Fig. 6
From: Ivermectin increases striatal cholinergic activity to facilitate dopamine terminal function
IVM increases DA release with L-DOPA. A Representative traces of single pulse electrical evoked DA release in the DS comparing pre-treatment ACSF (black), L-DOPA (blue) and L-DOPA + IVM (purple). Separate experiments showed the IVM increases DA release (ACSF: black, IVM: red). B Representative color plots of DA release with pre-treatment ACSF (first), L-DOPA (second), L-DOPA + IVM (third), and IVM (fourth). C L-DOPA and L-DOPA + IVM significantly increases single pulse DA release compared to ACSF pre-treatment levels. D L-DOPA + IVM significantly decreases the normalized 20 Hz 5 pulse ratio compared to ACSF pre-treatment, while L-DOPA alone and IVM alone have no effect. Asterisks *,**,***(grey) indicate significance levels p < 0.05, p < 0.01, and p < 0.001, respectively compared to ACSF pre-treatment. Asterisks ***(purple) indicate significance levels p < 0.001 compared to L-DOPA + IVM. Asterisks *(red) indicate significance levels p < 0.05 compared to IVM