Fig. 3

Immune cell infiltration analysis in CKD tubulointerstitium. A, C The percentage of 22 immune cells for each sample of GSE104954 and GSE108112. B Comparison of the proportion of each immune cell in the tubulointerstitium between Control and CKD groups. D Correlation between Klotho gene expression and the percentage of each immune cell of each sample in GSE104954 (CKD) and GSE108112 (CKD). The width of the band represented the correlation coefficient R in the chord diagram. The red band represented a positive correlation; the green band represented a negative correlation. The color of the upper outer band represented the P-value. The correlation was tested by Spearman correlation analysis. R represented correlation coefficient. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001