Fig. 3
From: Ivermectin increases striatal cholinergic activity to facilitate dopamine terminal function
IVM attenuation of nicotine effects is not through P2X4 receptors. A Representative traces of single pulse electrically evoked DA release in the DS. Nicotine (NIC) alone decreases single pulse DA release. B Representative traces of evoked DA release at multiple frequencies. Nicotine alone increases release with 20 Hz 5 pulse stimulation compared to co-application with IVM or IVM and 5-BDBD. C Nicotine decreases single pulse DA release while IVM + NIC, and IVM + NIC + 5-BDBD have no effect on single pulse DA release compared to ACSF pre-treatment. D Nicotine alone increases the 20 Hz 5 pulse ratio compared to ACSF, IVM + NIC, and IVM + NIC + 5-BDBD. E Nicotine alone shows increased DA release in response to high frequency, 5 pulse stimulations, with AUC represented in F. Asterisks **(grey) indicate significance levels p < 0.01 compared to ACSF pre-treatment. Asterisks **(orange) indicate significance levels p < 0.01 compared to IVM + NIC treatment. Asterisks ***(brown) indicate significance levels p < 0.001 compared to IVM + NIC + 5-BDBD. Asterisks ***(black) indicate significance levels p < 0.001 compared to all other treatments