Fig. 5
From: The multifaceted therapeutic value of targeting steroid receptor coactivator-1 in tumorigenesis
Potential mechanisms by which SRC-1 promotes prostate cancer progression. SRC-1 participates in androgen-induced AR activation and the regulation of several oncogenes related to prostate cancer progression. IL-6 can modulate AR-independent activation of SRC-1 and promote SRC-1 phosphorylation and nuclear transport by stimulating the MAPK pathway. RORγ can recruit SRC-1 to the AR-ROR response element to promote the transcriptional activity of AR-regulated genes