Fig. 2
From: Ivermectin increases striatal cholinergic activity to facilitate dopamine terminal function
IVM attenuates nicotine effects on DA release. A Representative traces of electrically evoked DA release in the DS at multiple frequencies. Comparing nicotine (NIC) and IVM + NIC, each trace is normalized to 1 pulse release (dotted line). B Representative traces of DS DA release at multiple frequencies comparing ACSF and IVM. Each trace is normalized to 1 pulse release (dotted line). C Ivermectin increases single pulse DA release while NIC decreases DA release. Ivermectin attenuates the effect of NIC on single pulse dopamine release. D Nicotine alone increases the 20 Hz 5 pulse ratio compared to ACSF, IVM, and IVM + NIC. E Nicotine alone shows increased DA release in response to high frequency, 5 pulse stimulations, with AUC represented in F. Asterisks *,**(grey) indicate significance levels p < 0.05 and p < 0.01 respectively compared to ACSF pre-treatment. Asterisks *,***(green) indicate significance levels p < 0.05 and p < 0.001 respectively compared to nicotine treatment. Asterisks ***(black) indicate significance levels p < 0.001 compared to all other treatments