Horvitz HR, Herskowitz I: Mechanisms of asymmetric cell division: two Bs or not two Bs, that is the question. Cell. 1992, 68: 237-255. 10.1016/0092-8674(92)90468-R
Article
CAS
PubMed
Google Scholar
Li L, Xie T: Stem cell niche: structure and function. Annu Rev Cell Dev Biol. 2005, 21: 605-631. 10.1146/annurev.cellbio.21.012704.131525
Article
CAS
PubMed
Google Scholar
Betschinger J, Knoblich JA: Dare to be different: asymmetric cell division in Drosophila, C. elegans and vertebrates. Curr Biol. 2004, 14: R674-R685. 10.1016/j.cub.2004.08.017
Article
CAS
PubMed
Google Scholar
Yu F, Kuo CT, Jan YN: Drosophila neuroblast asymmetric cell division: recent advances and implications for stem cell biology. Neuron. 2006, 51: 13-20. 10.1016/j.neuron.2006.06.016
Article
CAS
PubMed
Google Scholar
Gotz M, Huttner WB: The cell biology of neurogenesis. Nat Rev Mol Cell Biol. 2005, 6: 777-788. 10.1038/nrm1739
Article
PubMed
Google Scholar
Kriegstein A, Alvarez-Buylla A: The glial nature of embryonic and adult neural stem cells. Annu Rev Neurosci. 2009, 32: 149-184. 10.1146/annurev.neuro.051508.135600
Article
PubMed Central
CAS
PubMed
Google Scholar
Fortini ME: Notch signaling: the core pathway and its posttranslational regulation. Dev Cell. 2009, 16: 633-647. 10.1016/j.devcel.2009.03.010
Article
CAS
PubMed
Google Scholar
Kageyama R, Ohtsuka T, Shimojo H, Imayoshi I: Dynamic regulation of Notch signaling in neural progenitor cells. Curr Opin Cell Biol. 2009, 21: 733-740. 10.1016/j.ceb.2009.08.009
Article
CAS
PubMed
Google Scholar
Kopan R, Ilagan MX: The canonical Notch signaling pathway: unfolding the activation mechanism. Cell. 2009, 137: 216-233. 10.1016/j.cell.2009.03.045
Article
PubMed Central
CAS
PubMed
Google Scholar
Bertrand N, Castro DS, Guillemot F: Proneural genes and the specification of neural cell types. Nat Rev Neurosci. 2002, 3: 517-530. 10.1038/nrn874
Article
CAS
PubMed
Google Scholar
Ross SE, Greenberg ME, Stiles CD: Basic helix-loop-helix factors in cortical development. Neuron. 2003, 39: 13-25. 10.1016/S0896-6273(03)00365-9
Article
CAS
PubMed
Google Scholar
Lai EC, Deblandre GA, Kintner C, Rubin GM: Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta. Dev Cell. 2001, 1: 783-794. 10.1016/S1534-5807(01)00092-2
Article
CAS
PubMed
Google Scholar
Lai EC, Rubin GM: Neuralized is essential for a subset of Notch pathway-dependent cell fate decisions during Drosophila eye development. Proc Natl Acad Sci USA. 2001, 98: 5637-5642. 10.1073/pnas.101135498
Article
PubMed Central
CAS
PubMed
Google Scholar
Lai EC, Rubin GM: neuralized functions cell-autonomously to regulate a subset of notch-dependent processes during adult Drosophila development. Dev Biol. 2001, 231: 217-233. 10.1006/dbio.2000.0124
Article
CAS
PubMed
Google Scholar
Pavlopoulos E, Pitsouli C, Klueg KM, Muskavitch MA, Moschonas NK, Delidakis C: neuralized Encodes a peripheral membrane protein involved in delta signaling and endocytosis. Dev Cell. 2001, 1: 807-816. 10.1016/S1534-5807(01)00093-4
Article
CAS
PubMed
Google Scholar
Yeh E, Dermer M, Commisso C, Zhou L, McGlade CJ, Boulianne GL: Neuralized functions as an E3 ubiquitin ligase during Drosophila development. Curr Biol. 2001, 11: 1675-1679. 10.1016/S0960-9822(01)00527-9
Article
CAS
PubMed
Google Scholar
Honjo T: The shortest path from the surface to the nucleus: RBP-J kappa/Su(H) transcription factor. Genes Cells. 1996, 1: 1-9. 10.1046/j.1365-2443.1996.10010.x
Article
CAS
PubMed
Google Scholar
Kageyama R, Ohtsuka T, Kobayashi T: The Hes gene family: repressors and oscillators that orchestrate embryogenesis. Development. 2007, 134: 1243-1251. 10.1242/dev.000786
