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  1. Regulating cardiac differentiation to maintain normal heart development and function is very important. At present, biological functions of H19 in cardiac differentiation is not completely clear.

    Authors: Yu Han, Hongdang Xu, Jiangtao Cheng, Yanwei Zhang, Chuanyu Gao, Taibing Fan, Bangtian Peng, Bin Li, Lin Liu and Zhaoyun Cheng
    Citation: Cell & Bioscience 2016 6:58
  2. The ability to transform normal human cells into cancer cells with the introduction of defined genetic alterations is a valuable method for understanding the mechanisms of oncogenesis. Easy establishment of im...

    Authors: Jordan L. Smith, Liam C. Lee, Abigail Read, Qiuning Li, Bing Yu, Chih-Shia Lee and Ji Luo
    Citation: Cell & Bioscience 2016 6:57
  3. The serine/threonine kinase MAP4K4 is a member of the Ste20p (sterile 20 protein) family. MAP4K4 was initially discovered in 1995 as a key kinase in the mating pathway in Saccharomyces cerevisiae and was later fo...

    Authors: Xuan Gao, Chenxi Gao, Guoxiang Liu and Jing Hu
    Citation: Cell & Bioscience 2016 6:56
  4. 3-Nitro-4-hydroxy phenyl arsenic acid, roxarsone, is widely used as an organic arsenic feed additive for livestock and poultry, which may increase the level of arsenic in the environment and the risk of exposu...

    Authors: Yujing Wang, Donglai Yin, Chao Xu, Kai Wang, Lingmin Zheng and Yumei Zhang
    Citation: Cell & Bioscience 2016 6:54
  5. Enzyme catalysis has been studied for over a century. How it actually occurs has not been visualized until recently. By combining in crystallo reaction and X-ray diffraction analysis of reaction intermediates,...

    Authors: Wei Yang, Peter J. Weng and Yang Gao
    Citation: Cell & Bioscience 2016 6:51

    The Erratum to this article has been published in Cell & Bioscience 2017 7:32

  6. Aside from its importance in reproduction, estrogen (E2) is known to regulate the proliferation and differentiation of hematopoietic stem cells in rodents. However, the regulatory role of E2 in human hematopoi...

    Authors: Hye-Ryun Kim, Jong-Hee Lee, Hye-Ryeon Heo, Se-Ran Yang, Kwon-Soo Ha, Won Sun Park, Eun-Taek Han, Haengseok Song and Seok-Ho Hong
    Citation: Cell & Bioscience 2016 6:50
  7. The involvement of Wnt in carcinogenesis and progression of pancreatic cancer is currently intensely discussed. We evaluated activation of the Wnt signaling pathway by using a Wnt reporter mouse strain express...

    Authors: Dietmar Zechner, Tim Kroemer, Ann-Christin Albert, Maria Schönrogge, Tobias Radecke and Brigitte Vollmar
    Citation: Cell & Bioscience 2016 6:49
  8. The Eph family of receptor tyrosine kinases plays important roles in neural development. Previous studies have implicated Eph receptors and their ligands, the ephrins, in neuronal migration, axon bundling and ...

    Authors: Gitanjali Das, Qili Yu, Ryan Hui, Kenneth Reuhl, Nicholas W. Gale and Renping Zhou
    Citation: Cell & Bioscience 2016 6:48
  9. General control non-depressible 5 (GCN5) is a crucial catalytic component of a transcriptional regulatory complex that plays important roles in cellular functions from cell cycle regulation to DNA damage repai...

    Authors: Sidra Majaz, Zhangwei Tong, Kesong Peng, Wei Wang, Wenjing Ren, Ming Li, Kun Liu, Pingli Mo, Wengang Li and Chundong Yu
    Citation: Cell & Bioscience 2016 6:47
  10. The complications of clinical metastatic disease are responsible for the majority of breast cancer related deaths, and fewer therapies substantially prolong survival. Nitidine chloride (NC), a natural polyphen...

    Authors: Mingjuan Sun, Ning Zhang, Xiaolong Wang, Yaming Li, Wenwen Qi, Hanwen Zhang, Zengjun Li and Qifeng Yang
    Citation: Cell & Bioscience 2016 6:44
  11. Rheumatoid arthritis (RA) is characterized by excessive synovial inflammation. Cyclooxygenase-2 (COX-2) is an enzyme that catalyzes the conversion of arachidonic acid (AA) into prostaglandins. Epithelium-speci...

