The expanding functions of thyroid hormone
© The Author(s) 2017
Received: 1 September 2017
Accepted: 1 September 2017
Published: 19 October 2017
Thyroid hormone (TH) exerts a pleiotropic action on most, if not all, cell types, ranging from the regulation of development, metabolism, and neuronal signaling [1–3]. More than 50 years ago Jamshed Tata first reported that the response to TH involved transcriptional changes in the cell . It is clear now that this transcriptional effect, also termed genomic action, is primarily mediated by the nuclear thyroid hormone receptor (TR) . Accumulative studies indicate that TR regulates target gene expression through a diverse group of accessory proteins collectively termed corepressors and coactivators.
Besides the genomic actions through TR, TH can also act through non-genomic pathways . The non-genomic actions have been shown to involve binding of TH to membrane receptors, to membrane bound protein kinases, or to extranuclear TRs. For example, the rapid TH effect on cardiac cells appears to involve TR-mediated activation of phosphoinositide 3-kinase in the cytosol and binding of TH to the membrane receptor, integrin αVβ3, which in turn activates a MAPK signaling cascade .
Within the general themes of genomic and non-genomic actions of TH, the recent progresses in three new areas for TH actions are reviewed in this thematic series. First, Ying et al. sum up how TH regulates microRNA expression and how microRNAs can fine tune TH function in cardiac and skeletal muscle . Second, Yen et al. focus on the function and molecular mechanisms by which TH regulates autophagy and mitochondrial turnover and the implications for non-alcoholic fatty liver disease (NAFLD) . Third, Hsia et al. provides new insights on TH-mediated regulation of herpes virus infections through non-genomic action . It is our sincere hope that this thematic series brings our readers some of the new breakthroughs and developments in the field of TH action.
JH and SVH discussed and wrote the editorial together. Both authors read and approved the final manuscript.
The authors declare that they have no competing interests.
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- Mullur R, Liu YY, Brent GA. Thyroid hormone regulation of metabolism. Physiol Rev. 2014;94:355–82.View ArticlePubMedPubMed CentralGoogle Scholar
- Ng L, Kelley MW, Forrest D. Making sense with thyroid hormone—the role of T(3) in auditory development. Nat Rev Endocrinol. 2013;9:296–307.View ArticlePubMedGoogle Scholar
- Ortiga-Carvalho TM, Sidhaye AR, Wondisford FE. Thyroid hormone receptors and resistance to thyroid hormone disorders. Nat Rev Endocrinol. 2014;10:582–91.View ArticlePubMedPubMed CentralGoogle Scholar
- Tata JR. The road to nuclear receptors of thyroid hormone. Biochim Biophys Acta. 2013;1830:3860–6.View ArticlePubMedGoogle Scholar
- Brent GA. Mechanisms of thyroid hormone action. J Clin Invest. 2012;122:3035–43.View ArticlePubMedPubMed CentralGoogle Scholar
- Davis PJ, Goglia F, Leonard JL. Nongenomic actions of thyroid hormone. Nat Rev Endocrinol. 2016;12:111–21.PubMedGoogle Scholar
- Zhang D, Li Y, Liu S, Wang YC, Guo F, Zhai Q, Jiang J, Ying H. microRNA and thyroid hormone signaling in cardiac and skeletal muscle. Cell Biosci. 2017;7:14.View ArticlePubMedPubMed CentralGoogle Scholar
- Sinha RA, Yen PM. Thyroid hormone-mediated autophagy and mitochondrial turnover in NAFLD. Cell Biosci. 2016;6:46.View ArticlePubMedPubMed CentralGoogle Scholar
- Figliozzi RW, Chen F, Hsia SV. New insights on thyroid hormone mediated regulation of herpesvirus infections. Cell Biosci. 2017;7:13.View ArticlePubMedPubMed CentralGoogle Scholar