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  1. Previous studies have shown that bone morphogenetic protein 9 (BMP9) is almost exclusively produced in the liver and reaches tissues throughout the body as a secreted protein. However, the mechanism of BMP9 ac...

    Authors: Rui Liu, Wentao Xu, He Zhu, Zijian Dong, Huke Dong and Shi Yin
    Citation: Cell & Bioscience 2023 13:61
  2. Prostate cancer (PC) represents the most diagnosed and the second most lethal cancer in men worldwide. Its development and progression occur in concert with alterations in the surrounding tumor microenvironmen...

    Authors: Marzia Di Donato, Pia Giovannelli, Antimo Migliaccio and Gabriella Castoria
    Citation: Cell & Bioscience 2023 13:60
  3. The tetraspanins (TSPANs) are a family of four-transmembrane proteins with 33 members in mammals. They are variably expressed on the cell surface, various intracellular organelles and vesicles in nearly all ce...

    Authors: Zhihang Zhou, Zihan Yang, Li Zhou, Mengsu Yang and Song He
    Citation: Cell & Bioscience 2023 13:59
  4. Fetal hypoxia causes vital, systemic, developmental malformations in the fetus, particularly in the brain, and increases the risk of diseases in later life. We previously demonstrated that fetal hypoxia exposu...

    Authors: Isaac Kremsky, Qingyi Ma, Bo Li, Chiranjib Dasgupta, Xin Chen, Samir Ali, Shawnee Angeloni, Charles Wang and Lubo Zhang
    Citation: Cell & Bioscience 2023 13:58
  5. To study the protective effects of delayed remote ischemic preconditioning (RIPC) against spinal cord ischemia–reperfusion injury (SCIRI) in mice and determine whether SIRT3 is involved in this protection and ...

    Authors: Changjiang Gu, Fanqi Kong, Junkai Zeng, Xiangwu Geng, Yanqing Sun and Xiongsheng Chen
    Citation: Cell & Bioscience 2023 13:57
  6. Sphincter dysfunction often occurs at the end of tubule organs such as the urethra, anus, or gastroesophageal sphincters. It is the primary consequence of neuromuscular impairment caused by trauma, inflammatio...

    Authors: Shengzhou Shan, Qingfeng Li, Tracy Criswell, Anthony Atala and Yuanyuan Zhang
    Citation: Cell & Bioscience 2023 13:56
  7. Spinal cord injury (SCI) can result in irreversible sensory and motor disability with no effective treatment currently. After SCI, infiltrated macrophages accumulate in epicenter through destructed blood-spina...

    Authors: Xuhui Ge, Zheng Zhou, Siting Yang, Wu Ye, Zhuanghui Wang, Jiaxing Wang, Chenyu Xiao, Min Cui, Jiawen Zhou, Yufeng Zhu, Rixiao Wang, Yu Gao, Haofan Wang, Pengyu Tang, Xuhui Zhou, Ce Wang…
    Citation: Cell & Bioscience 2023 13:55
  8. Glucose homeostasis is dependent on functional pancreatic α and ß cells. The mechanisms underlying the generation and maturation of these endocrine cells remain unclear.

    Authors: Romana Bohuslavova, Valeria Fabriciova, Laura Lebrón-Mora, Jessica Malfatti, Ondrej Smolik, Lukas Valihrach, Sarka Benesova, Daniel Zucha, Zuzana Berkova, Frantisek Saudek, Sylvia M Evans and Gabriela Pavlinkova
    Citation: Cell & Bioscience 2023 13:53
  9. Alzheimer’s disease (AD) is characterized by a polyetiological origin. Despite the global burden of AD and the advances made in AD drug research and development, the cure of the disease remains elusive, since ...

    Authors: Triana Espinosa-Jiménez, Amanda Cano, Elena Sánchez-López, Jordi Olloquequi, Jaume Folch, Mònica Bulló, Ester Verdaguer, Carme Auladell, Caterina Pont, Diego Muñoz-Torrero, Antoni Parcerisas, Antoni Camins and Miren Ettcheto
    Citation: Cell & Bioscience 2023 13:52
  10. NK cell is one of innate immune cells and can protect the body from cancer-initiating cells. It has been reported that GPR116 receptor is involved in inflammation and tumors. However, the effect of GPR116 recepto...

