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  1. Merkel cell carcinoma (MCC) is a relatively new addition to the expanding category of oncovirus-induced cancers. Although still comparably rare, the number of cases has risen dramatically in recent years. Furt...

    Authors: Bianca P Gomez, Connie Wang, Raphael P Viscidi, Shiwen Peng, Liangmei He, T-C Wu and Chien-Fu Hung

    Citation: Cell & Bioscience 2012 2:36

    Content type: Research

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  2. Cell and Bioscience is on track to receive its first Impact Factor in mid-2013. What is the role of the Impact Factor as a measure of a journal’s success?

    Authors: Kuan-Teh Jeang

    Citation: Cell & Bioscience 2012 2:35

    Content type: Editorial

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  3. After liver injury, the repair process comprises activation and proliferation of hepatic stellate cells (HSCs), which produce extracellular matrix (ECM) proteins. Peroxisome proliferator-activated receptor bet...

    Authors: Radina Kostadinova, Alexandra Montagner, Erwan Gouranton, Sébastien Fleury, Hervé Guillou, David Dombrowicz, Pierre Desreumaux and Walter Wahli

    Citation: Cell & Bioscience 2012 2:34

    Content type: Research

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  4. Nuclear receptors are a family of ligand-activated, DNA sequence-specific transcription factors that regulate various aspects of animal development, cell proliferation, differentiation, and homeostasis. The ph...

    Authors: Simran Khurana, Leslie A Bruggeman and Hung-Ying Kao

    Citation: Cell & Bioscience 2012 2:33

    Content type: Review

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  5. Golgi phosphoprotein 2 (GOLPH2, also termed GP73 and GOLM1) is a type II transmembrane protein residing in the cis and medial-Golgi cisternae. GOLPH2 is predominantly expressed in the epithelial cells of many ...

    Authors: Ha-Jeong Kim, Dandan Lv, Yan Zhang, Tao Peng and Xiaojing Ma

    Citation: Cell & Bioscience 2012 2:31

    Content type: Review

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  6. Hypoxia is associated with many disease conditions in humans, such as cancer, stroke and traumatic injuries. Hypoxia elicits broad molecular and cellular changes in diverse eukaryotes. Our recent studies sugge...

    Authors: Ranita Ghosh Dastidar, Jagmohan Hooda, Ajit Shah, Thai M Cao, Robert Michael Henke and Li Zhang

    Citation: Cell & Bioscience 2012 2:30

    Content type: Research

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  7. The Wnt signaling pathway was initially discovered for its role in tumorigenesis and the development of Drosophila and other eukaryotic organisms. The key effector of this pathway, the bipartite transcription fac...

    Authors: Wilfred Ip, Yu-ting Alex Chiang and Tianru Jin

    Citation: Cell & Bioscience 2012 2:28

    Content type: Review

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  8. During normal development primordial germ cells (PGCs) derived from the epiblast are the precursors of spermatogonia and oogonia. In culture, PGCs can be induced to dedifferentiate to pluripotent embryonic ger...

    Authors: Lu Wang, Jinping Cao, Ping Ji, Di Zhang, Lianghong Ma, Martin Dym, Zhuo Yu and Lixin Feng

    Citation: Cell & Bioscience 2012 2:27

    Content type: Research

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  9. Thyroid hormone (T3) is important for adult organ function and vertebrate development. Amphibian metamorphosis is totally dependent on T3 and offers a unique opportunity to study how T3 controls postembryonic ...

    Authors: Kazuo Matsuura, Kenta Fujimoto, Biswajit Das, Liezhen Fu, Christopher D Lu and Yun-Bo Shi

    Citation: Cell & Bioscience 2012 2:25

    Content type: Research

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  10. Phosphatases are important regulators of intracellular signaling events, and their functions have been implicated in many biological processes. Dual-specificity phosphatases (DUSPs), whose family currently con...

    Authors: Ching-Yu Huang and Tse-Hua Tan

    Citation: Cell & Bioscience 2012 2:24

    Content type: Review

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  11. PDLIM2 is essential for the termination of the inflammatory transcription factors NF-κB and STAT but is dispensable for the development of immune cells and immune tissues/organs. Currently, it remains unknown ...

    Authors: Zhaoxia Qu, Jing Fu, Huihui Ma, Jingjiao Zhou, Meihua Jin, Markus Y Mapara, Michael J Grusby and Gutian Xiao

    Citation: Cell & Bioscience 2012 2:23

    Content type: Research

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  12. Mutations in LMNA encoding lamins A and C are associated with at least 10 different degenerative disorders affecting diverse tissues, collectively called laminopathies. A recent study showed that mis-accumulation...

    Authors: Baohua Liu, Dong-Yan Jin and Zhongjun Zhou

    Citation: Cell & Bioscience 2012 2:21

    Content type: Research highlight

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  13. Wounding following whole-body γ-irradiation (radiation combined injury, RCI) increases mortality. Wounding-induced increases in radiation mortality are triggered by sustained activation of inducible nitric oxi...

