13. The growth plate is a special region of the cartilage that drives longitudinal growth of long bones. Proliferating chondrocytes in the growth plate, arranged in columns, divide perpendicular to the long axis o...

    Authors: Huiyan Gan, Wenqian Xue, Ya Gao, Guixia Zhu, Danny Chan, Kathryn S. E. Cheah and Jiandong Huang

    Citation: Cell & Bioscience 2019 9:85

    Content type: Research

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  14. To investigate the mechanism of LncRNA H19 in Th17 cell differentiation and endometrial stromal cells (ESCs) proliferation in endometriosis (EMS).

    Authors: Zheying Liu, Liya Liu, Yun Zhong, Mingbo Cai, Junbi Gao, Chaoyue Tan, Xiaoxiao Han, Ruixia Guo and Liping Han

    Citation: Cell & Bioscience 2019 9:84

    Content type: Research

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  15. Cellular heterogeneity, which was initially defined for tumor cells, is a fundamental property of all cellular systems, ranging from genetic diversity to cell-to-cell variation driven by stochastic molecular i...

    Authors: Gang Ren and Keji Zhao

    Citation: Cell & Bioscience 2019 9:83

    Content type: Review

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  17. Increasing evidence has indicated that long noncoding RNAs (lncRNAs) are crucial regulators affecting the progression of human cancers. Recently, lncRNA downregulated in liver cancer stem cells (lnc-DILC) was ...

    Authors: Han Zhang, Pengtao Wei, Wenwei Lv, Xingtao Han, Jinhui Yang and Shuaifeng Qin

    Citation: Cell & Bioscience 2019 9:81

    Content type: Research

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  18. Babao Dan (BBD), a traditional Chinese medicine, has been used as a complementary and alternative medicine to treat multifarious liver diseases. In this study, we aimed to observe its protective effect on etha...

    Authors: Yang Yu, Zhi-qiang Tian, Lei Liang, Xue Yang, Dan-dan Sheng, Jian-xing Zeng, Xiao-yong Li, Rong-yu Shi, Zhi-peng Han and Li-xin Wei

    Citation: Cell & Bioscience 2019 9:80

    Content type: Research

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  19. Hepatocellular carcinoma (HCC) is among the most prevalent and lethal cancers in the human population. HCC is an inflammation-associated cancer caused by different etiological factors. The chronic inflammation...

    Authors: Zhiqiang Tian, Xiaojuan Hou, Wenting Liu, Zhipeng Han and Lixin Wei

    Citation: Cell & Bioscience 2019 9:79

    Content type: Review

    Published on:

  20. The long non-coding RNA UCA1 is reportedly increased in several human tumors and critical for the cell migration, invasion, or proliferation of several cancer cells. However, the potential roles of UCA1 in tro...

    Authors: Hongfang Shao, Feng Jin, Jiangshan Hu, Zhangying Zhu, Fuju Tian, Minfang Tao and Yincheng Teng

    Citation: Cell & Bioscience 2019 9:78

    Content type: Research

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  21. Babaodan (BBD), a traditional Chinese medicine, has been shown to have protective effects during liver injury and ameliorate liver disease progression, but little is known about its effect on non-alcoholic fat...

    Authors: Dandan Sheng, Shanmin Zhao, Lu Gao, Huifei Zheng, Wenting Liu, Jing Hou, Yuxiang Jin, Fei Ye, Qiudong Zhao, Rong Li, Naping Zhao, Li Zhang, Zhipeng Han and Lixin Wei

    Citation: Cell & Bioscience 2019 9:77

    Content type: Research

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  22. The prognosis of esophageal cancer is still dismal because of its high probability of metastasis that is likely related to the cellular process of epithelial–mesenchymal transition (EMT). Recent studies have s...

    Authors: Yuxiang Jin, Xinye Lu, Mingdong Wang, Xuewei Zhao and Lei Xue

    Citation: Cell & Bioscience 2019 9:76

    Content type: Research

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  24. Whether neurogenesis occurs in the adult human brain has been a long-debated topic fueled by conflicting data both for and against neurogenesis in the mature brain. Recent reports from two independent teams ma...

    Authors: Xinjuan Lei, Yajun Wu, MengMeng Xu, Odell D. Jones, Jianjie Ma and Xuehong Xu

    Citation: Cell & Bioscience 2019 9:74

    Content type: Research highlight

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  26. Increasing evidence has revealed that long non-coding RNAs (lncRNAs) play a pivotal role in the development of nervous system. Our previous studies have demonstrated that enhanced cholinergic neurogenesis occu...

