Articles
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Citation: Cell & Bioscience 2017 7:32
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Kv1.3 channel blocker (ImKTx88) maintains blood–brain barrier in experimental autoimmune encephalomyelitis
Disruption of blood–brain barrier (BBB) and subsequent infiltration of auto-reactive T lymphocytes are major characteristics of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). Kv1....
Citation: Cell & Bioscience 2017 7:31 -
iPSCs are safe!
Induced pluripotent stem cells (iPSCs) hold great promises in cell therapy. However, the potential safety issues have dampened the enthusiasm of their clinical development. One of the biggest concerns came fro...
Citation: Cell & Bioscience 2017 7:30 -
APOBEC3B, a molecular driver of mutagenesis in human cancers
Human cancers results in large part from the accumulation of multiple mutations. The progression of premalignant cells is an evolutionary process in which mutations provide the fundamental driving force for ge...
Citation: Cell & Bioscience 2017 7:29 -
Chloroquine inhibits Ca2+ permeable ion channels-mediated Ca2+ signaling in primary B lymphocytes
Chloroquine, a bitter tastant, inhibits Ca2+ signaling, resulting in suppression of B cell activation; however, the inhibitory mechanism remains unclear.
Citation: Cell & Bioscience 2017 7:28 -
Epigenetic regulation of Runx2 transcription and osteoblast differentiation by nicotinamide phosphoribosyltransferase
Bone degenerative disorders like osteoporosis may be initiated by age-related shifts in anabolic and catabolic responses that control bone homeostasis. Although there are studies suggesting that metabolic chan...
Citation: Cell & Bioscience 2017 7:27 -
Control of gene expression through the nonsense-mediated RNA decay pathway
Nonsense-mediated RNA decay (NMD) was originally discovered as a cellular surveillance pathway that safeguards the quality of mRNA transcripts in eukaryotic cells. In its canonical function, NMD prevents trans...
Citation: Cell & Bioscience 2017 7:26 -
Histone demethylases UTX and JMJD3 are required for NKT cell development in mice
Natural killer (NK)T cells and conventional T cells share phenotypic characteristic however they differ in transcription factor requirements and functional properties. The role of histone modifying enzymes in ...
Citation: Cell & Bioscience 2017 7:25 -
Brothers in arms: emerging roles of RNA epigenetics in DNA damage repair
N6-methyladenosine (m6A) is a widespread posttranscriptional RNA modification that occurs in tRNA, rRNA, snRNA, viral RNAs, and more recently is shown to occur in mRNA in a dynamic, reversible manner. At the epic...
Citation: Cell & Bioscience 2017 7:24 -
Gene expression profiling discerns molecular pathways elicited by ligand signaling to enhance the specification of embryonic stem cells into skeletal muscle lineage
Regulation of lineage specification and differentiation in embryonic stem (ES) cells can be achieved through the activation of endogenous signaling, an avenue for potential application in regenerative medicine...
Citation: Cell & Bioscience 2017 7:23 -
Retrospective analysis in oculocutaneous albinism patients for the 2.7 kb deletion in the OCA2 gene revealed a co-segregation of the controversial variant, p.R305W
Oculocutaneous albinism (OCA) is an autosomal recessive disorder. A significant portion of OCA patients has been found with a single pathogenic variant either in the TYR or the OCA2 gene. Diagnostic sequencing of...
Citation: Cell & Bioscience 2017 7:22 -
Plant genome editing with TALEN and CRISPR
Genome editing promises giant leaps forward in advancing biotechnology, agriculture, and basic research. The process relies on the use of sequence specific nucleases (SSNs) to make DNA double stranded breaks a...
