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  1. The expression of Kelch-like protein 18 (KLHL18) in non-small cell lung cancer (NSCLC) is lower than that in normal lung tissue according to the Gene Expression Profiling Interactive Analysis database. KLHL18 ...

    Authors: Xizi Jiang, Yitong XU, Hongjiu Ren, Jun Jiang, Muli Wudu, Qiongzi Wang, Jingqian Guan, Hongbo Su, Yao Zhang, Bo Zhang, Yuanzi Guo, Yujiao Hu, Lihong Jiang, Zongang Liu, Huanxi Wang, Yu Cheng…

    Citation: Cell & Bioscience 2020 10:139

    Content type: Research

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  2. Proliferation markers, such as proliferating cell nuclear antigen (PCNA), Ki-67, and thymidine kinase 1 (TK1), have potential as diagnostic tools and as prognostic factors in assessing cancer treatment and dis...

    Authors: Eliza E. Bitter, Michelle H. Townsend, Rachel Erickson, Carolyn Allen and Kim L. O’Neill

    Citation: Cell & Bioscience 2020 10:138

    Content type: Review

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  3. Macrophages that accumulate in atherosclerotic plaques contribute to progression of the lesions to more advanced and complex plaques. Although iron deposition was found in human atherosclerotic plaques, clinic...

    Authors: Jing Cai, Meng Zhang, Yutong Liu, Huihui Li, Longcheng Shang, Tianze Xu, Zhipeng Chen, Fudi Wang, Tong Qiao and Kuanyu Li

    Citation: Cell & Bioscience 2020 10:137

    Content type: Research

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  4. Epilepsy is characterized by the typical symptom of seizure, and anti-seizure medications are the main therapeutic method in clinical, but the effects of these therapy have not been satisfactory. To find a bet...

    Authors: Zheng Yu, Meiying Zhang, Bin Luo, Hongyang Jing, Yue Yu, Shunqi Wang and Shiwen Luo

    Citation: Cell & Bioscience 2020 10:135

    Content type: Research

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  5. Some chemokine receptors referred to as atypical chemokine receptors (ACKRs) are thought to non-signaling decoys because of their inability to activate typical G-protein signaling pathways. CXCR7, also known a...

    Authors: Huong Thi Nguyen, Arfaxad Reyes-Alcaraz, Hyo Jeong Yong, Lan Phuong Nguyen, Hee-Kyung Park, Asuka Inoue, Cheol Soon Lee, Jae Young Seong and Jong-Ik Hwang

    Citation: Cell & Bioscience 2020 10:134

    Content type: Research

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  6. Colostrum quality is a vital factor in mortality and growth performance for piglets. Lactoferrin is an immuno-active milk protein that contributes to the formation of a protective layer above intestinal mucosa...

    Authors: Xiaosong Han, Yang Gao, Guanglei Li, Youcai Xiong, Changzhi Zhao, Jinxue Ruan, Yunlong Ma, Xinyun Li, Changchun Li, Shuhong Zhao and Shengsong Xie

    Citation: Cell & Bioscience 2020 10:133

    Content type: Letter to the Editor

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  7. Aberration of estrogen (E2) and/or progesterone (P4) signaling pathways affects expression of their target genes, which may lead to failure of embryo implantation and following pregnancy. Although many target gen...

    Authors: Hee Kyoung Park, So Hee Park, Miji Lee, Gyeong Ryeong Kim, Mira Park, Seung Chel Yang, Yeon Sun Kim, Hyunjung J. Lim, Hye-Ryun Kim and Haengseok Song

    Citation: Cell & Bioscience 2020 10:132

    Content type: Research

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  8. Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular degradation, antigen presentation, intracellular pathogen destruc...