Article
CAS
PubMed
Google Scholar
Monastirioti M, Giagtzoglou N, Koumbanakis KA: Drosophila Hey is a target of Notch in asymmetric divisions during embryonic and larval neurogenesis. Development. 2010, 137: 191-201. 10.1242/dev.043604
Article
PubMed Central
CAS
PubMed
Google Scholar
San-Juan BP, Baonza A: The bHLH factor deadpan is a direct target of Notch signaling and regulates neuroblast self-renewal in Drosophila. Dev Biol. 2011, 352: 70-82. 10.1016/j.ydbio.2011.01.019
Article
CAS
PubMed
Google Scholar
Tio M, Toh J, Fang W, Blanco J, Udolph G: Asymmetric cell division and Notch signaling specify dopaminergic neurons in Drosophila. PLoS One. 2011, 6: e26879. 10.1371/journal.pone.0026879
Article
PubMed Central
CAS
PubMed
Google Scholar
Wang W, Liu W, Wang Y, Zhou L, Tang X, Luo H: Notch signaling regulates neuroepithelial stem cell maintenance and neuroblast formation in Drosophila optic lobe development. Dev Biol. 2011, 350: 414-428. 10.1016/j.ydbio.2010.12.002
Article
CAS
PubMed
Google Scholar
Rhyu MS, Jan LY, Jan YN: Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells. Cell. 1994, 76: 477-491. 10.1016/0092-8674(94)90112-0
Article
CAS
PubMed
Google Scholar
Le Borgne R, Bardin A, Schweisguth F: The roles of receptor and ligand endocytosis in regulating Notch signaling. Development. 2005, 132: 1751-1762. 10.1242/dev.01789
Article
CAS
PubMed
Google Scholar
Lee CY, Andersen RO, Cabernard C: Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation. Genes Dev. 2006, 20: 3464-3474. 10.1101/gad.1489406
Article
PubMed Central
CAS
PubMed
Google Scholar
Wang H, Somers GW, Bashirullah A, Heberlein U, Yu F, Chia W: Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts. Genes Dev. 2006, 20: 3453-3463. 10.1101/gad.1487506
Article
PubMed Central
CAS
PubMed
Google Scholar
Wang C, Chang KC, Somers G: Protein phosphatase 2A regulates self-renewal of Drosophila neural stem cells. Development. 2009, 136: 2287-2296. 10.1242/dev.035758
Article
CAS
PubMed
Google Scholar
Wang H, Ouyang Y, Somers WG, Chia W, Lu B: Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon. Nature. 2007, 449: 96-100. 10.1038/nature06056
Article
PubMed Central
CAS
PubMed
Google Scholar
Bello B, Reichert H, Hirth F: The brain tumor gene negatively regulates neural progenitor cell proliferation in the larval central brain of Drosophila. Development. 2006, 133: 2639-2648. 10.1242/dev.02429
Article
CAS
PubMed
Google Scholar
Betschinger J, Mechtler K, Knoblich JA: Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells. Cell. 2006, 124: 1241-1253. 10.1016/j.cell.2006.01.038
Article
CAS
PubMed
Google Scholar
Lee CY, Wilkinson BD, Siegrist SE, Wharton RP, Doe CQ: Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewal. Dev Cell. 2006, 10: 441-449. 10.1016/j.devcel.2006.01.017
Article
CAS
PubMed
Google Scholar
Knoblich JA: Mechanisms of asymmetric stem cell division. Cell. 2008, 132: 583-597. 10.1016/j.cell.2008.02.007
Article
CAS
PubMed
Google Scholar
Atwood SX, Prehoda KE: aPKC phosphorylates Miranda to polarize fate determinants during neuroblast asymmetric cell division. Curr Biol. 2009, 19: 723-729. 10.1016/j.cub.2009.03.056
Article
PubMed Central
CAS
PubMed
Google Scholar
Choksi SP, Southall TD, Bossing T: Prospero acts as a binary switch between self-renewal and differentiation in Drosophila neural stem cells. Dev Cell. 2006, 11: 775-789. 10.1016/j.devcel.2006.09.015
Article
CAS
PubMed
Google Scholar
Li L, Vaessin H: Pan-neural Prospero terminates cell proliferation during Drosophila neurogenesis. Genes Dev. 2000, 14: 147-151.
