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Figure 2 | Cell & Bioscience

Figure 2

From: Complex roles of filamin-A mediated cytoskeleton network in cancer progression

Figure 2

Schematic presentation of filamin-A functions. Through the interactions with its binding partners, filamin-A is endowed with versatile cellular functions, including maintenance of dynamic F-actin networks and regulating cell shape; mediating the communication between cytoskeleton and ECM; acting as a scaffold for cell signaling to regulate cell motility; facilitating intracellular trafficking and promoting membrane protein recycling; regulating RNA transcription through interactions with transcriptional factors and RNA polymerase machinery; modulating nuclear receptor signaling through the binding with androgen receptor; and mediating DNA damage response through interactions with BRCA1, BRCA2

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