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  1. Research

    Genome editing of the HIV co-receptors CCR5 and CXCR4 by CRISPR-Cas9 protects CD4+ T cells from HIV-1 infection

    The main approach to treat HIV-1 infection is combination antiretroviral therapy (cART). Although cART is effective in reducing HIV-1 viral load and controlling disease progression, it has many side effects, a...

    Zhepeng Liu, Shuliang Chen, Xu Jin, Qiankun Wang, Kongxiang Yang, Chenlin Li, Qiaoqiao Xiao, Panpan Hou, Shuai Liu, Shaoshuai Wu, Wei Hou, Yong Xiong, Chunyan Kong, Xixian Zhao, Li Wu, Chunmei Li…

    Cell & Bioscience 2017 7:47

    Published on: 9 September 2017

  2. Research

    Enhancing antitumor immunogenicity of HPV16-E7 DNA vaccine by fusing DNA encoding E7-antigenic peptide to DNA encoding capsid protein L1 of Bovine papillomavirus

    Human papillomavirus (HPV) has been identified as the primary etiologic factor of cervical cancer, the fourth leading cause of cancer death in females worldwide. We have previously shown that coadministration ...

    Andrew Yang, Shiwen Peng, Emily Farmer, Qi Zeng, Max A. Cheng, Xiaowu Pang, T. -C. Wu and Chien-Fu Hung

    Cell & Bioscience 2017 7:46

    Published on: 23 August 2017

  3. Research

    Investigation of host–pathogen interaction between Burkholderia pseudomallei and autophagy-related protein LC3 using hydrophobic chromatography-based technique

    Burkholderia pseudomallei is an intracellular bacteria causing Melioidosis, the disease widely disseminates in Southeast Asia and Northern Australia. B. pseudomallei has ability to inv...

    Pattamaporn Joompa, Saranyoo Ponnikorn, Sittiruk Roytrakul and Sumalee Tungpradabkul

    Cell & Bioscience 2017 7:45

    Published on: 23 August 2017

  4. Research

    Stromal Senp1 promotes mouse early folliculogenesis by regulating BMP4 expression

    Mammalian folliculogenesis, maturation of the ovarian follicles, require both growth factors derived from oocyte and surrounding cells, including stromal cells. However, the mechanism by which stromal cells an...

    Shu Tan, Boya Feng, Mingzhu Yin, Huanjiao Jenny Zhou, Ge Lou, Weidong Ji, Yonghao Li and Wang Min

    Cell & Bioscience 2017 7:36

    Published on: 25 July 2017

  5. Review

    The roles of microRNA families in hepatic fibrosis

    When hepatocytes are damaged severely, a variety of signaling pathways will be triggered by inflammatory factors and cytokines involving in the process of hepatic fibrosis. The microRNA (miRNA) family consists...

    Xue-Ping Jiang, Wen-Bing Ai, Lin-Yan Wan, Yan-Qiong Zhang and Jiang-Feng Wu

    Cell & Bioscience 2017 7:34

    Published on: 4 July 2017

  6. Research

    Kv1.3 channel blocker (ImKTx88) maintains blood–brain barrier in experimental autoimmune encephalomyelitis

    Disruption of blood–brain barrier (BBB) and subsequent infiltration of auto-reactive T lymphocytes are major characteristics of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). Kv1....

    Jie Huang, Song Han, Qi Sun, Yipeng Zhao, Junchen Liu, Xiaolu Yuan, Wenqian Mao, Biwen Peng, Wanhong Liu, Jun Yin and Xiaohua He

    Cell & Bioscience 2017 7:31

    Published on: 7 June 2017

  7. Review

    APOBEC3B, a molecular driver of mutagenesis in human cancers

    Human cancers results in large part from the accumulation of multiple mutations. The progression of premalignant cells is an evolutionary process in which mutations provide the fundamental driving force for ge...

    Jun Zou, Chen Wang, Xiangyi Ma, Edward Wang and Guang Peng

    Cell & Bioscience 2017 7:29

    Published on: 30 May 2017

  8. Research highlight

    iPSCs are safe!

    Induced pluripotent stem cells (iPSCs) hold great promises in cell therapy. However, the potential safety issues have dampened the enthusiasm of their clinical development. One of the biggest concerns came fro...

    Hualong Yan, Yun-Bo Shi and Jing Huang

    Cell & Bioscience 2017 7:30

    Published on: 30 May 2017

  9. Research

    Epigenetic regulation of Runx2 transcription and osteoblast differentiation by nicotinamide phosphoribosyltransferase

    Bone degenerative disorders like osteoporosis may be initiated by age-related shifts in anabolic and catabolic responses that control bone homeostasis. Although there are studies suggesting that metabolic chan...

    Min Ling, Peixin Huang, Shamima Islam, Daniel P. Heruth, Xuanan Li, Li Qin Zhang, Ding-You Li, Zhaohui Hu and Shui Qing Ye

    Cell & Bioscience 2017 7:27

    Published on: 23 May 2017

  10. Research

    Histone demethylases UTX and JMJD3 are required for NKT cell development in mice

    Natural killer (NK)T cells and conventional T cells share phenotypic characteristic however they differ in transcription factor requirements and functional properties. The role of histone modifying enzymes in ...

    Daniel Northrup, Ryoji Yagi, Kairong Cui, William R. Proctor, Chaochen Wang, Katarzyna Placek, Lance R. Pohl, Rongfu Wang, Kai Ge, Jinfang Zhu and Keji Zhao

    Cell & Bioscience 2017 7:25

    Published on: 17 May 2017

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