PubMed Central
CAS
PubMed
Google Scholar
Berger C, Kannan R, Myneni S, Renner S, Shashidhara LS, Technau GM: Cell cycle independent role of Cyclin E during neural cell fate specification in Drosophila is mediated by its regulation of Prospero function. Dev Biol. 2010, 337: 415-424. 10.1016/j.ydbio.2009.11.012
Article
CAS
PubMed
Google Scholar
Colonques J, Ceron J, Reichert H, Tejedor FJ: A transient expression of Prospero promotes cell cycle exit of Drosophila postembryonic neurons through the regulation of Dacapo. PLoS One. 2011, 6: e19342. 10.1371/journal.pone.0019342
Article
PubMed Central
CAS
PubMed
Google Scholar
Zhu Z, Bhat KM: The Drosophila Hem/Kette/Nap1 protein regulates asymmetric division of neural precursor cells by regulating localization of Inscuteable and Numb. Mech Dev. 2011, 128: 483-495. 10.1016/j.mod.2011.09.004
Article
PubMed Central
CAS
PubMed
Google Scholar
Nipper RW, Siller KH, Smith NR, Doe CQ, Prehoda KE: Galphai generates multiple Pins activation states to link cortical polarity and spindle orientation in Drosophila neuroblasts. Proc Natl Acad Sci USA. 2007, 104: 14306-14311. 10.1073/pnas.0701812104
Article
PubMed Central
CAS
PubMed
Google Scholar
Bowman SK, Neumuller RA, Novatchkova M, Du Q, Knoblich JA: The Drosophila NuMA Homolog Mud regulates spindle orientation in asymmetric cell division. Dev Cell. 2006, 10: 731-742. 10.1016/j.devcel.2006.05.005
Article
CAS
PubMed
Google Scholar
Izumi Y, Ohta N, Hisata K, Raabe T, Matsuzaki F: Drosophila Pins-binding protein Mud regulates spindle-polarity coupling and centrosome organization. Nat Cell Biol. 2006, 8: 586-593. 10.1038/ncb1409
Article
CAS
PubMed
Google Scholar
Siller KH, Cabernard C, Doe CQ: The NuMA-related Mud protein binds Pins and regulates spindle orientation in Drosophila neuroblasts. Nat Cell Biol. 2006, 8: 594-600. 10.1038/ncb1412
Article
CAS
PubMed
Google Scholar
Siller KH, Doe CQ: Lis1/dynactin regulates metaphase spindle orientation in Drosophila neuroblasts. Dev Biol. 2008, 319: 1-9. 10.1016/j.ydbio.2008.03.018
Article
PubMed Central
CAS
PubMed
Google Scholar
Johnston CA, Hirono K, Prehoda KE, Doe CQ: Identification of an Aurora-A/PinsLINKER/Dlg spindle orientation pathway using induced cell polarity in S2 cells. Cell. 2009, 138: 1150-1163. 10.1016/j.cell.2009.07.041
Article
PubMed Central
CAS
PubMed
Google Scholar
Siegrist SE, Doe CQ: Microtubule-induced Pins/Galphai cortical polarity in Drosophila neuroblasts. Cell. 2005, 123: 1323-1335. 10.1016/j.cell.2005.09.043
Article
CAS
PubMed
Google Scholar
Mauser JF, Prehoda KE: Inscuteable regulates the Pins-Mud spindle orientation pathway. PLoS One. 2012, 7: e29611. 10.1371/journal.pone.0029611
Article
PubMed Central
CAS
PubMed
Google Scholar
Goldstein B, Macara IG: The PAR proteins: fundamental players in animal cell polarization. Dev Cell. 2007, 13: 609-622. 10.1016/j.devcel.2007.10.007
Article
PubMed Central
