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Table 1 Key players in asymmetric cell division

From: Uncovering the link between malfunctions in Drosophila neuroblast asymmetric cell division and tumorigenesis

Asymmetric division protein Protein function Phenotype associated with mutation References
Numb Neuronal differentiation NB overproliferation [2327]
Pon Neuronal differentiation Delocalization of Numb [28]
Brat Regulates Prospero localization Inhibits translation Delocalization of Prospero; NB overproliferation [2932]
Miranda Localization of basal proteins Delocalization of basal proteins; NB overproliferation [3, 33]
Prospero Neuronal differentiation NB overproliferation [2931, 3437]
Staufen Localization of Prospero mRNA Delocalization of Prospero mRNA [3]
Pins, Gαi, Loco Spindle orientation Delocalization of basal proteins; NB overproliferation [3846]
Localization of basal proteins
Inscuteable Links the heterotrimeric G protein complex with the Par complex
aPKC, Bazooka/Par3, Par6 Maintaining apical and basal polarity Apical and basal polarity defects [28, 32, 33, 4757]
Mud Spindle orientation Spindle misorientation; NB overproliferation [3946, 56, 58, 59]
Lgl (cortical localization) Localization of basal proteins Delocalization of basal proteins; NB overproliferation [32, 4954]
Aurora A (centrosome) Maintaining apical/basal polarity Apical and basal polarity defects; spindle misorientation, NB overproliferation [25, 26, 6064]
Polo (centrosome) Spindle orientation
PP2A (cytoplasmic)
Dpn NB specification Loss of NB [20]
Zif Apical/basal polarity Apical and basal polarity defects; NB overproliferation [55]
  1. Cells are colored based on localization. Green denotes basal localization, blue denotes apical localization, and purple indicates nuclear localization.