Catala A: Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and/or pathological conditions. Chem Phys Lipids. 2009, 157: 1-11. 10.1016/j.chemphyslip.2008.09.004
Article
CAS
PubMed
Google Scholar
Esterbauer H, Schaur RJ, Zollner H: Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med. 1991, 11: 81-128. 10.1016/0891-5849(91)90192-6
Article
CAS
PubMed
Google Scholar
Siems W, Grune T: Intracellular metabolism of 4-hydroxynonenal. Mol Aspects Med. 2003, 24: 167-175. 10.1016/S0098-2997(03)00011-6
Article
CAS
PubMed
Google Scholar
Awasthi YC, Ansari GA, Awasthi S: Regulation of 4-hydroxynonenal mediated signaling by glutathione S-transferases. Methods Enzymol. 2005, 401: 379-407.
Article
CAS
PubMed
Google Scholar
Petersen DR, Doorn JA: Reactions of 4-hydroxynonenal with proteins and cellular targets. Free Radic Biol Med. 2004, 37: 937-945. 10.1016/j.freeradbiomed.2004.06.012
Article
CAS
PubMed
Google Scholar
Smathers RL, Galligan JJ, Stewart BJ, Petersen DR: Overview of lipid peroxidation products and hepatic protein modification in alcoholic liver disease. Chem Biol Interact. 2011, 192: 107-112. 10.1016/j.cbi.2011.02.021
Article
PubMed Central
CAS
PubMed
Google Scholar
Jaiswal AK: Nrf2 signaling in coordinated activation of antioxidant gene expression. Free Radic Biol Med. 2004, 36: 1199-1207. 10.1016/j.freeradbiomed.2004.02.074
Article
CAS
PubMed
Google Scholar
Xie T, Belinsky M, Xu Y, Jaiswal AK: ARE- and TRE-mediated regulation of gene expression. Response to xenobiotics and antioxidants. J Biol Chem. 1995, 270: 6894-6900. 10.1074/jbc.270.12.6894
Article
CAS
PubMed
Google Scholar
Shen G, Kong AN: Nrf2 plays an important role in coordinated regulation of Phase II drug metabolism enzymes and Phase III drug transporters. Biopharm Drug Dispos. 2009, 30: 345-355. 10.1002/bdd.680
Article
PubMed Central
CAS
PubMed
Google Scholar
Itoh K, Chiba T, Takahashi S, Ishii T, Igarashi K, Katoh Y, Oyake T, Hayashi N, Satoh K, Hatayama I, Yamamoto M, Nabeshima Y: An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun. 1997, 236: 313-322. 10.1006/bbrc.1997.6943
Article
CAS
PubMed
Google Scholar
Kensler TW, Wakabayashi N: Nrf2: friend or foe for chemoprevention?. Carcinogenesis. 2010, 31: 90-99. 10.1093/carcin/bgp231
Article
PubMed Central
CAS
PubMed
Google Scholar
Motohashi H, Yamamoto M: Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol Med. 2004, 10: 549-557. 10.1016/j.molmed.2004.09.003
Article
CAS
PubMed
Google Scholar
Li W, Kong AN: Molecular mechanisms of Nrf2-mediated antioxidant response. Mol Carcinog. 2009, 48: 91-104. 10.1002/mc.20465
Article
PubMed Central
CAS
PubMed
Google Scholar
Chen ZH, Saito Y, Yoshida Y, Sekine A, Noguchi N, Niki E: 4-Hydroxynonenal induces adaptive response and enhances PC12 cell tolerance primarily through induction of thioredoxin reductase 1 via activation of Nrf2. J Biol Chem. 2005, 280: 41921-41927. 10.1074/jbc.M508556200
Article
CAS
PubMed
Google Scholar
Ishikado A, Nishio Y, Morino K, Ugi S, Kondo H, Makino T, Kashiwagi A, Maegawa H: Low concentration of 4-hydroxy hexenal increases heme oxygenase-1 expression through activation of Nrf2 and antioxidative activity in vascular endothelial cells. Biochem Biophys Res Commun. 2010, 402: 99-104. 10.1016/j.bbrc.2010.09.124
Article
CAS
PubMed
Google Scholar
Katoh Y, Iida K, Kang MI, Kobayashi A, Mizukami M, Tong KI, McMahon M, Hayes JD, Itoh K, Yamamoto M: Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome. Arch Biochem Biophys. 2005, 433: 342-350. 10.1016/j.abb.2004.10.012
Article
CAS
PubMed
Google Scholar
Yu R, Mandlekar S, Lei W, Fahl WE, Tan TH, Kong AN: p38 mitogen-activated protein kinase negatively regulates the induction of phase II drug-metabolizing enzymes that detoxify carcinogens. J Biol Chem. 2000, 275: 2322-2327. 10.1074/jbc.275.4.2322
Article
CAS
PubMed
Google Scholar
Raza H, John A: 4-hydroxynonenal induces mitochondrial oxidative stress, apoptosis and expression of glutathione S-transferase A4-4 and cytochrome P450 2E1 in PC12 cells. Toxicol Appl Pharmacol. 2006, 216: 309-318. 10.1016/j.taap.2006.06.001
Article
CAS
PubMed
Google Scholar
Burczynski ME, Sridhar GR, Palackal NT, Penning TM: The reactive oxygen species–and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the alpha, beta-unsaturated aldehyde 4-hydroxy-2-nonenal to 1, 4-dihydroxy-2-nonene. J Biol Chem. 2001, 276: 2890-2897. 10.1074/jbc.M006655200
Article
CAS
PubMed
Google Scholar
Hayes JD, Flanagan JU, Jowsey IR: Glutathione transferases. Annu Rev Pharmacol Toxicol. 2005, 45: 51-88. 10.1146/annurev.pharmtox.45.120403.095857
Article
CAS
PubMed
Google Scholar
Burczynski ME, Lin HK, Penning TM: Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. Cancer Res. 1999, 59: 607-614.
