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  1. Autophagy is a prominent mechanism to preserve homeostasis and the response to intracellular or extracellular stress. Autophagic degradation can be selectively targeted to dysfunctional subcellular compartment...

    Authors: Qi Wu, Xin Yu, Le Liu, Shengrong Sun and Si Sun

    Citation: Cell & Bioscience 2021 11:49

    Content type: Review

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  3. Skeletal development and maintenance are complex processes known to be coordinated by multiple genetic and epigenetic signaling pathways. However, the role of long non-coding RNAs (lncRNAs), a class of crucial...

    Authors: Ting-ting Yu, Qiu-fan Xu, Si-Yang Li, Hui-jie Huang, Sarah Dugan, Lei Shao, Jennifer A. Roggenbuck, Xiao-tong Liu, Huai-ze Liu, Betsy A. Hirsch, Shen Yue, Chen Liu and Steven Y. Cheng

    Citation: Cell & Bioscience 2021 11:47

    Content type: Research

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  4. Hedgehog signaling is essential to the regulation of embryonic development, tissue homeostasis, and stem cell self-renewal, making it a prime target for developing cancer therapeutics. Given the close link bet...

    Authors: Junwan Fan, Haowen Li, Lun Kuang, Zichen Zhao, Wenyan He, Chen Liu, Yongjun Wang, Steven Y. Cheng and Wei Chen

    Citation: Cell & Bioscience 2021 11:46

    Content type: Research

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  6. Emerging evidence demonstrated dapagliflozin (DAPA), a sodium-glucose cotransporter 2 inhibitor, prevented various cardiovascular events. However, the detailed mechanisms underlying its cardioprotective proper...

    Authors: Kun-Ling Tsai, Pei-Ling Hsieh, Wan-Ching Chou, Hui-Ching Cheng, Yu-Ting Huang and Shih-Hung Chan

    Citation: Cell & Bioscience 2021 11:44

    Content type: Research

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  7. MicroRNA-derived structures play impressive roles in various biological processes. So dysregulation of miRNAs can lead to different human diseases. Recent studies have extended our comprehension of the control...

    Authors: Samaneh Heydarzadeh, Maryam Ranjbar, Farokh Karimi, Farhad Seif and Mohammad Reza Alivand

    Citation: Cell & Bioscience 2021 11:43

    Content type: Review

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  8. DNA primase subunit 1 (PRIM1) has been reported as a novel oncogene in several cancer types. However, its roles in hepatocellular carcinoma (HCC) remain unclear. This study aimed to investigate underlying mech...

    Authors: Mengqi Zhu, Mengna Wu, Saiyan Bian, Qianqian Song, Mingbing Xiao, Hua Huang, Li You, Jianping Zhang, Jie Zhang, Chun Cheng, Wenkai Ni and Wenjie Zheng

    Citation: Cell & Bioscience 2021 11:42

    Content type: Research

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  9. Treatment and rehabilitation of spinal cord injury (SCI) is a major problem in clinical medicine. Modern medicine has achieved minimal progress in improving the functions of injured nerves in patients with SCI...

    Authors: Nan An, Jiaxu Yang, Hequn Wang, Shengfeng Sun, Hao Wu, Lisha Li and Meiying Li

    Citation: Cell & Bioscience 2021 11:41

    Content type: Review

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  10. We report our discovery of an important player in the development of skin fibrosis, a hallmark of scleroderma. Scleroderma is a fibrotic disease, affecting 70,000 to 150,000 Americans. Fibrosis is a pathologic...

    Authors: Mary Yinghua Zhang, Shuyi Fang, Hongyu Gao, Xiaoli Zhang, Dongsheng Gu, Yunlong Liu, Jun Wan and Jingwu Xie

    Citation: Cell & Bioscience 2021 11:40

    Content type: Research

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  11. Papillary thyroid carcinoma (PTC) is the main pathological type of thyroid carcinoma (TC). Gender is a prominent background parameter for patients with PTC. Here, we aimed to delineate the differences in cell ...

