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  1. The directed differentiation of mesenchymal stem cells (MSCs) is tightly controlled by a complex network. Wnt signaling pathways have an important function in controlling the fate of MSCs. However, the mechan...

    Authors: Yuanfei Zhou, Zheng Zhou, Wei Zhang, Xiaoming Hu, Hongkui Wei, Jian Peng and Siwen Jiang
    Citation: Cell & Bioscience 2015 5:61
  2. Hepatocyte nuclear factor-1beta (HNF1β) was initially identified as a liver-specific transcription factor. It is a homeobox transcription factor that functions as a homodimer or heterodimer with HNF1α. HNF1β p...

    Authors: Dan-Dan Yu, Shi-Wei Guo, Ying-Ying Jing, Yu-Long Dong and Li-Xin Wei
    Citation: Cell & Bioscience 2015 5:58
  3. Some inherited coagulation factor deficiencies are caused by intracellular retention or degradation of misfolded proteins, and chemical chaperones have been shown to reverse protein misfolding. The purpose of ...

    Authors: Maria Eugenia Chollet, Ellen Skarpen, Nina Iversen, Per Morten Sandset and Grethe Skretting
    Citation: Cell & Bioscience 2015 5:57
  4. MicroRNA-720 (miR-720), a nonclassical miRNA, is involved in the initiation and progression of several tumors. In our previous studies, miR-720 was shown to be significantly upregulated in cervical cancer tiss...

    Authors: Yunlan Tang, Yi Lin, Chuang Li, Xunwu Hu, Yi Liu, Mingyang He, Jun Luo, Guihong Sun, Tao Wang, Wenxin Li and Mingxiong Guo
    Citation: Cell & Bioscience 2015 5:56
  5. I t is established that adipose-derived stem cells (ADSCs) produce and secrete cytokines/growth factors that antagonize mucosal injury. However, the exact molecular basis underlying the treatment effects exert...

    Authors: Xiao Xu, Liang Li, Cheng Wang, Yang Liu, Chong Chen, Junling Yan, Hong Ding and Su-yang Tang
    Citation: Cell & Bioscience 2015 5:54
  6. Colorectal cancer (CRC) is a heterogeneous disease that is associated with a gradual accumulation of genetic and epigenetic alterations. Among all CRC stages, stage II tumors are highly heterogeneous with a hi...

    Authors: Jialing Zhang, Bin Yan, Stephan Stanislaw Späth, Hu Qun, Shaleeka Cornelius, Daogang Guan, Jiaofang Shao, Koichi Hagiwara, Carter Van Waes, Zhong Chen, Xiulan Su and Yongyi Bi
    Citation: Cell & Bioscience 2015 5:53
  7. Deamination of adenine can occur spontaneously under physiological conditions generating the highly mutagenic lesion, hypoxanthine. This process is enhanced by ROS from exposure of DNA to ionizing radiation, U...

    Authors: Chia-Chia Lee, Ya-Chien Yang, Steven D. Goodman, Shi Chen, Teng-Yung Huang, Wern-Cherng Cheng, Liang-In Lin and Woei-horng Fang
    Citation: Cell & Bioscience 2015 5:52
  8. Preclinical evaluations of chemotherapies depend on clinically relevant animal models for pancreatic cancer. The injection of syngeneic murine adenocarcinoma cells is one efficient option to generate carcinoma...

    Authors: Dietmar Zechner, Florian Bürtin, Jonas Amme, Tobias Lindner, Tobias Radecke, Stefan Hadlich, Jens-Peter Kühn and Brigitte Vollmar
    Citation: Cell & Bioscience 2015 5:51
  9. Human DNA topoisomerase II-binding protein 1 (hTopBP1) plays an important role in DNA replication and the DNA damage checkpoint pathway. The human mutY homolog (hMYH) is a base excision repair DNA glycosylase ...

