Fig. 9

RCS estimated the dose–response relationships between Klotho and 95% CIs of biomarkers in CKD population. The model was fully adjusted for sex, age, race, educational attainment, BMI, smoking status, CVD, DM and hypertension. RCS, restricted cubic spline; 95% CI, 95% confidence interval; Blue solid line, beta value; Blue dot, the median level of Klotho; Black dashed line, reference level; Red dashed line, Klotho 1000 pg/ml level; Blue shade, 95% CI