Skip to main content

Articles

Page 1 of 30

  1. Observational studies have reported that gut microbiota composition is associated with metabolic syndrome. However, the causal effect of gut microbiota on metabolic syndrome has yet to be confirmed.

    Authors: Jiawu Yan, Zhongyuan Wang, Guojian Bao, Cailin Xue, Wenxuan Zheng, Rao Fu, Minglu Zhang, Jialu Ding, Fei Yang and Beicheng Sun
    Citation: Cell & Bioscience 2024 14:67
  2. Human patients often experience an episode of serious seizure activity, such as status epilepticus (SE), prior to the onset of temporal lobe epilepsy (TLE), suggesting that SE can trigger the development of ep...

    Authors: Zi-Yang Liu, Yuan-Quan Li, Die-Lin Wang, Ying Wang, Wan-Ting Qiu, Yu-Yang Qiu, He-Lin Zhang, Qiang-Long You, Shi-min Liu, Qiu-Ni Liang, Er-Jian Wu, Bing-Jie Hu and Xiang-Dong Sun
    Citation: Cell & Bioscience 2024 14:66
  3. In vitro disease modeling enables translational research by providing insight into disease pathophysiology and molecular mechanisms, leading to the development of novel therapeutics. Nevertheless, in vitro sys...

    Authors: Hyebin Koh, Woojoo Kang, Ying-Ying Mao, Jisoo Park, Sangjune Kim, Seok-Ho Hong and Jong-Hee Lee
    Citation: Cell & Bioscience 2024 14:65
  4. Retinitis pigmentosa (RP) is a genetically heterogeneous group of degenerative disorders causing progressive vision loss due to photoreceptor death. RP affects other retinal cells, including the retinal pigmen...

    Authors: Bruna Lopes da Costa, Peter M. J. Quinn, Wen-Hsuan Wu, Siyuan Liu, Nicholas D. Nolan, Aykut Demirkol, Yi-Ting Tsai, Salvatore Marco Caruso, Thiago Cabral, Nan-Kai Wang and Stephen H. Tsang
    Citation: Cell & Bioscience 2024 14:64
  5. Methylmalonic acidemia (MMA) is a rare inborn error of propionate metabolism caused by deficiency of the mitochondrial methylmalonyl-CoA mutase (MUT) enzyme. As matter of fact, MMA patients manifest impairment...

    Authors: Michele Costanzo, Armando Cevenini, Laxmikanth Kollipara, Marianna Caterino, Sabrina Bianco, Francesca Pirozzi, Gianluca Scerra, Massimo D’Agostino, Luigi Michele Pavone, Albert Sickmann and Margherita Ruoppolo
    Citation: Cell & Bioscience 2024 14:63
  6. Gut microbiota and their metabolites play a regulatory role in skeletal muscle growth and development, which be known as gut-muscle axis. 3-phenylpropionic acid (3-PPA), a metabolite produced by colonic microo...

    Authors: Penglin Li, Xiaohua Feng, Zewei Ma, Yexian Yuan, Hongfeng Jiang, Guli Xu, Yunlong Zhu, Xue Yang, Yujun Wang, Canjun Zhu, Songbo Wang, Ping Gao, Qingyan Jiang and Gang Shu
    Citation: Cell & Bioscience 2024 14:62
  7. Transcriptional coactivator with PDZ-biding motif (TAZ) is widely expressed in most tissues and interacts with several transcription factors to regulate cell proliferation, differentiation, and death, thereby ...

    Authors: Jiseo Song, Hyo Kyeong Kim, Hyunsoo Cho, Suh Jin Yoon, Jihae Lim, Kyunglim Lee and Eun Sook Hwang
    Citation: Cell & Bioscience 2024 14:60
  8. Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a family of broad substrate specificity serine (Ser)/threonine (Thr) protein kinases that play a crucial role in the Ca2+-dependent signaling pathways. Its ...

