Fig. 1
From: NF-κB RelA is a cell-intrinsic metabolic checkpoint restricting glycolysis
Critical role of RelA in the SCO2 expression, oxidative phosphorylation utilization and glycolysis restriction of macrophages. A Acidic metabolism of the monocyte/macrophage THP-1 cells by RelA knockdown. B Reduced oxygen consumption in RelA KO macrophages cultured in TCM. C Increased lactate production and ATP generation in RelA KO macrophages cultured in TCM. D Decreased Sco2 expression in RelA KO macrophages cultured in TCM. In B–D, data represent means ± SEM (n = 3). * P < 0.05; ** P < 0.01; Student’s t test