Citation: Cell & Bioscience 2017 7:21 -
Upregulation of heme oxygenase-1 expression by curcumin conferring protection from hydrogen peroxide-induced apoptosis in H9c2 cardiomyoblasts
Curcumin is a major constituent of rhizomes of Curcuma longa that elicits beneficial effects for oxidative damage. The aim of this study was to investigate whether curcumin could attenuate hydrogen peroxide (H2O2
Citation: Cell & Bioscience 2017 7:20 -
Long non-coding RNA MALAT1 contributes to cell apoptosis by sponging miR-124 in Parkinson disease
Parkinson disease (PD) is the most common movement disturbance characterized by the loss of dopaminergic (DA) neurons in midbrain. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is aberrantly ...
Citation: Cell & Bioscience 2017 7:19 -
Large is required for normal astrocyte migration and retinal vasculature development
Persistent fetal vasculature (PFV) is a congenital developmental anomaly of the eye that accounts for about 5% of childhood blindness. The molecular mechanism of PFV remains unclear. As a glycosyltransferase o...
Citation: Cell & Bioscience 2017 7:18 -
The role of GLI1 for 5-Fu resistance in colorectal cancer
Colorectal cancer is a leading cause of cancer-related mortality worldwide, with Fluorouracil (5-FU)-based chemotherapy as the major treatment for advanced disease. Many patients with advanced colorectal cance...
Citation: Cell & Bioscience 2017 7:17 -
Hepatitis B virus promotes cancer cell migration by downregulating miR-340-5p expression to induce STAT3 overexpression
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide, and infection with hepatitis B virus (HBV) is a leading cause of HCC. Previous studies have demonstrated that expre...
Citation: Cell & Bioscience 2017 7:16 -
Phosphorylation of LSD1 by PLK1 promotes its chromatin release during mitosis
Lysine-specific histone demethylase 1 (LSD1) modulates chromatin status through demethylation of H3K4 and H3K9. It has been demonstrated that LSD1 is hyperphosphorylated and dissociates from chromatin during m...
Citation: Cell & Bioscience 2017 7:15 -
microRNA and thyroid hormone signaling in cardiac and skeletal muscle
Thyroid hormone (TH) signaling plays critical roles in the differentiation, growth, metabolism, and physiological function of all organs or tissues, including heart and skeletal muscle. Due to the significant ...
Citation: Cell & Bioscience 2017 7:14 -
New insights on thyroid hormone mediated regulation of herpesvirus infections
Thyroid hormone (T3) has been suggested to participate in the regulation of herpesvirus replication during reactivation. Clinical observations and in vivo experiments suggest that T3 are involved in the suppressi...
Citation: Cell & Bioscience 2017 7:13 -
Mechanism of transcription-coupled DNA modification recognition
As a key enzyme for gene expression, RNA polymerase II (pol II) reads along the DNA template and catalyzes accurate mRNA synthesis during transcription. On the other hand, genomic DNA is under constant attack ...
Citation: Cell & Bioscience 2017 7:9 -
Maintenance of genome stability by Fanconi anemia proteins
Persistent dysregulation of the DNA damage response and repair in cells causes genomic instability. The resulting genetic changes permit alterations in growth and proliferation observed in virtually all cancer...
Citation: Cell & Bioscience 2017 7:8 -
Yeast help identify cytopathic factors of Zika virus
Accumulating evidence implicates Zika virus (ZIKV) in pathogenesis of microcephaly in newborns and Guillain-Barré syndrome in adults. However, it remains unclear which viral proteins are responsible for these ...
Citation: Cell & Bioscience 2017 7:12 -
Comparative analysis of pre- and post-parasitic transcriptomes and mining pioneer effectors of Heterodera avenae
The cereal cyst nematode (CCN, Heterodera avenae) is a devastating pathogen of wheat and barley crops in many countries. We aimed to prioritize genetic and molecular targets for H. avenae control via the powerful...
Citation: Cell & Bioscience 2017 7:11 -
New insights into genome maintenance
Citation: Cell & Bioscience 2017 7:10 -
Hsa-let-7c-5p augments enterovirus 71 replication through viral subversion of cell signaling in rhabdomyosarcoma cells
Human enterovirus 71 (EV71) causes severe hand, foot and mouse disease, accompanied by neurological complications. During the interaction between EV71 and the host, the virus subverts host cell machinery for i...
