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  1. Type II congenital pulmonary airway malformation (CPAM) is a rare pulmonary microcystic developmental malformation. Surgical excision is the primary treatment for CPAM, although maternal steroids and betametha...

    Authors: Fengxia Li, Zheng Tan, Hongyu Chen, Yue Gao, Jie Xia, Ting Huang, Liang Liang, Jian Zhang, Xianghong Zhang, Xucong Shi, Qiang Chen, Qiang Shu and Lan Yu
    Citation: Cell & Bioscience 2024 14:94
  2. Numerous studies have shown that somite development is a necessary stage of myogenesis chondrogenesis and osteogenesis. Our previous study has established a stable presomitic mesoderm progenitor cell line (UiP...

    Authors: Huiru Gao, Xingnan Huang, Zepo Cai, Baomei Cai, Kaipeng Wang, Junyang Li, Junqi Kuang, Bo Wang, Ziwei Zhai, Jin Ming, Shangtao Cao, Yue Qin and Duanqing Pei
    Citation: Cell & Bioscience 2024 14:93
  3. N1-Methyladenosine (m1A) is an abundant modification of transcripts regulating mRNA structure and translation efficiency. However, the characteristics and biological functions of mRNA m1A modification in adult hi...

    Authors: Huan Wang, Linjie Xie, Haomin Guo, Lishi Li, Shuwei Chen, Ye Fan, Jingyuan Tian, Liping Xu, Xuejian Kong and Aiguo Xuan
    Citation: Cell & Bioscience 2024 14:92
  4. Nor1/NR4A3 is a member of the NR4A subfamily of nuclear receptors that play essential roles in regulating gene expression related to development, cell homeostasis and neurological functions. However, Nor1 is s...

    Authors: Jonathan Gagnon, Véronique Caron and André Tremblay
    Citation: Cell & Bioscience 2024 14:91
  5. Metabolic disorders are currently threatening public health worldwide. Discovering new targets and developing promising drugs will reduce the global metabolic-related disease burden. Metabolic disorders primar...

    Authors: Jinming Zhang, Yixin Li, Liu Yang, Ningning Ma, Shengying Qian, Yingfen Chen, Yajun Duan, Xiaogang Xiang and Yong He
    Citation: Cell & Bioscience 2024 14:90
  6. This study investigates NADPH oxidase 4 (NOX4) involvement in iron-mediated astrocyte cell death in Alzheimer’s Disease (AD) using single-cell sequencing data and transcriptomes. We analyzed AD single-cell RNA...

    Authors: Yasenjiang Maimaiti, Ting Su, Zhanying Zhang, Lingling Ma, Yuan Zhang and Hong Xu
    Citation: Cell & Bioscience 2024 14:88
  7. Zinc finger SWIM-type containing 4 (ZSWIM4) is a zinc finger protein with its function largely uncharacterized. In this study, we aimed to investigate the role of ZSWIM4 in gastrointestinal stromal tumors (GIS...

    Authors: Xu Cao, Jinhai Tian, Man Yee Cheung, Liangying Zhang, Zimei Liu, Zongying Jiang, Shaoting Zhang, Kun Xiao, Sien Zhao, Ming Wang, Feng Ding, Shujing Li, Lijun Ma, Hui Zhao and Jianmin Sun
    Citation: Cell & Bioscience 2024 14:87
  8. Neurodevelopmental disorders (NDD), such as autism spectrum disorders (ASD) and intellectual disorders (ID), are highly debilitating childhood psychiatric conditions. Genetic factors are recognized as playing ...

    Authors: Shengyun Xu, Jiaoxiang Wang, Kexin Mao, Deling Jiao, Zhu Li, Heng Zhao, Yifei Sun, Jin Feng, Yuanhao Lai, Ruiqi Peng, Yu Fu, Ruoyi Gan, Shuhan Chen, Hong-Ye Zhao, Hong-Jiang Wei and Ying Cheng
    Citation: Cell & Bioscience 2024 14:86
  9. Microvascular destabilization is the primary cause of the inner blood-retinal barrier (iBRB) breakdown and increased vascular leakage in diabetic retinopathy (DR). Microvascular destabilization results from th...