    Authors: Miaoguan Peng, Guohong Wei, Yunjian Zhang, Hai Li, Yingrong Lai, Yan Guo, Yuxin Chen, Liehua Liu, Haipeng Xiao, Hongyu Guan and Yanbing Li

    Citation: Cell & Bioscience 2021 11:39

    Content type: Research

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  12. Emerging evidences suggests that Diosbulbin-B (DB) is effective to improve cisplatin (DDP)-sensitivity in gastric cancer (GC), but its molecular mechanisms were not fully delineated, and this study managed to ...

    Authors: Chunfeng Li, Junqiang Qiu and Yingwei Xue

    Citation: Cell & Bioscience 2021 11:38

    Content type: Research

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  13. Small extracellular vesicles (sEVs) are nanosized vesicles involved in cell-to-cell communication. sEVs have been widely studied for clinical applications such as early detection of diseases and as therapeutic...

    Authors: Jie-Min Wang, Yong-Jiang Li, Jun-Yong Wu, Jia-Xin Cai, Jing Wen, Da-Xiong Xiang, Xiong-Bin Hu and Wen-Qun Li

    Citation: Cell & Bioscience 2021 11:37

    Content type: Research

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  14. Alternative splicing (AS) is an important biological process for regulating the expression of various isoforms from a single gene and thus to promote proteome diversity. In this study, RNA-seq data from 15 pai...

    Authors: Jiyu Ding, Chunquan Li, Yinwei Cheng, Zepeng Du, Qiuyu Wang, Zhidong Tang, Chao Song, Qiaoxi Xia, Wenjing Bai, Ling Lin, Wei Liu, Liyan Xu, Enmin Li and Bingli Wu

    Citation: Cell & Bioscience 2021 11:36

    Content type: Research

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  15. Autophagy is a conserved cellular degradation process in eukaryotes that facilitates the recycling and reutilization of damaged organelles and compartments. It plays a pivotal role in cellular homeostasis, pat...

    Authors: Qingchun Lu, Po-Shun Wang and Ling Yang

    Citation: Cell & Bioscience 2021 11:35

    Content type: Review

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  17. Interleukin-15 (IL-15), a member of the ‘four α-helix bundle’ cytokine family, has been associated with many inflammatory and metabolic diseases. Abnormal expression of IL-15 has been linked to the occurrence ...

    Authors: Jiaqi Li, Yuan Li, Xuan Zhou, Lijie Wei, Jingyi Zhang, Shenglan Zhu, Huiting Zhang, Xuan Gao, Lali Mwamaka Sharifu, Shaoshuai Wang, Ling Xi and Ling Feng

    Citation: Cell & Bioscience 2021 11:33

    Content type: Research

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  18. Bidirectional integrin αIIbβ3 signaling is essential for platelet activation. The platelet adaptor protein Disabled-2 (Dab2) is a key regulator of integrin signaling and is phosphorylated at serine 24 in eukar...

    Authors: Hui-Ju Tsai, Ju-Chien Cheng, Man-Leng Kao, Hung-Pin Chiu, Yi-Hsuan Chiang, Ding-Ping Chen, Kun-Ming Rau, Hsiang-Ruei Liao and Ching-Ping Tseng

    Citation: Cell & Bioscience 2021 11:32

    Content type: Research

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  19. Heart failure (HF) is a clinical syndrome characterized by left ventricular dysfunction or elevated intracardiac pressures. Research supports that microRNAs (miRs) participate in HF by regulating  targeted gen...

    Authors: Jingtao Na, Haifeng Jin, Xin Wang, Kan Huang, Shuang Sun, Qiang Li and Wenting Zhang

    Citation: Cell & Bioscience 2021 11:31

    Content type: Research

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  20. Silica exposure underlies the development of silicosis, one of the most serious occupational hazards worldwide. We aimed to explore the interaction of the silica-induced epithelial–mesenchymal transition (EMT)...

    Authors: Zhao Ju, Jianlin Shao, Meiling Zhou, Jing Jin, Huiji Pan, Ping Ding and Ruixue Huang

    Citation: Cell & Bioscience 2021 11:30

    Content type: Research

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  21. The ketogenic diet (KD) has been recognized as a potentially effective therapy to treat neuropsychiatric diseases, including epilepsy. Previous studies have indicated that KD treatment elevates γ-Amino butyric...

