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  1. Akt regulates critical cellular processes including cell survival and proliferation, glucose metabolism, cell migration, cancer progression and metastasis through phosphorylation of a variety of downstream tar...

    Authors: Chia-Hsin Chan, Ukhyun Jo, Abraham Kohrman, Abdol Hossein Rezaeian, Ping-Chieh Chou, Christopher Logothetis and Hui-Kuan Lin
    Citation: Cell & Bioscience 2014 4:59
  2. Glucose and oxygen deprivation during ischemia is known to affect the homeostasis of the endoplasmic reticulum (ER) in ways predicted to activate the unfolded protein response (UPR). Activation of UPR signalli...

    Authors: Danielle E Read, Ananya Gupta, Yury Ladilov, Afshin Samali and Sanjeev Gupta
    Citation: Cell & Bioscience 2014 4:56
  3. Herpes simplex virus (HSV) type 1 has a 152 kb double-stranded DNA genome that may encode more than 80 gene products, many of which remain uncharacterized. The HSV-1 triplex is a complex of three protein subun...

    Authors: You Li, Dongwei Mao, Guoda Ma, Lili Cui, Hua Tao, Haihong Zhou, Wandong Liang, Bin Zhao and Keshen Li
    Citation: Cell & Bioscience 2014 4:55
  4. Both transcriptional factor Ets-1 and integrin αvβ6 play an important role in the development and progression of cancer. The aim of our study was to investigate the expression of Integrin αvβ6 and Ets-1, two p...

    Authors: Cheng Peng, Huijie Gao, Zhengchuan Niu, Ben Wang, Zhen Tan, Weibo Niu, Enyu Liu, Jiayong Wang, Jiuzheng Sun, Muhammad Shahbaz, Michael Agrez and Jun Niu
    Citation: Cell & Bioscience 2014 4:53
  5. Dihydroneopterin aldolase (DHNA) catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and also the epimerization of DHNP to 7,8-dihydromonapterin. Previously, we determined the...

    Authors: Jaroslaw Blaszczyk, Zhenwei Lu, Yue Li, Honggao Yan and Xinhua Ji
    Citation: Cell & Bioscience 2014 4:52
  6. Ductular reactions (DRs) are well documented in many acute and chronic liver disease. The DRs are thought to be the transit amplifying cells deriving from activation of the stem/progenitor cell compartments of...

    Authors: Fei Ye, Ying-Ying Jing, Shi-Wei Guo, Guo-Feng Yu, Qing-Min Fan, Fang-Fang Qu, Lu Gao, Yang Yang, Dong Wu, Yan Meng, Feng-Hai Yu and Li-Xin Wei
    Citation: Cell & Bioscience 2014 4:50
  7. Peptidylarginine deiminase IV (PADI4) is widely distributed in several tissues and the expression is correlated with many pathological processes. Chemotherapy remains a major treatment alternatively to surgery...

    Authors: Tingting Fan, Changsong Zhang, Ming Zong, Qiudong Zhao, Xue Yang, Chong Hao, Hui Zhang, Shanshan Yu, Jinhu Guo, Ruhan Gong, Shasha Fan, Lixin Wei and Lieying Fan
    Citation: Cell & Bioscience 2014 4:49
  8. Sirtuin1 (SIRT1) is an NAD+-dependent type III histone deacetylase (HDAC). This research investigated the prevalence of SIRT1 protein expression and its prognostic influence with the aim of validating its potenti...

    Authors: Guan-qing Chen, Hui Tian, Wei-ming Yue, Lin Li, Shu-hai Li, Lei Qi, Cun Gao, Li-bo Si, Ming Lu and Fei Feng
    Citation: Cell & Bioscience 2014 4:48
  9. Cholestasis is characterized by an abnormal accumulation of bile acids and causes hepatocellular injury. Recent studies show that autophagy is involved in the pathophysiology of many liver diseases. The potent...

    Authors: Lu Gao, Gang Lv, Xianling Guo, Yingying Jing, Zhipeng Han, Shanshan Zhang, Kai Sun, Rong Li, Yang Yang and Lixin Wei
    Citation: Cell & Bioscience 2014 4:47
  10. Cancer is a disease arising from both genetic and epigenetic modifications of DNA that contribute to changes in gene expression in the cell. Genetic modifications include loss or amplification of DNA, loss of ...

    Authors: Eva Baxter, Karolina Windloch, Frank Gannon and Jason S Lee
    Citation: Cell & Bioscience 2014 4:45
  11. Cells regulate gene expression at multiple levels leading to a balance between robustness and complexity within their proteome. One core molecular step contributing to this important balance during metazoan ge...

    Authors: Hsuan Liu, Chung-Pei Ma, Yi-Tung Chen, Scott C Schuyler, Kai-Ping Chang and Bertrand Chin-Ming Tan
    Citation: Cell & Bioscience 2014 4:44
  12. Pinocembrin is the most abundant flavonoid in propolis. In this study, we investigated the antimetastatic effect of pinocembrin on TGF-β1-induced epithelial-mesenchymal transition (EMT) and metastasis of human...