    Authors: Xia Sheng, Chunmei Zhang, Jiwei Zhao, Jianping Xu, Peng Zhang, Quanju Ding and Jingfa Zhang
    Citation: Cell & Bioscience 2024 14:85
  10. Polyamines (PA) are polycations with pleiotropic functions in cellular physiology and pathology. In particular, PA have been involved in the regulation of cell homeostasis and proliferation participating in th...

    Authors: Marianna Nicoletta Rossi, Cristian Fiorucci, Paolo Mariottini and Manuela Cervelli
    Citation: Cell & Bioscience 2024 14:84
  11. Clinical outcome after traumatic brain injury (TBI) is closely associated conditions of other organs, especially lungs as well as degree of brain injury. Even if there is no direct lung damage, severe brain in...

    Authors: Jong-Tae Kim, Kang Song, Sung Woo Han, Dong Hyuk Youn, Harry Jung, Keun-Suh Kim, Hyo-Jung Lee, Ji Young Hong, Yong-Jun Cho, Sung-Min Kang and Jin Pyeong Jeon
    Citation: Cell & Bioscience 2024 14:83
  12. Neural progenitor cells (NPCs) can be cultivated from developing brains, reproducing many of the processes that occur during neural development. They can be isolated from a variety of animal models, such as tr...

    Authors: Guilherme Juvenal, Carine Meinerz, Ana Carolina Ayupe, Henrique Correia Campos, Eduardo Moraes Reis, Beatriz Monteiro Longo, Micheli Mainardi Pillat and Henning Ulrich
    Citation: Cell & Bioscience 2024 14:82
  13. Histone ubiquitination modification is emerging as a critical epigenetic mechanism involved in a range of biological processes. In vitro reconstitution of ubiquitinated nucleosomes is pivotal for elucidating t...

    Authors: Weijie Li, Peirong Cao, Pengqi Xu, Fahui Sun, Chi Wang, Jiale Zhang, Shuqi Dong, Jon R. Wilson, Difei Xu, Hengxin Fan, Zhenhuan Feng, Xiaofei Zhang, Qingjun Zhu, Yingzhi Fan, Nick Brown, Neil Justin…
    Citation: Cell & Bioscience 2024 14:81
  14. About 1/3 of primary biliary cholangitis (PBC) patients suffered from poor response worldwide. And these patients present intestinal disturbances. We aimed to identify signatures of microbiota and metabolites ...

    Authors: Weijia Han, Ting Song, Zhongyi Huang, Yanmin Liu, Bin Xu and Chunyang Huang
    Citation: Cell & Bioscience 2024 14:80
  15. N6-methyladenosine (m6A) methylation is a prevalent RNA modification implicated in various diseases. However, its role in intervertebral disc degeneration (IDD), a common cause of low back pain, remains unclear.

    Authors: Yu Lei, Enyu Zhan, Chao Chen, Yaoquan Hu, Zhengpin Lv, Qicong He, Xuenan Wang, Xingguo Li and Fan Zhang
    Citation: Cell & Bioscience 2024 14:79
  16. The central nervous system (CNS) is the most delicate system in human body, with the most complex structure and function. It is vulnerable to trauma, infection, neurodegeneration and autoimmune diseases, and a...

    Authors: Lu Zhang, Yufen Tang, Peng Huang, Senlin Luo, Zhou She, Hong Peng, Yuqiong Chen, Jinwen Luo, Wangxin Duan, Jie Xiong, Lingjuan Liu and Liqun Liu
    Citation: Cell & Bioscience 2024 14:75
  17. The glycolytic enzyme alpha-enolase is a known biomarker of many cancers and involved in tumorigenic functions unrelated to its key role in glycolysis. Here, we show that expression of alpha-enolase correlates...

    Authors: Morgan L Marshall, Kim YC Fung, David A Jans and Kylie M Wagstaff
    Citation: Cell & Bioscience 2024 14:74
  18. Recent studies have shifted the spotlight from adult disease to gametogenesis and embryo developmental events, and these are greatly affected by various environmental chemicals, such as drugs, metabolites, pol...