    Authors: Jin Wang, Jie Huang, Yuan-Quan Li, Shan Yao, Cui-Hong Wu, Ying Wang, Feng Gao, Min-Dong Xu, Guo-Bin Huang, Chang-Qin Zhao, Jia-Hui Wu, Yun-Long Zhang, Renjie Jiao, Zi-Hao Deng, Wei Jie, Hui-Bin Li…

    Citation: Cell & Bioscience 2021 11:29

    Content type: Research

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  22. A systemic evaluation of immune cell infiltration patterns in experimental acute pancreatitis (AP) is lacking. Using multi-dimensional flow cytometry, this study profiled infiltrating immune cell types in mult...

    Authors: Baibing Yang, Joy M. Davis, Thomas H. Gomez, Mamoun Younes, Xiurong Zhao, Qiang Shen, Run Wang, Tien C. Ko and Yanna Cao

    Citation: Cell & Bioscience 2021 11:28

    Content type: Research

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  24. Colorectal cancer (CRC) is a gastrointestinal malignancy originating from either the colon or the rectum. A growing number of researches prove that the unfolded protein response (UPR) is closely related to the...

    Authors: Jingjing Huang, Huayang Pan, Jinge Wang, Tong Wang, Xiaoyan Huo, Yong Ma, Zhaoyang Lu, Bei Sun and Hongchi Jiang

    Citation: Cell & Bioscience 2021 11:26

    Content type: Review

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  25. Alveolar Rhabdomyosarcoma (ARMS) is a pediatric malignant soft tissue tumor with skeletal muscle phenotype. Little work about skeletal muscle proteins in ARMS was reported. PAX3-FOXO1 is a specific fusion gene ge...

    Authors: Qiande Hu, Liang Zhu, Yuan Li, Jianjun Zhou and Jun Xu

    Citation: Cell & Bioscience 2021 11:25

    Content type: Research

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  26. Human pluripotent stem cell-derived limbal stem cells (hPSC-derived LSCs) provide a promising cell source for corneal transplants and ocular surface reconstruction. Although recent efforts in the identificatio...

    Authors: Changbin Sun, Hailun Wang, Qiwang Ma, Chao Chen, Jianhui Yue, Bo Li and Xi Zhang

    Citation: Cell & Bioscience 2021 11:24

    Content type: Research

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  27. Cancer stem cells (CSCs) are the root of human cancer development and the major cause of treatment failure. Aberrant elevation of SOX4, a member of SOX (SRY-related HMG-box) family transcription factors, has b...

    Authors: Jingshu Liu, Jiangfeng Qiu, Zhiqi Zhang, Lei Zhou, Yunzhe Li, Dongyan Ding, Yang Zhang, Dongling Zou, Dong Wang, Qi Zhou and Tingyuan Lang

    Citation: Cell & Bioscience 2021 11:23

    Content type: Research

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  29. Previous studies demonstrated the dependence of cancer on nerve. Recently, a growing number of studies reveal that cancer cells share the property and regulatory network with neural stem/progenitor cells. Howe...

    Authors: Liyang Xu, Min Zhang, Lihua Shi, Xiaoli Yang, Lu Chen, Ning Cao, Anhua Lei and Ying Cao

    Citation: Cell & Bioscience 2021 11:21

    Content type: Research

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  30. Intestinal dysbiosis is believed to be one of the factors inducing neonatal necrotizing enterocolitis (NEC). Probiotics have been employed to treat NEC in a number of animal experiments and clinical trials, an...

    Authors: Xiuhao Zhao, Jin Zhou, Wenhua Liang, Qingfeng Sheng, Li Lu, Tong Chen, Jianglong Chen, Kezhe Tan and Zhibao Lv

    Citation: Cell & Bioscience 2021 11:20

    Content type: Research

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  31. Eukaryotic cells produce extracellular vesicles (EVs) mediating intercellular communication. These vesicles encompass many bio-molecules such as proteins, nucleic acids, and lipids that are transported between...