    Authors: Kun-Shiang Chen, Ming-Der Shi, Chi-Sheng Chien and Yuan-Wei Shih
    Citation: Cell & Bioscience 2014 4:41
  13. The human immunodeficiency virus (HIV-1) exploits host proteins to complete its life cycle. Genome-wide siRNA approaches suggested that host proteins affect HIV-1 replication. However, the results barely overl...

    Authors: Ying-Ju Lin, Chia-Yen Chen, Kuan-Teh Jeang, Xiang Liu, Jen-Hsien Wang, Chien-Hui Hung, Hsinyi Tsang, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Cheng-Wen Lin, Mao-Wang Ho, Wen-Kuei Chien, Jin-Hua Chen, Tsung-Jung Ho and Fuu-Jen Tsai
    Citation: Cell & Bioscience 2014 4:40
  14. Nrf2 plays a critical role in defending against oxidative stress and inflammation. We previously reported that Nrf2 confers protection against ultraviolet-B (UVB)-induced inflammation, sunburn reaction, and is...

    Authors: Constance Lay Lay Saw, Anne Yuqing Yang, Mou-Tuan Huang, Yue Liu, Jong Hun Lee, Tin Oo Khor, Zheng-Yuan Su, Limin Shu, Yaoping Lu, Allan H Conney and Ah-Ng Tony Kong
    Citation: Cell & Bioscience 2014 4:39
  15. Thyroid hormones (THs) are potent hormones modulating liver lipid homeostasis. The perturbation of lipid homeostasis is a hallmark of non-alcoholic fatty liver disease (NAFLD), a very common liver disorder. It...

    Authors: Xuan Yao, Sarina Hou, Duo Zhang, Hongfeng Xia, Yu-Cheng Wang, Jingjing Jiang, Huiyong Yin and Hao Ying
    Citation: Cell & Bioscience 2014 4:38
  16. Processing of homologous recombination intermediates is tightly coordinated to ensure that chromosomal integrity is maintained and tumorigenesis avoided. Decatenation of double Holliday junctions, for example,...

    Authors: Paolo Swuec and Alessandro Costa
    Citation: Cell & Bioscience 2014 4:36
  17. miRNAs play key regulatory roles in cellular pathological processes. We aimed to identify clinically meaningful biomarkers in pulmonary carcinoid tumors (PCTs), a member of neuroendocrine neoplasms, via profil...

    Authors: Bo Deng, Julian Molina, Marie C Aubry, Zhifu Sun, Liang Wang, Bruce W Eckloff, George Vasmatzis, Ming You, Eric D Wieben, Jin Jen, Dennis A Wigle and Ping Yang
    Citation: Cell & Bioscience 2014 4:35
  18. A team of scientists led by Professor DW Pang at Wuhan University have developed a new class of fluorescence probes based on bacterial cells. These microbial factories manufacture semiconductor nanocrystals in...

    Authors: Jing Shang and Xiaohu Gao
    Citation: Cell & Bioscience 2014 4:34
  19. The potential biodiesel plant castor bean (Ricinus communis) has been in the limelight for bioenergy research due to the availability of its genome which raises the bar for genome-wide studies claiming advances t...

    Authors: Umashankar Chandrasekaran, Wei Xu and Aizhong Liu
    Citation: Cell & Bioscience 2014 4:33
  20. Double-stranded DNA translocation is ubiquitous in living systems. Cell mitosis, bacterial binary fission, DNA replication or repair, homologous recombination, Holliday junction resolution, viral genome packag...

    Authors: Gian Marco De-Donatis, Zhengyi Zhao, Shaoying Wang, Lisa P Huang, Chad Schwartz, Oleg V Tsodikov, Hui Zhang, Farzin Haque and Peixuan Guo
    Citation: Cell & Bioscience 2014 4:30
  21. Non-alcoholic fatty liver disease, one of the most common liver diseases, has obtained increasing attention. Palmitate (PA)-induced liver injury is considered a risk factor for the development of non-alcoholic...

    Authors: Ning Cai, Xue Zhao, Yingying Jing, Kai Sun, Shufan Jiao, Xiaojing Chen, Haozheng Yang, Yan Zhou and Lixin Wei
    Citation: Cell & Bioscience 2014 4:28
  22. Protein phosphates 4 (PP4), encoded by the ppp4c gene, is a ubiquitously expressed phosphatase that has been implicated in the regulation of cytokine signaling and lymphocyte survival; recent reports suggest that...

    Authors: Fang-Hsuean Liao, Jr-Wen Shui, En-Wei Hsing, Wan-Yi Hsiao, Yu-Chun Lin, Yi-Chiao Chan, Tse-Hua Tan and Ching-Yu Huang
    Citation: Cell & Bioscience 2014 4:25
  23. Gastric cancer is one of the leading causes of cancer death world-wide and carries a high rate of metastatic risk. In addition to other protein-coding oncogenes and tumor suppressor genes, microRNAs play an im...

