Asymmetric division protein | Protein function | Phenotype associated with mutation | References |
---|---|---|---|
Numb | Neuronal differentiation | NB overproliferation | |
Pon | Neuronal differentiation | Delocalization of Numb | [28] |
Brat | Regulates Prospero localization Inhibits translation | Delocalization of Prospero; NB overproliferation | |
Miranda | Localization of basal proteins | Delocalization of basal proteins; NB overproliferation | |
Prospero | Neuronal differentiation | NB overproliferation | |
Staufen | Localization of Prospero mRNA | Delocalization of Prospero mRNA | [3] |
Pins, Gαi, Loco | Spindle orientation | Delocalization of basal proteins; NB overproliferation | |
Localization of basal proteins | |||
Inscuteable | Links the heterotrimeric G protein complex with the Par complex | ||
aPKC, Bazooka/Par3, Par6 | Maintaining apical and basal polarity | Apical and basal polarity defects | |
Mud | Spindle orientation | Spindle misorientation; NB overproliferation | |
Lgl (cortical localization) | Localization of basal proteins | Delocalization of basal proteins; NB overproliferation | |
Aurora A (centrosome) | Maintaining apical/basal polarity | Apical and basal polarity defects; spindle misorientation, NB overproliferation | |
Polo (centrosome) | Spindle orientation | ||
PP2A (cytoplasmic) | |||
Dpn | NB specification | Loss of NB | [20] |
Zif | Apical/basal polarity | Apical and basal polarity defects; NB overproliferation | [55] |