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  1. Exocytosis is a process by which vesicles are transported to and fused with specific areas of the plasma membrane. Although several studies have shown that sphingolipids are the main components of exocytic com...

    Authors: Qingguo Guo, Tianrui Zhang, Na Meng, Yuran Duan, Yuan Meng, Dong Sun, Ying Liu and Guangzuo Luo

    Citation: Cell & Bioscience 2020 10:53

    Content type: Research

    Published on:

  2. Thanks to the advancement in science and technology and a significant number of cancer research programs being carried out throughout the world, the prevention, prognosis and treatment of breast cancer are imp...

    Authors: Debparna Nandy, Sruthy Manuraj Rajam and Debasree Dutta

    Citation: Cell & Bioscience 2020 10:52

    Content type: Review

    Published on:

  3. Fndc5, a well-defined myokine and also identified as an adipokine, has a critical role in modulation of metabolism and protection against obesity. These important functions are mediated by irisin, a secretory ...

    Authors: Farzaneh Rabiee, Liana Lachinani, Sarvenaz Ghaedi, Mohammad Hossein Nasr-Esfahani, Timothy L. Megraw and Kamran Ghaedi

    Citation: Cell & Bioscience 2020 10:51

    Content type: Review

    Published on:

  4. OTUB1 (ovarian tumor domain protease domain-containing ubiquitin aldehyde-binding proteins)-mediated deubiquitination of FOXM1 (Forkhead box M1) participates in carcinogenesis of various tumors. We aim to inve...

    Authors: Kai Zhou, Haixing Mai, Song Zheng, Weizhong Cai, Xu Yang, Zhenlin Chen and Bin Zhan

    Citation: Cell & Bioscience 2020 10:50

    Content type: Research

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  9. Switching microglial polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype represents a novel therapeutic strategy for neuropathic pain (NP). This study aims to investigate ...

    Authors: Xianwei Gui, Hansen Wang, Lanxiang Wu, Sheng Tian, Xuan Wang, Heqing Zheng and Wei Wu

    Citation: Cell & Bioscience 2020 10:45

    Content type: Research

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  11. Induction of biliary epithelial cell apoptosis by toxic bile acids is involved in the development of cholestatic disease, but the underlying molecular mechanism is not clear. The purpose of this study was to i...

    Authors: Jiye Li, Dongsheng Yu, Sanyang Chen, Yifan Liu, Jihua Shi, Jiakai Zhang, Peihao Wen, Zhihui Wang, Jie Li, Wenzhi Guo and Shuijun Zhang

    Citation: Cell & Bioscience 2020 10:43

    Content type: Research

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  12. Microglia-mediated neuroinflammation is associated with epilepsy. Switching microglial polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype represents a novel therapeutic s...

    Authors: Lin Liu, Yingtong Xu, Hongmei Dai, Shan Tan, Xiao Mao and Zhiheng Chen

    Citation: Cell & Bioscience 2020 10:42

    Content type: Research

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  14. Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an ongoing global health emergency. Here we highlight nine most important research questions concer...

    Authors: Kit-San Yuen, Zi -Wei Ye, Sin-Yee Fung, Chi-Ping Chan and Dong-Yan Jin

    Citation: Cell & Bioscience 2020 10:40

    Content type: Research Highlight

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  15. Fanconi anemia (FA) is a recessive genetic disorder caused by biallelic mutations in at least one of 22 FA genes. Beyond its pathological presentation of bone marrow failure and congenital abnormalities, FA is...

    Authors: Wenjun Liu, Anna Palovcak, Fang Li, Alyan Zafar, Fenghua Yuan and Yanbin Zhang

    Citation: Cell & Bioscience 2020 10:39

    Content type: Review

    Published on:

  18. Kawasaki disease (KD) is one of the major causes of heart disease and vasculitis in children under 5 years old in the world. Clinical evidence has shown that coronary artery calcification may develop in KD pat...