    Authors: Se Hee Han, Soo-Hyun Hahm, An Hue Vy Tran, Ji Hyung Chung, Myoung-Ki Hong, Hyun-Dong Paik, Key-Sun Kim and Ye Sun Han
    Citation: Cell & Bioscience 2015 5:50
  10. The overall goal of this study was to demonstrate potential chemopreventive effects of ferulic acid (FA), an antioxidant, combined with aspirin (ASP), a commonly used anti-inflammatory drug for pancreatic canc...

    Authors: Arvind Thakkar, Sushma Chenreddy, Jeffrey Wang and Sunil Prabhu
    Citation: Cell & Bioscience 2015 5:46
  11. Acute kidney injury (AKI) is a severe disease with high morbidity and mortality. Methods that promote repair of the injured kidney have been extensively investigated. Cell-based therapy with mesenchymal stem c...

    Authors: Qing Li, Shou-fu Tian, Ye Guo, Xin Niu, Bin Hu, Shang-chun Guo, Nian-song Wang and Yang Wang
    Citation: Cell & Bioscience 2015 5:45
  12. Mutations in the Alpha-actinin-4 gene (ACTN4) cause a rare form of familial focal segmental glomerulosclerosis in humans. Individuals with kidney disease-associated ACTN4 mutations tend to have mild to moderat...

    Authors: Di Feng, Clark DuMontier and Martin R Pollak
    Citation: Cell & Bioscience 2015 5:44
  13. The physiological and pathological roles of hydrogen sulfide (H2S) in the regulation of cardiovascular functions have been recognized. H2S protects against the hypoxia/reoxygenation (H/R)-induced injury and apopt...

    Authors: Hongzhu Li, Chao Zhang, Weiming Sun, Lina Li, Bo Wu, Shuzhi Bai, Hongxia Li, Xin Zhong, Rui Wang, Lingyun Wu and Changqing Xu
    Citation: Cell & Bioscience 2015 5:43
  14. Pten plays a crucial role in the stem cell maintenance in a few organs. Pten defect also causes the premature oocytes and ovary aging. We and other groups have found that the phosphati...

    Authors: Wei Zhou, Hongfang Shao, Di Zhang, Jian Dong, Wei Cheng, Lu Wang, Yincheng Teng and Zhuo Yu
    Citation: Cell & Bioscience 2015 5:42
  15. Adult hematopoietic stem cells (HSCs) are maintained in a microenvironment, known as niche in the endosteal regions of the bone marrow. This stem cell niche with low oxygen tension requires HSCs to adopt a uni...

    Authors: Fatih Kocabas, Li Xie, Jingjing Xie, Zhuo Yu, Ralph J. DeBerardinis, Wataru Kimura, SuWannee Thet, Ahmed F. Elshamy, Hesham Abouellail, Shalini Muralidhar, Xiaoye Liu, Chiqi Chen, Hesham A. Sadek, Cheng Cheng Zhang and Junke Zheng
    Citation: Cell & Bioscience 2015 5:39
  16. Prostate cancer (PCa) is the most commonly diagnosed solid tumor and the second leading cancer death in the United States, and also one of the major cancer-related deaths in Chinese. Androgen deprivation thera...

    Authors: Yu-Wei Chou, Fen-Fen Lin, Sakthivel Muniyan, Frank C Lin, Ching-Shih Chen, Jue Wang, Chao-Cheng Huang and Ming-Fong Lin
    Citation: Cell & Bioscience 2015 5:38
  17. Due to their high proliferative requirements, tumorigenic cells possess altered metabolic systems whereby cells utilize higher quantities of glutamine and glucose. These altered metabolic requirements make it ...

    Authors: Michelle Helen Visagie, Thandi Vuyelwa Mqoco, Leon Liebenberg, Edward Henry Mathews, George Edward Mathews and Anna Margaretha Joubert
    Citation: Cell & Bioscience 2015 5:37
  18. DNA vaccines have emerged as attractive candidates for the control of human papillomavirus (HPV)-associated malignancies. However, DNA vaccines suffer from limited immunogenicity and thus strategies to enhance...