Citation: Cell & Bioscience 2017 7:7 -
Microhomology-mediated end joining: new players join the team
DNA double-strand breaks (DSBs) are the most deleterious type of DNA damage in cells arising from endogenous and exogenous attacks on the genomic DNA. Timely and properly repair of DSBs is important for genomi...
Citation: Cell & Bioscience 2017 7:6 -
A fission yeast cell-based system for multidrug resistant HIV-1 proteases
HIV-1 protease (PR) is an essential enzyme for viral production. Thus, PR inhibitors (PIs) are the most effective class of anti-HIV drugs. However, the main challenge to the successful use of PI drugs in patie...
Citation: Cell & Bioscience 2017 7:5 -
Identification of target genes for spermatogenic cell-specific KRAB transcription factor ZFP819 in a male germ cell line
Zfp819, a member of the Krüppel-associated box (KRAB) family, encodes a spermatogenic cell-specific transcription factor. Zfp819-overexpression induces apoptosis and inhibits prolifera...
Citation: Cell & Bioscience 2017 7:4 -
Characterization of tubular liquid crystal structure in embryonic stem cell derived embryoid bodies
Massive liquid crystal droplets have been found during embryonic development in more than twenty different tissues and organs, including the liver, brain and kidney. Liquid crystal deposits have also been iden...
Citation: Cell & Bioscience 2017 7:3 -
Ultrastructural changes during osteogenic differentiation in mesenchymal stromal cells cultured in alginate hydrogel
Osteogenic differentiation of mesenchymal stem cells has been extensively investigated with regards to different aspects, including the analysis of cell intracellular and extracellular proteome, cell gene expr...
Citation: Cell & Bioscience 2017 7:2 -
Vincristine alleviates adriamycin-induced nephropathy through stabilizing actin cytoskeleton
Antimicrotubule agent vincristine (VCR) has long been known as an alternative treatment for frequent relapse nephrotic syndrome and steroid-dependent nephrotic syndrome (SDNS). However, the mechanism is unknow...
Citation: Cell & Bioscience 2017 7:1 -
The emerging role of deubiquitinating enzymes in genomic integrity, diseases, and therapeutics
The addition of mono-ubiquitin or poly-ubiquitin chain to signaling proteins in response to DNA damage signal is thought to be a critical event that facilitates the recognition of DNA damage lesion site, the a...
Citation: Cell & Bioscience 2016 6:62 -
Small GTPase Arl6 controls RH30 rhabdomyosarcoma cell growth through ciliogenesis and Hedgehog signaling
Rhabdomyosarcoma (RMS) originates from skeletal muscle precursors that fail to differentiate. Hedgehog (Hh) signaling and primary cilia contribute to the pathobiology of RMS.
Citation: Cell & Bioscience 2016 6:61 -
Targeted genome engineering in Caenorhabditis elegans
The generation of mutants and transgenes are indispensible for biomedical research. In the nematode Caenorhabditis elegans, a series of methods have been developed to introduce genome modifications, including ran...
Citation: Cell & Bioscience 2016 6:60 -
Function and regulation of tau conformations in the development and treatment of traumatic brain injury and neurodegeneration
One of the two common hallmark lesions of Alzheimer’s disease (AD) brains is neurofibrillary tangles (NFTs), which are composed of hyperphosphorylated tau protein (p-tau). NFTs are also a defining feature of o...
Citation: Cell & Bioscience 2016 6:59 -
Downregulation of long non-coding RNA H19 promotes P19CL6 cells proliferation and inhibits apoptosis during late-stage cardiac differentiation via miR-19b-modulated Sox6
Regulating cardiac differentiation to maintain normal heart development and function is very important. At present, biological functions of H19 in cardiac differentiation is not completely clear.
