Fig. 2

Klotho gene expression is predominantly negatively associated with the inflammatory response in CKD tubulointerstitium. A-D The top 5 biological processes (BP), cellular components (CC), molecular functions (MF), and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were mostly related to the Klotho gene in the GSE104954 (CKD). E-H The top 5 biological processes (BP), cellular components (CC), molecular functions (MF), and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were mostly related to the Klotho gene in the GSE108112 (CKD). I, J The heatmaps showed Klotho gene expression and enrichment scores of inflammatory response functions of each patient in the GSE104954 (CKD) and GSE108112 (CKD). The samples were arranged in ascending order of Klotho gene expression. The bar and point line plots on the right showed the correlation coefficient R and P-value of the Spearman correlation analysis