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Table 1 Reported specific activities

From: Cellular and molecular mechanisms of aspartoacylase and its role in Canavan disease

Reported activity

Assay

Source

References

1185 μmol/h/mg ASPA

Malate dehydrogenase

Bovine brain

[57]

3 μmol/h/mg ASPA

Aspartase-coupled

E. coli

[49]a

 ~ 3 μmol/h/mg ASPA

TLC

Rat kidney

[26]b

600–900 μmol/h/mg ASPA

Aspartase-coupled

P. pastoris

[46]c

300 μmol/h/mg ASPA

HPLC

E. coli

[60]b

450 μmol/h/mg ASPA

Aspartase-coupled

P. pastoris

[63]c

  1. aSame specific activity was observed for mouse and human ASPA.
  2. bActivities were obtained as estimates from figure graphs.
  3. cNo unit definition included; we assumed 1 U to be 1 μmol/min
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Cell & Bioscience

ISSN: 2045-3701

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