    Authors: Juliann G Kiang, Bradley R Garrison, True M Burns, Min Zhai, Ian C Dews, Patrick H Ney, Lynnette H Cary, Risaku Fukumoto, Thomas B Elliott and G David Ledney

    Citation: Cell & Bioscience 2012 2:20

    Content type: Research

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  14. Glucocorticoids are steroid hormones that play critical and complex roles in the regulation of triglyceride (TG) homeostasis. Depending on physiological states, glucocorticoids can modulate both TG synthesis a...

    Authors: Jen-Chywan Wang, Nora E Gray, Taiyi Kuo and Charles A Harris

    Citation: Cell & Bioscience 2012 2:19

    Content type: Review

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  15. Caenorhabditis elegans sarcomeres have been studied extensively utilizing both forward and reverse genetic techniques to provide insight into muscle development and the mechanisms behind muscle contraction. A pre...

    Authors: Qian Liu, Takako I Jones, Rebecca A Bachmann, Mitchell Meghpara, Lauren Rogowski, Benjamin D Williams and Peter L Jones

    Citation: Cell & Bioscience 2012 2:18

    Content type: Research

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  16. Cell signaling mediated by morphogens is essential to coordinate growth and patterning, two key processes that govern the formation of a complex multi-cellular organism. During growth and patterning, cells are...

    Authors: Yingzi Yang

    Citation: Cell & Bioscience 2012 2:14

    Content type: Review

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  17. A novel, cancer-fighting function was recently discovered for Sm ad u biquitination r egulatory f actor 2 (Smurf2).

    Authors: Keji Zhao and Yun-Bo Shi

    Citation: Cell & Bioscience 2012 2:10

    Content type: Research highlight

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  18. TGF-β signaling regulates diverse cellular processes, including cell proliferation, differentiation, apoptosis, cell plasticity and migration. Its dysfunctions can result in various kinds of diseases, such as ...

    Authors: Fei Huang and Ye-Guang Chen

    Citation: Cell & Bioscience 2012 2:9

    Content type: Review

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  19. Germline mutations of the BRCA1 tumor suppressor gene are a major cause of familial breast and ovarian cancer. BRCA1 plays critical roles in the DNA damage response that regulates activities of multiple repair an...

    Authors: Bin Wang

    Citation: Cell & Bioscience 2012 2:6

    Content type: Review

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  20. The structural maintenance of chromosomes (Smc) proteins regulate nearly all aspects of chromosome biology and are critical for genomic stability. In eukaryotes, six Smc proteins form three heterodimers--Smc1/...

    Authors: Nan Wu and Hongtao Yu

    Citation: Cell & Bioscience 2012 2:5

    Content type: Review

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  21. The TGFβ and Ras-MAPK pathways play critical roles in cell development and cell cycle regulation, as well as in tumor formation and metastasis. In the absence of cellular transformation, these pathways operate...

    Authors: Douglas A Chapnick, Lisa Warner, Jennifer Bernet, Timsi Rao and Xuedong Liu

    Citation: Cell & Bioscience 2011 1:42

    Content type: Review

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  22. Smad proteins are classified in different groups based on their functions in mediating transforming growth factor β (TGFβ) superfamily components. Smad1/5/8 mainly mediate bone morphogenetic proteins (BMP) pat...

    Authors: Gangwen Han and Xiao-Jing Wang

    Citation: Cell & Bioscience 2011 1:41

    Content type: Review

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  23. It remains unclear whether retroviruses can encode and express an intragenomic microRNA (miRNA). Some have suggested that processing by the Drosha and Dicer enzymes might preclude the viability of a replicatin...

    Authors: Zachary Klase, Laurent Houzet and Kuan-Teh Jeang

    Citation: Cell & Bioscience 2011 1:38

    Content type: Research

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  24. Brown adipose tissue in mammals plays a critical role in maintaining energy balance by thermogenesis, which means dissipating energy in the form of heat. It is held that in mammals, long-term surplus food inta...

    Authors: Xuan Yao, Shifang Shan, Ying Zhang and Hao Ying

    Citation: Cell & Bioscience 2011 1:35

    Content type: Review

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  25. Cancer cells possess unique metabolic phenotypes that are determined by their underlying oncogenic pathways. Activation of the PI3K/Akt/mTOR signaling cascade promotes glycolysis and leads to glucose-dependenc...

    Authors: Xiuyun Jiang, Heidi L Kenerson and Raymond S Yeung

    Citation: Cell & Bioscience 2011 1:34

    Content type: Research

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  26. Despite detailed in vivo knowledge of glycolytic enolases and many bacterial non-enolase members of the superfamily, little is known about the in vivo function of vertebrate non-enolase enolase superfamily member...

    Authors: Steve Finckbeiner, Pin-Joe Ko, Blake Carrington, Raman Sood, Kenneth Gross, Bruce Dolnick, Janice Sufrin and Paul Liu

    Citation: Cell & Bioscience 2011 1:32

    Content type: Research

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