    Authors: Yuxin Sun, Mengyu Hao, Hao Wu, Chengzhi Zhang, Dong Wei, Siyu Li, Zongming Song and Ye Tao
    Citation: Cell & Bioscience 2024 14:59
  9. The cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase-stimulator of interferon genes (cGAS-STING) signaling pathway, an important component of the innate immune system, is involved in...

    Authors: Cheng An, Zhen Li, Yao Chen, Shaojun Huang, Fan Yang, Ying Hu, Tao Xu, Chengxin Zhang and Shenglin Ge
    Citation: Cell & Bioscience 2024 14:58
  10. Psoriasis is an inflammatory skin disease characterized by the hyperproliferative epidermal keratinocytes and significant immune cells infiltration, leading to cytokines production such as IL-1β, TNF-α, IL-23,...

    Authors: Jinju Lee, Mi-Yeon Kim, Hyo Jeong Kim, Woo Sun Choi and Hun Sik Kim
    Citation: Cell & Bioscience 2024 14:57
  11. Acute lung injury (ALI) is strongly associated with hospitalization and mortality in patients with sepsis. Recent evidence suggests that pyroptosis mediated by NLRP3(NOD-, LRR- and pyrin domain-containing 3) i...

    Authors: Jinlian Liu, Ke Song, Bingqi Lin, Zhenfeng Chen, Yan Liu, Xianshuai Qiu, Qi He, Zirui Zuo, Xiaodan Yao, Xiaoxia Huang, Zhuanhua Liu, Zhifeng Liu, Qiaobing Huang and Xiaohua Guo
    Citation: Cell & Bioscience 2024 14:56
  12. Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease with limited disease-modifying treatments. Drug repositioning strategy has now emerged as a promising approach for anti-AD drug discover...

    Authors: Chong Xu, Yilan Mei, Ruihan Yang, Qiudan Luo, Jienian Zhang, Xiaolin Kou, Jianfeng Hu, Yujie Wang, Yue Li, Rong Chen, Zhengping Zhang, Yuyuan Yao and Jian Sima
    Citation: Cell & Bioscience 2024 14:55
  13. Extensive hepatocyte mortality and the absence of specific medical therapy significantly contribute to the unfavorable prognosis of acute liver failure (ALF). Ferroptosis is a crucial form of cell death involv...

    Authors: Zi-Ying Lei, Zhi-Hui Li, Deng-Na Lin, Jing Cao, Jun-Feng Chen, Shi-Bo Meng, Jia-Lei Wang, Jing Liu, Jing Zhang and Bing-Liang Lin
    Citation: Cell & Bioscience 2024 14:54
  14. Data on the course of viral infections revealed severe inflammation as a consequence of antiviral immune response. Despite extensive research, there are insufficient data on the role of innate immune cells in ...

    Authors: Asta Lučiūnaitė, Kristina Mašalaitė, Ieva Plikusiene, Vincentas Maciulis, Silvija Juciute, Milda Norkienė and Aurelija Žvirblienė
    Citation: Cell & Bioscience 2024 14:53
  15. Pain is a common symptom of many diseases with a high incidence rate. Clinically, drug treatment, as the main method to relieve pain at present, is often accompanied by different degrees of adverse reactions. ...

    Authors: Daling Deng, Tianhao Zhang, Lulin Ma, Wenjing Zhao, Shiqian Huang, Kaixing Wang, Shaofang Shu and Xiangdong Chen
    Citation: Cell & Bioscience 2024 14:51
  16. Ivermectin (IVM) is a commonly prescribed antiparasitic treatment with pharmacological effects on invertebrate glutamate ion channels resulting in paralysis and death of invertebrates. However, it can also act...

    Authors: Hillary A. Wadsworth, Alicia M. P. Warnecke, Joshua C. Barlow, J. Kayden Robinson, Emma Steimle, Joakim W. Ronström, Pacen E. Williams, Christopher J. Galbraith, Jared Baldridge, Michael W. Jakowec, Daryl L. Davies and Jordan T. Yorgason
    Citation: Cell & Bioscience 2024 14:50
  17. Reciprocal interactions between the tumor microenvironment (TME) and cancer cells play important roles in tumorigenesis and progression of glioma. Glioma-associated macrophages (GAMs), either of peripheral ori...

