Cermenati G, et al. Lipids in the nervous system: from biochemistry and molecular biology to patho-physiology. Biochim Biophys Acta. 2005;1851(1):51–60.
Article
CAS
PubMed
Google Scholar
Korade Z, Kenworthy AK. Lipid rafts, cholesterol, and the brain. Neuropharmacology. 2008;55(8):1265–73.
Article
CAS
PubMed
PubMed Central
Google Scholar
Genaro-Mattos TC, et al. Cholesterol biosynthesis and uptake in developing neurons. ACS Chem Neurosci. 2019;10(8):3671–81.
Article
CAS
PubMed
Google Scholar
Linetti A, et al. Cholesterol reduction impairs exocytosis of synaptic vesicles. J Cell Sci. 2010;123(Pt 4):595–605.
Article
CAS
PubMed
Google Scholar
Boyles JK, et al. A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve. J Clin Invest. 1989;83(3):1015–31.
Article
CAS
PubMed
PubMed Central
Google Scholar
Nieweg K, et al. Marked differences in cholesterol synthesis between neurons and glial cells from postnatal rats产后大鼠神经元和神经胶质细胞之间胆固醇合成的显着差异. J Neurochem. 2009;109(1):125–34.
Article
CAS
PubMed
Google Scholar
Koudinov AR, Koudinova NV. Cholesterol’s role in synapse formation. Science. 2002;295(5563):2213.
Article
CAS
PubMed
Google Scholar
Morell P, Jurevics H. Origin of cholesterol in myelin. Neurochem Res. 1996;21(4):463–70.
Article
CAS
PubMed
Google Scholar
Mauch DH, et al. CNS synaptogenesis promoted by glia-derived cholesterol. Science. 2001;294(5545):1354–7.
Article
CAS
PubMed
Google Scholar
Chang TY, et al. Cholesterol sensing, trafficking, and esterification. Annu Rev Cell Dev Biol. 2006;22:129–57.
Article
CAS
PubMed
Google Scholar
Puglielli L, et al. Acyl-coenzyme a: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide. Nat Cell Biol. 2001;3(10):905–12.
Article
CAS
PubMed
Google Scholar
Bryleva EY, et al. ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD. Proc Natl Acad Sci USA. 2010;107(7):3081–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Astudillo L, et al. Human genetic disorders of sphingolipid biosynthesis. J Inherit Metab Dis. 2015;38(1):65–76.
Article
CAS
PubMed
Google Scholar
Bartke N, Hannun YA. Bioactive sphingolipids: metabolism and function. J Lipid Res. 2009;50(Suppl):S91–6.
Article
PubMed
PubMed Central
CAS
Google Scholar
Olsen ASB, Faergeman NJ. Sphingolipids: membrane microdomains in brain development, function and neurological diseases. Open Biol. 2017;7(5):170069.
Article
PubMed
PubMed Central
CAS
Google Scholar
Mullen TD, et al. Ceramide synthases at the centre of sphingolipid metabolism and biology. Biochem J. 2012;441(3):789–802.
Article
CAS
PubMed
Google Scholar
Satoi H, et al. Astroglial expression of ceramide in Alzheimer’s disease brains: a role during neuronal apoptosis. Neuroscience. 2005;130(3):657–66.
Article
CAS
PubMed
Google Scholar
Filippov V, et al. Increased ceramide in brains with Alzheimer’s and other neurodegenerative diseases. J Alzheimers Dis. 2012;29(3):537–47.
Article
CAS
PubMed
PubMed Central
Google Scholar
Senkal CE, et al. Ceramide is metabolized to acylceramide and stored in lipid droplets. Cell Metab. 2017;25(3):686–97.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yuyama K, et al. Sphingolipid-modulated exosome secretion promotes clearance of amyloid-β by microglia. J Biol Chem. 2012;287(14):10977–89.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hait NC, et al. Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science. 2009;325(5945):1254–7.
Article
CAS
PubMed
PubMed Central
Google Scholar
Spiegel S, Milstien S. The outs and the ins of sphingosine-1-phosphate in immunity. Nat Rev Immunol. 2011;11(6):403–15.
Article
CAS
PubMed
PubMed Central
Google Scholar
Karunakaran I, et al. Neural sphingosine 1-phosphate accumulation activates microglia and links impaired autophagy and inflammation. Glia. 2019;67(10):1859–72.
