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  1. Cells show directed migration response to electric signals, namely electrotaxis or galvanotaxis. PI3K and PTEN jointly play counterbalancing roles in this event via a bilateral regulation of PIP3 signaling. PI...

    Authors: Bing Song, Yu Gu, Wenkai Jiang, Ying Li, Wayne Nishio Ayre, Zhipeng Liu, Tao Yin, Christopher Janetopoulos, Miho Iijima, Peter Devreotes and Min Zhao

    Citation: Cell & Bioscience 2021 11:111

    Content type: Research

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  2. Mesenchymal stem cells (MSCs) play a central role in the intercellular signaling within the tumor microenvironment (TME), exchanging signals with cancer cells and tumor stromal cells, such as cancer-associated...

    Authors: Noemi Eiro, Maria Fraile, Silvia Fernández-Francos, Rosario Sánchez, Luis A. Costa and Francisco J. Vizoso

    Citation: Cell & Bioscience 2021 11:109

    Content type: Review

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  3. Microbubbles are nanosized gas-filled bubbles. They are used in clinical diagnostics, in medical imaging, as contrast agents in ultrasound imaging, and as transporters for targeted drug delivery. They can also...

    Authors: Asma Akbar, Nagavalli Pillalamarri, Sriya Jonnakuti and Mujib Ullah

    Citation: Cell & Bioscience 2021 11:108

    Content type: Viewpoint

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  4. Autophagy is required for oogenesis and plays a critical role in response to aging caused by oxidative stress. However, there have been no reports on regulation of cytoprotective autophagy in female germline s...

    Authors: Xiaoyan Yuan, Geng. G. Tian, Xiuying Pei, Xiaopeng Hu and Ji Wu

    Citation: Cell & Bioscience 2021 11:107

    Content type: Research

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  5. Coronavirus (CoV) nonstructural protein 14 (nsp14) has exoribonuclease (ExoN) activity, responsible for proofreading and contributing to replication fidelity. It has been reported that CoVs exhibit variable se...

    Authors: Xiaoyu Niu, Fanzhi Kong, Yixuan J. Hou and Qiuhong Wang

    Citation: Cell & Bioscience 2021 11:106

    Content type: Research

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  6. The neuromuscular junction (NMJ) is a peripheral synapse critical to muscle contraction. Like acetylcholine receptors (AChRs), many essential proteins of NMJ are extremely concentrated at the postjunctional me...

    Authors: Hongyang Jing, Peng Chen, Tiankun Hui, Zheng Yu, Jin Zhou, Erkang Fei, Shunqi Wang, Dongyan Ren, Xinsheng Lai and Baoming Li

    Citation: Cell & Bioscience 2021 11:105

    Content type: Research

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  7. The advent of the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 technology marked the beginning of a new era in the field of molecular biology, allowing the efficient and precise crea...

    Authors: Marina Zoppo, Nicole Okoniewski, Stanislav Pantelyushin, Johannes vom Berg and Kristin Schirmer

    Citation: Cell & Bioscience 2021 11:103

    Content type: Methodology

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  8. Preferentially expressed antigen in melanoma (PRAME) is a cancer/testis antigen (CTA) that is predominantly expressed in normal gametogenic tissues and a variety of tumors. Members of the PRAME gene family encode...

    Authors: Wan-Sheng Liu, Chen Lu and Bhavesh V. Mistry

    Citation: Cell & Bioscience 2021 11:102

    Content type: Research

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  9. Crotonylation of proteins is a newly found type of post-translational modifications (PTMs) which occurs leadingly on the lysine residue, namely, lysine crotonylation (Kcr). Kcr is conserved and is regulated by...

    Authors: Jia-Yi Hou, Lan Zhou, Jia-Lei Li, De-Ping Wang and Ji-Min Cao

    Citation: Cell & Bioscience 2021 11:101

    Content type: Review

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  10. The ongoing global pandemic of coronavirus disease 2019 (COVID-19) has resulted in the infection of over 128 million people and has caused over 2.8 million deaths as of April 2021 in more than 220 countries an...

    Authors: Brian Hetrick, Dongyang Yu, Adeyemi A. Olanrewaju, Linda D. Chilin, Sijia He, Deemah Dabbagh, Ghaliah Alluhaibi, Yuan-Chun Ma, Lewis A. Hofmann, Ramin M. Hakami and Yuntao Wu

    Citation: Cell & Bioscience 2021 11:100

    Content type: Research

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  11. Endometriosis is a refractory and recurrent disease and it affects nearly 10% of reproductive-aged women and 40% of infertile patients. The commonly accepted theory for endometriosis is retrograde menstruation...