    Authors: Xiang Cheng, Haoming Li, Heyan Zhao, Wen Li, Jianbing Qin and Guohua Jin

    Citation: Cell & Bioscience 2019 9:72

    Content type: Research

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  27. Pluripotency is proposed to exist in two different stages: Naive and Primed. Conventional human pluripotent cells are essentially in the primed stage. In recent years, several protocols have claimed to generat...

    Authors: Meisam Yousefi, Sayed-Amir Marashi, Ali Sharifi-Zarchi and Sara Taleahmad

    Citation: Cell & Bioscience 2019 9:71

    Content type: Research

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  28. Dual-specificity phosphatases (DUSPs) are a subset of protein tyrosine phosphatases (PTPs), many of which dephosphorylate the residues of phosphor-serine/threonine and phosphor-tyrosine on mitogen-activated pr...

    Authors: Tao Ding, Ya Zhou, Runying Long, Chao Chen, Juanjuan Zhao, Panpan Cui, Mengmeng Guo, Guiyou Liang and Lin Xu

    Citation: Cell & Bioscience 2019 9:70

    Content type: Review

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  29. Congenital coagulation factor (F) VII deficiency is a rare bleeding disorder caused by mutations in the F7 gene. The missense factor FVII variant p.Q160R is the disease-causing mutation in all Norwegian FVII defi...

    Authors: Elisabeth Andersen, Maria Eugenia Chollet, Marcello Baroni, Mirko Pinotti, Francesco Bernardi, Ellen Skarpen, Per Morten Sandset and Grethe Skretting

    Citation: Cell & Bioscience 2019 9:69

    Content type: Research

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  30. The protective effect of metformin (MET) on abdominal aortic aneurysm (AAA) has been reported. However, the related mechanism is still poor understood. In this study, we deeply investigated the role of metform...

    Authors: Zhu Wang, Jingjing Guo, Xinqiang Han, Ming Xue, Wenming Wang, Lei Mi, Yuguo Sheng, Chao Ma, Jian Wu and Xuejun Wu

    Citation: Cell & Bioscience 2019 9:68

    Content type: Research

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  32. Epitranscriptomics, also known as “RNA epigenetics”, is a chemical modification for RNA regulation. Ribonucleic acid (RNA) methylation is considered to be a major discovery following the deoxyribonucleic acid ...

    Authors: Jiashuo Li, Xinxin Yang, Zhipeng Qi, Yanqi Sang, Yanan Liu, Bin Xu, Wei Liu, Zhaofa Xu and Yu Deng

    Citation: Cell & Bioscience 2019 9:66

    Content type: Review

    Published on:

  33. Autophagy is a catabolic process for degradation of intracellular components. Damaged proteins and organelles are engulfed in double-membrane vesicles ultimately fused with lysosomes. These vesicles, known as ...

    Authors: Bahareh Kardideh, Zahra Samimi, Fatemeh Norooznezhad, Sarah Kiani and Kamran Mansouri

    Citation: Cell & Bioscience 2019 9:65

    Content type: Review

    Published on:

  34. Chronic hepatitis B virus (HBV) infection is one of the most serious global public health problems. The role of steroid receptor coactivator 3 (SRC-3) in HBV biosynthesis is unknown. The aim of this study is t...

    Authors: Ming Li, Yi Wang, Xiaochun Xia, Pingli Mo, Jianming Xu, Chundong Yu and Wengang Li

    Citation: Cell & Bioscience 2019 9:64

    Content type: Research

    Published on:

  35. Non-small-cell lung cancer (NSCLC) is the most common malignancy worldwide. Platinum-based chemotherapy is the standard of care for these patients. Recent research showed that miR-7 methylation status is a bio...

    Authors: Carlos Rodríguez-Antolín, Laura Felguera-Selas, Olga Pernía, Olga Vera, Isabel Esteban, Itsaso Losantos García, Javier de Castro, Rocío Rosas-Alonso and Inmaculada Ibanez de Caceres

    Citation: Cell & Bioscience 2019 9:63

    Content type: Letter to the Editor

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  36. Colon-cancer-cell-derived exosomes (CDEs) are emerging mediators of tumorigenesis and serve as messengers of intercellular communication; however, whether the CDEs affect the proliferation of colon cancer cell...

