Drews G, Krippeit-Drews P, Dufer M: Oxidative stress and beta-cell dysfunction. Pflugers Arch. 2010, 460: 703-718. 10.1007/s00424-010-0862-9
Article
CAS
PubMed
Google Scholar
Kim HS, Lee MS: Role of innate immunity in triggering and tuning of autoimmune diabetes. Curr Mol Med. 2009, 9: 30-44. 10.2174/156652409787314471
Article
CAS
PubMed
Google Scholar
Thomas HE, McKenzie MD, Angstetra E, Campbell PD, Kay TW: Beta cell apoptosis in diabetes. Apoptosis. 2009, 14: 1389-1404. 10.1007/s10495-009-0339-5
Article
PubMed
Google Scholar
Araki E, Oyadomari S, Mori M: Impact of endoplasmic reticulum stress pathway on pancreatic beta-cells and diabetes mellitus. Exp Biol Med (Maywood). 2003, 228: 1213-1217.
CAS
Google Scholar
Sivitz WI, Yorek MA: Mitochondrial dysfunction in diabetes: from molecular mechanisms to functional significance and therapeutic opportunities. Antioxid Redox Signal. 2010, 12: 537-577. 10.1089/ars.2009.2531
Article
PubMed Central
CAS
PubMed
Google Scholar
Schattenberg JM, Worns MA, Zimmermann T, He YW, Galle PR, Schuchmann M: The role of death effector domain (DED)-containing proteins in acute oxidative cell injury in hepatocytes. Free Radic Biol Med. 2012, 52 (9): 1911-7. 10.1016/j.freeradbiomed.2012.02.049
Article
PubMed Central
CAS
PubMed
Google Scholar
Das J, Sil PC: Taurine ameliorates alloxan-induced diabetic renal injury, oxidative stress-related signaling pathways and apoptosis in rats. Amino Acids [Epub ahead of print]. 2012.
Low FM, Hampton MB, Winterbourn CC: Peroxiredoxin 2 and peroxide metabolism in the erythrocyte. Antioxid Redox Signal. 2008, 10: 1621-1630. 10.1089/ars.2008.2081
Article
CAS
PubMed
Google Scholar
Gehrmann W, Elsner M, Lenzen S: Role of metabolically generated reactive oxygen species for lipotoxicity in pancreatic beta-cells. Diabetes Obes Metab. 2010, 12 Suppl 2: 149-158.
Article
CAS
PubMed
Google Scholar
Lenzen S, Drinkgern J, Tiedge M: Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radic Biol Med. 1996, 20: 463-466. 10.1016/0891-5849(96)02051-5
Article
CAS
PubMed
Google Scholar
Szabadkai G, Duchen MR: Mitochondria mediated cell death in diabetes. Apoptosis. 2009, 14: 1405-1423. 10.1007/s10495-009-0363-5
Article
CAS
PubMed
Google Scholar
Bonner-Weir S: Life and death of the pancreatic beta cells. Trends Endocrinol Metab. 2000, 11: 375-378. 10.1016/S1043-2760(00)00305-2
Article
CAS
PubMed
Google Scholar
Dudek NL, Thomas HE, Mariana L, Sutherland RM, Allison J, Estella E, Angstetra E, Trapani JA, Santamaria P, Lew AM, Kay TW: Cytotoxic T-cells from T-cell receptor transgenic NOD8.3 mice destroy beta-cells via the perforin and Fas pathways. Diabetes. 2006, 55: 2412-2418. 10.2337/db06-0109
Article
CAS
PubMed
Google Scholar
Eizirik DL, Mandrup-Poulsen T: A choice of death–the signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia. 2001, 44: 2115-2133. 10.1007/s001250100021
Article
CAS
PubMed
Google Scholar
Schonfeld P, Wojtczak L: Fatty acids as modulators of the cellular production of reactive oxygen species. Free Radic Biol Med. 2008, 45: 231-241. 10.1016/j.freeradbiomed.2008.04.029
Article
PubMed
Google Scholar
Tjälve H: Streptozotocin: distribution, metabolism and mechanisms of action. Uppsala J Med Sci Suppl. 1983, 39: 145-157.
