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  1. Cancer stem cells (CSCs) are the root of human cancer development and the major cause of treatment failure. Aberrant elevation of SOX4, a member of SOX (SRY-related HMG-box) family transcription factors, has b...

    Authors: Jingshu Liu, Jiangfeng Qiu, Zhiqi Zhang, Lei Zhou, Yunzhe Li, Dongyan Ding, Yang Zhang, Dongling Zou, Dong Wang, Qi Zhou and Tingyuan Lang

    Citation: Cell & Bioscience 2021 11:23

    Content type: Research

    Published on:

  2. Previous studies demonstrated the dependence of cancer on nerve. Recently, a growing number of studies reveal that cancer cells share the property and regulatory network with neural stem/progenitor cells. Howe...

    Authors: Liyang Xu, Min Zhang, Lihua Shi, Xiaoli Yang, Lu Chen, Ning Cao, Anhua Lei and Ying Cao

    Citation: Cell & Bioscience 2021 11:21

    Content type: Research

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  3. Intestinal dysbiosis is believed to be one of the factors inducing neonatal necrotizing enterocolitis (NEC). Probiotics have been employed to treat NEC in a number of animal experiments and clinical trials, an...

    Authors: Xiuhao Zhao, Jin Zhou, Wenhua Liang, Qingfeng Sheng, Li Lu, Tong Chen, Jianglong Chen, Kezhe Tan and Zhibao Lv

    Citation: Cell & Bioscience 2021 11:20

    Content type: Research

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  4. Eukaryotic cells produce extracellular vesicles (EVs) mediating intercellular communication. These vesicles encompass many bio-molecules such as proteins, nucleic acids, and lipids that are transported between...

    Authors: Jafar Rezaie, Cynthia Aslan, Mahdi Ahmadi, Naime Majidi Zolbanin, Fatah Kashanchi and Reza Jafari

    Citation: Cell & Bioscience 2021 11:19

    Content type: Review

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  5. Haematopoiesis, the process by which a restrained population of stem cells terminally differentiates into specific types of blood cells, depends on the tightly regulated temporospatial activity of several tran...

    Authors: Alessia Oppezzo and Filippo Rosselli

    Citation: Cell & Bioscience 2021 11:18

    Content type: Review

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  6. Polyploidy is widespread in angiosperms and has a significant impact on plant evolution, diversity, and breeding program. However, the changes in the flower development regulatory mechanism in autotetraploid p...

    Authors: Janeen Braynen, Yan Yang, Jiachen Yuan, Zhengqing Xie, Gangqiang Cao, Xiaochun Wei, Gongyao Shi, Xiaowei Zhang, Fang Wei and Baoming Tian

    Citation: Cell & Bioscience 2021 11:17

    Content type: Research

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  7. Oral mesenchymal stem cells (MSCs) and their secretomes are considered important factors in the field of medical tissue engineering and cell free biotherapy due to their ease of access, differentiation potenti...

    Authors: Leila Gholami, Vajihe Taghdiri Nooshabadi, Shiva Shahabi, Marzieh Jazayeri, Rana Tarzemany, Zohreh Afsartala and Khatereh Khorsandi

    Citation: Cell & Bioscience 2021 11:16

    Content type: Review

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  8. M6A methyltransferases, acting as a writer in N6-methyladenosine, have attracted wide attention due to their dynamic regulation of life processes. In this review, we first briefly introduce the individual compon....

    Authors: Jianzhong Gu, Yu Zhan, Lvjia Zhuo, Qin Zhang, Guohua Li, Qiujie Li, Shasha Qi, Jinyu Zhu, Qun Lv, Yingying Shen, Yong Guo, Shuiping Liu, Tian Xie and Xinbing Sui

    Citation: Cell & Bioscience 2021 11:15

    Content type: Review

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  9. Mechanotransduction couples mechanical stimulation with ion flux, which is critical for normal biological processes involved in neuronal cell development, pain sensation, and red blood cell volume regulation. ...

    Authors: Xiang-Zhi Fang, Ting Zhou, Ji-Qian Xu, Ya-Xin Wang, Miao-Miao Sun, Ya-Jun He, Shang-Wen Pan, Wei Xiong, Zhe-Kang Peng, Xue-Hui Gao and You Shang

    Citation: Cell & Bioscience 2021 11:13

    Content type: Review

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  10. Mucosal-associated invariant T (MAIT) cells are an invariant T cell subset, which have been reported to play an antimicrobial role in infectious diseases. However, little is known about it in malignant disease...