    Authors: Gen Zou, Jianzhang Wang, Xinxin Xu, Ping Xu, Libo Zhu, Qin Yu, Yangying Peng, Xinyue Guo, Tiantian Li and Xinmei Zhang

    Citation: Cell & Bioscience 2021 11:98

    Content type: Research

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  12. The mechanisms leading to retinal ganglion cell (RGC) death after optic nerve injury have not been fully elucidated. Current evidence indicates that microglial activation and M1- and M2-like dynamics may be an...

    Authors: Liu Yun-Jia, Chen Xi, Zhang Jie-Qiong, Zhu Jing-Yi, Lin Sen and Ye Jian

    Citation: Cell & Bioscience 2021 11:97

    Content type: Research

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  13. Poxviruses comprise many members that infect both vertebrate and invertebrate animals, including humans. Despite the eradication of the historically notorious smallpox, poxviruses remain significant public hea...

    Authors: Zhilong Yang, Mark Gray and Lake Winter

    Citation: Cell & Bioscience 2021 11:96

    Content type: Review

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  14. Despite their important functions and nearly ubiquitous presence in cells, an understanding of the biology of intracellular lipid droplets (LDs) in goose follicle development remains limited. An integrated stu...

    Authors: Xin Yuan, Shenqiang Hu, Liang Li, Chunchun Han, Hehe Liu, Hua He, Lu Xia, Jiwei Hu, Bo Hu, Mingxia Ran, Yali Liu and Jiwen Wang

    Citation: Cell & Bioscience 2021 11:95

    Content type: Research

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  15. The ketogenic diet (KD)has been considered an effective treatment for epilepsy, whereas its underlying mechanisms remain obscure. We have previously reported that the KD feeding increased Neuregulin 1 (NRG1) e...

    Authors: Jin Wang, Jie Huang, Shan Yao, Jia-Hui Wu, Hui-Bin Li, Feng Gao, Ying Wang, Guo-Bin Huang, Qiang-Long You, Jianhua Li, Xiaohui Chen and Xiang-Dong Sun

    Citation: Cell & Bioscience 2021 11:93

    Content type: Research

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  16. Cigarette smoke (CS) exposure increases corticosteroid insensitive asthma related to increased Th17 phenotype, and new treatment strategies are needed for CS-associated asthma. Histone deacetylase 2 (HDAC2), f...

    Authors: Hongtao Li, Qimei Ye, Yusen Lin, Xuena Yang, Xiaoling Zou, Hailing Yang, Wenbin Wu, Ping Meng and Tiantuo Zhang

    Citation: Cell & Bioscience 2021 11:92

    Content type: Research

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  17. The shift of oral microbiota is a critical factor of radiation caries in head and neck cancer patients after the radiotherapy. However, the direct effects of irradiation on the genome and virulence of cariogen...

    Authors: Zheng Wang, Yujie Zhou, Qi Han, Xingchen Ye, Yanyan Chen, Yan Sun, Yaqi Liu, Jing Zou, Guohai Qi, Xuedong Zhou, Lei Cheng and Biao Ren

    Citation: Cell & Bioscience 2021 11:91

    Content type: Research

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  18. Iron deficiency (ID) is common in patients with heart failure (HF) and is associated with poor outcomes, yet its role in the pathophysiology of HF is not well-defined. We sought to determine the consequences o...

    Authors: M. Tajes, C. Díez-López, C. Enjuanes, P. Moliner, J. L. Ferreiro, A. Garay, S. Jiménez-Marrero, S. Yun, S. G. Sosa, L. Alcoberro, J. González-Costello, E. García-Romero, L. Yañez-Bisbe, B. Benito and J. Comín-Colet

    Citation: Cell & Bioscience 2021 11:89

    Content type: Research

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  19. Bone marrow mesenchymal stem cells (BMSCs) refer to a heterogeneous population of cells with the capacity for self-renewal. BMSCs have multi-directional differentiation potential and can differentiate into cho...

    Authors: Yuanxiu Sun, Yu Yuan, Wei Wu, Le Lei and Lingli Zhang

    Citation: Cell & Bioscience 2021 11:88

    Content type: Review

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  20. Mesenchymal stem cells (MSCs) play a crucial role in cancer development and tumor resistance to therapy in prostate cancer, but the influence of MSCs on the stemness potential of PCa cells by cell–cell contact...