CAS
PubMed
Google Scholar
Suzuki A, Ohno S: The PAR-aPKC system: lessons in polarity. J Cell Sci. 2006, 119: 979-987. 10.1242/jcs.02898
Article
CAS
PubMed
Google Scholar
Betschinger J, Mechtler K, Knoblich JA: The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl. Nature. 2003, 422: 326-330. 10.1038/nature01486
Article
CAS
PubMed
Google Scholar
Plant PJ, Fawcett JP, Lin DC: A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl. Nat Cell Biol. 2003, 5: 301-308. 10.1038/ncb948
Article
CAS
PubMed
Google Scholar
Yamanaka T, Horikoshi Y, Sugiyama Y: Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity. Curr Biol. 2003, 13: 734-743. 10.1016/S0960-9822(03)00244-6
Article
CAS
PubMed
Google Scholar
Ohshiro T, Yagami T, Zhang C, Matsuzaki F: Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast. Nature. 2000, 408: 593-596. 10.1038/35046087
Article
CAS
PubMed
Google Scholar
Peng CY, Manning L, Albertson R, Doe CQ: The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblasts. Nature. 2000, 408: 596-600. 10.1038/35046094
Article
CAS
PubMed
Google Scholar
Smith CA, Lau KM, Rahmani Z: aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb. EMBO J. 2007, 26: 468-480. 10.1038/sj.emboj.7601495
Article
PubMed Central
CAS
PubMed
Google Scholar
Chang KC, Garcia-Alvarez G, Somers G: Interplay between the transcription factor Zif and aPKC regulates neuroblast polarity and self-renewal. Dev Cell. 2010, 19: 778-785. 10.1016/j.devcel.2010.10.007
Article
CAS
PubMed
Google Scholar
Hafer N, Xu S, Bhat KM, Schedl P: The Drosophila CPEB protein Orb2 has a novel expression pattern and is important for asymmetric cell division and nervous system function. Genetics. 2011, 189: 907-921. 10.1534/genetics.110.123646
Article
PubMed Central
CAS
PubMed
Google Scholar
Lee CY, Robinson KJ, Doe CQ: Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation. Nature. 2006, 439: 594-598. 10.1038/nature04299
Article
CAS
PubMed
Google Scholar
Speicher S, Fischer A, Knoblich J, Carmena A: The PDZ protein Canoe regulates the asymmetric division of Drosophila neuroblasts and muscle progenitors. Curr Biol. 2008, 18: 831-837. 10.1016/j.cub.2008.04.072
Article
CAS
PubMed
Google Scholar
Carmena A, Makarova A, Speicher S: The Rap1-Rgl-Ral signaling network regulates neuroblast cortical polarity and spindle orientation. J Cell Biol. 2011, 195: 553-562. 10.1083/jcb.201108112
Article
PubMed Central
CAS
PubMed
Google Scholar
Wirtz-Peitz F, Nishimura T, Knoblich JA: Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization. Cell. 2008, 135: 161-173. 10.1016/j.cell.2008.07.049
Article
PubMed Central
CAS
PubMed
Google Scholar
Chabu C, Doe CQ: Twins/PP2A regulates aPKC to control neuroblast cell polarity and self-renewal. Dev Biol. 2009, 330: 399-405. 10.1016/j.ydbio.2009.04.014
Article
PubMed Central
CAS
PubMed
Google Scholar
