Fig. 3
From: The multifaceted therapeutic value of targeting steroid receptor coactivator-1 in tumorigenesis
The role of SRC-1 in promoting various biological and pathological processes. SRC-1 has various biological functions and serves as a coactivator for various genes that regulatemetabolic homeostasis, food intake, learning/memory, parturition, and tumorigenesis. SRC-1 is recognized as a coactivator of PPARγ, NR2F6, PGC-1α, and acetyltransferase and participates in the regulation of genes involved in lipid metabolism and adipocyte differentiation. SRC-1 transactivates pyruvate carboxylase by elevating the expression of C/EBPα and regulates both glucose and NAD+/NADH homeostasis, thus participating in the Warburg effect. SRC-1 promotes leptin-mediated STAT3 depolarization and Pomc expression, participating in regulating food intake. In the brain, SRC-1 regulates ER-mediated induction of PR-related gene expression and plays a key role in regulating hippocampal synaptic plasticity and spatial learning and memory. Additionally, SRC-1 promotes parturition by regulating the expression of several genes, including SP-A, partner genes of NF-κb activation, PGF2α, and Il13ra2