CAS
PubMed
Google Scholar
Levonen AL, Landar A, Ramachandran A, Ceaser EK, Dickinson DA, Zanoni G, Morrow JD, Darley-Usmar VM: Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products. Biochem J. 2004, 378: 373-382. 10.1042/BJ20031049
Article
PubMed Central
CAS
PubMed
Google Scholar
Numazawa S, Ishikawa M, Yoshida A, Tanaka S, Yoshida T: Atypical protein kinase C mediates activation of NF-E2-related factor 2 in response to oxidative stress. Am J Physiol Cell Physiol. 2003, 285: C334-C342.
Article
CAS
PubMed
Google Scholar
Chen J, Wang L, Chen Y, Sternberg P, Cai J: Phosphatidylinositol 3 kinase pathway and 4-hydroxy-2-nonenal-induced oxidative injury in the RPE. Invest Ophthalmol Vis Sci. 2009, 50: 936-942.
Article
PubMed Central
PubMed
Google Scholar
Long EK, Murphy TC, Leiphon LJ, Watt J, Morrow JD, Milne GL, Howard JR, Picklo MJ: Trans-4-hydroxy-2-hexenal is a neurotoxic product of docosahexaenoic (22:6; n-3) acid oxidation. J Neurochem. 2008, 105: 714-724. 10.1111/j.1471-4159.2007.05175.x
Article
CAS
PubMed
Google Scholar
Vladykovskaya E, Sithu SD, Haberzettl P, Wickramasinghe NS, Merchant ML, Hill BG, McCracken J, Agarwal A, Dougherty S, Gordon SA, Schuschke DA, Barski OA, O'Toole T, D'Souza SE, Bhatnagar A, Srivastava S: Lipid peroxidation product 4-hydroxy-trans-2-nonenal causes endothelial activation by inducing endoplasmic reticulum stress. J Biol Chem. 2012, 287: 11398-11409. 10.1074/jbc.M111.320416
Article
PubMed Central
CAS
PubMed
Google Scholar
Copple IM, Goldring CE, Jenkins RE, Chia AJ, Randle LE, Hayes JD, Kitteringham NR, Park BK: The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system. Hepatology. 2008, 48: 1292-1301. 10.1002/hep.22472
Article
CAS
PubMed
Google Scholar
Pettazzoni P, Ciamporcero E, Medana C, Pizzimenti S, Dal Bello F, Minero VG, Toaldo C, Minelli R, Uchida K, Dianzani MU, Pili R, Barrera G: Nuclear factor erythroid 2-related factor-2 activity controls 4-hydroxynonenal metabolism and activity in prostate cancer cells. Free Radic Biol Med. 2011, 51: 1610-1618. 10.1016/j.freeradbiomed.2011.07.009
Article
CAS
PubMed
Google Scholar
Gallagher EP, Huisden CM, Gardner JL: Transfection of HepG2 cells with hGSTA4 provides protection against 4-hydroxynonenal-mediated oxidative injury. Toxicol In Vitro. 2007, 21: 1365-1372. 10.1016/j.tiv.2007.04.004
Article
PubMed Central
CAS
PubMed
Google Scholar
Kim JH, Yu S, Chen JD, Kong AN: The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting with transactivation domains. Oncogene. 2012, Epub ahead of print.
Singh A, Misra V, Thimmulappa RK, Lee H, Ames S, Hoque MO, Herman JG, Baylin SB, Sidransky D, Gabrielson E, Brock MV, Biswal S: Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer. PLoS Med. 2006, 3: e420. 10.1371/journal.pmed.0030420
Article
PubMed Central
PubMed
Google Scholar