Krahn MP, Egger-Adam D, Wodarz A: PP2A antagonizes phosphorylation of Bazooka by PAR-1 to control apical-basal polarity in dividing embryonic neuroblasts. Dev Cell. 2009, 16: 901-908. 10.1016/j.devcel.2009.04.011
Article
CAS
PubMed
Google Scholar
Ogawa H, Ohta N, Moon W, Matsuzaki F: Protein phosphatase 2A negatively regulates aPKC signaling by modulating phosphorylation of Par-6 in Drosophila neuroblast asymmetric divisions. J Cell Sci. 2009, 122: 3242-3249. 10.1242/jcs.050955
Article
CAS
PubMed
Google Scholar
Chang KC, Wang C, Wang H: Balancing self-renewal and differentiation by asymmetric division: insights from brain tumor suppressors in Drosophila neural stem cells. BioEssays. 2012, 34: 301-310. 10.1002/bies.201100090
Article
PubMed
Google Scholar
Schweisguth F: Regulation of notch signaling activity. Curr Biol. 2004, 14: R129-R138.
Article
CAS
PubMed
Google Scholar
Berdnik D, Torok T, Gonzalez-Gaitan M, Knoblich JA: The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila. Dev Cell. 2002, 3: 221-231. 10.1016/S1534-5807(02)00215-0
Article
CAS
PubMed
Google Scholar
Bhat KM, Gaziova I, Katipalla S: Neuralized mediates asymmetric division of neural precursors by two distinct and sequential events: promoting asymmetric localization of Numb and enhancing activation of Notch-signaling. Dev Biol. 2011, 351: 186-198. 10.1016/j.ydbio.2010.12.008
Article
PubMed Central
CAS
PubMed
Google Scholar
Morin X, Bellaiche Y: Mitotic spindle orientation in asymmetric and symmetric cell divisions during animal development. Dev Cell. 2011, 21: 102-119. 10.1016/j.devcel.2011.06.012
Article
CAS
PubMed
Google Scholar
Siller KH, Doe CQ: Spindle orientation during asymmetric cell division. Nat Cell Biol. 2009, 11: 365-374. 10.1038/ncb0409-365
Article
CAS
PubMed
Google Scholar
Kraut R, Chia W, Jan LY, Jan YN, Knoblich JA: Role of inscuteable in orienting asymmetric cell divisions in Drosophila. Nature. 1996, 383: 50-55. 10.1038/383050a0
Article
CAS
PubMed
Google Scholar
Gonzalez C: Spindle orientation, asymmetric division and tumour suppression in Drosophila stem cells. Nat Rev Genet. 2007, 8: 462-472. 10.1038/nrg2103
Article
CAS
PubMed
Google Scholar
Beaucher M, Hersperger E, Page-McCaw A, Shearn A: Metastatic ability of Drosophila tumors depends on MMP activity. Dev Biol. 2007, 303: 625-634. 10.1016/j.ydbio.2006.12.001
Article
CAS
PubMed
Google Scholar
Caussinus E, Gonzalez C: Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster. Nat Genet. 2005, 37: 1125-1129. 10.1038/ng1632
Article
CAS
PubMed
Google Scholar
Zhong W, Chia W: Neurogenesis and asymmetric cell division. Curr Opin Neurobiol. 2008, 18: 4-11. 10.1016/j.conb.2008.05.002
Article
PubMed
Google Scholar
Laurenson A, Saini N, Jiang Y, Reichert H: Targeted transgenic RNAi knockdown of cell fate determinants induces neoplastic tumor growth and metastasis in a Drosophila transplantation model of neural stem cell derived cancer. J Stem Cell Res Ther. 2012, S12: 8.