    Authors: Jafar Rezaie, Cynthia Aslan, Mahdi Ahmadi, Naime Majidi Zolbanin, Fatah Kashanchi and Reza Jafari

    Citation: Cell & Bioscience 2021 11:19

    Content type: Review

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  32. Haematopoiesis, the process by which a restrained population of stem cells terminally differentiates into specific types of blood cells, depends on the tightly regulated temporospatial activity of several tran...

    Authors: Alessia Oppezzo and Filippo Rosselli

    Citation: Cell & Bioscience 2021 11:18

    Content type: Review

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  33. Polyploidy is widespread in angiosperms and has a significant impact on plant evolution, diversity, and breeding program. However, the changes in the flower development regulatory mechanism in autotetraploid p...

    Authors: Janeen Braynen, Yan Yang, Jiachen Yuan, Zhengqing Xie, Gangqiang Cao, Xiaochun Wei, Gongyao Shi, Xiaowei Zhang, Fang Wei and Baoming Tian

    Citation: Cell & Bioscience 2021 11:17

    Content type: Research

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  34. Oral mesenchymal stem cells (MSCs) and their secretomes are considered important factors in the field of medical tissue engineering and cell free biotherapy due to their ease of access, differentiation potenti...

    Authors: Leila Gholami, Vajihe Taghdiri Nooshabadi, Shiva Shahabi, Marzieh Jazayeri, Rana Tarzemany, Zohreh Afsartala and Khatereh Khorsandi

    Citation: Cell & Bioscience 2021 11:16

    Content type: Review

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  35. M6A methyltransferases, acting as a writer in N6-methyladenosine, have attracted wide attention due to their dynamic regulation of life processes. In this review, we first briefly introduce the individual compon....

    Authors: Jianzhong Gu, Yu Zhan, Lvjia Zhuo, Qin Zhang, Guohua Li, Qiujie Li, Shasha Qi, Jinyu Zhu, Qun Lv, Yingying Shen, Yong Guo, Shuiping Liu, Tian Xie and Xinbing Sui

    Citation: Cell & Bioscience 2021 11:15

    Content type: Review

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  37. Mechanotransduction couples mechanical stimulation with ion flux, which is critical for normal biological processes involved in neuronal cell development, pain sensation, and red blood cell volume regulation. ...

    Authors: Xiang-Zhi Fang, Ting Zhou, Ji-Qian Xu, Ya-Xin Wang, Miao-Miao Sun, Ya-Jun He, Shang-Wen Pan, Wei Xiong, Zhe-Kang Peng, Xue-Hui Gao and You Shang

    Citation: Cell & Bioscience 2021 11:13

    Content type: Review

    Published on:

  38. Mucosal-associated invariant T (MAIT) cells are an invariant T cell subset, which have been reported to play an antimicrobial role in infectious diseases. However, little is known about it in malignant disease...

    Authors: Chunyan Shao, Chenwen Zhu, Yun Zhu, Jiqing Hao, Yongxiang Li, Huaqing Hu, Li Si, Fei Zhong, Xuefu Wang and Hua Wang

    Citation: Cell & Bioscience 2021 11:12

    Content type: Research

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  39. Numerous signaling pathways have been demonstrated experimentally to affect the pathogenesis of cerebral cavernous malformations (CCM), a disease that can be caused by CCM3 deficiency. However, the understandi...

    Authors: Kang Wang, Haixuan Chen, Zhongyang Zhou, Haifeng Zhang, Huanjiao Jenny Zhou and Wang Min

    Citation: Cell & Bioscience 2021 11:11

    Content type: Research

    Published on:

  41. Acute liver failure (ALF) is associated with a high mortality rate, and there are still no effective treatments except liver transplantation and artificial liver therapies. This study aimed to determine the ef...