Article
PubMed
Google Scholar
Dhopeshwarkar GA, Mead JF. Fatty acid uptake by the brain. 3. Incorporation of (1–14C)oleic acid into the adult rat brain. Biochim Biophys Acta. 1970;210(2):250–6.
Article
CAS
PubMed
Google Scholar
Ebert D, et al. Energy contribution of octanoate to intact rat brain metabolism measured by 13C nuclear magnetic resonance spectroscopy. J Neurosci. 2003;23(13):5928–35.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ioannou MS, et al. Neuron-astrocyte metabolic coupling protects against activity-induced fatty acid toxicity. Cell. 2019;177(6):1522-1535 e14.
Article
CAS
PubMed
Google Scholar
Butterfield DA, et al. (2010) Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer’s disease. Biochim Biophys Acta. 1801;8:924–9.
Google Scholar
Lee J, et al. Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington’s disease mice. Acta Neuropathol. 2011;121(4):487–98.
Article
CAS
PubMed
Google Scholar
Ruiperez V, et al. Alpha-synuclein, lipids and Parkinson’s disease. Prog Lipid Res. 2010;49(4):420–8.
Article
CAS
PubMed
Google Scholar
Ferrante RJ, et al. Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis. J Neurochem. 1997;69(5):2064–74.
Article
CAS
PubMed
Google Scholar
Sultana R, et al. Lipid peroxidation triggers neurodegeneration: a redox proteomics view into the Alzheimer disease brain. Free Radic Biol Med. 2013;62:157–69.
Article
CAS
PubMed
Google Scholar
Pfrieger FW. Outsourcing in the brain: do neurons depend on cholesterol delivery by astrocytes? BioEssays. 2003;25(1):72–8.
Article
PubMed
CAS
Google Scholar
van Deijk AF, et al. Astrocyte lipid metabolism is critical for synapse development and function in vivo. Glia. 2017;65(4):670–82.
Article
PubMed
Google Scholar
Ferris HA, et al. Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism. Proc Natl Acad Sci U S A. 2017;114(5):1189–94.
Article
CAS
PubMed
PubMed Central
Google Scholar
Karten B, et al. Expression of ABCG1, but not ABCA1, correlates with cholesterol release by cerebellar astroglia. J Biol Chem. 2006;281(7):4049–57.
Article
CAS
PubMed
Google Scholar
de Wit NM, et al. Astrocytic ceramide as possible indicator of neuroinflammation. J Neuroinflammation. 2019;16(1):48.
Article
PubMed
PubMed Central
Google Scholar
Chao CC, et al. Metabolic control of astrocyte pathogenic activity via cPLA2-MAVS. Cell. 2019;179(7):1483-1498.e22.
Article
CAS
PubMed
PubMed Central
Google Scholar
Choi JW, et al. FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation. Proc Natl Acad Sci USA. 2011;108(2):751–6.
Article
CAS
PubMed
Google Scholar
Hickman SE, et al. The microglial sensome revealed by direct RNA sequencing. Nat Neurosci. 2013;16(12):1896–905.
Article
CAS
PubMed
PubMed Central
Google Scholar
Grajchen E, et al. CD36-mediated uptake of myelin debris by macrophages and microglia reduces neuroinflammation. J Neuroinflammation. 2020;17(1):224.
Article
CAS
PubMed
PubMed Central
Google Scholar
Nugent AA, et al. TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge. Neuron. 2020;105(5):837-854.e9.
Article
CAS
PubMed
Google Scholar
Yeh FL, et al. TREM2 binds to apolipoproteins, including APOE and CLU/APOJ, and thereby facilitates uptake of amyloid-beta by microglia. Neuron. 2016;91(2):328–40.
Article
CAS
PubMed
Google Scholar
Gaultier A, et al. Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis. J Cell Sci. 2009;122(Pt 8):1155–62.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bogie JF, et al. Myelin-derived lipids modulate macrophage activity by liver X receptor activation. PLoS ONE. 2012;7(9):e44998.
Article
CAS
PubMed
PubMed Central
Google Scholar
Liang Y, et al. A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes. J Neurochem. 2004;88(3):623–34.
Article
CAS
PubMed
Google Scholar
Jain A, Holthuis JCM. (2017) Membrane contact sites, ancient and central hubs of cellular lipid logistics. Biochim Biophys Acta Mol Cell Res. 1864;9:1450–8.
Google Scholar
Cantuti-Castelvetri L, et al. Defective cholesterol clearance limits remyelination in the aged central nervous system. Science. 2018;359(6376):684–8.
Article
CAS
PubMed
Google Scholar
Bogie JFJ, et al. Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain. J Exp Med. 2020;217(5):e20191660.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hendrickx DA, et al. Enhanced uptake of multiple sclerosis-derived myelin by THP-1 macrophages and primary human microglia. J Neuroinflammation. 2014;11:64.
Article
PubMed
PubMed Central
CAS
Google Scholar
Lynch JR, et al. APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response. J Biol Chem. 2003;278(49):48529–33.
Article
CAS
PubMed
Google Scholar
Bergner CG, et al. Microglia damage precedes major myelin breakdown in X-linked adrenoleukodystrophy and metachromatic leukodystrophy. Glia. 2019;67(6):1196–209.
Article
PubMed
PubMed Central
Google Scholar
Valachovic M, et al. Squalene is lipotoxic to yeast cells defective in lipid droplet biogenesis. Biochem Biophys Res Commun. 2016;469(4):1123–8.
Article
CAS
PubMed
Google Scholar
Schmidt C, et al. Analysis of yeast lipid droplet proteome and lipidome. Methods Cell Biol. 2013;116:15–37.
Article
CAS
PubMed
Google Scholar
Weiss SB, et al. The enzymatic synthesis of triglycerides. J Biol Chem. 1960;235:40–4.
Article
CAS
PubMed
Google Scholar
Nguyen TB, Olzmann JA. Lipid droplets and lipotoxicity during autophagy. Autophagy. 2017;13(11):2002–3.
Article
CAS
PubMed
PubMed Central
Google Scholar
Stone SJ, et al. The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria. J Biol Chem. 2009;284(8):5352–61.
Article
CAS
PubMed
PubMed Central
Google Scholar
Nguyen TB, et al. DGAT1-dependent lipid droplet biogenesis protects mitochondrial function during starvation-induced autophagy. Dev Cell. 2017;42(1):9-21 e5.
Article
CAS
PubMed
PubMed Central
Google Scholar
Olzmann JA, Carvalho P. Dynamics and functions of lipid droplets. Nat Rev Mol Cell Biol. 2019;20(3):137–55.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gross DA, et al. Direct binding of triglyceride to fat storage-inducing transmembrane proteins 1 and 2 is important for lipid droplet formation. Proc Natl Acad Sci USA. 2011;108(49):19581–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Murphy DJ. The dynamic roles of intracellular lipid droplets: from archaea to mammals. Protoplasma. 2012;249(3):541–85.
Article
CAS
PubMed
Google Scholar
Walther TC, Farese RV Jr. Lipid droplets and cellular lipid metabolism. Annu Rev Biochem. 2012;81:687–714.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sztalryd C, Brasaemle DL. (2017) The perilipin family of lipid droplet proteins: Gatekeepers of intracellular lipolysis. Biochim Biophys Acta Mol Cell Biol Lipids. 1862;10 Pt B:1221–32.
Google Scholar
Jin Y, et al. Reactive oxygen species induces lipid droplet accumulation in HepG2 cells by increasing perilipin 2 expression. Int J Mol Sci. 2018;19(11):3445.
Article
PubMed Central
CAS
Google Scholar
Kounakis K, et al. Emerging roles of lipophagy in health and disease. Front Cell Dev Biol. 2019;7:185.
Article
PubMed
PubMed Central
Google Scholar
Ritzel RM, et al. Age- and location-related changes in microglial function. Neurobiol Aging. 2015;36(6):2153–63.
Article
CAS
PubMed
Google Scholar
Yu W, et al. Phosphatidylinositide 3-kinase localizes to cytoplasmic lipid bodies in human polymorphonuclear leukocytes and other myeloid-derived cells. Blood. 2000;95(3):1078–85.
Article
CAS
PubMed
Google Scholar
Bozza PT, Viola JP. Lipid droplets in inflammation and cancer. Prostaglandins Leukot Essent Fatty Acids. 2010;82(4–6):243–50.
Article
CAS
PubMed
Google Scholar
Liu L, et al. Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration. Cell. 2015;160(1–2):177–90.
Article
CAS
PubMed
PubMed Central
Google Scholar
Marschallinger J, et al. Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain. Nat Neurosci. 2020;23(2):194–208.
Article
CAS
PubMed
PubMed Central
Google Scholar
Shimabukuro MK, et al. Lipid-laden cells differentially distributed in the aging brain are functionally active and correspond to distinct phenotypes. Sci Rep. 2016;6:23795.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yin F, et al. Energy metabolism and inflammation in brain aging and Alzheimer’s disease. Free Radical Biol Med. 2016;100:108–22.
Article
CAS
Google Scholar
Fowler SD, et al. Foam cells and atherogenesis. Ann NY Acad Sci. 1985;454:79–90.
Article
CAS
PubMed
Google Scholar
Brown MS, et al. The cholesteryl ester cycle in macrophage foam cells. Continual hydrolysis and re-esterification of cytoplasmic cholesteryl esters. J Biol Chem. 1980;255(19):9344–52.
Article
CAS
PubMed
Google Scholar
Smolic T, et al. Astrocytes in stress accumulate lipid droplets. Glia. 2021;69(6):1540–62.
Article
CAS
PubMed
PubMed Central
Google Scholar
Dienel GA, Cruz NF. Aerobic glycolysis during brain activation: adrenergic regulation and influence of norepinephrine on astrocytic metabolism. J Neurochem. 2016;138(1):14–52.
Article
CAS
PubMed
Google Scholar
Chandak PG, et al. Efficient phagocytosis requires triacylglycerol hydrolysis by adipose triglyceride lipase. J Biol Chem. 2010;285(26):20192–201.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zielke HR, et al. Direct measurement of oxidative metabolism in the living brain by microdialysis: a review. J Neurochem. 2009;109(Suppl 1):24–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pellerin L, Magistretti PJ. Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. Proc Natl Acad Sci USA. 1994;91(22):10625–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Volkenhoff A, et al. Glial glycolysis is essential for neuronal survival in drosophila. Cell Metab. 2015;22(3):437–47.
Article
CAS
PubMed
Google Scholar
Funfschilling U, et al. Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity. Nature. 2012;485(7399):517–21.
Article
PubMed
PubMed Central
CAS
Google Scholar
Lee Y, et al. Oligodendroglia metabolically support axons and contribute to neurodegeneration. Nature. 2012;487(7408):443–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Machler P, et al. In vivo evidence for a lactate gradient from astrocytes to neurons. Cell Metab. 2016;23(1):94–102.
Article
CAS
PubMed
Google Scholar
Schonfeld P, Reiser G. Brain energy metabolism spurns fatty acids as fuel due to their inherent mitotoxicity and potential capacity to unleash neurodegeneration. Neurochem Int. 2017;109:68–77.
Article
PubMed
CAS
Google Scholar
Belanger M, Magistretti PJ. The role of astroglia in neuroprotection. Dialogues Clin Neurosci. 2009;11(3):281–95.
Article
PubMed
PubMed Central
Google Scholar
Mahley RW, Rall SC Jr. Apolipoprotein E: far more than a lipid transport protein. Annu Rev Genomics Hum Genet. 2000;1:507–37.
Article
CAS
PubMed
Google Scholar
Mahley RW. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science. 1988;240(4852):622–30.
Article
CAS
PubMed
Google Scholar
Xu Q, et al. Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus. J Neurosci. 2006;26(19):4985–94.
Article
CAS
PubMed
PubMed Central
Google Scholar
Keren-Shaul H, et al. A unique microglia type associated with restricting development of Alzheimer’s disease. Cell. 2017;169(7):1276-1290 e17.
Article
CAS
PubMed
Google Scholar
Farmer BC, et al. Apolipoprotein E4 alters astrocyte fatty acid metabolism and lipid droplet formation. Cells. 2019;8(2):182.
Article
CAS
PubMed Central
Google Scholar
Edmond J, et al. Capacity for substrate utilization in oxidative metabolism by neurons, astrocytes, and oligodendrocytes from developing brain in primary culture. J Neurosci Res. 1987;18(4):551–61.
Article
CAS
PubMed
Google Scholar
Lovatt D, et al. The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex. J Neurosci. 2007;27(45):12255–66.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hong C, Tontonoz P. Liver X receptors in lipid metabolism: opportunities for drug discovery. Nat Rev Drug Discovery. 2014;13(6):433–44.
Article
CAS
PubMed
Google Scholar
Rambold AS, et al. Fatty acid trafficking in starved cells: regulation by lipid droplet lipolysis, autophagy, and mitochondrial fusion dynamics. Dev Cell. 2015;32(6):678–92.
Article
CAS
PubMed
PubMed Central
Google Scholar
Eraso-Pichot A, et al. GSEA of mouse and human mitochondriomes reveals fatty acid oxidation in astrocytes. Glia. 2018;66(8):1724–35.
Article
PubMed
Google Scholar
Bosch M, et al. Lipid droplets, bioenergetic fluxes, and metabolic flexibility. Semin Cell Dev Biol. 2020;108:33–46.
Article
CAS
PubMed
Google Scholar
Freyre CAC, et al. MIGA2 links mitochondria, the ER, and lipid droplets and promotes de novo lipogenesis in adipocytes. Mol Cell. 2019;76(5):811-825 e14.
Article
CAS
PubMed
Google Scholar
Benador IY, et al. Mitochondria bound to lipid droplets have unique bioenergetics, composition, and dynamics that support lipid droplet expansion. Cell Metab. 2018;27(4):869-885 e6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang H, et al. Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria. J Lipid Res. 2011;52(12):2159–68.
Article
CAS
PubMed
PubMed Central
Google Scholar
Twig G, et al. Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J. 2008;27(2):433–46.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yu J, et al. (2015) Lipid droplet remodeling and interaction with mitochondria in mouse brown adipose tissue during cold treatment. Biochim Biophys Acta. 1853;5:918–28.
Google Scholar
Boutant M, et al. Mfn2 is critical for brown adipose tissue thermogenic function. EMBO J. 2017;36(11):1543–58.
Article
CAS
PubMed
PubMed Central
Google Scholar
Aflaki E, et al. Triacylglycerol accumulation activates the mitochondrial apoptosis pathway in macrophages. J Biol Chem. 2011;286(9):7418–28.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mottillo EP, et al. Coupling of lipolysis and de novo lipogenesis in brown, beige, and white adipose tissues during chronic beta3-adrenergic receptor activation. J Lipid Res. 2014;55(11):2276–86.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bird TD. Alzheimer Disease Overview. In GeneReviews((R)) (Adam, M.P. et al. eds). 1993
Alzheimer A, et al. An English translation of Alzheimer’s 1907 paper, “Uber eine eigenartige Erkankung der Hirnrinde.” Clin Anat. 1995;8(6):429–31.
Article
CAS
PubMed
Google Scholar
van der Kant R, et al. Cholesterol metabolism is a druggable axis that independently regulates Tau and Amyloid-β in iPSC-derived Alzheimer’s Disease neurons. Cell Stem Cell. 2019;24(3):363–3759.
Article
PubMed
PubMed Central
CAS
Google Scholar
Roca-Agujetas V, et al. Cholesterol alters mitophagy by impairing optineurin recruitment and lysosomal clearance in Alzheimer’s disease. Mol Neurodegener. 2021;16(1):15.
Article
CAS
PubMed
PubMed Central
Google Scholar
Demuro A, et al. Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers. J Biol Chem. 2005;280(17):17294–300.
Article
CAS
PubMed
Google Scholar
Demuro A, et al. Calcium signaling and amyloid toxicity in Alzheimer disease. J Biol Chem. 2010;285(17):12463–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Puglielli L, et al. Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis. J Biol Chem. 2003;278(22):19777–83.
Article
CAS
PubMed
Google Scholar
Haughey NJ, et al. (2010) Roles for dysfunctional sphingolipid metabolism in Alzheimer’s disease neuropathogenesis. Biochim Biophys Acta. 1801;8:878–86.
Google Scholar
Dinkins MB, et al. Neutral sphingomyelinase-2 deficiency ameliorates Alzheimer’s disease pathology and improves cognition in the 5XFAD mouse. J Neurosci. 2016;36(33):8653–67.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhao N, et al. Apolipoprotein E, receptors, and modulation of Alzheimer’s disease. Biol Psychiatry. 2018;83(4):347–57.
Article
CAS
PubMed
Google Scholar
Shi Y, et al. ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy. Nature. 2017;549(7673):523–7.
Article
PubMed
PubMed Central
CAS
Google Scholar
Reger MA, et al. Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired older adults. J Alzheimers Dis. 2008;13(3):323–31.
Article
CAS
PubMed
PubMed Central
Google Scholar
Claxton A, et al. Long-acting intranasal insulin detemir improves cognition for adults with mild cognitive impairment or early-stage Alzheimer’s disease dementia. J Alzheimers Dis. 2015;44(3):897–906.
Article
CAS
PubMed
Google Scholar
Jofre-Monseny L, et al. Impact of apoE genotype on oxidative stress, inflammation and disease risk. Mol Nutr Food Res. 2008;52(1):131–45.
Article
CAS
PubMed
Google Scholar
Simonovitch S, et al. Impaired Autophagy in APOE4 Astrocytes. J Alzheimer’s Dis. 2016;51(3):915–27.
Article
CAS
Google Scholar
Dickson DW, et al. Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease. Acta Neuropathol. 2008;115(4):437–44.
Article
PubMed
Google Scholar
Gai WP, et al. In situ and in vitro study of colocalization and segregation of alpha-synuclein, ubiquitin, and lipids in Lewy bodies. Exp Neurol. 2000;166(2):324–33.
Article
CAS
PubMed
Google Scholar
Cole NB, et al. Lipid droplet binding and oligomerization properties of the Parkinson’s disease protein alpha-synuclein. J Biol Chem. 2002;277(8):6344–52.
Article
CAS
PubMed
Google Scholar
Doria M, et al. Contribution of cholesterol and oxysterols to the pathophysiology of Parkinson’s disease. Free Radic Biol Med. 2016;101:393–400.
Article
CAS
PubMed
Google Scholar
Spassieva SD, et al. Ectopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency. Proc Natl Acad Sci USA. 2016;113(21):5928–33.
Article
CAS
PubMed
PubMed Central
Google Scholar
Abbott SK, et al. Altered ceramide acyl chain length and ceramide synthase gene expression in Parkinson’s disease. Mov Disord. 2014;29(4):518–26.
Article
CAS
PubMed
Google Scholar
Pchelina S, et al. Oligomeric α-synuclein and glucocerebrosidase activity levels in GBA-associated Parkinson’s disease. Neurosci Lett. 2017;636:70–6.
Article
CAS
PubMed
Google Scholar
Rocha EM, et al. Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in Parkinson’s disease. Neurobiol Dis. 2018;109(Pt B):249–57.
Article
CAS
PubMed
Google Scholar
Sanhueza M, et al. Network analyses reveal novel aspects of ALS pathogenesis. PLoS Genet. 2015;11(3):e1005107.
Article
PubMed
PubMed Central
CAS
Google Scholar
Huttlin EL, et al. The BioPlex network: a systematic exploration of the human interactome. Cell. 2015;162(2):425–40.
Article
CAS
PubMed
PubMed Central
Google Scholar
Cunnane SC, et al. Can ketones help rescue brain fuel supply in later life? Implications for cognitive health during aging and the treatment of Alzheimer’s disease. Front Mol Neurosci. 2016;9:53.
Article
PubMed
PubMed Central
CAS
Google Scholar
Nair RR, et al. Impaired mitochondrial fatty acid synthesis leads to neurodegeneration in mice. J Neurosci. 2018;38(45):9781–800.
Article
CAS
PubMed
PubMed Central
Google Scholar
Valdearcos M, et al. Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function. Cell Rep. 2014;9(6):2124–38.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bailey AP, et al. Antioxidant role for lipid droplets in a stem cell niche of drosophila. Cell. 2015;163(2):340–53.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tremblay ME, et al. Remodeling of lipid bodies by docosahexaenoic acid in activated microglial cells. J Neuroinflammation. 2016;13(1):116.
Article
PubMed
PubMed Central
CAS
Google Scholar
Bazan NG. Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection. Mol Aspects Med. 2018;64:18–33.
Article
CAS
PubMed
PubMed Central
Google Scholar