    Authors: Tao Tang, Ze-yu Yang, Di Wang, Xian-yan Yang, Jun Wang, Lin Li, Qian Wen, Lei Gao, Xiu-wu Bian and Shi-cang Yu

    Citation: Cell & Bioscience 2020 10:131

    Content type: Review

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  9. Mesenchymal stem cells (MSCs) represent a promising treatment option for acute kidney injury (AKI). The main drawbacks of MSCs therapy, including the lack of specific homing after systemic infusion and early c...

    Authors: Song Zhou, Yu-ming Qiao, Yong-guang Liu, Ding Liu, Jian-min Hu, Jun Liao, Min Li, Ying Guo, Li-pei Fan, Liu-Yang Li and Ming Zhao

    Citation: Cell & Bioscience 2020 10:130

    Content type: Research

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  10. Both testis and ovary can be produced sequentially in an individual with the same genome when sex reversal occurs in the teleost Monopterus albus, and epigenetic modification is supposed to be involved in gonadal...

    Authors: Xin Wang, Fengling Lai, Jun Xiong, Wang Zhu, Bifeng Yuan, Hanhua Cheng and Rongjia Zhou

    Citation: Cell & Bioscience 2020 10:129

    Content type: Research

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  11. The tumor microenvironment (TME) is a complex multicellular functional compartment that includes fibroblasts, myofibroblasts, endothelial cells, immune cells, and extracellular matrix (ECM) elements. The micro...

    Authors: Jie Zhang, Chaoyu Gu, Qianqian Song, Mengqi Zhu, Yuqing Xu, Mingbing Xiao and Wenjie Zheng

    Citation: Cell & Bioscience 2020 10:127

    Content type: Review

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  12. Mesenchymal stem cells (MSCs) isolated from bone marrow have different developmental origins, including neural crest. MSCs can differentiate into neural progenitor-like cells (NPCs) under the influence of bFGF...

    Authors: Amir Ali Khan, Tee Jong Huat, Abdullah Al Mutery, Ahmed Taher El-Serafi, Hassen Hadj Kacem, Sallam Hasan Abdallah, Muhammed Faruque Reza, Jafri Malin Abdullah and Hasnan Jaafar

    Citation: Cell & Bioscience 2020 10:126

    Content type: Research

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  13. Asthma is one of the main intractable diseases recognized by the international medical community. The current widely used bronchodilators for asthma—β2-adrenal receptor agonists—have limited therapeutic effect...

    Authors: Ping Zhao, Jia Liu, Qian Ming, Di Tian, Jingwen He, Ziwei Yang, Jinhua Shen, Qing-Hua Liu and Xinzhou Yang

    Citation: Cell & Bioscience 2020 10:125

    Content type: Research

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  14. Glioblastoma (GBM) is an immunosuppressive, highly vascular and devastating malignant brain tumor. Even with progressive combination treatment that includes surgery, radiotherapy, and chemotherapy, the prognos...

    Authors: Qing Zhang, Junwen Zhang, Yifu Tian, Guidong Zhu, Sisi Liu and Fusheng Liu

    Citation: Cell & Bioscience 2020 10:124

    Content type: Research

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  15. Risk stratifications for endometrial carcinoma (EC) depend on histopathology and molecular pathology. Histopathological risk stratification lacks reproducibility, neglects heterogeneity and contributes little ...

    Authors: Yuan Li, Jiaqi Li, Ensong Guo, Jia Huang, Guangguang Fang, Shaohua Chen, Bin Yang, Yu Fu, Fuxia Li, Zizhuo Wang, Rourou Xiao, Chen Liu, Yuhan Huang, Xue Wu, Funian Lu, Lixin You…

    Citation: Cell & Bioscience 2020 10:122

    Content type: Research

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  16. Acute lung injury (ALI) is a serious disease with highly morbidity and mortality that causes serious health problems worldwide. Atypical mitogen activated protein kinases (MAPKs) play critical roles in the dev...