    Authors: Shun-Fu Chang, Shih-Feng Liu, Cheng-Nan Chen and Ho-Chang Kuo

    Citation: Cell & Bioscience 2020 10:36

    Content type: Research

    Published on:

  19. Poly(ADP-ribose) polymerase (PARP) inhibitors represent one of the successful novel approaches to targeted cancer treatment. Indeed, the US Food and Drug Administration (FDA) has recently approved PARP inhibit...

    Authors: Mausam Patel, Somaira Nowsheen, Sanjay Maraboyina and Fen Xia

    Citation: Cell & Bioscience 2020 10:35

    Content type: Review

    Published on:

  20. The discovery of novel biomarkers of stroke etiology would be most helpful in management of acute ischemic stroke patients. Recently, circular RNAs (circRNAs) have been proposed as candidate biomarkers of neur...

    Authors: Aiora Ostolaza, Idoia Blanco-Luquin, Amaya Urdánoz-Casado, Idoya Rubio, Alberto Labarga, Beatriz Zandio, Miren Roldán, Judith Martínez-Cascales, Sergio Mayor, María Herrera, Nuria Aymerich, Jaime Gallego, Roberto Muñoz and Maite Mendioroz

    Citation: Cell & Bioscience 2020 10:34

    Content type: Research

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  22. Ovarian cancer is known as a serious malignancy that affects women’s reproductive tract and can considerably threat their health. A wide range of molecular mechanisms and genetic modifications have been involv...

    Authors: Asma Vafadar, Zahra Shabaninejad, Ahmad Movahedpour, Farzaneh Fallahi, Mona Taghavipour, Younes Ghasemi, Maryam Akbari, Alimohammad Shafiee, Sarah Hajighadimi, Sanaz Moradizarmehri, Ebrahim Razi, Amir Savardashtaki and Hamed Mirzaei

    Citation: Cell & Bioscience 2020 10:32

    Content type: Review

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  25. Common fragile sites (CFSs) are large chromosomal regions that exhibit breakage on metaphase chromosomes upon replication stress. They become preferentially unstable at the early stage of cancer development an...

    Authors: Shibo Li and Xiaohua Wu

    Citation: Cell & Bioscience 2020 10:29

    Content type: Review

    Published on:

  26. The increasing prevalence of depression and diabetes mellitus has become a major public health problem worldwide. Studies have shown that people with diabetes are at a high risk of being diagnosed with depress...

    Authors: Danwen Wang, Hui Wang, Haixia Gao, Heng Zhang, Hua Zhang, Qiuling Wang and Zhiling Sun

    Citation: Cell & Bioscience 2020 10:28

    Content type: Review

    Published on:

  27. Glutamate (Glu) is the predominant excitatory neurotransmitter in the central nervous system (CNS). Glutamatergic transmission is critical for controlling neuronal activity. In presynaptic neurons, Glu is stor...

    Authors: Xianchao Du, Jiashuo Li, Minghui Li, Xinxin Yang, Zhipeng Qi, Bin Xu, Wei Liu, Zhaofa Xu and Yu Deng

    Citation: Cell & Bioscience 2020 10:26

    Content type: Review

    Published on:

  28. Persistent infection with hepatitis B virus (HBV) accounts for the majority of hepatocellular carcinoma (HCC), but the molecular mechanisms underlying liver carcinogenesis are still not completely understood. ...

    Authors: Xiaoming Dai, Ruixue Huang, Sai Hu, Yao Zhou, Xiaoya Sun, Pucheng Gui, Zijian Yu and Pingkun Zhou

    Citation: Cell & Bioscience 2020 10:24

    Content type: Research

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  29. Mesenchymal stem cells (MSCs) have been extensively studied and implicated for the cell-based therapy in several diseases due to theirs immunomodulatory properties. Embryonic stem cells and induced-pluripotent...