    Authors: Chan-Mi Lee, Sahil Gupta, Jiafeng Wang, Elizabeth M. Johnson, Leslie J. Crofford, John C. Marshall, Mohit Kapoor and Jim Hu
    Citation: Cell & Bioscience 2016 6:43
  12. The single-stranded RNA Flavivirus, Zika virus (ZIKV), has recently re-emerged and spread rapidly across the western hemisphere’s equatorial countries, primarily through Aedes mosquito transmission. While symptom...

    Authors: Alyssa J. Rolfe, Dale B. Bosco, Jingying Wang, Richard S. Nowakowski, Jianqing Fan and Yi Ren
    Citation: Cell & Bioscience 2016 6:42
  13. Concerted hormone secretion is essential for glucose homeostasis and growth. The oocyte testis gene 1 (Otg1) has limited information in mammals before. Human OTG1 has been identified as an antigen associated with...

    Authors: Guangxue Wang, Rongbo Li, Ying Yang, Liang Cai, Sheng Ding, Tian Xu, Min Han and Xiaohui Wu
    Citation: Cell & Bioscience 2016 6:41
  14. Pituitary adenylate cyclase-activating polypeptide (PACAP) plays several important roles in vasodilation, neurotransmission, neuromodulation and neurotrophy, as well as activation of the trigeminovascular syst...

    Authors: Lei Hou, Dongjun Wan, Zhao Dong, Wenjing Tang, Xun Han, Li Li, Fei Yang and Shengyuan Yu
    Citation: Cell & Bioscience 2016 6:40
  15. The nematode Radopholus similis is an important migratory endoparasite of plants. Cysteine proteinases such as cathepsin S (CPS) play key roles during embryonic development, invasion, and pathogenesis in nematode...

    Authors: Ke Wang, Yu Li, Xin Huang, Dong-wei Wang, Chun-ling Xu and Hui Xie
    Citation: Cell & Bioscience 2016 6:39
  16. Leiomodin proteins, Lmod1, Lmod2 and Lmod3, are key regulators of the thin filament length in muscles. While Lmod1 is specifically expressed in smooth muscles, both Lmod2 and Lmod3 are expressed in striated muscl...

    Authors: Shuang Li, Kaiqi Mo, Hong Tian, Chen Chu, Shuna Sun, Lei Tian, Sheng Ding, Tong-ruei Li, Xiaohui Wu, Fang Liu, Zhen Zhang, Tian Xu and Ling V. Sun
    Citation: Cell & Bioscience 2016 6:38
  17. Diabetes mellitus has multiple complications including neuropathy and increases cardiovascular events. Paeoniflorin (PF), a monoterpene glycoside, plays an essential role in neuroprotection and ischemic heart ...

    Authors: Fei Han, Dongchen Zhou, Xiang Yin, Zewei Sun, Jie Han, Lifang Ye, Wengting Zhao, Yuanyuan Zhang, Zhen Wang and Liangrong Zheng
    Citation: Cell & Bioscience 2016 6:37
  18. Vascular smooth muscle cell (VSMC) proliferation in response to hyperglycemia is an important process in the development of arterial vessel hyperplasia. The shape change of mitochondria is dynamic and closely ...

    Authors: Aili Sun, Yan Wang, Jiaqi Liu, Xiangjing Yu, Yu Sun, Fan Yang, Shiyun Dong, Jichao Wu, Yajun Zhao, Changqing Xu, Fanghao Lu and Weihua Zhang
    Citation: Cell & Bioscience 2016 6:36
  19. Genetic aberrations have been identified in nasopharyngeal carcinoma (NPC), however, the underlying mechanism remains elusive. There are increasing evidences that the apoptotic nuclease caspase-activated deoxy...

    Authors: Sang-Nee Tan, Sai-Peng Sim and Alan S. B. Khoo
    Citation: Cell & Bioscience 2016 6:35
  20. Myeloproliferative neoplasms (MPN) are a group of blood cancers that boost normal blood cell production in the bone marrow. Abnormal mutations in stem cells were found accompanying with the occurrence of MPN. ...

    Authors: Chunjie Yu, Qiong Yang, Yuhong Chen, Demin Wang, Ross Levine, John Crispino, Qiang Wen and Zan Huang
    Citation: Cell & Bioscience 2016 6:34
  21. Excessive autophagy induced by extravagant oxidative stress is the main reason for diabetes-induced vascular endothelial cells dysfunction. Hydrogen sulfide (H2S) has anti-oxidative effects but its regulation on ...

    Authors: Jiaqi Liu, Jichao Wu, Aili Sun, Yu Sun, Xiangjing Yu, Ning Liu, Shiyun Dong, Fan Yang, Linxue Zhang, Xin Zhong, Changqing Xu, Fanghao Lu and Weihua Zhang
    Citation: Cell & Bioscience 2016 6:33
  22. The excessive accumulation of extracellular matrix of hepatic fibrosis is positively correlated with tissue inhibitors of metalloproteinase 1 (TIMP1). Here we aimed to investigate whether TIMP1 may be down-reg...