    Authors: Guohua Lou, Aichun Li, Yelei Cen, Qin Yang, Tianbo Zhang, Jinjin Qi, Zhi Chen and Yanning Liu

    Citation: Cell & Bioscience 2021 11:9

    Content type: Research

    Published on:

  42. The evasion from apoptosis is a common strategy adopted by most tumors, and inhibitors of apoptosis proteins (IAPs) are among the most studied molecular and therapeutic targets. BIRC3 (cellular IAP2) and BIRC5 (s...

    Authors: Raffaele Frazzi

    Citation: Cell & Bioscience 2021 11:8

    Content type: Review

    Published on:

  43. Mesenchymal stem cells (MSCs) have been proved to drive castration resistant prostate cancer (CRPC). In this study, we aim to investigate the contribution of MSCs to the development of docetaxel resistance in ...

    Authors: Yang Yu, Fu-han Yang, Wen-tao Zhang, Ya-dong Guo, Lin Ye and Xu-dong Yao

    Citation: Cell & Bioscience 2021 11:7

    Content type: Research

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  44. Current studies have enlightened the rosy prospects of human pluripotent stem cell (hPSC)-derived mesenchymal stem/stromal cells (MSCs) in regenerative medicine. However, systematic investigation of their sign...

    Authors: Leisheng Zhang, Yimeng Wei, Ying Chi, Dengke Liu, Sijun Yang, Zhongchao Han and Zongjin Li

    Citation: Cell & Bioscience 2021 11:6

    Content type: Research

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  45. Goserelin is an effective alternative to surgery or estrogen therapy in prostate cancer palliation, and possibly to ovariectomy in premenopausal breast cancer. However, not all users of goserelin can benefit f...

    Authors: Yue Zhao, Huimin Sun, Jianzhong Zheng, Chen Shao and Dongwei Zhang

    Citation: Cell & Bioscience 2021 11:5

    Content type: Research

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  46. The fertilizing spermatozoon is a highly specialized cell that selects from millions along the female tract until the oocyte. The paternal components influence the oocyte activation during fertilization and ar...

    Authors: Mohammad Ishraq Zafar, Shi Lu and Honggang Li

    Citation: Cell & Bioscience 2021 11:4

    Content type: Review

    Published on:

  47. Hepatic stellate cells (HSCs) are activated in response to liver injury with TIF1γ-suppression, leading to liver fibrosis. Here, we examined the mechanism how reduction of TIF1γ in HSCs induces damage on hepat...

    Authors: Injoo Hwang, Eun Ju Lee, Hyomin Park, Dodam Moon and Hyo-Soo Kim

    Citation: Cell & Bioscience 2021 11:3

    Content type: Research

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  48. Interleukin-22 (IL-22), a member of the IL-10 family of cytokines, is produced by a number of immune cells involved in the immune microenvironment of the body. IL-22 plays its pivotal roles by binding to the I...

    Authors: Xiuyun Xuan, Lin Zhang, Chunxia Tian, Ting Wu, Haihua Ye, Juanmei Cao, Fangqi Chen, Yan Liang, Huilan Yang and Changzheng Huang

    Citation: Cell & Bioscience 2021 11:2

    Content type: Review

    Published on:

  49. Drug resistance is a major impediment in cancer therapy which strongly reduces the efficiency of anti-cancer drugs. Exosomes are extracellular vesicles with cup or spherical shape with a size range of 40–150 n...

    Authors: Mostafa Mostafazadeh, Nasser Samadi, Houman Kahroba, Behzad Baradaran, Sanya Haiaty and Mohammad Nouri

    Citation: Cell & Bioscience 2021 11:1

    Content type: Review

    Published on:

  50. The angiotensin-converting enzyme 2 (ACE2) is the host functional receptor for the new virus SARS-CoV-2 causing Coronavirus Disease 2019. ACE2 is expressed in 72 different cell types. Some factors that can aff...

    Authors: Miriam Marlene Medina-Enríquez, Sandra Lopez-León, José Alberto Carlos-Escalante, Zuleika Aponte-Torres, Angelica Cuapio and Talia Wegman-Ostrosky

    Citation: Cell & Bioscience 2020 10:148

    Content type: Review

    Published on:

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Cell & Bioscience

ISSN: 2045-3701

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