    Authors: Yue Deng, Qinyan Chen, Chao Wan, Yajie Sun, Fang Huang, Yan Hu and Kunyu Yang
    Citation: Cell & Bioscience 2024 14:49
  18. Stress is a recognized risk factor for cognitive decline, which triggers neuroinflammation involving microglial activation. However, the specific mechanism for microglial activation under stress and affects le...

    Authors: Xue Wang, Yuhan Wu, Yingrui Tian, Hui Hu, Yun Zhao, Binghua Xue, Zhaowei Sun, Aijun Wei, Fang Xie and Ling-Jia Qian
    Citation: Cell & Bioscience 2024 14:48
  19. Brain function and neuronal activity depend on a constant supply of blood from the cerebral circulation. The cerebral venous system (CVS) contains approximately 70% of the total cerebral blood volume; similar ...

    Authors: Huimin Wei, Huimin Jiang, Yifan Zhou, Lu Liu, Wei Ma, Shanshan Ni, Chen Zhou and Xunming Ji
    Citation: Cell & Bioscience 2024 14:47
  20. The anti-aging protein Klotho plays a protective role in kidney disease, but its potential as a biomarker for chronic kidney disease (CKD) is controversial. Additionally, the main pathways through which Klotho...

    Authors: Junhui Liu, Huaicheng Wang, Qinyu Liu, Shushu Long, Yanfang Wu, Nengying Wang, Wei Lin, Gang Chen, Miao Lin and Junping Wen
    Citation: Cell & Bioscience 2024 14:46
  21. Autophagy is a cellular self-degradation process that plays a crucial role in maintaining metabolic functions in cells and organisms. Dysfunctional autophagy has been linked to various diseases, including canc...

    Authors: Tao Chen, Liying Zheng, Peiyue Luo, Jun Zou, Wei Li, Qi Chen, Junrong Zou and Biao Qian
    Citation: Cell & Bioscience 2024 14:44
  22. The prevalence of Crohn’s disease (CD), a subtype of inflammatory bowel disease (IBD), is increasing worldwide. The pathogenesis of CD is hypothesized to be related to environmental, genetic, immunological, an...

    Authors: Zichen Wang and Jun Shen
    Citation: Cell & Bioscience 2024 14:43
  23. Repeated neonatal sevoflurane exposures led to neurocognitive disorders in young mice. We aimed to assess the role of microglia and complement C1q in sevoflurane-induced neurotoxicity and explore the underlyin...

    Authors: Gang Wang, Hua-yue Liu, Xiao-wen Meng, Ying Chen, Wei-ming Zhao, Wen-ting Li, Han-bing Xu, Ke Peng and Fu-hai Ji
    Citation: Cell & Bioscience 2024 14:42
  24. Mesenchymal stem cells (MSCs) hold immense promise for use in immunomodulation and regenerative medicine. However, their inherent heterogeneity makes it difficult to achieve optimal therapeutic outcomes for a ...

    Authors: Zhiwei Hu, Duanduan Li, Shiduo Wu, Ke Pei, Zeqin Fu, Yulin Yang, Yinfu Huang, Jian Yang, Chuntao Liu, Junyuan Hu, Cheguo Cai and Yan Liao
    Citation: Cell & Bioscience 2024 14:40
  25. Bacterial cancer therapy was first trialled in patients at the end of the nineteenth century. More recently, tumour-targeting bacteria have been harnessed to deliver plasmid-expressed therapeutic interfering R...

    Authors: Jason S. Williams, Adam T. Higgins, Katie J. Stott, Carly Thomas, Lydia Farrell, Cleo S. Bonnet, Severina Peneva, Anna V. Derrick, Trevor Hay, Tianqi Wang, Claire Morgan, Sarah Dwyer, Joshua D’Ambrogio, Catherine Hogan, Matthew J. Smalley, Lee Parry…
    Citation: Cell & Bioscience 2024 14:38
  26. Glioma is a highly heterogeneous brain tumor categorized into World Health Organization (WHO) grades 1–4 based on its malignancy. The suppressive immune microenvironment of glioma contributes significantly to ...