    Authors: Jun Ren, Hui-jie Huang, Yu Gong, Shen Yue, Li-ming Tang and Steven Y Cheng
    Citation: Cell & Bioscience 2014 4:26
  24. It is well established that adipose-derived stem cells (ADSCs) produce and secrete cytokines/growth factors that antagonize UV-induced photoaging of skin. However, the exact molecular basis underlying the anti...

    Authors: Xiao Xu, Hong-yi Wang, Yu Zhang, Yang Liu, Yan-qi Li, Kai Tao, Chu-Tse Wu, Ji-de Jin and Xiao-yan Liu
    Citation: Cell & Bioscience 2014 4:24
  25. Both eukaryotic translation initiation factor 4E (eIF4E) and integrin αvβ6 play an important role in the development and progression of cancer. The aim of this study was to investigate the expression of eIF4E ...

    Authors: Zhengchuan Niu, Jiayong Wang, Shahbaz Muhammad, Weibo Niu, Enyu Liu, Cheng Peng, Benjia Liang, Qi Sun, Shinichi Obo, Zhaobin He, Song Liu, Xueqing Zou and Jun Niu
    Citation: Cell & Bioscience 2014 4:23
  26. Mesenchymal stem cells (MSCs) have been reported to play an important role in tumor growth. Inflammation is an important feature of hepatocellular carcinoma (HCC). Certain inflammatory cytokines produced in tu...

    Authors: Zhipeng Han, Yingying Jing, Yong Xia, Shanshan Zhang, Jing Hou, Yan Meng, Fenghai Yu, Xiaoqing Liu, Mengchao Wu, Ping Zhang and Lixin Wei
    Citation: Cell & Bioscience 2014 4:22
  27. Steroid receptor coactivator 3 (SRC-3) is a multifunctional protein that plays an important role in malignancy of several cancers and in regulation of bacterial LPS-induced inflammation. However, the involveme...

    Authors: Xiaochun Xia, Wei Wan, Qiang Chen, Kun Liu, Sidra Majaz, Pingli Mo, Jianming Xu and Chundong Yu
    Citation: Cell & Bioscience 2014 4:21
  28. PKM2 is an attractive target for cancer therapy, however, for many cancer cells, PKM2 knockdown only leads to a modest impairment of survival and proliferation. It is not known whether PKM2 knockdown rewires c...

    Authors: Xiaodong Qin, Yuping Du, Xing Chen, Wuyan Li, Jinghong Zhang and Jinbo Yang
    Citation: Cell & Bioscience 2014 4:20
  29. Iron is an important mineral element used by the body in a variety of metabolic and physiologic processes. These processes are highly active when the body is undergoing physical exercises. Prevalence of exerci...

    Authors: Wei-Na Kong, Guofen Gao and Yan-Zhong Chang
    Citation: Cell & Bioscience 2014 4:19
  30. The human ether-a-go-go-related gene potassium channel (hERG) has an unusual long turret, whose role in recognizing scorpion toxins remains controversial. Here, BmKKx2, the first specific blocker of hERG chann...

    Authors: You-Tian Hu, Jun Hu, Tian Li, Jing-Jing Wei, Jing Feng, Yi-Mei Du, Zhi-Jian Cao, Wen-Xin Li and Ying-Liang Wu
    Citation: Cell & Bioscience 2014 4:18
  31. Autophagy (macroautophagy), a cellular process of “self-eating”, segregates damaged/aged organelles into vesicles, fuses with lysosomes, and enables recycling of the digested materials. The precise origin(s) o...

    Authors: Katherine L Cook, David R Soto-Pantoja, Mones Abu-Asab, Pamela AG Clarke, David D Roberts and Robert Clarke
    Citation: Cell & Bioscience 2014 4:16
  32. To clone and express a truncated, soluble vascular endothelial growth factor receptor 2 (sVEGFR2) possessing the combined-functional domains 1–3 and 5 in eukaryotic cells and to test the inhibitory effects of ...

    Authors: Wei Liu, Xinyuan Zhang, Ching Song, Shisan Bao, Donna Lai, Jianqiu Mou, Tao Jiang and Ningli Wang
    Citation: Cell & Bioscience 2014 4:14
  33. Human papillomavirus (HPV) infections are particularly problematic for HIV + and solid organ transplant patients with compromised CD4+ T cell-dependent immunity as they produce more severe and progressive dise...

    Authors: Shiwen Peng, Liwen Song, Jayne Knoff, Joshua W Wang, Yung-Nien Chang, Drew Hannaman, T-C Wu, Ronald D Alvarez, Richard BS Roden and Chien-Fu Hung
    Citation: Cell & Bioscience 2014 4:11
  34. Autophagy1 is a complex of adaptive cellular response that enhances cancer cell survival in the face of cellular stresses such as chemothery. Here we show that in human gallbladder carcinoma (GBC) cells lines,...

    Authors: Xiao Liang, JiaCheng Tang, YueLong Liang, RenAn Jin and XiuJun Cai
    Citation: Cell & Bioscience 2014 4:10