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Fig. 4 | Cell & Bioscience

Fig. 4

From: PRC1 promotes GLI1-dependent osteopontin expression in association with the Wnt/β-catenin signaling pathway and aggravates liver fibrosis

Fig. 4

Knockdown of PRC1 attenuated LF progression. a The effect of tail vein injection of Ad-shPRC1 on plasma levels of AST and ATL in mice liver tissues. **Represents LF + Ad-shNC vs. Sham, p < 0.01. ##LF + Ad-shPRC1 vs. LF + Ad-shNC, p < 0.01. b Masson staining of liver tissues from Sham mice and LF mice injected with Ad-shNC or Ad-shPRC1. c Quantitative analysis of liver Hyp content from Sham mice and LF mice injected with Ad-shNC or Ad-shPRC1. **Represents LF + Ad-shNC vs. Sham, p < 0.01. ##LF + Ad-shPRC1 vs. LF + Ad-shNC, p < 0.01. d mRNA expression of PRC1 in liver tissues from Sham mice and LF mice injected with Ad-shNC or Ad-shPRC1. **Represents LF + Ad-shNC vs. Sham, p < 0.01. ##LF + Ad-shPRC1 vs. LF + Ad-shNC, p < 0.01. e Immunohistochemistry analysis of PRC1 in in liver tissues from Sham mice and LF mice injected with Ad-shNC or Ad-shPRC1. f Proteins expression of α-SMA, type I collagen, PRC1, GLI1 and osteopontin of liver tissues from Sham mice and LF mice injected with Ad-shNC or Ad-shPRC1. **Represents LF + Ad-shNC vs. Sham, p < 0.01. ##LF + Ad-shPRC1 vs. LF + Ad-shNC, p < 0.01

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Cell & Bioscience

ISSN: 2045-3701

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