Google Scholar
Ishrat T, Khan MB, Hoda MN, Yousuf S, Ahmad M, Ansari MA, Ahmad AS, Islam F: Coenzyme Q10 modulates cognitive impairment against intracerebroventricular injection of streptozotocin in rats. Behav Brain Res. 2006, 171: 9-16. 10.1016/j.bbr.2006.03.009
Article
CAS
PubMed
Google Scholar
Nukatsuka M, Sakurai H, Yoshimura Y, Nishida M, Kawada J: Enhancement by streptozotocin of O2- radical generation by the xanthine oxidase system of pancreatic beta-cells. FEBS Lett. 1988, 239: 295-298. 10.1016/0014-5793(88)80938-4
Article
CAS
PubMed
Google Scholar
Takasu N, Komiya I, Asawa T, Nagasawa Y, Yamada T: Streptozocin- and alloxan-induced H2O2 generation and DNA fragmentation in pancreatic islets. H2O2 as mediator for DNA fragmentation. Diabetes. 1991, 40: 1141-1145. 10.2337/diabetes.40.9.1141
Article
CAS
PubMed
Google Scholar
Nukatsuka M, Sakurai H, Yoshimura Y, Nishida M, Kawada J: Enhancement by streptozotocin of O2- radical generation by the xanthine oxidase system of pancreatic beta-cells. FEBS Lett. 1988, 239: 295-298. 10.1016/0014-5793(88)80938-4
Article
CAS
PubMed
Google Scholar
Chae HZ, Kim IH, Kim K, Rhee SG: Cloning, sequencing, and mutation of thiol-specific antioxidant gene of Saccharomyces cerevisiae. J Biol Chem. 1993, 268: 16815-16821.
CAS
PubMed
Google Scholar
Robinson MW, Hutchinson AT, Dalton JP, Donnelly S: Peroxiredoxin: a central player in immune modulation. Parasite Immunol. 2010, 32: 305-313. 10.1111/j.1365-3024.2010.01201.x
Article
CAS
PubMed
Google Scholar
Zhang B, Wang Y, Su Y: Peroxiredoxins, a novel target in cancer radiotherapy. Cancer Lett. 2009, 286: 154-160. 10.1016/j.canlet.2009.04.043
Article
CAS
PubMed
Google Scholar
ten Berge D, Brouwer A, Korving J, Reijnen MJ, van Raaij EJ, Verbeek F, Gaffield W, Meijlink F: Prx1 and Prx2 are upstream regulators of sonic hedgehog and control cell proliferation during mandibular arch morphogenesis. Development. 2001, 128: 2929-2938.
CAS
PubMed
Google Scholar
Yan Y, Sabharwal P, Rao M, Sockanathan S: The antioxidant enzyme Prdx1 controls neuronal differentiation by thiol-redox-dependent activation of GDE2. Cell. 2009, 138: 1209-1221. 10.1016/j.cell.2009.06.042
Article
PubMed Central
CAS
PubMed
Google Scholar
Kang SW, Chae HZ, Seo MS, Kim K, Baines IC, Rhee SG: Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-alpha. J Biol Chem. 1998, 273: 6297-6302. 10.1074/jbc.273.11.6297
Article
CAS
PubMed
Google Scholar
Yang S, Luo A, Hao X, Lai Z, Ding T, Ma X, Mayinuer M, Shen W, Wang X, Lu Y, Ma D, Wang S: Peroxiredoxin 2 Inhibits Granulosa Cell Apoptosis During Follicle Atresia Through the NFKB Pathway in Mice. Biol Reprod. 2011, 84 (6): 1182-9. 10.1095/biolreprod.110.087569
Article
CAS
PubMed
Google Scholar
Chen J, Gan Y, Ji X, Hu X, Luo Y, Zhang L, Li P, Liu X, Yan F, Vosler P, Gao Y, Stetler RA: Transgenic overexpression of peroxiredoxin-2 attenuates ischemic neuronal injury via suppression of a redox-sensitive pro-death signaling pathway. Antioxid Redox Signal [Epub ahead of print]. 2012.
