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Fig. 3 | Cell & Bioscience

Fig. 3

From: Cloning, expression and identification of KTX-Sp4, a selective Kv1.3 peptidic blocker from Scorpiops pococki

Fig. 3

Modulation of KTX-Sp4 on endogenous voltage-gated potassium channels. a Representative traces illustrate that 100 nM KTX-Sp4 inhibited the Kv1.3 current in a Jurkat T cell reversibly. b Concentration–response curve of KTX-Sp4 inhibition of Kv1.3 current in Jurkat T cells. Currents were normalized to the control and fitted by a Hill equation; IC50 value was 235.02 ± 3.36 nM (n = 8). c Current traces of voltage-gated potassium channels in DRG cells in the absence (control) or presence of 1 μM KTX-Sp4

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