    Authors: Benjamin Yang, Andrew Yang, Shiwen Peng, Xiaowu Pang, Richard B.S. Roden, T.-C. Wu and Chien-Fu Hung
    Citation: Cell & Bioscience 2015 5:35
  19. The Clustered Regions of Interspersed Palindromic Repeats-Cas9 (CRISPR/Cas9), a viral defense system found in bacteria and archaea, has emerged as a tour de force genome editing tool. The CRISPR/Cas9 system is mu...

    Authors: Sean M. Riordan, Daniel P. Heruth, Li Q. Zhang and Shui Qing Ye
    Citation: Cell & Bioscience 2015 5:33
  20. MicroRNAs (miRNAs) are small noncoding regulatory RNAs that regulate gene expression post-transcriptionally by either inhibiting protein translation or degrading target mRNAs. The differential expression profi...

    Authors: Lei Zhou, Fan Liu, Xiaomin Wang and Gaoliang Ouyang
    Citation: Cell & Bioscience 2015 5:32
  21. Leishmaniases are caused by obligate intracellular protozoan parasites of the genus Leishmania. They cause a spectrum of diseases, most notably visceral (VL), cutaneous (CL), and mucosal (ML) leishmaniasis, which...

    Authors: Milena de Paiva-Cavalcanti, Rayana Carla Silva de Morais, Rômulo Pessoa-e-Silva, Lays Adrianne Mendonça Trajano-Silva, Suênia da Cunha Gonçalves-de-Albuquerque, Diego de Hollanda Cavalcanti Tavares, Maria Carolina Accioly Brelaz-de-Castro, Rafael de Freitas e Silva and Valéria Rêgo Alves Pereira
    Citation: Cell & Bioscience 2015 5:31
  22. One major challenge in gene therapy is the host immune responses against viral vectors. Previous studies indicate the involvement of NK cells in stunted gene expression in viral vector mediated gene therapy. T...

    Authors: Manjunatha Ankathatti Munegowda and Jim Hu
    Citation: Cell & Bioscience 2015 5:29
  23. Adipogenesis is tightly controlled by a complex network of transcription factors acting at different stages of differentiation. Kruppel-like factors (KLFs) as a family of zinc-finger transcription factors play...

    Authors: Shuzhong Jiang, Hongkui Wei, Tongxing Song, Yang Yang, Feng Zhang, Yuanfei Zhou, Jian Peng and Siwen Jiang
    Citation: Cell & Bioscience 2015 5:28
  24. Burkholderia pseudomallei is an emerging pathogen that causes melioidosis, a serious and potentially fatal disease which requires prolonged antibiotics to prevent relapse. However, diagnosis of...

    Authors: Susanna K. P. Lau, Ching-Wan Lam, Shirly O. T. Curreem, Kim-Chung Lee, Wang-Ngai Chow, Candy C. Y. Lau, Siddharth Sridhar, Sally C. Y. Wong, Paolo Martelli, Suk-Wai Hui, Kwok-Yung Yuen and Patrick C. Y. Woo
    Citation: Cell & Bioscience 2015 5:26
  25. Interleukin-22 (IL-22), a cytokine with important functions in anti-microbial defense and tissue repair, has been recently suggested to have beneficial effects in obesity and metabolic syndrome in some but not...

    Authors: Ogyi Park, Sung Hwan Ki, Mingjiang Xu, Hua Wang, Dechun Feng, Joseph Tam, Douglas Osei-Hyiaman, George Kunos and Bin Gao
    Citation: Cell & Bioscience 2015 5:25
  26. Aberrant DNA methylation at the 5-carbon on cytosine residues (5mC) in CpG dinucleotides is probably the most extensively characterized epigenetic modification in colon cancer. It has been suggested that the l...