    Authors: Ling Mao, Ya Zhou, Longqing Chen, Lin Hu, Shiming Liu, Wen Zheng, Juanjuan Zhao, Mengmeng Guo, Chao Chen, Zhixu He and Lin Xu

    Citation: Cell & Bioscience 2020 10:121

    Content type: Research

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  17. Heat shock protein (HSP) 20 is a molecular chaperone that exerts multiple protective functions in various kinds of tissues. However, the expression of HSP20 and its specific functions in airway epithelial cell...

    Authors: Aihua Bao, Aying Ma, Hui Zhang, Lihua Qiao, Suqin Ben, Xin Zhou and Min Zhang

    Citation: Cell & Bioscience 2020 10:120

    Content type: Research

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  18. Alternative splicing (AS), a crucial post-transcriptional regulatory mechanism in expanding the coding capacities of genomes and increasing the diversity of proteins, still faces various challenges in the spli...

    Authors: Nan Zhang, Ping Zhang, Ying Chen, Shifeng Lou, Hanqing Zeng and Jianchuan Deng

    Citation: Cell & Bioscience 2020 10:118

    Content type: Research

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  19. Destruction and death of neurons can lead to neurodegenerative diseases. One possible way to treat neurodegenerative diseases and damage of the nervous system is replacing damaged and dead neurons by cell tran...

    Authors: Ziran Xu, Shengnan Su, Siyan Zhou, Wentao Yang, Xin Deng, Yingying Sun, Lisha Li and Yulin Li

    Citation: Cell & Bioscience 2020 10:116

    Content type: Review

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  20. Thyroid cancer (TC) is the most common type of endocrine malignancy and its incidence is increasing over years. Conventional surgery, radiotherapy and chemotherapy are difficult to improve the significant effe...

    Authors: Guohong Zhao, Jianqin Kang, Guanghui Xu, Jing Wei, Xiaoguang Wang, Xiaorui Jing, Lan Zhang, Aili Yang, Kai Wang, Jue Wang, Li Wang, Junfeng Hou, Qingquan Liu, Kai Jiao and Bin Gao

    Citation: Cell & Bioscience 2020 10:115

    Content type: Research

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  21. Phloretin is isolated from apple trees and could increase lipolysis in 3T3-L1 adipocytes. Previous studies have found that phloretin could prevent obesity in mice. In this study, we investigated whether phlore...

    Authors: Chian-Jiun Liou, Shu-Ju Wu, Szu-Chuan Shen, Li-Chen Chen, Ya-Ling Chen and Wen-Chung Huang

    Citation: Cell & Bioscience 2020 10:114

    Content type: Research

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  22. Angiogenesis is a critical step in the growth of pancreatic neuroendocrine tumors (PNETs) and may be a selective target for PNET therapy. However, PNETs are robustly resistant to current anti-angiogenic therap...

    Authors: Xi Luo, Jiang-yi He, Jie Xu, Shao-yi Hu, Bang-hui Mo, Qiu-xia Shu, Can Chen, Yu-zhu Gong, Xiao-long Zhao, Gan-feng Xie and Song-tao Yu

    Citation: Cell & Bioscience 2020 10:113

    Content type: Research

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  23. Spinal cord injury (SCI) is the damage to the spinal cord that can lead to temporary or permanent loss of function due to injury to the nerve. The SCI patients are often associated with poor quality of life.

    Authors: Ling Ling Liau, Qi Hao Looi, Wui Chuen Chia, Thayaalini Subramaniam, Min Hwei Ng and Jia Xian Law

    Citation: Cell & Bioscience 2020 10:112

    Content type: Review

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  24. Ten-eleven translocation (TET) proteins, encoding dioxygenase for DNA hydroxymethylation, are important players in nervous system development and disease. In addition to their proverbial enzymatic role, TET pr...

