Miller FW, Alfredsson L, Costenbader KH, Kamen DL, Nelson LM, Norris JM, De Roos AJ. Epidemiology of environmental exposures and human autoimmune diseases: findings from a National Institute of Environmental Health Sciences Expert Panel Workshop. J Autoimmun. 2012;39(4):259–71.
Article
PubMed
PubMed Central
Google Scholar
Ly KH, Dalmay F, Gondran G, Palat S, Bezanahary H, Cypierre A, Fauchais AL, Liozon E. Steroid-sparing effect and toxicity of dapsone treatment in giant cell arteritis: a single-center, retrospective study of 70 patients. Medicine. 2016;95(42):e4974.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kim J, Chan JJ. Cyclophosphamide in dermatology. Australas J Dermatol. 2017;58(1):5–17.
Article
PubMed
Google Scholar
Tavakolpour S. Towards personalized medicine for patients with autoimmune diseases: opportunities and challenges. Immunol Lett. 2017;190:130–8.
Article
CAS
PubMed
Google Scholar
Alvarez-Sanchez N, Cruz-Chamorro I, Lopez-Gonzalez A, Utrilla JC, Fernandez-Santos JM, Martinez-Lopez A, Lardone PJ, Guerrero JM, Carrillo-Vico A. Melatonin controls experimental autoimmune encephalomyelitis by altering the T effector/regulatory balance. Brain Behav Immun. 2015;50:101–14.
Article
CAS
PubMed
Google Scholar
Wulff H, Calabresi PA, Allie R, Yun S, Pennington M, Beeton C, Chandy KG. The voltage-gated Kv1.3 K(+) channel in effector memory T cells as new target for MS. J Clin Investig. 2003;111(11):1703–13.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fung-Leung WP, Edwards W, Liu Y, Ngo K, Angsana J, Castro G, Wu N, Liu X, Swanson RV, Wickenden AD. T cell subset and stimulation strength-dependent modulation of T cell activation by Kv1.3 blockers. PLoS ONE. 2017;12(1):e0170102.
Article
PubMed
PubMed Central
Google Scholar
Tanner MR, Tajhya RB, Huq R, Gehrmann EJ, Rodarte KE, Atik MA, Norton RS, Pennington MW, Beeton C. Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog. Clin Immunol. 2017;180:45–57.
Article
CAS
PubMed
Google Scholar
Huang J, Han S, Sun Q, Zhao Y, Liu J, Yuan X, Mao W, Peng B, Liu W, Yin J, et al. Kv1.3 channel blocker (ImKTx88) maintains blood–brain barrier in experimental autoimmune encephalomyelitis. Cell Biosci. 2017;7:31.
Article
PubMed
PubMed Central
Google Scholar
Kundu-Raychaudhuri S, Chen YJ, Wulff H, Raychaudhuri SP. Kv1.3 in psoriatic disease: pAP-1, a small molecule inhibitor of Kv1.3 is effective in the SCID mouse psoriasis–xenograft model. J Autoimmun. 2014;55:63–72.
Article
CAS
PubMed
PubMed Central
Google Scholar
Shen B, Cao Z, Li W, Sabatier JM, Wu Y. Treating autoimmune disorders with venom-derived peptides. Expert Opin Biol Ther. 2017;17(9):1065–75.
Article
CAS
PubMed
Google Scholar
Zhong J, Zeng XC, Zeng X, Nie Y, Zhang L, Wu S, Bao A. Transcriptomic analysis of the venom glands from the scorpion Hadogenes troglodytes revealed unique and extremely high diversity of the venom peptides. J Proteom. 2017;150:40–62.
Article
CAS
Google Scholar
Abdel-Rahman MA, Quintero-Hernandez V, Possani LD. Venom proteomic and venomous glands transcriptomic analysis of the Egyptian scorpion Scorpio maurus palmatus (Arachnida: Scorpionidae). Toxicon. 2013;74:193–207.
Article
CAS
PubMed
Google Scholar
Kazemi-Lomedasht F, Khalaj V, Bagheri KP, Behdani M, Shahbazzadeh D. The first report on transcriptome analysis of the venom gland of Iranian scorpion, Hemiscorpius lepturus. Toxicon. 2017;125:123–30.
Article
CAS
PubMed
Google Scholar
Shijin Y, Hong Y, Yibao M, Zongyun C, Han S, Yingliang W, Zhijian C, Wenxin L. Characterization of a new Kv1.3 channel-specific blocker, J123, from the scorpion Buthus martensii Karsch. Peptides. 2008;29(9):1514–20.