    Authors: Dong Jia, Yi-Ran Ni, Yan-Qiong Zhang, Chun Rao, Jun Hou, He-Qing Tang, Chang-Bai Liu and Jiang-Feng Wu
    Citation: Cell & Bioscience 2016 6:31
  23. Lymphopenia promotes naïve T-cell homeostatic proliferation and adoptive effector T-cell survival and memory formation. IL-7 plays a critical role in homeostatic proliferation, survival and memory formation of...

    Authors: Aizhang Xu, Kalpana Kalyanasundaram Bhanumathy, Jie Wu, Zhenmin Ye, Andrew Freywald, Scot C. Leary, Rongxiu Li and Jim Xiang
    Citation: Cell & Bioscience 2016 6:30
  24. Maturity-onset diabetes of the young (MODY), one of the specific types of diabetes mellitus, is a monogenetic disorder characterized by an autosomal dominant (AD) inheritance and β-cell dysfunction. To study a...

    Authors: Jing Yang, Feng Jiang, Hui Guo, Thadimacca Soniya, Chun-xia Yan, Zhu-fang Tian and Bing-yin Shi
    Citation: Cell & Bioscience 2016 6:29
  25. Hydrogen sulfide (H2S), a third member of gasotransmitter family along with nitric oxide and carbon monoxide, generated from mainly catalyzed by cystathionine-lyase, possesses important functions in the cardiovas...

    Authors: Lina Li, Meixiu Li, Youyou Li, Weiming Sun, Yuehong Wang, Shuzhi Bai, Hongxia Li, Bo Wu, Guangdong Yang, Rui Wang, Lingyun Wu, Hongzhu Li and Changing Xu
    Citation: Cell & Bioscience 2016 6:26
  26. The mitochondria are double membrane-bound organelles found in most eukaryotic cells. They generate most of the cell’s energy supply of adenosine triphosphate (ATP). Protein phosphorylation and dephosphorylati...

    Authors: Sangbin Lim, Kelly R. Smith, Ssang-Taek Steve Lim, Rong Tian, Jianrong Lu and Ming Tan
    Citation: Cell & Bioscience 2016 6:25
  27. Non-small cell lung cancer (NSCLC) is the most commonly diagnosed and fatal cancer worldwide. Sclerostin domain containing protein 1 (SOSTDC1) has been found to be tumor-suppressive in several types of cancers...

    Authors: Lei Liu, Shanshan Wu, Yi Yang, Junchao Cai, Xun Zhu, Jueheng Wu, Mengfeng Li and Hongyu Guan
    Citation: Cell & Bioscience 2016 6:24
  28. The prognosis of acute megakaryoblastic leukemia (AMKL) is really dismal, which urges for development of novel treatment. Baicalein is one type of flavonoids extracted from Scutellaria baicalensis Georgi (Huang Q...

    Authors: Chunjie Yu, Jiancheng Zeng, Zhenzhen Yan, Zi Ma, Shangqin Liu and Zan Huang
    Citation: Cell & Bioscience 2016 6:20
  29. The RNA guided CRISPR/Cas9 nucleases have been proven to be effective for gene disruption in various animal models including Xenopus tropicalis. The neural crest (NC) is a transient cell population during embryon...

    Authors: Zhongzhen Liu, Tina Tsz Kwan Cheng, Zhaoying Shi, Ziran Liu, Yong Lei, Chengdong Wang, Weili Shi, Xiongfeng Chen, Xufeng Qi, Dongqing Cai, Bo Feng, Yi Deng, Yonglong Chen and Hui Zhao
    Citation: Cell & Bioscience 2016 6:22
  30. Varicella-zoster virus (VZV) is the causative agent of varicella and zoster. The immediate-early protein, IE62 is the predominant VZ virion tegument protein, transactivating the expression of all kinetic class...

    Authors: Chia-Chi Ku, Yi-Hsuan Chang, Yun Chien and Tsung-Lin Lee
    Citation: Cell & Bioscience 2016 6:21
  31. Exposure of the American bullfrog Lithobates catesbeianus tadpoles to low temperature affects many biological processes including lipid metabolism and the thyroid hormone (TH) signaling pathway, resulting in arre...