    Authors: Dandan Guo, Chenxu Jin, Yaoxin Gao, Haizhen Lin, Li Zhang, Ying Zhou, Jie Yao, Yixin Duan, Yaojun Ren, Xinhui Hui, Yujia Ge, Renzheng Yang and Wenzheng Jiang
    Citation: Cell & Bioscience 2023 13:51
  11. Breast cancer (BC) metastasis is the leading cause of poor prognosis and therapeutic failure. However, the mechanisms underlying cancer metastasis are far from clear.

    Authors: Jingyao Zhang, Fengzhu Guo, Chunxiao Li, Yang Wang, Jinsong Wang, Fangzhou Sun, Yantong Zhou, Fei Ma, Bailin Zhang and Haili Qian
    Citation: Cell & Bioscience 2023 13:50
  12. Itaconate, a crucial immunometabolite, plays a critical role in linking immune and metabolic functions to influence host defense and inflammation. Due to its polar structure, the esterified cell-permeable deri...

    Authors: Young Jae Kim, Eun-Jin Park, Sang-Hee Lee, Prashanta Silwal, Jin Kyung Kim, Jeong Seong Yang, Jake Whang, Jichan Jang, Jin-Man Kim and Eun-Kyeong Jo
    Citation: Cell & Bioscience 2023 13:49
  13. Parkin dysfunction associated with the progression of parkinsonism contributes to a progressive systemic skeletal disease characterized by low bone mineral density. However, the role of parkin in bone remodeli...

    Authors: Eun-Young Kim, Ji-Eun Kim, Young-Eun Kim, Bongkun Choi, Dong Hyun Sohn, Si-On Park, Yeon-Ho Chung, Yongsub Kim, William H. Robinson, Yong-Gil Kim and Eun-Ju Chang
    Citation: Cell & Bioscience 2023 13:48
  14. Sex differences in susceptibility, severity, and progression are prevalent for various diseases in multiple organ systems. This phenomenon is particularly apparent in respiratory diseases. Asthma demonstrates ...

    Authors: Karosham Diren Reddy and Brian Gregory George Oliver
    Citation: Cell & Bioscience 2023 13:47
  15. Sepsis-associated AKI has been shown to be related to sepsis mortality. Macrophage activation and endothelial cell damage are involved in the progression of sepsis-associated AKI, but the specific mechanisms a...

    Authors: Huiling Xiang, Zhifeng Xu, Chun Zhang and Jing Xiong
    Citation: Cell & Bioscience 2023 13:46
  16. In recent years, progress in nanotechnology provided new tools to treat cancer more effectively. Advances in biomaterials tailored for drug delivery have the potential to overcome the limited selectivity and s...

    Authors: Tania B. López-Méndez, Miguel Sánchez-Álvarez, Flavia Trionfetti, José L. Pedraz, Marco Tripodi, Marco Cordani, Raffaele Strippoli and Juan González-Valdivieso
    Citation: Cell & Bioscience 2023 13:44

    The Correction to this article has been published in Cell & Bioscience 2023 13:104

  17. Fibrosis is a pathological wound healing process characterized by excessive extracellular matrix deposition, which interferes with normal organ function and contributes to ~ 45% of human mortality. Fibrosis de...

    Authors: Dongsheng Gu, Arvin H. Soepriatna, Wenjun Zhang, Jun Li, Jenny Zhao, Xiaoli Zhang, Xianhong Shu, Yongshi Wang, Benjamin J. Landis, Craig J. Goergen and Jingwu Xie
    Citation: Cell & Bioscience 2023 13:43
  18. Oligodendrocytes have robust regenerative ability and are key players in remyelination during physiological and pathophysiological states. However, the mechanisms of brain microenvironmental cue in regulation ...

