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  1. Stem cell-based regenerative medicine is a promising approach for tissue reconstruction. However, a large number of cells are needed in a typical clinical study, where conventional monolayer cultures might pos...

    Authors: Benson Koh, Nadiah Sulaiman, Mh Busra Fauzi, Jia Xian Law, Min Hwei Ng, Ruszymah Bt Hj Idrus and Muhammad Dain Yazid

    Citation: Cell & Bioscience 2020 10:75

    Content type: Review

    Published on:

  3. Interleukin-17A (IL-17) is an evolutionary conserved cytokine and best known for its role in boosting immune response. However, recent clinical researches showed that abundant IL-17 in tumor microenvironment w...

    Authors: Shijia Wang, Guan Wang, Liying Zhang, Fengying Li, Keli Liu, Ying Wang, Yufang Shi and Kai Cao

    Citation: Cell & Bioscience 2020 10:73

    Content type: Research

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  4. Arginine vasopressin (AVP) is elevated in patients with heart failure, and the increase in the AVP concentration in plasma is positively correlated with disease severity and mortality. Metoprolol (Met) is a be...

    Authors: Jieqiong Zhao, Yonghong Lei, Yanping Yang, Haibo Gao, Zhongchao Gai and Xue Li

    Citation: Cell & Bioscience 2020 10:72

    Content type: Research

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  5. Acute Liver failure (ALF) is a life-threatening disease and is determined by coagulopathy (with INR ≥ 1.5) and hepatic encephalopathy as a result of severe liver injury in patients without preexisting liver di...

    Authors: Mahshid Saleh, Mohammad Taher, Amir Ali Sohrabpour, Amir Abbas Vaezi, Mohsen Nasiri Toosi, Maria Kavianpour, Zeinab Ghazvinian, Shahrokh Abdolahi and Javad Verdi

    Citation: Cell & Bioscience 2020 10:71

    Content type: Review

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  6. Herpesvirus is ranked as one of the grand old members of all pathogens. Of all the viruses in the superfamily, Herpes simplex virus type 1 (HSV-1) is considered as a model virus for a variety of reasons. In a ...

    Authors: Qiaojuan Zhang, Miguel Martin-Caraballo and Shaochung V. Hsia

    Citation: Cell & Bioscience 2020 10:70

    Content type: Review

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  7. Mesenchymal stem cells (MSCs) were known to have excellent properties in cell therapy. However, the risk of immune rejection associated with cell transplant therapy hampers its use. Extracellular vesicles secr...

    Authors: Jiaxin Cai, Junyong Wu, Jiemin Wang, Yongjiang Li, Xiongbin Hu, Shifu Luo and Daxiong Xiang

    Citation: Cell & Bioscience 2020 10:69

    Content type: Review

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  9. Teleost fishes account for over half of extant vertebrate species. A core question in biology is how genomic changes drive phenotypic diversity that relates to the origin of teleost fishes.

    Authors: Yibin Cheng, Dantong Shang, Majing Luo, Chunhua Huang, Fengling Lai, Xin Wang, Xu Xu, Ruhong Ying, Lingling Wang, Yu Zhao, Li Zhang, Manyuan Long, Hanhua Cheng and Rongjia Zhou

    Citation: Cell & Bioscience 2020 10:67

    Content type: Research

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  11. Mesenchymal stromal cells (MSCs) are multiple stromal cells existing in various tissues and have already been employed in animal models and clinical trials to treat immune disorders through potent immunosuppre...

    Authors: Menghui Jiang, Jiayin Ye, Xuefeng Wang, Na Li, Ying Wang and Yufang Shi

    Citation: Cell & Bioscience 2020 10:65

    Content type: Research

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  12. Eukaryotic cells demonstrate two tightly linked vesicular transport systems, comprising intracellular vesicle transport and extracellular vesicle transport system. Intracellular transport vesicles can transloc...