    Authors: Shunsuke Suzuki, Koichiro Awai, Akinori Ishihara and Kiyoshi Yamauchi
    Citation: Cell & Bioscience 2016 6:19
  32. Nasopharyngeal carcinoma (NPC) is one of the most common human head and neck cancers with high incidence in Southern China, Southeast Asia and North Africa. Because of its nonspecific symptoms, the early diagn...

    Authors: Yuanwei Guo, Weihao Luo, Zheng Hu, Jia Li, Xiaojie Li, Huiqiu Cao, Jun Li, Bo Wen, Jian Zhang, Hao Cheng, Wangyuan Guo, Tan Tan and Dixian Luo
    Citation: Cell & Bioscience 2016 6:18
  33. Human Papillomavirus is responsible for over 99 % of cervical cancers and is associated with cancers of the head and neck. The currently available prophylactic vaccines against HPV do not generate therapeutic ...

    Authors: Ming-Chieh Yang, Andrew Yang, Jin Qiu, Benjamin Yang, Liangmei He, Ya-Chea Tsai, Jessica Jeang, T.-C. Wu and Chien-Fu Hung
    Citation: Cell & Bioscience 2016 6:17
  34. Human papillomavirus (HPV) has been identified as the primary etiologic factor of cervical cancer as well as subsets of anogenital and oropharyngeal cancers. The two HPV viral oncoproteins, E6 and E7, are uniq...

    Authors: Shiwen Peng, Jin Qiu, Andrew Yang, Benjamin Yang, Jessica Jeang, Joshua W. Wang, Yung-Nien Chang, Cory Brayton, Richard B. S. Roden, Chien-Fu Hung and T.-C. Wu
    Citation: Cell & Bioscience 2016 6:16
  35. Transcriptional activation is a complex, multistage process implemented by hundreds of proteins. Many transcriptional proteins are organized into coactivator complexes, which participate in transcription regul...

    Authors: Aleksey N. Krasnov, Marina Yu. Mazina, Julia V. Nikolenko and Nadezhda E. Vorobyeva
    Citation: Cell & Bioscience 2016 6:15
  36. Glycans play essential roles in biological functions such as differentiation and cancer. Recently, glycans have been considered as biomarkers for physiological aging. However, details regarding the specific gl...

    Authors: Yoko Itakura, Norihiko Sasaki, Daisuke Kami, Satoshi Gojo, Akihiro Umezawa and Masashi Toyoda
    Citation: Cell & Bioscience 2016 6:14
  37. Leishmania contains a concatenated mitochondrial DNA, kDNA. Universal minicircle sequence binding protein (UMSBP), a mitochondrial protein, initiates kDNA replication by binding with ...

    Authors: Ruby Singh, Bidyut Purkait, Kumar Abhishek, Savita Saini, Sushmita Das, Sudha Verma, Abhishek Mandal, Ayan Kr. Ghosh, Yousuf Ansari, Ashish Kumar, Abul H. Sardar, Ajay Kumar, Pradeep Parrack and Pradeep Das
    Citation: Cell & Bioscience 2016 6:13
  38. The proline rich homeodomain protein (PRH), also known as haematopoietically expressed homeobox (HHEX), is an essential transcription factor in embryonic development and in the adult. The PRH protein forms oli...

    Authors: Kevin Gaston, Maria-Angela Tsitsilianos, Kerry Wadey and Padma-Sheela Jayaraman
    Citation: Cell & Bioscience 2016 6:12
  39. Progenitor cells display interesting features for tissue repair and reconstruction. In the last years, such cells have been identified in different cartilage types. In this study, we isolated a migrative subpo...

    Authors: A. F. Elsaesser, S. Schwarz, H. Joos, L. Koerber, R. E. Brenner and N. Rotter
    Citation: Cell & Bioscience 2016 6:11
  40. The runt-related transcription factor 2 (Runx2) is a cell-fate-determining factor that controls osteoblast differentiation and bone formation. It has been previously demonstrated that microRNAs (miRNAs) play i...

    Authors: Shouhe Yu, Qianqian Geng, Qiuhui Pan, Zhongyu Liu, Shan Ding, Qi Xiang, Fenyong Sun, Can Wang, Yadong Huang and An Hong
    Citation: Cell & Bioscience 2016 6:10
  41. The ability of Zn(II) and Cu(II) metal complexes of non-steroidal anti-inflammatory drugs (NSAIDs) to inhibit acute arterial inflammation in vivo has been studied.

    Authors: Rajesh Puranik, Shisan Bao, Antonio M. Bonin, Ravinder Kaur, Jane E. Weder, Llewellyn Casbolt, Trevor W. Hambley, Peter A. Lay, Philip J. Barter and Kerry-Anne Rye
    Citation: Cell & Bioscience 2016 6:9