    Authors: Ji-wen Cheng, Li-xia Duan, Yang Yu, Pu Wang, Jia-le Feng, Guan-zheng Feng and Yan Liu

    Citation: Cell & Bioscience 2021 11:87

    Content type: Research

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  21. Pancreatic tumors are classified into endocrine and exocrine types, and the clinical manifestations in patients are nonspecific. Most patients, especially those with pancreatic ductal adenocarcinoma (PDAC), ha...

    Authors: Qun Chen, Wu-Jun Wang, Yun-Xuan Jia, Hao Yuan, Peng-Fei Wu, Wan-Li Ge, Ling-Dong Meng, Xu-Min Huang, Peng Shen, Tao-Yue Yang, Yi Miao, Jing-Jing Zhang and Kui-Rong Jiang

    Citation: Cell & Bioscience 2021 11:86

    Content type: Review

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  22. Asthma is a heterogeneous chronic inflammatory disease of the airway, involving reversible airflow limitation and airway remodeling. T helper 17 (Th17) cells play an important role in the pathogenesis of aller...

    Authors: Jing Zhou, Ning Zhang, Wei Zhang, Caiju Lu and Fei Xu

    Citation: Cell & Bioscience 2021 11:84

    Content type: Research

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  23. The Slit diaphragm (SD) is the key filtration structure in human glomerular kidney that is affected in many types of renal diseases. SD proteins are known to undergo endocytosis and recycling to maintain the i...

    Authors: Luyao Wang, Pei Wen, Joyce van de Leemput, Zhanzheng Zhao and Zhe Han

    Citation: Cell & Bioscience 2021 11:83

    Content type: Research

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  24. Neovascularization is a leading cause of visual loss typically associated with diabetic retinopathy (DR) and retinopathy of prematurity (ROP). Interleukin-17A (IL-17A) and endoplasmic reticulum (ER) stress bot...

    Authors: Ya’nuo Wang, Shuang Gao, Sha Gao, Na Li, Bing Xie and Xi Shen

    Citation: Cell & Bioscience 2021 11:82

    Content type: Research

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  25. Peritoneal fibrosis is one of the major complications induced by peritoneal dialysis (PD). Damaged integrity and function of peritoneum caused by peritoneal fibrosis not only limits the curative efficacy of PD...

    Authors: Yanhong Guo, Liuwei Wang, Rong Gou, Yulin Wang, Xiujie Shi, Yage Zhang, Xinxin Pang and Lin Tang

    Citation: Cell & Bioscience 2021 11:79

    Content type: Research

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  26. Alzheimer’s disease (AD) is the most common cause of dementia and is characterized by the deposition of extracellular aggregates of amyloid-β (Aβ), the formation of intraneuronal tau neurofibrillary tangles an...

    Authors: Yinyin Tan, Yanqun Zheng, Daiwen Xu, Zhanfang Sun, Huan Yang and Qingqing Yin

    Citation: Cell & Bioscience 2021 11:78

    Content type: Review

    Published on:

  27. Hepatitis B virus (HBV) infection remains a major health issue worldwide and the leading cause of cirrhosis and hepatocellular carcinoma (HCC). It has been reported previously that HBV invasion can extensively...

    Authors: Sen Yuan, Yousaf Tanzeel, Xuezhang Tian, Dandan Zheng, Naz Wajeeha, Jiaqi Xu, Yujia Ke, Zuopeng Zhang, Xiaojun Peng, Long Lu, Guihong Sun, Deyin Guo and Min Wang

    Citation: Cell & Bioscience 2021 11:75

    Content type: Research

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  28. As one of the most common malignancy, lung adenocarcinoma (LUAD) is characterized by low 5-year survival rate. This research aimed to investigate the effects of ribonucleotide reductase regulatory subunit M2 (...

    Authors: Xueping Jiang, Yangyi Li, Nannan Zhang, Yanping Gao, Linzhi Han, Shuying Li, Jiali Li, Xingyu Liu, Yan Gong and Conghua Xie

    Citation: Cell & Bioscience 2021 11:74

    Content type: Research

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  29. Dysregulation of KLF7 participates in the development of various cancers, but it is unclear whether there is a link between HCC and aberrant expression of KLF7. The aim of this study was to investigate the rol...

