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Table 2 Common protein components of exosomes

From: Exosomes: biogenesis, biologic function and clinical potential

Protein category and description Examples
Tetraspanins CD9, CD63, CD81, CD82, CD37, CD53
Heat shock proteins (HSP) HSP90, HSP70, HSP27, HSP60
Cell adhesion Integrins, Lactadherin, Intercellular Adhesion Molecule 1
Antigen presentation Human leukocyte antigen class I and II/peptide complexes
Multivesicular body Biogenesis Tsg101, Alix, Vps, Rab proteins
Membrane transport Lysosomal-associated membrane protein 1/2, CD13, PG regulatory-like protein
Signaling proteins GTPase HRas, Ras-related protein, furloss, extracellular signal-regulated kinase, Src homology 2 domain phosphatase, GDP dissociation inhibitor, Syntenin-1, 14-3-3 Proteins, Transforming protein RhoA
Cytoskeleton components Actins, Cofilin-1, Moesin, Myosin, Tubulins, Erzin, Radixin, Vimentin
Transcription and protein synthesis Histone1, 2, 3, Ribosomal proteins, Ubiquitin, major vault protein, Complement factor 3
Metabolic enzymes Fatty acid synthase Glyceraldehyde-3-phosphate dehydrogenase Phosphoglycerate kinase 1 Phosphoglycerate mutase 1 Pyruvate kinase isozymes M1/M2 ATP citrate lyase ATPase Glucose-6-phosphate isomerase Peroxiredoxin 1 Aspartate aminotransferase Aldehyde reductase
Trafficking and membrane fusion Ras-related protein 5, 7 Annexins I, II, IV, V, VI Synaptosomal-associated protein Dynamin, Syntaxin-3
Antiapoptosis Alix, Thioredoxine, Peroxidase
Growth factors and cytokine Tumor Necrosis Factor (TNF)-α, TNF Receptors, Transforming growth factor-β
Death receptors FasL, TNF-related apoptosis inducing ligand
Iron transport Transferrin receptor
References [18, 99, 129, 130]