    Authors: Shyam Kishor Sah, Gaurav Agrahari and Tae-Yoon Kim

    Citation: Cell & Bioscience 2020 10:22

    Content type: Review

    Published on:

  30. Cardiovascular diseases are currently the leading cause of death in humans. The high mortality of cardiac diseases is associated with myocardial ischemia and reperfusion (I/R). Recent studies have reported tha...

    Authors: Bifeng Yao, Xiaoya Wan, Xinbin Zheng, Ting Zhong, Jia Hu, Yu Zhou, Anna Qin, Yeshuo Ma and Deling Yin

    Citation: Cell & Bioscience 2020 10:20

    Content type: Research

    Published on:

  32. KIT mutations are the predominant driver mutations in gastrointestinal stromal tumors (GISTs), and targeted therapy against KIT has improved treatment outcome dramatically. However, gaining secondary mutation ...

    Authors: Guangrong Zhu, Jun Shi, Shaoting Zhang, Yue Guo, Ling Huang, Hui Zhao, Yideng Jiang and Jianmin Sun

    Citation: Cell & Bioscience 2020 10:16

    Content type: Research

    Published on:

  33. γδ T cells are an important subset of T lymphocytes that play important roles in innate and adaptive immunity via the secretion of various cytokines. Previous studies have found that long noncoding RNAs (lncRN...

    Authors: Chuan Yang, Ting Feng, Fang Lin, Tinxiang Gong, Shuo Yang, Yuhong Tao and Hong Li

    Citation: Cell & Bioscience 2020 10:15

    Content type: Research

    Published on:

  35. MicroRNAs or miRNAs are a component of the non-coding RNAs family which is engaged in many cellular functions such as cell proliferation, apoptosis, gene expression, signaling pathways, angiogenesis, and etc. ...

    Authors: Mona Taghavipour, Fatemeh Sadoughi, Hamed Mirzaei, Bahman Yousefi, Bahram Moazzami, Shahla Chaichian, Mohammad Ali Mansournia and Zatollah Asemi

    Citation: Cell & Bioscience 2020 10:12

    Content type: Review

    Published on:

  36. Mesenchymal stem cells (MSCs) are considered the most promising seed cells for regenerative medicine because of their considerable therapeutic properties and accessibility. Fine-tuning of cell biological proce...

    Authors: Jianhan Ren, Delan Huang, Runze Li, Weicai Wang and Chen Zhou

    Citation: Cell & Bioscience 2020 10:11

    Content type: Review

    Published on:

  37. DNA mismatch repair (MMR) maintains replication fidelity by correcting mispaired nucleotides incorporated by DNA polymerases. Defects in MMR lead to cancers characterized by microsatellite instability. Recentl...

    Authors: Yaping Huang and Guo-Min Li

    Citation: Cell & Bioscience 2020 10:10

    Content type: Review

    Published on:

  38. Histone marks control many cellular processes including DNA damage repair. This review will focus primarily on the active histone mark H3K36me3 in the regulation of DNA damage repair and the maintenance of gen...

    Authors: Zhongxing Sun, Yanjun Zhang, Junqi Jia, Yuan Fang, Yin Tang, Hongfei Wu and Dong Fang

    Citation: Cell & Bioscience 2020 10:9

    Content type: Review

    Published on:

  40. Poly(ADP-ribosyl)ation (PARylation) mediated by poly ADP-ribose polymerases (PARPs) plays a key role in DNA damage repair. Suppression of PARylation by PARP inhibitors impairs DNA damage repair and induces apo...

    Authors: Muzaffer Ahmad Kassab, Lily L. Yu and Xiaochun Yu

    Citation: Cell & Bioscience 2020 10:7

    Content type: Review

    Published on:

  42. Vascular calcification is the major reason for high mortality of cardiovascular complications for diabetes. Interleukin (IL)-1β has been implicated in this pathogenesis, but its precise role and clinical evide...