    Authors: Lu Chen, Zhuo Yu, Li Xie, Xiaoxiao He, Xingmei Mu, Chiqi Chen, Wenqian Yang, Xiaoping Tong, Junling Liu, Zhengliang Gao, Suya Sun, NanJie Xu, Zhigang Lu, Junke Zheng and Yaping Zhang
    Citation: Cell & Bioscience 2023 13:42

    The Correction to this article has been published in Cell & Bioscience 2023 13:68

  19. The placenta, as a unique exchange organ between mother and fetus, is essential for successful human pregnancy and fetal health. Preeclampsia (PE) caused by placental dysfunction contributes to both maternal a...

    Authors: Hao Wang, Zhaoyue Zhang, Haicheng Li, Jinzhao Li, Hanshuang Li, Mingzhu Liu, Pengfei Liang, Qilemuge Xi, Yongqiang Xing, Lei Yang and Yongchun Zuo
    Citation: Cell & Bioscience 2023 13:41
  20. Animal regeneration is the natural process of replacing or restoring damaged or missing cells, tissues, organs, and even entire body to full function. Studies in mammals have revealed that many organs lose reg...

    Authors: Shouhong Wang, Yuki Shibata, Liezhen Fu, Yuta Tanizaki, Nga Luu, Lingyu Bao, Zhaoyi Peng and Yun-Bo Shi
    Citation: Cell & Bioscience 2023 13:40
  21. Prostate cancer (PCa) is a common malignant tumor of the genitourinary system. Clinical intervention in advanced PCa remains challenging. Tropomyosins 2 (TPM2) are actin-binding proteins and have been found as...

    Authors: Zonglong Wu, Liyuan Ge, Lulin Ma, Min Lu, Yimeng Song, Shaohui Deng, Peichen Duan, Tan Du, Yaqian Wu, Zhanyi Zhang and Shudong Zhang
    Citation: Cell & Bioscience 2023 13:39
  22. This study aimed to identify potential biomarkers for prostate cancer (PCa) progression and metastasis, and to discern their biological functions.

    Authors: Ye-Hui Chen, Hang Chen, Ting-Ting Lin, Jun-Ming Zhu, Jia-Yin Chen, Ru-Nan Dong, Shao-Hao Chen, Fei Lin, Zhi-Bin Ke, Jin-Bei Huang, Yong Wei, Qing-Shui Zheng, Xue-Yi Xue and Ning Xu
    Citation: Cell & Bioscience 2023 13:38
  23. Macro-autophagy/Autophagy is an evolutionarily well-conserved recycling process to maintain the balance through precise spatiotemporal regulation. However, the regulatory mechanisms of biomolecular condensates...

    Authors: Qin Xia, Yang Li, Wanting Xu, Chengwei Wu, Hanfei Zheng, Liqun Liu and Lei Dong
    Citation: Cell & Bioscience 2023 13:37
  24. Anaplastic thyroid carcinoma (ATC) is one of the most aggressive malignancies, frequently accompanied by metastasis and aerobic glycolysis. Cancer cells adjust their metabolism by modulating the PKM alternative s...

    Authors: Debin Xu, Jichun Yu, Yuting Yang, Yunyan Du, Hongcheng Lu, Shouhua Zhang, Qian Feng, Yi Yu, Liang Hao, Jun Shao and Leifeng Chen
    Citation: Cell & Bioscience 2023 13:36
  25. Cell cycle regulators act as inhibitors or activators to prevent cancerogenesis. It has also been established that they can play an active role in differentiation, apoptosis, senescence, and other cell process...

    Authors: Alisha Shaikh, Austin A. Wesner, Mohanad Abuhattab, Raman G. Kutty and Priyatha Premnath
    Citation: Cell & Bioscience 2023 13:35
  26. Autosomal dominant lateral temporal epilepsy (ADLTE) is an inherited syndrome caused by mutations in the leucine-rich glioma inactivated 1 (LGI1) gene. It is known that functional LGI1 is secreted by excitator...

