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Table 1 Abnormal expression of subunits of human condensins and changes of structure of chromosomes in four types of cellular senescence

From: Explore a novel function of human condensins in cellular senescence

Types of cellular senescence Abnormal expression of subunits of human condensins Changes of structure of chromosomes Number of literature
OIS hCAPH2↑
hCAPH2ΔN↑
SMC2↓, SMC4↓
Formation of senescence-associated heterochromatic foci (SAHF), drives senescence via nuclear/genomic reorganization; strengthen and expand euchromatic A compartments and promote/maintain BA transitions upon senescence [36, 37, 41 (Supplementary Fig. 8)]
RS SMC2↓
SMC4↓
hCAP-D2(NCAPD2)↓
hCAP-D3(NCAPD3)↓
hCAP-G(NCAPG)↓
hCAP-G2(NCAPG2)↓
hCAP-H()(NCAPH)↑, hCAPH2((NCAPH2)↑
SAHF were not detected in RS cells, the sizes of both A and B compartments became significantly enlarged and the numbers of A and B compartments decreased; heterochromatin reorganization to restrain DNA damage and progression of MSC senescence via transcriptionally activating human condensins; telomere shortening [37, 41, 43,44,45, 49 (Supplementary Figure S4)]
SIPS Unpublished   [37, 41, 49]
TIS Unpublished   [37, 41, 49]
  1. “↑” is a symbol as upregulation of expression, “↓” is a symbol as downregulation of expression