    Authors: Yuedi Cao, Geng G. Tian, Xiaokun Hong, Qing Lu, Ting Wei, Hai-Feng Chen and Ji Wu
    Citation: Cell & Bioscience 2024 14:73
  19. Cardiovascular diseases (CVDs) have emerged as a predominant threat to human health, surpassing the incidence and mortality rates of neoplastic diseases. Extracellular vesicles (EVs) serve as vital mediators i...

    Authors: De-Xin Chen, Chuang-Hong Lu, Na Na, Rui-Xing Yin and Feng Huang
    Citation: Cell & Bioscience 2024 14:72
  20. Ototoxicity is a major side effect of many broadly used aminoglycoside antibiotics (AGs) and no FDA-approved otoprotective drug is available currently. The zebrafish has recently become a valuable model to inv...

    Authors: Yipu Fan, Yihan Zhang, Dajiang Qin and Xiaodong Shu
    Citation: Cell & Bioscience 2024 14:71
  21. The adult intestinal epithelium is a complex, self-renewing tissue composed of specialized cell types with diverse functions. Intestinal stem cells (ISCs) located at the bottom of crypts, where they divide to ...

    Authors: Zhaoyi Peng, Lingyu Bao, James Iben, Shouhong Wang, Bingyin Shi and Yun-Bo Shi
    Citation: Cell & Bioscience 2024 14:70
  22. Hepatocellular carcinoma (HCC) incidence is continuously increasing worldwide, due to the rise of metabolic dysfunction-associated steatohepatitis (MASH) cases. Cholesterol is an essential driver of the metabo...

    Authors: Elena Piccinin, Maria Arconzo, Emanuela Pasculli, Angela Fulvia Tricase, Silvia Cultrera, Justine Bertrand-Michel, Nicolas Loiseau, Gaetano Villani, Hervé Guillou and Antonio Moschetta
    Citation: Cell & Bioscience 2024 14:69
  23. Mammalian or mechanistic target of rapamycin complex 1 (mTORC1) is an effective therapeutic target for diseases such as cancer, diabetes, aging, and neurodegeneration. However, an efficient tool for monitoring...

    Authors: Canrong Li, Yuguo Yi, Yingyi Ouyang, Fengzhi Chen, Chuxin Lu, Shujun Peng, Yifan Wang, Xinyu Chen, Xiao Yan, Haolun Xu, Shuiming Li, Lin Feng and Xiaoduo Xie
    Citation: Cell & Bioscience 2024 14:68
  24. Observational studies have reported that gut microbiota composition is associated with metabolic syndrome. However, the causal effect of gut microbiota on metabolic syndrome has yet to be confirmed.

    Authors: Jiawu Yan, Zhongyuan Wang, Guojian Bao, Cailin Xue, Wenxuan Zheng, Rao Fu, Minglu Zhang, Jialu Ding, Fei Yang and Beicheng Sun
    Citation: Cell & Bioscience 2024 14:67
  25. Human patients often experience an episode of serious seizure activity, such as status epilepticus (SE), prior to the onset of temporal lobe epilepsy (TLE), suggesting that SE can trigger the development of ep...

    Authors: Zi-Yang Liu, Yuan-Quan Li, Die-Lin Wang, Ying Wang, Wan-Ting Qiu, Yu-Yang Qiu, He-Lin Zhang, Qiang-Long You, Shi-min Liu, Qiu-Ni Liang, Er-Jian Wu, Bing-Jie Hu and Xiang-Dong Sun
    Citation: Cell & Bioscience 2024 14:66
  26. In vitro disease modeling enables translational research by providing insight into disease pathophysiology and molecular mechanisms, leading to the development of novel therapeutics. Nevertheless, in vitro sys...

    Authors: Hyebin Koh, Woojoo Kang, Ying-Ying Mao, Jisoo Park, Sangjune Kim, Seok-Ho Hong and Jong-Hee Lee
    Citation: Cell & Bioscience 2024 14:65
  27. Retinitis pigmentosa (RP) is a genetically heterogeneous group of degenerative disorders causing progressive vision loss due to photoreceptor death. RP affects other retinal cells, including the retinal pigmen...