    Authors: Yarong Guo, Bao Chai, Junmei Jia, Mudan Yang, Yanjun Li, Rui Zhang, Shunmin Wang and Jun Xu

    Citation: Cell & Bioscience 2021 11:73

    Content type: Research

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  30. As the predominant modification in RNA, N6-methyladenosine (m6A) has attracted increasing attention in the past few years since it plays vital roles in many biological processes. This chemical modification is dyn...

    Authors: Zhihao Fang, Yiqiu Hu, Jinhui Hu, Yanqin Huang, Shu Zheng and Cheng Guo

    Citation: Cell & Bioscience 2021 11:72

    Content type: Review

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  31. Tissue regeneration is of fast growing importance in the development of biomedicine, particularly organ replacement therapies. Unfortunately, many human organs cannot regenerate. Anuran Xenopus laevis has been us...

    Authors: Shouhong Wang and Yun-Bo Shi

    Citation: Cell & Bioscience 2021 11:71

    Content type: Letter to the Editor

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    The Correction to this article has been published in Cell & Bioscience 2021 11:104

  32. Epithelial to mesenchymal transition (EMT) contributes to tumor metastasis and chemoresistance. Eukaryotic initiation factor 5A2 (EIF5A2) is highly expressed in a variety of human cancers but rarely expressed ...

    Authors: Guannan Zhao, Wenjing Zhang, Peixin Dong, Hidemichi Watari, Yuqi Guo, Lawrence M. Pfeffer, Gabor Tigyi and Junming Yue

    Citation: Cell & Bioscience 2021 11:70

    Content type: Research

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  33. Managing the limits of temperature adaptation is relevant both in medicine and in biotechnology. There are numerous scattered publications on the identification of the temperature limits of existence for vario...

    Authors: K. B. Aslanidi and D. P. Kharakoz

    Citation: Cell & Bioscience 2021 11:69

    Content type: Research

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  34. Breast cancer (BC) remains a public-health issue on a global scale. Long non-coding RNAs (lncRNAs) play functional roles in BC. This study focuses on effects of NEAT1 on BC cell invasion, migration and chemoth...

    Authors: DaoPing Zhou, Juan Gu, YuePing Wang, HuaiGuo Wu, Wei Cheng, QingPing Wang, GuoPei Zheng and XueDong Wang

    Citation: Cell & Bioscience 2021 11:68

    Content type: Research

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  35. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Haoyu Wang, Jing Yuan, Xiaoqian Dang, Zhibin Shi, Wenrui Ban and Dong Ma

    Citation: Cell & Bioscience 2021 11:67

    Content type: Correction

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    The original article was published in Cell & Bioscience 2021 11:52

  36. Alternative splicing (AS) regulates gene expression patterns at the post-transcriptional level and generates a striking expansion of coding capacities of genomes and cellular protein diversity. RNA splicing co...

    Authors: Yunqi Chao, Yonghui Jiang, Mianling Zhong, Kaiyan Wei, Chenxi Hu, Yifang Qin, Yiming Zuo, Lili Yang, Zheng Shen and Chaochun Zou

    Citation: Cell & Bioscience 2021 11:66

    Content type: Review

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  37. Posttranscriptional gene regulation includes mRNA transport, localization, translation, and regulation of mRNA stability. CPEB (cytoplasmic polyadenylation element binding) family proteins bind to specific sites ...

    Authors: Eugene Kozlov, Yulii V. Shidlovskii, Rudolf Gilmutdinov, Paul Schedl and Mariya Zhukova

    Citation: Cell & Bioscience 2021 11:64

    Content type: Review

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  38. Temozolomide (TMZ)-resistance hampers the therapeutic efficacy of this drug for glioblastoma (GBM) treatment in clinic, and emerging evidences suggested that exosomes from GBM-derived stem cells (GSCs) contrib...

    Authors: Yong Zheng, Liang Liu, Yan Wang, Shan Xiao, Rongkang Mai, Zifeng Zhu and Yiyao Cao

    Citation: Cell & Bioscience 2021 11:63

    Content type: Research

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  39. Astrocytes participate in innate inflammatory responses within the mammalian central nervous system (CNS). HECT domain E3 ubiquitin protein ligase 1 (HECTD1) functions during microglial activation, suggesting ...

    Authors: Ying Tang, Mengchun Zhou, Rongrong Huang, Ling Shen, Li Yang, Zhongqiu Zhou, Hui Ren and Ying Bai

    Citation: Cell & Bioscience 2021 11:62

    Content type: Research

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