Fig. 5
From: Ivermectin increases striatal cholinergic activity to facilitate dopamine terminal function
IVM effect on DA release is through nAChRs. A Representative traces of single pulse electrical evoked DA release in the DS with HEX (purple) and HEX + IVM (maroon) compared to ACSF pre-treatment (black). Separate experiments showed the IVM increases DA release (ACSF: black, IVM: red). B Time course of single pulse DA release showing HEX induced decreases in DA release which is not rescued by concurrent IVM application. C Hexamethonium, and HEX + IVM decrease single pulse DA release compared to pre-treatment ACSF levels and to IVM, which increases single pulse DA release. D Hexamethonium and HEX + IVM increase the 20 Hz 5 pulse ratio compared to ACSF pre-treatment. E Both HEX and HEX + IVM show increased DA release in response to high frequency, 5 pulse stimulations compared to ACSF pre-treatment. F Overall frequency response as measured by AUC. Asterisks *,**,***(grey) indicate significance levels p < 0.05, p < 0.01, and p < 0.001, respectively compared to ACSF pre-treatment. Asterisks ***(red) indicate significance levels p < 0.001 compared to IVM