    Authors: Ruixue Ren, Hua Sun, Cui Ma, Jiatao Liu and Hua Wang

    Citation: Cell & Bioscience 2019 9:62

    Content type: Research

    Published on:

  38. Mutated epidermal growth factor receptor (EGFR) is one of the most successful targets in cancer targeted therapy. While this treatment has benefited many patients with an activating EGFR mutation (EGFRm), almo...

    Authors: Yihong Zhan, Yue Wang, Miao Qi, Panpan Liang, Yu Ma, Ting Li, Hui Li, Congmei Dai, Zhifeng An, Yitao Qi, Hongmei Wu and Huanjie Shao

    Citation: Cell & Bioscience 2019 9:60

    Content type: Research

    Published on:

  41. In the publication of this article [1], there is an error in one of the contributing author names.

    Authors: Le Zhang, Rong Lian, Jingjing Zhao, Xianming Feng, Runyi Ye, Lingxiao Pan, Jueheng Wu, Mengfeng Li, Yongbo Huang and Junchao Cai

    Citation: Cell & Bioscience 2019 9:57

    Content type: Correction

    Published on:

    The original article was published in Cell & Bioscience 2019 9:44

  42. Water scarcity is considered to be a severe environmental constraint to plant survival and productivity. Studies on drought-tolerant plants would definitely promote a better understanding of the regulatory mec...

    Authors: Huihui Gu, Yan Yang, Minghui Xing, Caipeng Yue, Fang Wei, Yanjie Zhang, Wenen Zhao and Jinyong Huang

    Citation: Cell & Bioscience 2019 9:56

    Content type: Research

    Published on:

  43. Recent evidence has shown that C-X-C chemokine receptor type 4 (CXCR4) plays a crucial role in acute lung injury (ALI). Macrophages are key factors in the pathogenesis of ALI. The aim of this study was to inve...

    Authors: Xue Tian, Guogang Xie, Hui Xiao, Fengming Ding, Wuping Bao and Min Zhang

    Citation: Cell & Bioscience 2019 9:55

    Content type: Research

    Published on:

  46. Pyruvate kinase (PK), as one of the key enzymes for glycolysis, can encode four different subtypes from two groups of genes, although the M2 subtype PKM2 is expressed mainly during embryonic development in nor...

    Authors: Ze Zhang, Xinyue Deng, Yuanda Liu, Yahui Liu, Liankun Sun and Fangfang Chen

    Citation: Cell & Bioscience 2019 9:52

    Content type: Review

    Published on:

    The Correction to this article has been published in Cell & Bioscience 2019 9:59

  47. An underlying state of inflammation is thought to be an important cause of cardiovascular disease. Among cells involved in the early steps of atherosclerosis, monocyte-derived dendritic cells (Mo-DCs) respond ...

    Authors: Geneviève Hamel-Côté, Fanny Lapointe, Steeve Véronneau, Marian Mayhue, Marek Rola-Pleszczynski and Jana Stankova

    Citation: Cell & Bioscience 2019 9:51

    Content type: Research

    Published on:

  48. Gemcitabine is the standard first-line chemotherapy regimen for pancreatic cancer. However, its therapeutic value is substantially limited in pancreatic cancer patients due to occurrence of resistance towards ...

    Authors: Hehe Li, Zhengle Zhang, Chenggang Gao, Shihong Wu, Qingke Duan, Heshui Wu, Chunyou Wang, Qiang Shen and Tao Yin

    Citation: Cell & Bioscience 2019 9:50

    Content type: Research

    Published on:

  49. Polyploidy is considered as a basic event in plant speciation and evolution in nature, and the cytological and proteomic profilings of floral buds at meiosis (FAM) would definitely contribute to a better under...

    Authors: Yan Yang, Fang Wei, Janeen Braynen, Xiaochun Wei, Baoming Tian, Gongyao Shi, Gangqiang Cao, Jiachen Yuan and Xiaowei Zhang

    Citation: Cell & Bioscience 2019 9:49

    Content type: Research

    Published on:

  50. Adipocyte accumulation is a predominant feature of age-related thymic involution, but the mechanisms responsible for thymic adipogenesis remain to be elucidated. The aim of this study was to identify key regul...

    Authors: Jianxin Tan, Yajun Wang, Siliang Wang, Simeng Wu, Zhe Yuan and Xike Zhu

    Citation: Cell & Bioscience 2019 9:48

    Content type: Research

    Published on:

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