    Authors: Chunyan Shao, Chenwen Zhu, Yun Zhu, Jiqing Hao, Yongxiang Li, Huaqing Hu, Li Si, Fei Zhong, Xuefu Wang and Hua Wang

    Citation: Cell & Bioscience 2021 11:12

    Content type: Research

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  11. Numerous signaling pathways have been demonstrated experimentally to affect the pathogenesis of cerebral cavernous malformations (CCM), a disease that can be caused by CCM3 deficiency. However, the understandi...

    Authors: Kang Wang, Haixuan Chen, Zhongyang Zhou, Haifeng Zhang, Huanjiao Jenny Zhou and Wang Min

    Citation: Cell & Bioscience 2021 11:11

    Content type: Research

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  12. Acute liver failure (ALF) is associated with a high mortality rate, and there are still no effective treatments except liver transplantation and artificial liver therapies. This study aimed to determine the ef...

    Authors: Guohua Lou, Aichun Li, Yelei Cen, Qin Yang, Tianbo Zhang, Jinjin Qi, Zhi Chen and Yanning Liu

    Citation: Cell & Bioscience 2021 11:9

    Content type: Research

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  13. The evasion from apoptosis is a common strategy adopted by most tumors, and inhibitors of apoptosis proteins (IAPs) are among the most studied molecular and therapeutic targets. BIRC3 (cellular IAP2) and BIRC5 (s...

    Authors: Raffaele Frazzi

    Citation: Cell & Bioscience 2021 11:8

    Content type: Review

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  14. Mesenchymal stem cells (MSCs) have been proved to drive castration resistant prostate cancer (CRPC). In this study, we aim to investigate the contribution of MSCs to the development of docetaxel resistance in ...

    Authors: Yang Yu, Fu-han Yang, Wen-tao Zhang, Ya-dong Guo, Lin Ye and Xu-dong Yao

    Citation: Cell & Bioscience 2021 11:7

    Content type: Research

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  15. Current studies have enlightened the rosy prospects of human pluripotent stem cell (hPSC)-derived mesenchymal stem/stromal cells (MSCs) in regenerative medicine. However, systematic investigation of their sign...

    Authors: Leisheng Zhang, Yimeng Wei, Ying Chi, Dengke Liu, Sijun Yang, Zhongchao Han and Zongjin Li

    Citation: Cell & Bioscience 2021 11:6

    Content type: Research

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  16. Goserelin is an effective alternative to surgery or estrogen therapy in prostate cancer palliation, and possibly to ovariectomy in premenopausal breast cancer. However, not all users of goserelin can benefit f...

    Authors: Yue Zhao, Huimin Sun, Jianzhong Zheng, Chen Shao and Dongwei Zhang

    Citation: Cell & Bioscience 2021 11:5

    Content type: Research

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  17. The fertilizing spermatozoon is a highly specialized cell that selects from millions along the female tract until the oocyte. The paternal components influence the oocyte activation during fertilization and ar...

    Authors: Mohammad Ishraq Zafar, Shi Lu and Honggang Li

    Citation: Cell & Bioscience 2021 11:4

    Content type: Review

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  18. Hepatic stellate cells (HSCs) are activated in response to liver injury with TIF1γ-suppression, leading to liver fibrosis. Here, we examined the mechanism how reduction of TIF1γ in HSCs induces damage on hepat...

    Authors: Injoo Hwang, Eun Ju Lee, Hyomin Park, Dodam Moon and Hyo-Soo Kim

    Citation: Cell & Bioscience 2021 11:3

    Content type: Research

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  19. Interleukin-22 (IL-22), a member of the IL-10 family of cytokines, is produced by a number of immune cells involved in the immune microenvironment of the body. IL-22 plays its pivotal roles by binding to the I...

    Authors: Xiuyun Xuan, Lin Zhang, Chunxia Tian, Ting Wu, Haihua Ye, Juanmei Cao, Fangqi Chen, Yan Liang, Huilan Yang and Changzheng Huang

    Citation: Cell & Bioscience 2021 11:2

    Content type: Review

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  20. Drug resistance is a major impediment in cancer therapy which strongly reduces the efficiency of anti-cancer drugs. Exosomes are extracellular vesicles with cup or spherical shape with a size range of 40–150 n...

    Authors: Mostafa Mostafazadeh, Nasser Samadi, Houman Kahroba, Behzad Baradaran, Sanya Haiaty and Mohammad Nouri

    Citation: Cell & Bioscience 2021 11:1

    Content type: Review

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  21. The angiotensin-converting enzyme 2 (ACE2) is the host functional receptor for the new virus SARS-CoV-2 causing Coronavirus Disease 2019. ACE2 is expressed in 72 different cell types. Some factors that can aff...