Citation: Cell & Bioscience 2016 6:58 -
One-step immortalization of primary human airway epithelial cells capable of oncogenic transformation
The ability to transform normal human cells into cancer cells with the introduction of defined genetic alterations is a valuable method for understanding the mechanisms of oncogenesis. Easy establishment of im...
Citation: Cell & Bioscience 2016 6:57 -
MAP4K4: an emerging therapeutic target in cancer
The serine/threonine kinase MAP4K4 is a member of the Ste20p (sterile 20 protein) family. MAP4K4 was initially discovered in 1995 as a key kinase in the mating pathway in Saccharomyces cerevisiae and was later fo...
Citation: Cell & Bioscience 2016 6:56 -
Germline mutations of KIT in gastrointestinal stromal tumor (GIST) and mastocytosis
Somatic mutations of KIT are frequently found in mastocytosis and gastrointestinal stromal tumor (GIST), while germline mutations of KIT are rare, and only found in few cases of familial GIST and mastocytosis....
Citation: Cell & Bioscience 2016 6:55 -
Roxarsone induces angiogenesis via PI3K/Akt signaling
3-Nitro-4-hydroxy phenyl arsenic acid, roxarsone, is widely used as an organic arsenic feed additive for livestock and poultry, which may increase the level of arsenic in the environment and the risk of exposu...
Citation: Cell & Bioscience 2016 6:54 -
Anticancer bioactive peptide-3 inhibits human gastric cancer growth by targeting miR-338-5p
Cancer incidence and mortality have been increasing in China, making cancer the leading cause of death since 2010 and a major public health concern in the country. Cancer stem cells have been studied in relati...
Citation: Cell & Bioscience 2016 6:53 -
Thanking cell and bioscience reviewers
Citation: Cell & Bioscience 2016 6:52 -
A new paradigm of DNA synthesis: three-metal-ion catalysis
Enzyme catalysis has been studied for over a century. How it actually occurs has not been visualized until recently. By combining in crystallo reaction and X-ray diffraction analysis of reaction intermediates,...
Citation: Cell & Bioscience 2016 6:51 -
Improved hematopoietic differentiation of human pluripotent stem cells via estrogen receptor signaling pathway
Aside from its importance in reproduction, estrogen (E2) is known to regulate the proliferation and differentiation of hematopoietic stem cells in rodents. However, the regulatory role of E2 in human hematopoi...
Citation: Cell & Bioscience 2016 6:50 -
Analysis of Axin2 expression and function in murine models for pancreatic cancer
The involvement of Wnt in carcinogenesis and progression of pancreatic cancer is currently intensely discussed. We evaluated activation of the Wnt signaling pathway by using a Wnt reporter mouse strain express...
Citation: Cell & Bioscience 2016 6:49 -
EphA5 and EphA6: regulation of neuronal and spine morphology
The Eph family of receptor tyrosine kinases plays important roles in neural development. Previous studies have implicated Eph receptors and their ligands, the ephrins, in neuronal migration, axon bundling and ...
Citation: Cell & Bioscience 2016 6:48 -
Histone acetyl transferase GCN5 promotes human hepatocellular carcinoma progression by enhancing AIB1 expression
General control non-depressible 5 (GCN5) is a crucial catalytic component of a transcriptional regulatory complex that plays important roles in cellular functions from cell cycle regulation to DNA damage repai...
Citation: Cell & Bioscience 2016 6:47 -
Thyroid hormone-mediated autophagy and mitochondrial turnover in NAFLD
Non-alcoholic fatty liver disease (NAFLD) is a fast-growing silent epidemic that is present in both developed and developing countries. Initially thought as a benign deposition of lipids in the liver, it now h...
Citation: Cell & Bioscience 2016 6:46 -
Long noncoding RNAs in DNA methylation: new players stepping into the old game
Long non-coding RNAs (lncRNAs) are being discovered as a novel family of regulators of gene expression at the epigenetic level. Emerging lines of evidence demonstrate that interplays between lncRNAs and DNA me...
Citation: Cell & Bioscience 2016 6:45
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- ISSN: 2045-3701 (electronic)