    Authors: Lin Zhou, Kang Wang, Yuxiang Xu, Bin-Bin Dong, Deng-Chang Wu, Zhao-Xiang Wang, Xin-Tai Wang, Xin-Yu Cai, Jin-Tao Yang, Rui Zheng, Wei Chen, Ying Shen and Jian-She Wei
    Citation: Cell & Bioscience 2023 13:34
  27. Loss of the transcription factor GLI-Similar 3 (GLIS3) function causes congenital hypothyroidism (CH) in both humans and mice due to decreased expression of several thyroid hormone (TH) biosynthetic genes in thyr...

    Authors: Hong Soon Kang, Sara A. Grimm, Raja Jothi, Pilar Santisteban and Anton M. Jetten
    Citation: Cell & Bioscience 2023 13:32
  28. Acute myeloid leukemia (AML) is a genetically and phenotypically heterogeneous disease that has been suffering from stagnant survival curves for decades. In the endeavor toward improved diagnosis and treatment...

    Authors: Constantin Blöchl, Di Wang, Oleg A. Mayboroda, Guinevere S. M. Lageveen-Kammeijer and Manfred Wuhrer
    Citation: Cell & Bioscience 2023 13:31
  29. Botulinum toxin type A (BoNT/A) is extensively applied in spasticity and dystonia as it cleaves synaptosome-associated protein 25 (SNAP25) in the presynaptic terminals, thereby inhibiting neurotransmission. An...

    Authors: Linhui Ni, Hanze Chen, Xinxin Xu, Di Sun, Huaying Cai, Li Wang, Qiwen Tang, Yonggang Hao, Shuxia Cao and Xingyue Hu
    Citation: Cell & Bioscience 2023 13:30
  30. Recently, it was reported that the adult X. tropicalis heart can regenerate in a nearly scar-free manner after injury via apical resection. Thus, a cardiac regeneration model in adult X. tropicalis provides a pow...

    Authors: Luocheng Lv, Weimin Guo, Wei Guan, Yilin Chen, Ruijin Huang, Ziqiang Yuan, Qin Pu, Shanshan Feng, Xin Zheng, Yanmei Li, Luanjuan Xiao, Hui Zhao, Xufeng Qi and Dongqing Cai
    Citation: Cell & Bioscience 2023 13:29
  31. Activation of RNA-dependent stress kinase PKR, especially by viral double-stranded RNA, induces eukaryotic initiation factor 2 α-chain (eIF2α) phosphorylation, attenuating thereby translation. We report that t...

    Authors: Lise Sarah Namer, Alex Harwig, Stephan P. Heynen, Atze T. Das, Ben Berkhout and Raymond Kaempfer
    Citation: Cell & Bioscience 2023 13:28
  32. The phenotypic heterogeneity observed in Cystic Fibrosis (CF) patients suggests the involvement of other genes, besides CFTR. Here, we combined transcriptome and proteome analysis to understand the global gene ex...

    Authors: Lúcia Santos, Rui Nascimento, Aires Duarte, Violeta Railean, Margarida D. Amaral, Patrick T. Harrison, Margarida Gama-Carvalho and Carlos M. Farinha
    Citation: Cell & Bioscience 2023 13:26
  33. Impaired metabolic functions of gut microbiota have been demonstrated in alcohol-related liver disease (ALD), but little is known about changes in phenylalanine metabolism.

    Authors: Liuying Chen, Pengcheng Yang, Lilin Hu, Ling Yang, Huikuan Chu and Xiaohua Hou
    Citation: Cell & Bioscience 2023 13:24
  34. Inflammatory response is an essential part of secondary injury after spinal cord injury (SCI). During this period, the injury may be exacerbated through the release of a large number of inflammatory factors an...

    Authors: Guangjin Gu, Bin Zhu, Jie Ren, Xiaomeng Song, Baoyou Fan, Han Ding, Jun Shang, Heng Wu, Junjin Li, Hongda Wang, Jinze Li, Zhijian Wei and Shiqing Feng
    Citation: Cell & Bioscience 2023 13:23
  35. Foraging for food precedes food consumption and is an important component of the overall metabolic programming that regulates feeding. Foraging is governed by central nervous system neuronal circuits but how i...

