Table 1 Abnormal expression of subunits of human condensins and changes of structure of chromosomes in four types of cellular senescence

OIS

hCAPH2↑

hCAPH2ΔN↑

SMC2↓, SMC4↓

Formation of senescence-associated heterochromatic foci (SAHF), drives senescence via nuclear/genomic reorganization; strengthen and expand euchromatic A compartments and promote/maintain BA transitions upon senescence

[36, 37, 41 (Supplementary Fig. 8)]

RS

SMC2↓

SMC4↓

hCAP-D2(NCAPD2)↓

hCAP-D3(NCAPD3)↓

hCAP-G(NCAPG)↓

hCAP-G2(NCAPG2)↓

hCAP-H()(NCAPH)↑, hCAPH2((NCAPH2)↑

SAHF were not detected in RS cells, the sizes of both A and B compartments became significantly enlarged and the numbers of A and B compartments decreased; heterochromatin reorganization to restrain DNA damage and progression of MSC senescence via transcriptionally activating human condensins; telomere shortening

[37, 41, 43,44,45, 49 (Supplementary Figure S4)]

SIPS

Unpublished

[37, 41, 49]

TIS

Unpublished

[37, 41, 49]