    Authors: Miriam Marlene Medina-Enríquez, Sandra Lopez-León, José Alberto Carlos-Escalante, Zuleika Aponte-Torres, Angelica Cuapio and Talia Wegman-Ostrosky

    Citation: Cell & Bioscience 2020 10:148

    Content type: Review

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  22. Increased reactive oxygen species (ROS) production by arsenic treatment in solid tumors showed to be effective to sensitize cancer cells to chemotherapies. Arsenic nano compounds are known to increase the ROS ...

    Authors: Wei Zhou, Meiyue Liu, Xia Li, Peng Zhang, Jiong Li, Yue Zhao, Guogui Sun and Weimin Mao

    Citation: Cell & Bioscience 2020 10:146

    Content type: Research

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    The Correction to this article has been published in Cell & Bioscience 2021 11:22

  23. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Aihua Bao, Aying Ma, Hui Zhang, Lihua Qiao, Suqin Ben, Xin Zhou and Min Zhang

    Citation: Cell & Bioscience 2020 10:145

    Content type: Correction

    Published on:

    The original article was published in Cell & Bioscience 2020 10:120

  24. Accumulating evidence shows that Parkinson’s disease is negatively associated with colon cancer risk, indicating that Parkinson’s disease family proteins may be involved in the initiation of colon cancer. Here...

    Authors: Qian Chen, Li Zhong, Chao Zhou, Yan Feng, Quan-xing Liu, Dong Zhou, Xiao Lu, Guang-Sheng Du, Dan Jian, Hao Luo, Dong Wang, Hong Zheng and Yuan Qiu

    Citation: Cell & Bioscience 2020 10:144

    Content type: Research

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  25. Enhancer of zeste homolog 2 (EZH2), as a main component of Polycomb Repressive Complex 2, catalyzes histone H3K27me3 to silence its target gene expression. EZH2 upregulation results in cancer development and p...

    Authors: Zhongwei Li, Minle Li, Diandian Wang, Pingfu Hou, Xintian Chen, Sufang Chu, Dafei Chai, Junnian Zheng and Jin Bai

    Citation: Cell & Bioscience 2020 10:143

    Content type: Review

    Published on:

  26. The expression of Kelch-like protein 18 (KLHL18) in non-small cell lung cancer (NSCLC) is lower than that in normal lung tissue according to the Gene Expression Profiling Interactive Analysis database. KLHL18 ...

    Authors: Xizi Jiang, Yitong XU, Hongjiu Ren, Jun Jiang, Muli Wudu, Qiongzi Wang, Jingqian Guan, Hongbo Su, Yao Zhang, Bo Zhang, Yuanzi Guo, Yujiao Hu, Lihong Jiang, Zongang Liu, Huanxi Wang, Yu Cheng…

    Citation: Cell & Bioscience 2020 10:139

    Content type: Research

    Published on:

  27. Proliferation markers, such as proliferating cell nuclear antigen (PCNA), Ki-67, and thymidine kinase 1 (TK1), have potential as diagnostic tools and as prognostic factors in assessing cancer treatment and dis...

    Authors: Eliza E. Bitter, Michelle H. Townsend, Rachel Erickson, Carolyn Allen and Kim L. O’Neill

    Citation: Cell & Bioscience 2020 10:138

    Content type: Review

    Published on:

  28. Macrophages that accumulate in atherosclerotic plaques contribute to progression of the lesions to more advanced and complex plaques. Although iron deposition was found in human atherosclerotic plaques, clinic...

    Authors: Jing Cai, Meng Zhang, Yutong Liu, Huihui Li, Longcheng Shang, Tianze Xu, Zhipeng Chen, Fudi Wang, Tong Qiao and Kuanyu Li

    Citation: Cell & Bioscience 2020 10:137

    Content type: Research

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  29. Epilepsy is characterized by the typical symptom of seizure, and anti-seizure medications are the main therapeutic method in clinical, but the effects of these therapy have not been satisfactory. To find a bet...

    Authors: Zheng Yu, Meiying Zhang, Bin Luo, Hongyang Jing, Yue Yu, Shunqi Wang and Shiwen Luo

    Citation: Cell & Bioscience 2020 10:135

    Content type: Research

    Published on:

  30. Some chemokine receptors referred to as atypical chemokine receptors (ACKRs) are thought to non-signaling decoys because of their inability to activate typical G-protein signaling pathways. CXCR7, also known a...

    Authors: Huong Thi Nguyen, Arfaxad Reyes-Alcaraz, Hyo Jeong Yong, Lan Phuong Nguyen, Hee-Kyung Park, Asuka Inoue, Cheol Soon Lee, Jae Young Seong and Jong-Ik Hwang

    Citation: Cell & Bioscience 2020 10:134

    Content type: Research

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  31. Colostrum quality is a vital factor in mortality and growth performance for piglets. Lactoferrin is an immuno-active milk protein that contributes to the formation of a protective layer above intestinal mucosa...

