Fig. 6

Functional assessment of gene module and pathways. a Gene module assignment was assessed with WGCNA in EPL (A_SM, B_SM, and C_RM) and ET (D_EA). The color bar labeled as “Gene Module” beneath the dendrogram represents the module assignment of genes. Each color bar represents the correlation of genes with developmental stage. Red indicates that a gene is positively correlated with a developmental stage and therefore tends to be upregulated at this stage, and green indicates that a gene is negatively correlated with a developmental stage and therefore tends to be downregulated at this stage. b Gene set variation analysis (GSVA) showed the top-20 highly enriched pathways, which are associated with human pathological conditions, in the groups of EPL (A_SM, B_SM, C_RM) and ET (D_ET)