    Authors: Leila Salimi, Ali Akbari, Nassrollah Jabbari, Behnam Mojarad, Ali Vahhabi, Sławomir Szafert, Sadegh Asghari Kalashani, Hamid Soraya, Muhammad Nawaz and Jafar Rezaie

    Citation: Cell & Bioscience 2020 10:64

    Content type: Review

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  13. Compared to radiation injury alone (RI), radiation injury combined wound (CI) further enhances acute radiation syndrome and subsequently mortality. We previously reported that therapy with Ghrelin, the 28-amin...

    Authors: Juliann G. Kiang, Joan T. Smith, Georgetta Cannon, Marsha N. Anderson, Connie Ho, Min Zhai, Wanchang Cui and Mang Xiao

    Citation: Cell & Bioscience 2020 10:63

    Content type: Research

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  14. Following publication of the original article [1], one of the funding was missing in the Funding section.

    Authors: Sheng Wang, Kristyn Gumpper, Tao Tan, Xianzhang Luo, Hui Guo, Changsheng Ming, Hanying Jiang, Jiangguo Fang, Guang Du, Hua Zhu, Jianjie Ma, Zhishui Chen and Nianqiao Gong

    Citation: Cell & Bioscience 2020 10:62

    Content type: Correction

    Published on:

    The original article was published in Cell & Bioscience 2018 8:28

  15. Following publication of the original article [1], the authors identified an error in Figs. 1b, 5b.

    Authors: Yi Wang, Zhiheng Guo, Yongmei Gao, Ping Liang, Yanhong Shan and Jin He

    Citation: Cell & Bioscience 2020 10:61

    Content type: Correction

    Published on:

    The original article was published in Cell & Bioscience 2019 9:86

  16. Thyroid hormone (T3) plays an important role in vertebrate development. Compared to the postembryonic development of uterus-enclosed mammalian embryos, T3-dependent amphibian metamorphosis is advantageous for ...

    Authors: Wonho Na, Liezhen Fu, Nga Luu and Yun-Bo Shi

    Citation: Cell & Bioscience 2020 10:60

    Content type: Research

    Published on:

  17. The benefit of inducing cellular senescence as a tumor suppressive strategy remains questionable due to the senescence-associated secretory phenotype. Hence, studies and development of senolytic compounds that...

    Authors: Thanakorn Pungsrinont, Malika Franziska Sutter, Maren C. C. M. Ertingshausen, Gopinath Lakshmana, Miriam Kokal, Amir Saeed Khan and Aria Baniahmad

    Citation: Cell & Bioscience 2020 10:59

    Content type: Research

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  18. The freshwater snail Oncomelania hupensis is the obligate intermediate host for Schistosoma japonicum in China. Transcriptomic examination of snail–schistosome interactions can provide valuable information of hos...

    Authors: Xinyu Feng, Lingqian Zhu, Zhiqiang Qin, Xiaojin Mo, Yuwan Hao, Ying Jiang, Wei Hu and Shizhu Li

    Citation: Cell & Bioscience 2020 10:58

    Content type: Research

    Published on:

  19. Forced polyploidization is an effective strategy for acute megakaryoblastic leukemia (AMKL) therapy and factors controlling polyploidization are potential targets for drug development. Although bone morphology...

    Authors: Manman Wang, Tan Zhang, Xuechun Zhang, Zhou Jiang, Min Peng and Zan Huang

    Citation: Cell & Bioscience 2020 10:57

    Content type: Research

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  20. Radiation damage to normal tissues is a serious concern. P53 is a well-known transcription factor which is closely associated with radiation-induced cell damage. Increasing evidence has indicated that regulati...

    Authors: Ruixue Huang, Xiaodan Liu, He Li, Yao Zhou and Ping-Kun Zhou

    Citation: Cell & Bioscience 2020 10:56

    Content type: Research

    Published on:

  21. In the past 30 years, incidences of non-alcoholic fatty liver disease (NAFLD) has risen by 30%. However, there is still no clear mechanism or accurate method of anticipating liver failure. Here we reveal the p...

