Table 1 The novel role of SRC-1 in promoting various tumor progression

Breast

SRC-3

—

Interacting with ER to regulate the core genes of breast cancer progression

[58, 59]

Cyclin D1

—

Cyclin D1 serves as a bridging factor between ER and SRC-1

[60]

Ets2

c-Myc, MMP9, HER2, CSF-1

Interacting with Ets2 to upregulate target gene expression

[61, 68,69,70]

HOXC11

S100beta

Collaborate with HOXC11 to promote S100beta expression

[63]

—

ADAM22

Promoting steroid resistance by upregulating ADAM22 expression

[62]

Methylation factor complex

NR2F2, NTRK2, SETBP1, CTDP1, POU3F2

Promoting endocrine resistance through an epigenetics reprogramming pathway

[64]

STAT1

SMAD2, ASCL1, NFIA, E2F7

Binding with STAT1 to promote its transcriptional activity

[65]

Ets1/2

HER2

Ets1/2 upregulates HER2 expression by recruiting SRC-1

[67].

c-Fos

CSF-1

SRC-1 and c-Fos can be recruited to the functional AP-1 site in the CSF-1 promoter

[71]

c-Fos, HIF1α

VEGFa

Combining and recruiting the AP-1 site or HIF1α-binding element of VEGFa promoter

[72]

PEA3

Twist, N-cadherin, vimentin

Collaborating with PEA3 to promote Twist expression to regulate target genes

[73]

AP-1

ITGA5

Collaborating with AP-1 to promote transcriptional activity of ITGA5

[74]

STAT3

Leptin mediated genes

Interacting with the STAT3 activation domain to enhance its signal transduction

[75].

Prostate Cancer

AR, Androgen, IL-6, MAPK

AR-regulated genes

Enhancing the transactivation of AR

[76,77,78]

AR

PSA

Promoting the proliferation of prostate cancer cells by regulating PSA

[79, 80]

RORγ

AR-regulated genes

Be recruited to AR-ROR response elements by RORγ

[82]

Endometrial cancer

—

Mig-6

SRC-1 is reduced in endometrial cancer tissue

[97, 98]

Ovarian cancer

ERα, Estrogens

c-Myc

c-Myc is downregulated in SRC-1-deficient cells

[99]

Meningioma

Progesterone, PR

PR-regulated genes

SRC-1 is expressed in the tissues of meningioma patients

[88]

Astrocytoma

Progesterone, PR

VEGF

VEGF downregulated in SRC-1 deficient cells

[89, 91].

Estradiol, ERα

—

Promoting estradiol induced astrocytoma cell growth

[92]

Glioblastoma

bFGF, PEA3

VEGF, MMP9

Enhancing bFGF or PEA3 mediated angiogenesis

[93]

XIST/mi-152

KLF4

Promoting KLF4 expression and cell glioma of glioblastoma

[94]

Liver cancer

β-catenin

c-Myc, PCNA

Interacting with β-catenin directly to enhance Wnt/β-catenin signaling

[83, 84]

miR-105-1

—

miR-105-1 negatively regulates the mRNA level of SRC-1

[85]

Colorectal cancer

miR-4443

—

miR-4443 negatively regulates the mRNA level of SRC-1

[86]

GLI2

cyclin D1, Bcl-2, Slug, N-cadherin, Vimentin

Enhancing Hedgehog signaling by directly binding to the zinc finger domain of GLI2

[16]

Melanoma

HOXC11

S100beta

Collaborating with HOXC11 to promote S100beta expression

[100]

Thyroid cancer

NF-κB

VEGFC

Combining with NF-κB to form a coactivating complex that directly promotes VEGFC transcription

[101, 102]