    Authors: Wenshu Tang, Cario W. S. Lo, Wei Ma, Annie T. W. Chu, Amy H. Y. Tong and Brian H. Y. Chung
    Citation: Cell & Bioscience 2024 14:37
  27. Glucose-lowering drug is associated with various cancers, but the causality with gastrointestinal cancer risk is rarely reported. We aimed to explore the causality between them in this Mendelian randomization ...

    Authors: Yi Yang, Bo Chen, Chongming Zheng, Hao Zeng, Junxi Zhou, Yaqing Chen, Qing Su, Jingxian Wang, Juejin Wang, Yurong Wang, Hongli Wang, Ruxue Jin, Zhiyuan Bo, Gang Chen and Yi Wang
    Citation: Cell & Bioscience 2024 14:36
  28. Ubiquitination is a critical post-translational modification which can be reversed with an enzyme family known as deubiquitinating enzymes (DUBs). It has been reported that dysregulation of deubiquitination le...

    Authors: Chen Luo, Yi Yu, Jinfeng Zhu, Leifeng Chen, Dan Li, Xingyu Peng, Zitao Liu, Qing Li, Qing Cao, Kai Huang and Rongfa Yuan
    Citation: Cell & Bioscience 2024 14:35
  29. Malignant mesothelioma is a type of infrequent tumor that is substantially related to asbestos exposure and has a terrible prognosis. We tried to produce a fibroblast differentiation-related gene set for creat...

    Authors: Jun Liu, Yuwei Lu, Yifan Liu, Wei Zhang, Shuyuan Xian, Siqiao Wang, Zixuan Zheng, Ruoyi Lin, Minghao Jin, Mengyi Zhang, Weijin Qian, Jieling Tang, Bingnan Lu, Yiting Yang, Zichang Liu, Mingyu Qu…
    Citation: Cell & Bioscience 2024 14:33
  30. Cancer stem-like capacities are major factors contributing to unfavorable prognosis. However, the associated molecular mechanisms underlying cancer stem-like cells (CSCs) maintain remain unclear. This study ai...

    Authors: Junlong Zhuang, Lingli Zhang, Siyuan Zhang, Zhongqing Zhang, Tianlei Xie, Wei Zhao and Yantao Liu
    Citation: Cell & Bioscience 2024 14:32
  31. Heart failure (HF) is an end-stage of many cardiac diseases and one of the main causes of death worldwide. The current management of this disease remains suboptimal. The adult mammalian heart was considered a ...

    Authors: Rut Bryl, Magdalena Kulus, Artur Bryja, Dominika Domagała, Paul Mozdziak, Paweł Antosik, Dorota Bukowska, Maciej Zabel, Piotr Dzięgiel and Bartosz Kempisty
    Citation: Cell & Bioscience 2024 14:30
  32. PRAME constitutes one of the largest multi-copy gene families in Eutherians, encoding cancer-testis antigens (CTAs) with leucine-rich repeats (LRR) domains, highly expressed in cancer cells and gametogenic ger...

    Authors: Mingyao Yang, Francisco Diaz, Ana Rita T. Krause, Yuguo Lei and Wan-Sheng Liu
    Citation: Cell & Bioscience 2024 14:28
  33. Sodium-Glucose cotransporter 1 and 2 (SGLT1/2) belong to the family of glucose transporters, encoded by SLC5A1 and SLC5A2, respectively. SGLT2 is almost exclusively expressed in the renal proximal convoluted tubu...

