Fig. 2
From: The multifaceted therapeutic value of targeting steroid receptor coactivator-1 in tumorigenesis
The pattern of SRC-1 coactivation. The classical pattern is that SRC-1 serves as a coactivator in a nuclear receptor-dependent, non-DNA binding manner; SRC-1 induces structural changes in nuclear receptors and recruits CBP/P300, PRMT1, and CARM1 to form a transcriptional complex. The emerging model is that SRC-1 directly binds to TFs and co-recruits to the target gene promoter to promote target gene transcription