    Authors: Bruna Lopes da Costa, Peter M. J. Quinn, Wen-Hsuan Wu, Siyuan Liu, Nicholas D. Nolan, Aykut Demirkol, Yi-Ting Tsai, Salvatore Marco Caruso, Thiago Cabral, Nan-Kai Wang and Stephen H. Tsang
    Citation: Cell & Bioscience 2024 14:64
  28. Methylmalonic acidemia (MMA) is a rare inborn error of propionate metabolism caused by deficiency of the mitochondrial methylmalonyl-CoA mutase (MUT) enzyme. As matter of fact, MMA patients manifest impairment...

    Authors: Michele Costanzo, Armando Cevenini, Laxmikanth Kollipara, Marianna Caterino, Sabrina Bianco, Francesca Pirozzi, Gianluca Scerra, Massimo D’Agostino, Luigi Michele Pavone, Albert Sickmann and Margherita Ruoppolo
    Citation: Cell & Bioscience 2024 14:63
  29. Gut microbiota and their metabolites play a regulatory role in skeletal muscle growth and development, which be known as gut-muscle axis. 3-phenylpropionic acid (3-PPA), a metabolite produced by colonic microo...

    Authors: Penglin Li, Xiaohua Feng, Zewei Ma, Yexian Yuan, Hongfeng Jiang, Guli Xu, Yunlong Zhu, Xue Yang, Yujun Wang, Canjun Zhu, Songbo Wang, Ping Gao, Qingyan Jiang and Gang Shu
    Citation: Cell & Bioscience 2024 14:62
  30. Transcriptional coactivator with PDZ-biding motif (TAZ) is widely expressed in most tissues and interacts with several transcription factors to regulate cell proliferation, differentiation, and death, thereby ...

    Authors: Jiseo Song, Hyo Kyeong Kim, Hyunsoo Cho, Suh Jin Yoon, Jihae Lim, Kyunglim Lee and Eun Sook Hwang
    Citation: Cell & Bioscience 2024 14:60
  31. Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a family of broad substrate specificity serine (Ser)/threonine (Thr) protein kinases that play a crucial role in the Ca2+-dependent signaling pathways. Its ...

    Authors: Yuxin Sun, Mengyu Hao, Hao Wu, Chengzhi Zhang, Dong Wei, Siyu Li, Zongming Song and Ye Tao
    Citation: Cell & Bioscience 2024 14:59
  32. The cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase-stimulator of interferon genes (cGAS-STING) signaling pathway, an important component of the innate immune system, is involved in...

    Authors: Cheng An, Zhen Li, Yao Chen, Shaojun Huang, Fan Yang, Ying Hu, Tao Xu, Chengxin Zhang and Shenglin Ge
    Citation: Cell & Bioscience 2024 14:58
  33. Psoriasis is an inflammatory skin disease characterized by the hyperproliferative epidermal keratinocytes and significant immune cells infiltration, leading to cytokines production such as IL-1β, TNF-α, IL-23,...

    Authors: Jinju Lee, Mi-Yeon Kim, Hyo Jeong Kim, Woo Sun Choi and Hun Sik Kim
    Citation: Cell & Bioscience 2024 14:57
  34. Acute lung injury (ALI) is strongly associated with hospitalization and mortality in patients with sepsis. Recent evidence suggests that pyroptosis mediated by NLRP3(NOD-, LRR- and pyrin domain-containing 3) i...

    Authors: Jinlian Liu, Ke Song, Bingqi Lin, Zhenfeng Chen, Yan Liu, Xianshuai Qiu, Qi He, Zirui Zuo, Xiaodan Yao, Xiaoxia Huang, Zhuanhua Liu, Zhifeng Liu, Qiaobing Huang and Xiaohua Guo
    Citation: Cell & Bioscience 2024 14:56
  35. Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease with limited disease-modifying treatments. Drug repositioning strategy has now emerged as a promising approach for anti-AD drug discover...