    Authors: Xiaosong Han, Yang Gao, Guanglei Li, Youcai Xiong, Changzhi Zhao, Jinxue Ruan, Yunlong Ma, Xinyun Li, Changchun Li, Shuhong Zhao and Shengsong Xie

    Citation: Cell & Bioscience 2020 10:133

    Content type: Letter to the Editor

    Published on:

  32. Aberration of estrogen (E2) and/or progesterone (P4) signaling pathways affects expression of their target genes, which may lead to failure of embryo implantation and following pregnancy. Although many target gen...

    Authors: Hee Kyoung Park, So Hee Park, Miji Lee, Gyeong Ryeong Kim, Mira Park, Seung Chel Yang, Yeon Sun Kim, Hyunjung J. Lim, Hye-Ryun Kim and Haengseok Song

    Citation: Cell & Bioscience 2020 10:132

    Content type: Research

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  33. Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular degradation, antigen presentation, intracellular pathogen destruc...

    Authors: Tao Tang, Ze-yu Yang, Di Wang, Xian-yan Yang, Jun Wang, Lin Li, Qian Wen, Lei Gao, Xiu-wu Bian and Shi-cang Yu

    Citation: Cell & Bioscience 2020 10:131

    Content type: Review

    Published on:

  34. Mesenchymal stem cells (MSCs) represent a promising treatment option for acute kidney injury (AKI). The main drawbacks of MSCs therapy, including the lack of specific homing after systemic infusion and early c...

    Authors: Song Zhou, Yu-ming Qiao, Yong-guang Liu, Ding Liu, Jian-min Hu, Jun Liao, Min Li, Ying Guo, Li-pei Fan, Liu-Yang Li and Ming Zhao

    Citation: Cell & Bioscience 2020 10:130

    Content type: Research

    Published on:

  35. Both testis and ovary can be produced sequentially in an individual with the same genome when sex reversal occurs in the teleost Monopterus albus, and epigenetic modification is supposed to be involved in gonadal...

    Authors: Xin Wang, Fengling Lai, Jun Xiong, Wang Zhu, Bifeng Yuan, Hanhua Cheng and Rongjia Zhou

    Citation: Cell & Bioscience 2020 10:129

    Content type: Research

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  36. The tumor microenvironment (TME) is a complex multicellular functional compartment that includes fibroblasts, myofibroblasts, endothelial cells, immune cells, and extracellular matrix (ECM) elements. The micro...

    Authors: Jie Zhang, Chaoyu Gu, Qianqian Song, Mengqi Zhu, Yuqing Xu, Mingbing Xiao and Wenjie Zheng

    Citation: Cell & Bioscience 2020 10:127

    Content type: Review

    Published on:

  37. Mesenchymal stem cells (MSCs) isolated from bone marrow have different developmental origins, including neural crest. MSCs can differentiate into neural progenitor-like cells (NPCs) under the influence of bFGF...

    Authors: Amir Ali Khan, Tee Jong Huat, Abdullah Al Mutery, Ahmed Taher El-Serafi, Hassen Hadj Kacem, Sallam Hasan Abdallah, Muhammed Faruque Reza, Jafri Malin Abdullah and Hasnan Jaafar

    Citation: Cell & Bioscience 2020 10:126

    Content type: Research

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  38. Asthma is one of the main intractable diseases recognized by the international medical community. The current widely used bronchodilators for asthma—β2-adrenal receptor agonists—have limited therapeutic effect...

    Authors: Ping Zhao, Jia Liu, Qian Ming, Di Tian, Jingwen He, Ziwei Yang, Jinhua Shen, Qing-Hua Liu and Xinzhou Yang

    Citation: Cell & Bioscience 2020 10:125

    Content type: Research

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  39. Glioblastoma (GBM) is an immunosuppressive, highly vascular and devastating malignant brain tumor. Even with progressive combination treatment that includes surgery, radiotherapy, and chemotherapy, the prognos...

    Authors: Qing Zhang, Junwen Zhang, Yifu Tian, Guidong Zhu, Sisi Liu and Fusheng Liu

    Citation: Cell & Bioscience 2020 10:124

    Content type: Research

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  40. Risk stratifications for endometrial carcinoma (EC) depend on histopathology and molecular pathology. Histopathological risk stratification lacks reproducibility, neglects heterogeneity and contributes little ...

    Authors: Yuan Li, Jiaqi Li, Ensong Guo, Jia Huang, Guangguang Fang, Shaohua Chen, Bin Yang, Yu Fu, Fuxia Li, Zizhuo Wang, Rourou Xiao, Chen Liu, Yuhan Huang, Xue Wu, Funian Lu, Lixin You…

    Citation: Cell & Bioscience 2020 10:122

    Content type: Research

    Published on: