Fig. 1

Astrocyte-neuron coupling in lipid metabolism. A Exogenous lactate may enter astrocytes and neurons through lactate MCTs, moreover, the reduction of MCT levels delayed neurodegeneration. B Glia-derived lactate is decarboxylated in neuronal mitochondria and the resulting acetyl-CoA generates FAs that are shuttled back to the glial compartment, where they accumulate in LDs. C Due to the low capacity of neurons to utilize LDs, it translocates excess FAs into astrocytes via vesicles containing apolipoprotein E-like particles. D Neuron-derived FAs are delivered to astrocyte LDs that protect astrocytes from the lipotoxicity of FAs. E Astrocytes can use FFAs during β-oxidation and provide the energy generated during β-oxidation to mitochondria