    Authors: Ming Zhang, Kaixiang Zhang, Jian Wang, Yuming Liu, Guangxin Liu, Weilin Jin, Shengxi Wu and Xianghui Zhao

    Citation: Cell & Bioscience 2020 10:110

    Content type: Research

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  25. Alzheimer’s disease (AD) is a neurodegenerative disease that leads to progressive loss of memory and dementia. The pathological hallmarks of AD include extracellular accumulation of amyloid-β peptides forming ...

    Authors: Hariharakrishnan Chidambaram, Rashmi Das and Subashchandrabose Chinnathambi

    Citation: Cell & Bioscience 2020 10:109

    Content type: Review

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  26. Fear is an adaptive response across species in the face of threatening cues. It can be either innate or learned through postnatal experience. We have previously shown that genetic deletion of both Rap1a and Ra...

    Authors: Wen-Bing Chen, Han-Qing Pan, Ye He, Xue-Hui Wang, Wen-Hua Zhang and Bing-Xing Pan

    Citation: Cell & Bioscience 2020 10:107

    Content type: Research

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  27. Huntington’s disease (HD) is a neurodegenerative disease that involves a complex combination of psychiatric, cognitive and motor impairments. Synaptic dysfunction has been implicated in HD pathogenesis. Howeve...

    Authors: Li Niu, Li Li, Shiming Yang, Weixi Wang, Cuifang Ye and He Li

    Citation: Cell & Bioscience 2020 10:106

    Content type: Research

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  28. Shwachman-Diamond syndrome (SDS) is a congenital disease that affects the bone marrow, skeletal system, and pancreas. The majority of patients with SDS have mutations in the SBDS gene, involved in ribosome biogen...

    Authors: Ayushi Jain, Phubed Nilatawong, Narinrat Mamak, Laran T. Jensen and Amornrat Naranuntarat Jensen

    Citation: Cell & Bioscience 2020 10:105

    Content type: Research

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  29. Mesenchymal stem cells (MSCs), also referred to as multipotent stromal cells or mesenchymal stromal cells, are present in multiple tissues and capable of differentiating into diverse cell lineages, holding a g...

    Authors: Yizhen Sima and Yisong Chen

    Citation: Cell & Bioscience 2020 10:104

    Content type: Review

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  30. Long bones of limbs are formed through endochondral bone formation, which depends on the coordinated development of growth plates. Our previous studies have demonstrated that dysfunction of mitogen-activated p...

    Authors: Xiaoming Yang, Dongmei Zhong, Wenjie Gao, Zhiheng Liao, Yuyu Chen, Shun Zhang, Hang Zhou, Peiqiang Su and Caixia Xu

    Citation: Cell & Bioscience 2020 10:103

    Content type: Research

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  31. Patients with type 2 diabetes mellitus (T2DM), especially those with poor glycemic control, are characterized by low bone mass and destruction of bone microstructure. Nowadays, autologous mesenchymal stem cell...

    Authors: Lei Wang, Shaojie Shi, Ruiping Bai, Yue Wang, Zhao Guo and Doudou Li

    Citation: Cell & Bioscience 2020 10:102

    Content type: Research

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  32. Autophagy has a crucial role in the defense against parasites. The interplay existing between host autophagy and parasites has varied outcomes due to the kind of host cell and microorganism. The presence of au...

    Authors: George Ghartey-Kwansah, Frank Adu-Nti, Benjamin Aboagye, Amandus Ankobil, Edward Eyipe Essuman, Yeboah Kwaku Opoku, Samuel Abokyi, Emmanuel Kwasi Abu and Johnson Nyarko Boampong

    Citation: Cell & Bioscience 2020 10:101

    Content type: Review

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  33. Ribosomal protein 34 (RPL34) is a highly conserved protein belonging to the 60S large subunit of mammalian ribosomes that has been found to be dysregulated in a variety of human tumors. However, there are limi...