Hu X, Weng Z, Chu CT, Zhang L, Cao G, Gao Y, Signore A, Zhu J, Hastings T, Greenamyre JT, Chen J: Peroxiredoxin-2 protects against 6-hydroxydopamine-induced dopaminergic neurodegeneration via attenuation of the apoptosis signal-regulating kinase (ASK1) signaling cascade. J Neurosci. 2011, 31: 247-261. 10.1523/JNEUROSCI.4589-10.2011
Article
PubMed Central
CAS
PubMed
Google Scholar
Su AI, Wiltshire T, Batalov S, Lapp H, Ching KA, Block D, Zhang J, Soden R, Hayakawa M, Kreiman G, Cooke MP, Walker JR, Hogenesch JB: A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci U S A. 2004, 101: 6062-6067. %20. 10.1073/pnas.0400782101
Article
PubMed Central
CAS
PubMed
Google Scholar
Matte A, Low PS, Turrini F, Bertoldi M, Campanella ME, Spano D, Pantaleo A, Siciliano A, De FL: Peroxiredoxin-2 expression is increased in beta-thalassemic mouse red cells but is displaced from the membrane as a marker of oxidative stress. Free Radic Biol Med. 2010, 49: 457-466. 10.1016/j.freeradbiomed.2010.05.003
Article
PubMed Central
CAS
PubMed
Google Scholar
Meier JJ: Beta cell mass in diabetes: a realistic therapeutic target?. Diabetologia. 2008, 51: 703-713. 10.1007/s00125-008-0936-9
Article
CAS
PubMed
Google Scholar
Wang Q, Jin T: The role of insulin signaling in the development of beta-cell dysfunction and diabetes. Islets. 2009, 1: 95-101. 10.4161/isl.1.2.9263
Article
PubMed
Google Scholar
Lee MS, Chang I, Kim S: Death effectors of beta-cell apoptosis in type 1 diabetes. Mol Genet Metab. 2004, 83: 82-92. 10.1016/j.ymgme.2004.08.002
Article
CAS
PubMed
Google Scholar
Haskins K, Bradley B, Powers K, Fadok V, Flores S, Ling X, Pugazhenthi S, Reusch J, Kench J: Oxidative stress in type 1 diabetes. Ann N Y Acad Sci. 2003, 1005: 43-54. 10.1196/annals.1288.006
Article
CAS
PubMed
Google Scholar
Sakuraba H, Mizukami H, Yagihashi N, Wada R, Hanyu C, Yagihashi S: Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients. Diabetologia. 2002, 45: 85-96. 10.1007/s125-002-8248-z
Article
CAS
PubMed
Google Scholar
Bast A, Wolf G, Oberbaumer I, Walther R: Oxidative and nitrosative stress induces peroxiredoxins in pancreatic beta cells. Diabetologia. 2002, 45: 867-876. 10.1007/s00125-002-0846-1
Article
CAS
PubMed
Google Scholar
Ortis F, Pirot P, Naamane N, Kreins AY, Rasschaert J, Moore F, Theatre E, Verhaeghe C, Magnusson NE, Chariot A, Orntoft TF, Eizirik DL: Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells. Diabetologia. 2008, 51: 1213-1225. 10.1007/s00125-008-0999-7
Article
CAS
PubMed
Google Scholar
Igoillo-Esteve M, Marselli L, Cunha DA, Ladriere L, Ortis F, Grieco FA, Dotta F, Weir GC, Marchetti P, Eizirik DL, Cnop M: Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes. Diabetologia. 2010, 53: 1395-1405. 10.1007/s00125-010-1707-y
Article
CAS
PubMed
Google Scholar
Han YH, Kwon JH, Yu DY, Moon EY: Inhibitory effect of peroxiredoxin II (Prx II) on Ras-ERK-NFkappaB pathway in mouse embryonic fibroblast (MEF) senescence. Free Radic Res. 2006, 40: 1182-1189. 10.1080/10715760600868552
Article
CAS
PubMed
Google Scholar
Wolf G, Aumann N, Michalska M, Bast A, Sonnemann J, Beck JF, Lendeckel U, Newsholme P, Walther R: Peroxiredoxin III protects pancreatic β-cells from apoptosis. J Endocrinol. 2010, 207: 163-175. 10.1677/JOE-09-0455
Article
CAS
PubMed