    Authors: Liyang Wang, MengMeng Xu, Odell D. Jones, Zhongguang Li, Yu Liang, Qiuxia Yu, Jiali Li, Yajun Wu, Xinjuan Lei, Boling He, Huimin Yue, Liqin Xiao, Rong Zhou, Wei Zhang, Xin Zhou, Yuhui Zhang…

    Citation: Cell & Bioscience 2020 10:55

    Content type: Research

    Published on:

  23. Exocytosis is a process by which vesicles are transported to and fused with specific areas of the plasma membrane. Although several studies have shown that sphingolipids are the main components of exocytic com...

    Authors: Qingguo Guo, Tianrui Zhang, Na Meng, Yuran Duan, Yuan Meng, Dong Sun, Ying Liu and Guangzuo Luo

    Citation: Cell & Bioscience 2020 10:53

    Content type: Research

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  24. Thanks to the advancement in science and technology and a significant number of cancer research programs being carried out throughout the world, the prevention, prognosis and treatment of breast cancer are imp...

    Authors: Debparna Nandy, Sruthy Manuraj Rajam and Debasree Dutta

    Citation: Cell & Bioscience 2020 10:52

    Content type: Review

    Published on:

  25. Fndc5, a well-defined myokine and also identified as an adipokine, has a critical role in modulation of metabolism and protection against obesity. These important functions are mediated by irisin, a secretory ...

    Authors: Farzaneh Rabiee, Liana Lachinani, Sarvenaz Ghaedi, Mohammad Hossein Nasr-Esfahani, Timothy L. Megraw and Kamran Ghaedi

    Citation: Cell & Bioscience 2020 10:51

    Content type: Review

    Published on:

  26. OTUB1 (ovarian tumor domain protease domain-containing ubiquitin aldehyde-binding proteins)-mediated deubiquitination of FOXM1 (Forkhead box M1) participates in carcinogenesis of various tumors. We aim to inve...

    Authors: Kai Zhou, Haixing Mai, Song Zheng, Weizhong Cai, Xu Yang, Zhenlin Chen and Bin Zhan

    Citation: Cell & Bioscience 2020 10:50

    Content type: Research

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  31. Switching microglial polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype represents a novel therapeutic strategy for neuropathic pain (NP). This study aims to investigate ...

    Authors: Xianwei Gui, Hansen Wang, Lanxiang Wu, Sheng Tian, Xuan Wang, Heqing Zheng and Wei Wu

    Citation: Cell & Bioscience 2020 10:45

    Content type: Research

    Published on:

  33. Induction of biliary epithelial cell apoptosis by toxic bile acids is involved in the development of cholestatic disease, but the underlying molecular mechanism is not clear. The purpose of this study was to i...

    Authors: Jiye Li, Dongsheng Yu, Sanyang Chen, Yifan Liu, Jihua Shi, Jiakai Zhang, Peihao Wen, Zhihui Wang, Jie Li, Wenzhi Guo and Shuijun Zhang

    Citation: Cell & Bioscience 2020 10:43

    Content type: Research

    Published on:

  34. Microglia-mediated neuroinflammation is associated with epilepsy. Switching microglial polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype represents a novel therapeutic s...

    Authors: Lin Liu, Yingtong Xu, Hongmei Dai, Shan Tan, Xiao Mao and Zhiheng Chen

    Citation: Cell & Bioscience 2020 10:42

    Content type: Research

    Published on:

  36. Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an ongoing global health emergency. Here we highlight nine most important research questions concer...

    Authors: Kit-San Yuen, Zi -Wei Ye, Sin-Yee Fung, Chi-Ping Chan and Dong-Yan Jin

    Citation: Cell & Bioscience 2020 10:40

    Content type: Research Highlight

    Published on:

  37. Fanconi anemia (FA) is a recessive genetic disorder caused by biallelic mutations in at least one of 22 FA genes. Beyond its pathological presentation of bone marrow failure and congenital abnormalities, FA is...