    Authors: Te-Chuan Chen, Chia-Kung Yen, Ying-Chen Lu, Chung-Sheng Shi, Rong-Ze Hsieh, Shun-Fu Chang and Cheng-Nan Chen

    Citation: Cell & Bioscience 2020 10:5

    Content type: Research

    Published on:

  43. Plenty of long non-coding RNAs (lncRNAs) play vital roles in the progression of atherosclerosis. Small nucleolar RNA host gene 6 (SNHG6) is a well known lncRNA that is aberrantly high expressed in atherosclero...

    Authors: Haiyan Shan, Dawei Guo, Siyang Zhang, Huimeng Qi, Shen Liu, Yanmei Du, Yini He, Bofu Wang, Ming Xu and Xiaosong Yu

    Citation: Cell & Bioscience 2020 10:4

    Content type: Research

    Published on:

  44. When a protein is covalently and irreversibly bound to DNA (i.e., a DNA–protein cross-link [DPC]), it may obstruct any DNA-based transaction, such as transcription and replication. DPC formation is very common...

    Authors: Huimin Zhang, Yun Xiong and Junjie Chen

    Citation: Cell & Bioscience 2020 10:3

    Content type: Review

    Published on:

  45. A two-stage method of obtaining viable human amniotic stem cells (hAMSCs) in large-scale is described. First, human amniotic stem cells are isolated via dual enzyme (collagenase II and DNAase I) digestion. Nex...

    Authors: Bi Foua Claude Alain Gohi, Xue-Ying Liu, Hong-Yan Zeng, Sheng Xu, Kouassi Marius Honore Ake, Xiao-Ju Cao, Kai-Min Zou and Sheila Namulondo

    Citation: Cell & Bioscience 2020 10:2

    Content type: Research

    Published on:

  46. miRNAs, the smallest nucleotide molecules able to regulate gene expression at post transcriptional level, are found in both animals and plants being involved in fundamental processes for growth and development...

    Authors: Bernardetta Ledda, Laura Ottaggio, Alberto Izzotti, Samir G. Sukkar and Mariangela Miele

    Citation: Cell & Bioscience 2020 10:1

    Content type: Review

    Published on:

  47. Breast cancer is a most common type of cancer in women. Circular RNAs (circRNAs) are involved in cancer development and progression, but their roles and regulatory mechanisms are unclear in breast cancer. Our ...

    Authors: Zhongli Geng, Wei Wang, Hui Chen, Jianya Mao, Zhenguo Li and Jing Zhou

    Citation: Cell & Bioscience 2019 9:104

    Content type: Research

    Published on:

  48. The failure of remodeling process that constantly regenerates effete, aged bone is highly associated with bone nonunion and degenerative bone diseases. Numerous studies have demonstrated that aspirin and other...

    Authors: Yong Xie, Meng Pan, Yanpan Gao, Licheng Zhang, Wei Ge and Peifu Tang

    Citation: Cell & Bioscience 2019 9:103

    Content type: Review

    Published on:

  49. Lung cancer is one of very important malignancies which are related to high mobility and mortality in the world. Despite several efforts for improving diagnosis and treatment strategies of lung cancer, finding...

    Authors: Hadis Fathizadeh and Zatollah Asemi

    Citation: Cell & Bioscience 2019 9:102

    Content type: Review

    Published on:

  50. Drosophila Prominin-like is a homolog of mammalian CD133, which is recognized as a biomarker for stem cells. The interacting proteins of CD133 and their biological functions remain elusive.

    Authors: Xuexiang Wang, Huimei Zheng, Zexiao Jia, Zhaoying Lei, Mengyao Li, Qianqian Zhuang, Hui Zhou, Yue Qiu, Yong Fu, Xiaohang Yang, Yongmei Xi and Qingfeng Yan

    Citation: Cell & Bioscience 2019 9:101

    Content type: Research

    Published on:

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