    Authors: Chong Xu, Yilan Mei, Ruihan Yang, Qiudan Luo, Jienian Zhang, Xiaolin Kou, Jianfeng Hu, Yujie Wang, Yue Li, Rong Chen, Zhengping Zhang, Yuyuan Yao and Jian Sima
    Citation: Cell & Bioscience 2024 14:55
  36. Extensive hepatocyte mortality and the absence of specific medical therapy significantly contribute to the unfavorable prognosis of acute liver failure (ALF). Ferroptosis is a crucial form of cell death involv...

    Authors: Zi-Ying Lei, Zhi-Hui Li, Deng-Na Lin, Jing Cao, Jun-Feng Chen, Shi-Bo Meng, Jia-Lei Wang, Jing Liu, Jing Zhang and Bing-Liang Lin
    Citation: Cell & Bioscience 2024 14:54
  37. Data on the course of viral infections revealed severe inflammation as a consequence of antiviral immune response. Despite extensive research, there are insufficient data on the role of innate immune cells in ...

    Authors: Asta Lučiūnaitė, Kristina Mašalaitė, Ieva Plikusiene, Vincentas Maciulis, Silvija Juciute, Milda Norkienė and Aurelija Žvirblienė
    Citation: Cell & Bioscience 2024 14:53
  38. Pain is a common symptom of many diseases with a high incidence rate. Clinically, drug treatment, as the main method to relieve pain at present, is often accompanied by different degrees of adverse reactions. ...

    Authors: Daling Deng, Tianhao Zhang, Lulin Ma, Wenjing Zhao, Shiqian Huang, Kaixing Wang, Shaofang Shu and Xiangdong Chen
    Citation: Cell & Bioscience 2024 14:51
  39. Ivermectin (IVM) is a commonly prescribed antiparasitic treatment with pharmacological effects on invertebrate glutamate ion channels resulting in paralysis and death of invertebrates. However, it can also act...

    Authors: Hillary A. Wadsworth, Alicia M. P. Warnecke, Joshua C. Barlow, J. Kayden Robinson, Emma Steimle, Joakim W. Ronström, Pacen E. Williams, Christopher J. Galbraith, Jared Baldridge, Michael W. Jakowec, Daryl L. Davies and Jordan T. Yorgason
    Citation: Cell & Bioscience 2024 14:50
  40. Reciprocal interactions between the tumor microenvironment (TME) and cancer cells play important roles in tumorigenesis and progression of glioma. Glioma-associated macrophages (GAMs), either of peripheral ori...

    Authors: Yue Deng, Qinyan Chen, Chao Wan, Yajie Sun, Fang Huang, Yan Hu and Kunyu Yang
    Citation: Cell & Bioscience 2024 14:49
  41. Stress is a recognized risk factor for cognitive decline, which triggers neuroinflammation involving microglial activation. However, the specific mechanism for microglial activation under stress and affects le...

    Authors: Xue Wang, Yuhan Wu, Yingrui Tian, Hui Hu, Yun Zhao, Binghua Xue, Zhaowei Sun, Aijun Wei, Fang Xie and Ling-Jia Qian
    Citation: Cell & Bioscience 2024 14:48
  42. Brain function and neuronal activity depend on a constant supply of blood from the cerebral circulation. The cerebral venous system (CVS) contains approximately 70% of the total cerebral blood volume; similar ...

    Authors: Huimin Wei, Huimin Jiang, Yifan Zhou, Lu Liu, Wei Ma, Shanshan Ni, Chen Zhou and Xunming Ji
    Citation: Cell & Bioscience 2024 14:47
  43. The anti-aging protein Klotho plays a protective role in kidney disease, but its potential as a biomarker for chronic kidney disease (CKD) is controversial. Additionally, the main pathways through which Klotho...

    Authors: Junhui Liu, Huaicheng Wang, Qinyu Liu, Shushu Long, Yanfang Wu, Nengying Wang, Wei Lin, Gang Chen, Miao Lin and Junping Wen
    Citation: Cell & Bioscience 2024 14:46