    Authors: Wenjun Liu, Anna Palovcak, Fang Li, Alyan Zafar, Fenghua Yuan and Yanbin Zhang

    Citation: Cell & Bioscience 2020 10:39

    Content type: Review

    Published on:

  40. Kawasaki disease (KD) is one of the major causes of heart disease and vasculitis in children under 5 years old in the world. Clinical evidence has shown that coronary artery calcification may develop in KD pat...

    Authors: Shun-Fu Chang, Shih-Feng Liu, Cheng-Nan Chen and Ho-Chang Kuo

    Citation: Cell & Bioscience 2020 10:36

    Content type: Research

    Published on:

  41. Poly(ADP-ribose) polymerase (PARP) inhibitors represent one of the successful novel approaches to targeted cancer treatment. Indeed, the US Food and Drug Administration (FDA) has recently approved PARP inhibit...

    Authors: Mausam Patel, Somaira Nowsheen, Sanjay Maraboyina and Fen Xia

    Citation: Cell & Bioscience 2020 10:35

    Content type: Review

    Published on:

  42. The discovery of novel biomarkers of stroke etiology would be most helpful in management of acute ischemic stroke patients. Recently, circular RNAs (circRNAs) have been proposed as candidate biomarkers of neur...

    Authors: Aiora Ostolaza, Idoia Blanco-Luquin, Amaya Urdánoz-Casado, Idoya Rubio, Alberto Labarga, Beatriz Zandio, Miren Roldán, Judith Martínez-Cascales, Sergio Mayor, María Herrera, Nuria Aymerich, Jaime Gallego, Roberto Muñoz and Maite Mendioroz

    Citation: Cell & Bioscience 2020 10:34

    Content type: Research

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  44. Ovarian cancer is known as a serious malignancy that affects women’s reproductive tract and can considerably threat their health. A wide range of molecular mechanisms and genetic modifications have been involv...

    Authors: Asma Vafadar, Zahra Shabaninejad, Ahmad Movahedpour, Farzaneh Fallahi, Mona Taghavipour, Younes Ghasemi, Maryam Akbari, Alimohammad Shafiee, Sarah Hajighadimi, Sanaz Moradizarmehri, Ebrahim Razi, Amir Savardashtaki and Hamed Mirzaei

    Citation: Cell & Bioscience 2020 10:32

    Content type: Review

    Published on:

  47. Common fragile sites (CFSs) are large chromosomal regions that exhibit breakage on metaphase chromosomes upon replication stress. They become preferentially unstable at the early stage of cancer development an...

    Authors: Shibo Li and Xiaohua Wu

    Citation: Cell & Bioscience 2020 10:29

    Content type: Review

    Published on:

  48. The increasing prevalence of depression and diabetes mellitus has become a major public health problem worldwide. Studies have shown that people with diabetes are at a high risk of being diagnosed with depress...

    Authors: Danwen Wang, Hui Wang, Haixia Gao, Heng Zhang, Hua Zhang, Qiuling Wang and Zhiling Sun

    Citation: Cell & Bioscience 2020 10:28

    Content type: Review

    Published on:

  49. Glutamate (Glu) is the predominant excitatory neurotransmitter in the central nervous system (CNS). Glutamatergic transmission is critical for controlling neuronal activity. In presynaptic neurons, Glu is stor...

    Authors: Xianchao Du, Jiashuo Li, Minghui Li, Xinxin Yang, Zhipeng Qi, Bin Xu, Wei Liu, Zhaofa Xu and Yu Deng

    Citation: Cell & Bioscience 2020 10:26

    Content type: Review

    Published on:

  50. Mesenchymal stem cells (MSCs) have been extensively studied and implicated for the cell-based therapy in several diseases due to theirs immunomodulatory properties. Embryonic stem cells and induced-pluripotent...

    Authors: Shyam Kishor Sah, Gaurav Agrahari and Tae-Yoon Kim

    Citation: Cell & Bioscience 2020 10:22

    Content type: Review

    Published on:

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