Google Scholar
Aktan F: iNOS-mediated nitric oxide production and its regulation. Life Sci. 2004, 75: 639-653. 10.1016/j.lfs.2003.10.042
Article
CAS
PubMed
Google Scholar
Hynes SO, McCabe C, O'Brien T: beta cell protection by inhibition of iNOS through lentiviral vector-based strategies. Methods Mol Biol. 2011, 704: 153-168. 10.1007/978-1-61737-964-2_12
Article
CAS
PubMed
Google Scholar
Tiedge M, Lortz S, Drinkgern J, Lenzen S: Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells. Diabetes. 1997, 46: 1733-1742. 10.2337/diabetes.46.11.1733
Article
CAS
PubMed
Google Scholar
Cnop M: Fatty acids and glucolipotoxicity in the pathogenesis of Type 2 diabetes. Biochem Soc Trans. 2008, 36: 348-352. 10.1042/BST0360348
Article
CAS
PubMed
Google Scholar
Giacca A, Xiao C, Oprescu AI, Carpentier AC, Lewis GF: Lipid-induced pancreatic beta-cell dysfunction: focus on in vivo studies. Am J Physiol Endocrinol Metab. 2011, 300: E255-E262. 10.1152/ajpendo.00416.2010
Article
CAS
PubMed
Google Scholar
Lang F, Ullrich S, Gulbins E: Ceramide formation as a target in beta-cell survival and function. Expert Opin Ther Targets. 2011, 15: 1061-1071. 10.1517/14728222.2011.588209
Article
CAS
PubMed
Google Scholar
Higa M, Shimabukuro M, Shimajiri Y, Takasu N, Shinjyo T, Inaba T: Protein kinase B/Akt signalling is required for palmitate-induced beta-cell lipotoxicity. Diabetes Obes Metab. 2006, 8: 228-233. 10.1111/j.1463-1326.2005.00488.x
Article
CAS
PubMed
Google Scholar
Shimabukuro M, Ohneda M, Lee Y, Unger RH: Role of nitric oxide in obesity-induced beta cell disease. J Clin Invest. 1997, 100: 290-295. 10.1172/JCI119534
Article
PubMed Central
CAS
PubMed
Google Scholar
Saitoh Y, Chun-ping C, Noma K, Ueno H, Mizuta M, Nakazato M: Pioglitazone attenuates fatty acid-induced oxidative stress and apoptosis in pancreatic beta-cells. Diabetes Obes Metab. 2008, 10: 564-573. 10.1111/j.1463-1326.2007.00749.x
Article
CAS
PubMed
Google Scholar
Zhang N, Kumar M, Xu G, Ju W, Yoon T, Xu E, Huang X, Gaisano H, Peng C, Wang Q: Activin receptor-like kinase 7 induces apoptosis of pancreatic beta cells and beta cell lines. Diabetologia. 2006, 49: 506-518. 10.1007/s00125-005-0095-1
Article
CAS
PubMed
Google Scholar
Xu E, Kumar M, Zhang Y, Ju W, Obata T, Zhang N, Liu S, Wendt A, Deng S, Ebina Y, Wheeler MB, Braun M, Wang Q: Intra-islet insulin suppresses glucagon release via GABA-GABAA receptor system. Cell Metab. 2006, 3: 47-58. 10.1016/j.cmet.2005.11.015
Article
CAS
PubMed
Google Scholar
Zhang N, Kumar M, Xu G, Ju W, Yoon T, Xu E, Huang X, Gaisano H, Peng C, Wang Q: Activin receptor-like kinase 7 induces apoptosis of pancreatic beta cells and beta cell lines. Diabetologia. 2006, 49: 506-518. 10.1007/s00125-005-0095-1
Article
CAS
PubMed
Google Scholar
Xu E, Kumar M, Zhang Y, Ju W, Obata T, Zhang N, Liu S, Wendt A, Deng S, Ebina Y, Wheeler MB, Braun M, Wang Q: Intra-islet insulin suppresses glucagon release via GABA-GABAA receptor system. Cell Metab. 2006, 3: 47-58. 10.1016/j.cmet.2005.11.015
Article
CAS
PubMed
Google Scholar
Wang Q, Chen K, Liu R, Zhao F, Gupta S, Zhang N, Prud'homme GJ: Novel GLP-1 fusion chimera as potent long acting GLP-1 receptor agonist. PLoS One. 2010, 5: e12734. 10.1371/journal.pone.0012734
Article
PubMed Central
PubMed
Google Scholar