    Authors: Yifei Sun, Yihan Zhang, Jifeng Zhang, Y. Eugene Chen, Jian-Ping Jin, Kezhong Zhang, Hongmei Mou, Xiubin Liang and Jie Xu
    Citation: Cell & Bioscience 2024 14:27
  34. Archetypical cross-β spines sharpen the boundary between functional and pathological proteins including β-amyloid, tau, α-synuclein and transthyretin are linked to many debilitating human neurodegenerative and...

    Authors: Karthika Suresh, Eshan Dahal and Aldo Badano
    Citation: Cell & Bioscience 2024 14:26
  35. Patients with cirrhosis have intestinal barrier dysfunction but the role of the individual cell types in human small intestine is unclear. We performed single-nuclear RNA sequencing (snRNAseq) in the pinch bio...

    Authors: Xixian Jiang, Ying Xu, Andrew Fagan, Bhaumik Patel, Huiping Zhou and Jasmohan S. Bajaj
    Citation: Cell & Bioscience 2024 14:25
  36. Vaccination is a valid strategy to prevent and control newly emerging and reemerging infectious diseases in humans and animals. However, synthetic and recombinant antigens are poor immunogenic to stimulate eff...

    Authors: Guangyu Wang, Yongkang Wang and Fang Ma
    Citation: Cell & Bioscience 2024 14:24
  37. Viral infection elicits the type I interferon (IFN-I) response in host cells and subsequently inhibits viral infection through inducing hundreds of IFN-stimulated genes (ISGs) that counteract many steps in the...

    Authors: Qiaomei Cai, Nina Sun, Yurui Zhang, Jingfeng Wang, Chaohu Pan, Yu Chen, Lili Li, Xiaorong Li, Wancheng Liu, Saba R. Aliyari, Heng Yang and Genhong Cheng
    Citation: Cell & Bioscience 2024 14:23
  38. Protein post-translational modifications (PPTMs) refer to a series of chemical modifications that occur after the synthesis of protein. Proteins undergo different modifications such as phosphorylation, acetyla...

    Authors: Wei Li, Hong-Lian Li, Jian-Zhi Wang, Rong Liu and Xiaochuan Wang
    Citation: Cell & Bioscience 2024 14:22
  39. Neovascular eye disease is characterized by pathological neovascularization, with clinical manifestations such as intraocular exudation, bleeding, and scar formation, ultimately leading to blindness in million...

    Authors: Peiyu Liu, Dandan Sun, Shuchang Zhang, Shimei Chen, Xiaoqian Wang, Huiming Li and Fang Wei
    Citation: Cell & Bioscience 2024 14:21
  40. Within the last decade, poly(ADP-ribose) polymerase inhibitors (PARPi) have emerged in the clinic as an effective treatment for numerous malignancies. Preclinical data have demonstrated powerful combination ef...

    Authors: Aaron Sorrin, Anika Dasgupta, Kathryn McNaughton, Carla Arnau Del Valle, Keri Zhou, Cindy Liu, Dana M. Roque and Huang Chiao Huang
    Citation: Cell & Bioscience 2024 14:20
  41. The tumour microenvironment (TME) consists of tumour-supportive immune cells, endothelial cells, and fibroblasts. PhenoCycler, a high-plex single cell spatial biology imaging platform, is used to characterize ...

    Authors: Madelyn J. Abraham, Christophe Goncalves, Paige McCallum, Vrinda Gupta, Samuel E. J. Preston, Fan Huang, Hsiang Chou, Natascha Gagnon, Nathalie A. Johnson, Wilson H. Miller, Koren K. Mann and Sonia V. del Rincon
    Citation: Cell & Bioscience 2024 14:19
  42. The development of alcohol-associated liver disease (ALD) is influenced by the amount and duration of alcohol consumption. The resulting liver damage can range from reversible stages, such as steatosis, steato...

    Authors: Ying-Wei Lan, Wan-Ru Chen, Gary Ro-Lin Chang, Ying-Cheng Chen, Kowit-Yu Chong, Kai-Cheng Chuang, Yung-Tsung Kao, Ming-Shan Chen and Chuan-Mu Chen
    Citation: Cell & Bioscience 2024 14:18