    Authors: Alyssa Huang, Matthew T. Maier, Eirini Vagena and Allison W. Xu
    Citation: Cell & Bioscience 2023 13:20
  36. Multiple myeloma (MM) is a hematological malignancy characterized by clonal proliferation of malignant plasma cells. Despite extensive research, molecular mechanisms in MM that drive drug sensitivity and clini...

    Authors: Mengping Chen, Yike Wan, Xin Li, Jing Xiang, Xiaotong Chen, Jinxing Jiang, Xiaofeng Han, Lu Zhong, Fei Xiao, Jia Liu, Honghui Huang, Hua Li, Junling Liu and Jian Hou
    Citation: Cell & Bioscience 2023 13:19
  37. Mutations in the human gene encoding the neuron-specific Eag1 (KV10.1; KCNH1) potassium channel are linked to congenital neurodevelopmental diseases. Disease-causing mutant Eag1 channels manifest aberrant gating ...

    Authors: Chang-Heng Hsieh, Chia-Cheng Chou, Ya-Ching Fang, Po-Hao Hsu, Yi-Hung Chiu, Chi-Sheng Yang, Guey-Mei Jow, Chih-Yung Tang and Chung-Jiuan Jeng
    Citation: Cell & Bioscience 2023 13:18
  38. Recurrent glioblastoma multiforme (GBM) is a highly aggressive primary malignant brain tumor that is resistant to existing treatments. Recently, we reported that activated autologous natural killer (NK) cell t...

    Authors: Sohyun Hwang, Jaejoon Lim, Haeyoun Kang, Ju-Yeon Jeong, Je-Gun Joung, Jinhyung Heo, Daun Jung, Kyunggi Cho and Hee Jung An
    Citation: Cell & Bioscience 2023 13:17
  39. Neurodegenerative disorders are accompanied by neuronal degeneration and glial dysfunction, resulting in cognitive, psychomotor, and behavioral impairment. Multiple factors including genetic, environmental, me...

    Authors: Archana Arjunan, Dhiraj Kumar Sah, Minna Woo and Juhyun Song
    Citation: Cell & Bioscience 2023 13:16
  40. Medulloblastoma (MB) is one of the most common malignant pediatric brain tumors. Metastasis and relapse are the leading causes of death in MB patients. The initiation of the SHH subgroup of MB (SHH-MB) is due ...

    Authors: Jing Cai, Yue Wang, Xinfa Wang, Zihe Ai, Tianyuan Li, Xiaohong Pu, Xin Yang, Yixing Yao, Junping He, Steven Y. Cheng, Tingting Yu, Chen Liu and Shen Yue
    Citation: Cell & Bioscience 2023 13:15
  41. Brain–heart interaction has raised up increasing attentions. Nuclear receptors (NRs) are abundantly expressed in the brain, and emerging evidence indicates that a number of these brain NRs regulate multiple as...

    Authors: Mengjie Wang, Yongjie Yang and Yong Xu
    Citation: Cell & Bioscience 2023 13:14
  42. Atherosclerosis (AS) is the leading underlying cause of the majority of clinical cardiovascular events. Retention of foamy macrophages in plaques is the main factor initiating and promoting the atherosclerotic...

    Authors: Xi Yang, Limei Ma, Jun Zhang, Linmu Chen, Zhen Zou, Di Shen, Hui He, Lei Zhang, Jun Chen, Zhiyi Yuan, Xia Qin and Chao Yu
    Citation: Cell & Bioscience 2023 13:13
  43. Ischemic diseases represent a major global health care burden. Angiogenesis is critical in recovery of blood flow and repair of injured tissue in ischemic diseases. Ten–eleven translocation protein 2 (TET2), a...

    Authors: Yefei Shi, Bo Li, Xinru Huang, Wenxin Kou, Ming Zhai, Yanxi Zeng, Shuangjie You, Qing Yu, Yifan Zhao, Jianhui Zhuang, Wenhui Peng and Weixia Jian
    Citation: Cell & Bioscience 2023 13:12