Fig. 6
From: The multifaceted therapeutic value of targeting steroid receptor coactivator-1 in tumorigenesis
The potential role of SRC-1 in promoting the progression of liver and colorectal cancer. SRC-1 promotes the expression of c-Myc and PCNA by enhancing Wnt/β-catenin signalling, and miR-105-1 negatively regulates SRC-1 by binding to the 3’-UTR of SRC-1 mRNA in HCC. Similarly, SRC-1 promotes CRC progression by promoting the transcription of GLI2 target genes, and miR-4443 inhibits CRC cell proliferation and invasion through the negative regulation of SRC-1