Article
PubMed
Google Scholar
Wu W, Yin S, Ma Y, Wu YL, Zhao R, Gan G, Ding J, Cao Z, Li W. Molecular cloning and electrophysiological studies on the first K(+) channel toxin (LmKTx8) derived from scorpion Lychas mucronatus. Peptides. 2007;28(12):2306–12.
Article
CAS
PubMed
Google Scholar
Yin S, Luo J, Qian A, Yu W, Hu H. LE135, a retinoid acid receptor antagonist, produces pain through direct activation of TRP channels. Br J Pharmacol. 2014;171(6):1510–20.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yin SJ, Jiang L, Yi H, Han S, Yang DW, Liu ML, Liu H, Cao ZJ, Wu YL, Li WX. Different residues in channel turret determining the selectivity of ADWX-1 inhibitor peptide between Kv1.1 and Kv1.3 channels. J Proteome Res. 2008;7(11):4890–7.
Article
CAS
PubMed
Google Scholar
Yin S, Hu Q, Luo J, Li Y, Lu C, Chen X, Hu H. Loureirin B, an essential component of Sanguis draxonis, inhibits Kv13 channel and suppresses cytokine release from Jurkat T cells. Cell Biosci. 2014;4:78.
Article
PubMed
PubMed Central
Google Scholar
Yang EK, Takimoto K, Hayashi Y, de Groat WC, Yoshimura N. Altered expression of potassium channel subunit mRNA and alpha-dendrotoxin sensitivity of potassium currents in rat dorsal root ganglion neurons after axotomy. Neuroscience. 2004;123(4):867–74.
Article
CAS
PubMed
Google Scholar
Mobli M, Undheim EAB, Rash LD. Modulation of ion channels by cysteine-rich peptides: from sequence to structure. Adv Pharmacol. 2017;79:199–223.
Article
PubMed
Google Scholar
Kudryavtsev DS, Shelukhina IV, Son LV, Ojomoko LO, Kryukova EV, Lyukmanova EN, Zhmak MN, Dolgikh DA, Ivanov IA, Kasheverov IE, et al. Neurotoxins from snake venoms and alpha-conotoxin ImI inhibit functionally active ionotropic gamma-aminobutyric acid (GABA) receptors. J Biol Chem. 2015;290(37):22747–58.
Article
CAS
PubMed
PubMed Central
Google Scholar
Cardoso FC, Dekan Z, Smith JJ, Deuis JR, Vetter I, Herzig V, Alewood PF, King GF, Lewis RJ. Modulatory features of the novel spider toxin mu-TRTX-Df1a isolated from the venom of the spider Davus fasciatus. Br J Pharmacol. 2017;174(15):2528–44.
Article
CAS
PubMed
Google Scholar
Isbister GK, Bawaskar HS, Brown SG. Scorpion envenomation. N Engl J Med. 2014;371(16):1559–60.
PubMed
Google Scholar
Mao Q, Ruan J, Cai X, Lu W, Ye J, Yang J, Yang Y, Sun X, Cao J, Cao P. Antinociceptive effects of analgesic-antitumor peptide (AGAP), a neurotoxin from the scorpion Buthus martensii Karsch, on formalin-induced inflammatory pain through a mitogen-activated protein kinases-dependent mechanism in mice. PLoS ONE. 2013;8(11):e78239.
Article
PubMed
PubMed Central
Google Scholar
Lin S, Wang X, Hu X, Zhao Y, Zhao M, Zhang J, Cui Y. Recombinant expression, functional characterization of two scorpion venom toxins with three disulfide bridges from the Chinese scorpion Buthus martensii Karsch. Protein Pept Lett. 2017;24(3):235–40.
Article
CAS
PubMed
Google Scholar
Han S, Yi H, Yin SJ, Chen ZY, Liu H, Cao ZJ, Wu YL, Li WX. Structural basis of a potent peptide inhibitor designed for Kv1.3 channel, a therapeutic target of autoimmune disease. J Biol Chem. 2008;283(27):19058–65.
Article
CAS
PubMed
Google Scholar
Feng J, Hu Y, Yi H, Yin S, Han S, Hu J, Chen Z, Yang W, Cao Z, De Waard M, et al. Two conserved arginine residues from the SK3 potassium channel outer vestibule control selectivity of recognition by scorpion toxins. J Biol Chem. 2013;288(18):12544–53.
Article
CAS
PubMed
PubMed Central
Google Scholar