    Authors: Yue Guo, Jong Hun Lee, Limin Shu, Ying Huang, Wenji Li, Chengyue Zhang, Anne Yuqing Yang, Sarandeep SS Boyanapalli, Ansu Perekatt, Ronald P Hart, Michael Verzi and Ah-Ng Tony Kong
    Citation: Cell & Bioscience 2015 5:24
  27. Mycoepoxydiene (MED) is a polyketide that can be isolated from a marine fungus and is associated with various activities, including antitumor and anti-inflammatory functions. However, its effects on atheroscle...

    Authors: Xiaochun Xia, Yang Li, Qiang Su, Zhengrong Huang, Yuemao Shen, Weihua Li and Chundong Yu
    Citation: Cell & Bioscience 2015 5:23
  28. Cellular senescence is linked to aging and tumorigenesis. The senescence of mesenchymal stem cells (MSCs) may influence the tumor growth, metastasis, and angiogenesis by secreting a variety of cytokines and gr...

    Authors: Yanju Li, Xiao Xu, Lihua Wang, Guangjin Liu, Yanqi Li, Xiaobing Wu, Yongguang Jing, Haiyan Li and Guihua Wang
    Citation: Cell & Bioscience 2015 5:21
  29. Whilst there have been a number of insights into the subsets of CD4+ T cells induced by pathogenic Bacillus anthracis infections in animal models, how these findings relate to responses generated in naturally inf...

    Authors: Rebecca J Ingram, Stephanie Ascough, Catherine J Reynolds, Gökhan Metan, Mehmet Doganay, Les Baillie, Diane E Williamson, John H Robinson, Bernard Maillere, Rosemary J Boyton and Daniel M Altmann
    Citation: Cell & Bioscience 2015 5:20
  30. Research involving antimitotic compounds identified 2-methoxyestradiol (2ME2), as a promising anticancer endogenous metabolite. Owing to its low bioavailability, several in silico-designed 2ME2 analogues were syn...

    Authors: Michelle Helen Visagie, Lyn-Marie Birkholtz and Anna Margaretha Joubert
    Citation: Cell & Bioscience 2015 5:19
  31. Cellular antiviral activities are critically controlled by transcriptional activation of interferon-inducible genes, involving interferon regulatory factors (IRFs). Previous data suggested that IRF1 is an acti...

    Authors: Gang Ren, Kairong Cui, Zhiying Zhang and Keji Zhao
    Citation: Cell & Bioscience 2015 5:17
  32. Aedes albopictus is an important vector of Dengue virus (DENV) and it has quickly invaded the tropical and temperate environments worldwide. A few studies have shown that, microRNAs (miRNAs) re...

    Authors: Yanxia Liu, Yanhe Zhou, Jinya Wu, Peiming Zheng, Yiji Li, Xiaoying Zheng, Santhosh Puthiyakunnon, Zhijian Tu and Xiao-Guang Chen
    Citation: Cell & Bioscience 2015 5:16
  33. Development of a tumor is a very complex process, and invasion and metastasis of malignant tumors are hallmarks and are difficult problems to overcome. The tumor microenvironment plays an important role in con...

    Authors: Xue Yang, Dan-Dan Yu, Fei Yan, Ying-Ying Jing, Zhi-Peng Han, Kai Sun, Lei Liang, Jing Hou and Li-Xin Wei
    Citation: Cell & Bioscience 2015 5:14
  34. Intestinal remodeling during amphibian metamorphosis has long been studied as a model for the formation of the adult organs in vertebrates, especially the formation of adult organ-specific stem cells. Like all...

    Authors: Luan Wen, Takashi Hasebe, Thomas C Miller, Atsuko Ishizuya-Oka and Yun-Bo Shi
    Citation: Cell & Bioscience 2015 5:13
  35. Growth hormone secretagogue receptor (GHSR) and its ligand, ghrelin, are important modulators in weight control and energy homeostasis. Recently, ghrelin is also involved in experimental colitis, but the role ...

    Authors: Zhen-ze Liu, Wei-gang Wang, Qing Li, Miao Tang, Jun Li, Wen-ting Wu, Ying-han Wan, Zhu-gang Wang, Shi-san Bao and Jian Fei
    Citation: Cell & Bioscience 2015 5:12