Google Scholar
Rolls MM, Albertson R, Shih HP, Lee CY, Doe CQ: Drosophila aPKC regulates cell polarity and cell proliferation in neuroblasts and epithelia. J Cell Biol. 2003, 163: 1089-1098. 10.1083/jcb.200306079
Article
PubMed Central
CAS
PubMed
Google Scholar
Kitajima A, Fuse N, Isshiki T, Matsuzaki F: Progenitor properties of symmetrically dividing Drosophila neuroblasts during embryonic and larval development. Dev Biol. 2010, 347: 9-23. 10.1016/j.ydbio.2010.06.029
Article
CAS
PubMed
Google Scholar
Cabernard C, Doe CQ: Apical/basal spindle orientation is required for neuroblast homeostasis and neuronal differentiation in Drosophila. Dev Cell. 2009, 17: 134-141. 10.1016/j.devcel.2009.06.009
Article
CAS
PubMed
Google Scholar
Godin JD, Colombo K, Molina-Calavita M: Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis. Neuron. 2010, 67: 392-406. 10.1016/j.neuron.2010.06.027
Article
CAS
PubMed
Google Scholar
Chia W, Somers WG, Wang H: Drosophila neuroblast asymmetric divisions: cell cycle regulators, asymmetric protein localization, and tumorigenesis. J Cell Biol. 2008, 180: 267-272. 10.1083/jcb.200708159
Article
PubMed Central
CAS
PubMed
Google Scholar
Tio M, Udolph G, Yang X, Chia W: cdc2 links the Drosophila cell cycle and asymmetric division machineries. Nature. 2001, 409: 1063-1067. 10.1038/35059124
Article
CAS
PubMed
Google Scholar
Slack C, Overton PM, Tuxworth RI, Chia W: Asymmetric localisation of Miranda and its cargo proteins during neuroblast division requires the anaphase-promoting complex/cyclosome. Development. 2007, 134: 3781-3787. 10.1242/dev.010900
Article
CAS
PubMed
Google Scholar
Peters JM: The anaphase promoting complex/cyclosome: a machine designed to destroy. Nat Rev Mol Cell Biol. 2006, 7: 644-656. 10.1038/nrm1988
Article
CAS
PubMed
Google Scholar
Sigrist S, Jacobs H, Stratmann R, Lehner CF: Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A, B and B3. EMBO J. 1995, 14: 4827-4838.
PubMed Central
CAS
PubMed
Google Scholar
Zur A, Brandeis M: Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis. EMBO J. 2001, 20: 792-801. 10.1093/emboj/20.4.792
Article
PubMed Central
CAS
PubMed
Google Scholar
Leismann O, Lehner CF: Drosophila securin destruction involves a D-box and a KEN-box and promotes anaphase in parallel with Cyclin A degradation. J Cell Sci. 2003, 116: 2453-2460. 10.1242/jcs.00411
Article
CAS
PubMed
Google Scholar
Konishi Y, Stegmuller J, Matsuda T, Bonni S, Bonni A: Cdh1-APC controls axonal growth and patterning in the mammalian brain. Science. 2004, 303: 1026-1030. 10.1126/science.1093712
Article
CAS
PubMed
Google Scholar
Juo P, Kaplan JM: The anaphase-promoting complex regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of C. elegans. Curr Biol. 2004, 14: 2057-2062. 10.1016/j.cub.2004.11.010
Article
CAS
PubMed
Google Scholar
Rappleye CA, Tagawa A, Lyczak R, Bowerman B, Aroian RV: The anaphase-promoting complex and separin are required for embryonic anterior-posterior axis formation. Dev Cell. 2002, 2: 195-206. 10.1016/S1534-5807(02)00114-4
Article
CAS
PubMed
Google Scholar
Neumuller RA, Richter C, Fischer A, Novatchkova M, Neumuller KG, Knoblich JA: Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi. Cell Stem Cell. 2011, 8: 580-593. 10.1016/j.stem.2011.02.022
Article
PubMed Central
PubMed
Google Scholar