    Authors: Jianxin Qian, Lin Xu, Wenlong Yu, Xiaoqiang Gu, Yongjun Zuo, Ying Chen, Feng Xie and Lixin Wei

    Citation: Cell & Bioscience 2020 10:100

    Content type: Research

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  34. Schwann cells (SCs) play a crucial role in Wallerian degeneration after peripheral nerve injury. The expression of genes in SCs undergo a series of changes, which greatly affect the proliferation and apoptosis...

    Authors: Jiang-Bo Wang, Zhan Zhang, Jian-Nan Li, Tuo Yang, Shuang Du, Rang-Juan Cao and Shu-Sen Cui

    Citation: Cell & Bioscience 2020 10:98

    Content type: Research

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  35. Sex differences are prevalent in normal development, physiology and disease pathogeneses. Recent studies have demonstrated that mosaic loss of Y chromosome and aberrant activation of its genes could modify the...

    Authors: Yun-Fai Chris Lau

    Citation: Cell & Bioscience 2020 10:97

    Content type: Review

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  36. Openers of mitochondrial adenosine triphosphate-dependent potassium (mKATP) channels like diazoxide increase reactive oxygen species (ROS) production in cardiac cells and reduce Ca2+ elevations produced by ischem...

    Authors: Joice T. Gavali, Elba D. Carrillo, María C. García and Jorge A. Sánchez

    Citation: Cell & Bioscience 2020 10:96

    Content type: Research

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  37. Human pyruvate dehydrogenase phosphatase 1 (PDP1) plays an important physiological role in energy metabolism; however, its expression and function in human pancreatic adenocarcinoma (PDAC) remain unknown. This...

    Authors: Ye Li, Jia Shen, Chien-shan Cheng, HuiFeng Gao, Jiangang Zhao and Lianyu Chen

    Citation: Cell & Bioscience 2020 10:95

    Content type: Research

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  38. Gastric cancer (GC) is a malignancy with high morbidity/mortality, partly due to a lack of reliable biomarkers for early diagnosis. It is important to develop reliable biomarker(s) with specificity, sensitivit...

    Authors: Qinghua Liu, Ying Zhang, Jiwei Zhang, Kun Tao, Brett D. Hambly and Shisan Bao

    Citation: Cell & Bioscience 2020 10:94

    Content type: Research

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  39. Cancer stem cells are the main reason of relapse, metastasis and resistance to anti-cancer therapies of Hepatocellular carcinoma (HCC). Mesenchymal stem cells (MSCs) are an important part of the tumor microenv...

    Authors: Jing Hou, Naping Zhao, Pengxi Zhu, Jun Chang, Yan Du and Wei Shen

    Citation: Cell & Bioscience 2020 10:93

    Content type: Research

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  40. Vesicular system of mammalian cells is composed of two intracellular and extracellular vesicles systems, which contributes to the intra/intercellular communication and cellular homeostasis. These systems media...

    Authors: Mehdi Hassanpour, Aysa Rezabakhsh, Jafar Rezaie, Mohammad Nouri and Reza Rahbarghazi

    Citation: Cell & Bioscience 2020 10:92

    Content type: Review

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  41. Arsenic exposure has become a matter of worldwide concern, which is associated with immune-related diseases. However, little is known about its effect on inflammatory immune-related homeostasis. The purpose of...

    Authors: Nan Yan, Guowei Xu, Chenchen Zhang, Xuping Liu, Xin Li, Lin Sun, Da Wang, Xiaoxu Duan and Bing Li

    Citation: Cell & Bioscience 2020 10:91

    Content type: Research

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  42. NF-E2-related factor 2 (Nrf2) is involved in the radiation resistance of esophageal squamous cell carcinoma (ESCC), but the underlying molecular mechanism is unclear. The purpose of our study was to explore th...

    Authors: Di Xia, Xiao-Ran Zhang, Yan-Li Ma, Zhi-Jun Zhao, Ren Zhao and Yan-Yang Wang

    Citation: Cell & Bioscience 2020 10:90

    Content type: Research

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